LOCUS       NM_182925               5833 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens fms related receptor tyrosine kinase 4 (FLT4),
            transcript variant 1, mRNA.
ACCESSION   NM_182925
VERSION     NM_182925.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5833)
  AUTHORS   Zhang,Y., Dong,X., Zhang,J., Zhao,M., Wang,J., Chu,J., Yang,Z.,
            Ma,S., Lin,K., Sun,H. and Luo,Z.
  TITLE     FLT4 gene polymorphisms influence isolated ventricular septal
            defect predisposition in a Southwest China population
  JOURNAL   BMC Med Genomics 17 (1), 197 (2024)
   PUBMED   39107825
  REMARK    GeneRIF: FLT4 gene polymorphisms influence isolated ventricular
            septal defect predisposition in a Southwest China population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5833)
  AUTHORS   Schmidt,A., Hrupka,B., van Bebber,F., Sunil Kumar,S., Feng,X.,
            Tschirner,S.K., Assfalg,M., Muller,S.A., Hilger,L.S., Hofmann,L.I.,
            Pigoni,M., Jocher,G., Voytyuk,I., Self,E.L., Ito,M., Hyakkoku,K.,
            Yoshimura,A., Horiguchi,N., Feederle,R., De Strooper,B.,
            Schulte-Merker,S., Lammert,E., Moechars,D., Schmid,B. and
            Lichtenthaler,S.F.
  TITLE     The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and
            modulates its signaling
  JOURNAL   J Clin Invest 134 (16), e170550 (2024)
   PUBMED   38888964
  REMARK    GeneRIF: The Alzheimer's disease-linked protease BACE2 cleaves
            VEGFR3 and modulates its signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5833)
  AUTHORS   Fournier,E., Dubreuil,P., Birnbaum,D. and Borg,J.P.
  TITLE     Mutation at tyrosine residue 1337 abrogates ligand-dependent
            transforming capacity of the FLT4 receptor
  JOURNAL   Oncogene 11 (5), 921-931 (1995)
   PUBMED   7675451
REFERENCE   4  (bases 1 to 5833)
  AUTHORS   Borg,J.P., deLapeyriere,O., Noguchi,T., Rottapel,R., Dubreuil,P.
            and Birnbaum,D.
  TITLE     Biochemical characterization of two isoforms of FLT4, a VEGF
            receptor-related tyrosine kinase
  JOURNAL   Oncogene 10 (5), 973-984 (1995)
   PUBMED   7898938
REFERENCE   5  (bases 1 to 5833)
  AUTHORS   Pajusola,K., Aprelikova,O., Armstrong,E., Morris,S. and Alitalo,K.
  TITLE     Two human FLT4 receptor tyrosine kinase isoforms with distinct
            carboxy terminal tails are produced by alternative processing of
            primary transcripts
  JOURNAL   Oncogene 8 (11), 2931-2937 (1993)
   PUBMED   7692369
REFERENCE   6  (bases 1 to 5833)
  AUTHORS   Galland,F., Karamysheva,A., Pebusque,M.J., Borg,J.P., Rottapel,R.,
            Dubreuil,P., Rosnet,O. and Birnbaum,D.
  TITLE     The FLT4 gene encodes a transmembrane tyrosine kinase related to
            the vascular endothelial growth factor receptor
  JOURNAL   Oncogene 8 (5), 1233-1240 (1993)
   PUBMED   8386825
REFERENCE   7  (bases 1 to 5833)
  AUTHORS   Van Zanten,M., Mansour,S., Ostergaard,P., Mortimer,P. and Gordon,K.
  TITLE     Milroy Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301417
REFERENCE   8  (bases 1 to 5833)
  AUTHORS   Pajusola,K., Aprelikova,O., Korhonen,J., Kaipainen,A.,
            Pertovaara,L., Alitalo,R. and Alitalo,K.
  TITLE     FLT4 receptor tyrosine kinase contains seven immunoglobulin-like
            loops and is expressed in multiple human tissues and cell lines
  JOURNAL   Cancer Res 52 (20), 5738-5743 (1992)
   PUBMED   1327515
  REMARK    Erratum:[Cancer Res 1993 Aug 15;53(16):3845]
REFERENCE   9  (bases 1 to 5833)
  AUTHORS   Galland,F., Karamysheva,A., Mattei,M.G., Rosnet,O., Marchetto,S.
            and Birnbaum,D.
  TITLE     Chromosomal localization of FLT4, a novel receptor-type tyrosine
            kinase gene
  JOURNAL   Genomics 13 (2), 475-478 (1992)
   PUBMED   1319394
REFERENCE   10 (bases 1 to 5833)
  AUTHORS   Aprelikova,O., Pajusola,K., Partanen,J., Armstrong,E., Alitalo,R.,
            Bailey,S.K., McMahon,J., Wasmuth,J., Huebner,K. and Alitalo,K.
  TITLE     FLT4, a novel class III receptor tyrosine kinase in chromosome
            5q33-qter
  JOURNAL   Cancer Res 52 (3), 746-748 (1992)
   PUBMED   1310071
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB455035.2, AY233383.1,
            X68203.1 and AC122714.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_182925.4.
            
            Summary: This gene encodes a tyrosine kinase receptor for vascular
            endothelial growth factors C and D. The protein is thought to be
            involved in lymphangiogenesis and maintenance of the lymphatic
            endothelium. Mutations in this gene cause hereditary lymphedema
            type IA. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY233383.1, SRR11853559.27248.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261937.11/ ENSP00000261937.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                DB455035.2         25-59
            36-125              AY233383.1         1-90
            126-3252            X68203.1           90-3216
            3253-3435           AY233383.1         3218-3400
            3436-3948           X68203.1           3400-3912
            3949-4347           AY233383.1         3914-4312
            4348-5833           AC122714.2         90981-92466         c
FEATURES             Location/Qualifiers
     source          1..5833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..5833
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /note="fms related receptor tyrosine kinase 4"
                     /db_xref="GeneID:2324"
                     /db_xref="HGNC:HGNC:3767"
                     /db_xref="MIM:136352"
     exon            1..113
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..4147
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; vascular endothelial growth factor receptor 3;
                     VEGF receptor-3; Feline McDonough Sarcoma (FMS)-like
                     tyrosine kinase 4; fms related tyrosine kinase 4; primary
                     congenital lymphedema; fms-like tyrosine kinase 4;
                     tyrosine-protein kinase receptor FLT4"
                     /codon_start=1
                     /product="vascular endothelial growth factor receptor 3
                     isoform 1 precursor"
                     /protein_id="NP_891555.2"
                     /db_xref="CCDS:CCDS4457.1"
                     /db_xref="GeneID:2324"
                     /db_xref="HGNC:HGNC:3767"
                     /db_xref="MIM:136352"
                     /translation="MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTG
                     DSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVH
                     ANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLV
                     SIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSN
                     PFLVHITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERG
                     KWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFIS
                     VEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEA
                     STGTYTLALWNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGV
                     PLPLSIQWHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWT
                     EFVEGKNKTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSE
                     ELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASL
                     EEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQ
                     NLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVRE
                     EDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFC
                     NMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAF
                     GKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLG
                     ACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRR
                     RPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLAS
                     RKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFD
                     KVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRR
                     IMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFSQVST
                     MALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTP
                     TTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFSCKGPGQNVAVTRAHPDSQGRRR
                     RPERGARGGQVFYNSEYGELSEPSEEDHCSPSARVTFFTDNSY"
     exon            114..210
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            211..455
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            456..568
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            569..731
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            732..871
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1040
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1158
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1313
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1476
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1603
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1712
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..2075
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2222
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2354
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2461
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2597
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2702
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2816
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2905
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3056
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3151
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3274
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3275..3386
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3486
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3592
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3741
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3742..3862
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3863..3948
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..5833
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5785..5790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /note="hexamer: AACAAG"
     regulatory      5798..5803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /note="hexamer: AATAAA"
     polyA_site      5808
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
     polyA_site      5833
                     /gene="FLT4"
                     /gene_synonym="CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL;
                     VEGFR-3; VEGFR3"
                     /note="major polyA site"
ORIGIN      
        1 actttcagcc ccgagccgcg gccgctcggg tcggacccac gcgcagcggc cggagatgca
       61 gcggggcgcc gcgctgtgcc tgcgactgtg gctctgcctg ggactcctgg acggcctggt
      121 gagtggctac tccatgaccc ccccgacctt gaacatcacg gaggagtcac acgtcatcga
      181 caccggtgac agcctgtcca tctcctgcag gggacagcac cccctcgagt gggcttggcc
      241 aggagctcag gaggcgccag ccaccggaga caaggacagc gaggacacgg gggtggtgcg
      301 agactgcgag ggcacagacg ccaggcccta ctgcaaggtg ttgctgctgc acgaggtaca
      361 tgccaacgac acaggcagct acgtctgcta ctacaagtac atcaaggcac gcatcgaggg
      421 caccacggcc gccagctcct acgtgttcgt gagagacttt gagcagccat tcatcaacaa
      481 gcctgacacg ctcttggtca acaggaagga cgccatgtgg gtgccctgtc tggtgtccat
      541 ccccggcctc aatgtcacgc tgcgctcgca aagctcggtg ctgtggccag acgggcagga
      601 ggtggtgtgg gatgaccggc ggggcatgct cgtgtccacg ccactgctgc acgatgccct
      661 gtacctgcag tgcgagacca cctggggaga ccaggacttc ctttccaacc ccttcctggt
      721 gcacatcaca ggcaacgagc tctatgacat ccagctgttg cccaggaagt cgctggagct
      781 gctggtaggg gagaagctgg tcctgaactg caccgtgtgg gctgagttta actcaggtgt
      841 cacctttgac tgggactacc cagggaagca ggcagagcgg ggtaagtggg tgcccgagcg
      901 acgctcccag cagacccaca cagaactctc cagcatcctg accatccaca acgtcagcca
      961 gcacgacctg ggctcgtatg tgtgcaaggc caacaacggc atccagcgat ttcgggagag
     1021 caccgaggtc attgtgcatg aaaatccctt catcagcgtc gagtggctca aaggacccat
     1081 cctggaggcc acggcaggag acgagctggt gaagctgccc gtgaagctgg cagcgtaccc
     1141 cccgcccgag ttccagtggt acaaggatgg aaaggcactg tccgggcgcc acagtccaca
     1201 tgccctggtg ctcaaggagg tgacagaggc cagcacaggc acctacaccc tcgccctgtg
     1261 gaactccgct gctggcctga ggcgcaacat cagcctggag ctggtggtga atgtgccccc
     1321 ccagatacat gagaaggagg cctcctcccc cagcatctac tcgcgtcaca gccgccaggc
     1381 cctcacctgc acggcctacg gggtgcccct gcctctcagc atccagtggc actggcggcc
     1441 ctggacaccc tgcaagatgt ttgcccagcg tagtctccgg cggcggcagc agcaagacct
     1501 catgccacag tgccgtgact ggagggcggt gaccacgcag gatgccgtga accccatcga
     1561 gagcctggac acctggaccg agtttgtgga gggaaagaat aagactgtga gcaagctggt
     1621 gatccagaat gccaacgtgt ctgccatgta caagtgtgtg gtctccaaca aggtgggcca
     1681 ggatgagcgg ctcatctact tctatgtgac caccatcccc gacggcttca ccatcgaatc
     1741 caagccatcc gaggagctac tagagggcca gccggtgctc ctgagctgcc aagccgacag
     1801 ctacaagtac gagcatctgc gctggtaccg cctcaacctg tccacgctgc acgatgcgca
     1861 cgggaacccg cttctgctcg actgcaagaa cgtgcatctg ttcgccaccc ctctggccgc
     1921 cagcctggag gaggtggcac ctggggcgcg ccacgccacg ctcagcctga gtatcccccg
     1981 cgtcgcgccc gagcacgagg gccactatgt gtgcgaagtg caagaccggc gcagccatga
     2041 caagcactgc cacaagaagt acctgtcggt gcaggccctg gaagcccctc ggctcacgca
     2101 gaacttgacc gacctcctgg tgaacgtgag cgactcgctg gagatgcagt gcttggtggc
     2161 cggagcgcac gcgcccagca tcgtgtggta caaagacgag aggctgctgg aggaaaagtc
     2221 tggagtcgac ttggcggact ccaaccagaa gctgagcatc cagcgcgtgc gcgaggagga
     2281 tgcgggacgc tatctgtgca gcgtgtgcaa cgccaagggc tgcgtcaact cctccgccag
     2341 cgtggccgtg gaaggctccg aggataaggg cagcatggag atcgtgatcc ttgtcggtac
     2401 cggcgtcatc gctgtcttct tctgggtcct cctcctcctc atcttctgta acatgaggag
     2461 gccggcccac gcagacatca agacgggcta cctgtccatc atcatggacc ccggggaggt
     2521 gcctctggag gagcaatgcg aatacctgtc ctacgatgcc agccagtggg aattcccccg
     2581 agagcggctg cacctgggga gagtgctcgg ctacggcgcc ttcgggaagg tggtggaagc
     2641 ctccgctttc ggcatccaca agggcagcag ctgtgacacc gtggccgtga aaatgctgaa
     2701 agagggcgcc acggccagcg agcaccgcgc gctgatgtcg gagctcaaga tcctcattca
     2761 catcggcaac cacctcaacg tggtcaacct cctcggggcg tgcaccaagc cgcagggccc
     2821 cctcatggtg atcgtggagt tctgcaagta cggcaacctc tccaacttcc tgcgcgccaa
     2881 gcgggacgcc ttcagcccct gcgcggagaa gtctcccgag cagcgcggac gcttccgcgc
     2941 catggtggag ctcgccaggc tggatcggag gcggccgggg agcagcgaca gggtcctctt
     3001 cgcgcggttc tcgaagaccg agggcggagc gaggcgggct tctccagacc aagaagctga
     3061 ggacctgtgg ctgagcccgc tgaccatgga agatcttgtc tgctacagct tccaggtggc
     3121 cagagggatg gagttcctgg cttcccgaaa gtgcatccac agagacctgg ctgctcggaa
     3181 cattctgctg tcggaaagcg acgtggtgaa gatctgtgac tttggccttg cccgggacat
     3241 ctacaaagac cccgactacg tccgcaaggg cagtgcccgg ctgcccctga agtggatggc
     3301 ccctgaaagc atcttcgaca aggtgtacac cacgcagagt gacgtgtggt cctttggggt
     3361 gcttctctgg gagatcttct ctctgggggc ctccccgtac cctggggtgc agatcaatga
     3421 ggagttctgc cagcggctga gagacggcac aaggatgagg gccccggagc tggccactcc
     3481 cgccatacgc cgcatcatgc tgaactgctg gtccggagac cccaaggcga gacctgcatt
     3541 ctcggagctg gtggagatcc tgggggacct gctccagggc aggggcctgc aagaggaaga
     3601 ggaggtctgc atggccccgc gcagctctca gagctcagaa gagggcagct tctcgcaggt
     3661 gtccaccatg gccctacaca tcgcccaggc tgacgctgag gacagcccgc caagcctgca
     3721 gcgccacagc ctggccgcca ggtattacaa ctgggtgtcc tttcccgggt gcctggccag
     3781 aggggctgag acccgtggtt cctccaggat gaagacattt gaggaattcc ccatgacccc
     3841 aacgacctac aaaggctctg tggacaacca gacagacagt gggatggtgc tggcctcgga
     3901 ggagtttgag cagatagaga gcaggcatag acaagaaagc ggcttcagct gtaaaggacc
     3961 tggccagaat gtggctgtga ccagggcaca ccctgactcc caagggaggc ggcggcggcc
     4021 tgagcggggg gcccgaggag gccaggtgtt ttacaacagc gagtatgggg agctgtcgga
     4081 gccaagcgag gaggaccact gctccccgtc tgcccgcgtg actttcttca cagacaacag
     4141 ctactaagca gcatcggaca agacccccag cacttggggg ttcaggcccg gcagggcggg
     4201 cagagggctg gaggcccagg ctgggaactc atctggttga actctggtgg cacaggagtg
     4261 tcctcttccc tctctgcaga cttcccagct aggaagagca ggactccagg cccaaggctc
     4321 ccggaattcc gtcaccacga ctggccaggg ccacgctcca gctgccccgg cccctccccc
     4381 tgagattcag atgtcattta gttcagcatc cgcaggtgct ggtcccgggg ccagcacttc
     4441 catgggaatg tctctttggc gacctccttt catcacactg ggtggtggcc tggtccctgt
     4501 tttcccacga ggaatctgtg ggtctgggag tcacacagtg ttggaggtta aggcatacga
     4561 gagcagaggt ctcccaaacg ccctttcctc ctcaggcaca cagctactct ccccacgagg
     4621 gctggctggc ctcacccacc cctgcacagt tgaagggagg ggctgtgttt ccatctcaaa
     4681 gaaggcattt gcagggtcct cttctgggcc tgaccaaaca gccaactagc ccctggggtg
     4741 gccaccagta tgacagtatt atacgctggc aacacagagg cagcccgcac acctgcgcct
     4801 gggtgttgag agccatcctg caagtctttt tcaacagaac ttcacagact gttagagctg
     4861 ctgagaagaa tttgctttcc gaattcagcc tggaaggcgc ccagggacag ctgtactgag
     4921 tctagatgac tctgaccccc gccccaggtc aaggccagca gagcagtcag tgcctctgga
     4981 gaaggccctt gctctcccac ctggcccaga ctccgaggag cctgggtctg gagctgccgg
     5041 tctggttctt ccctttagag cccggatctg ccacctgcgg cccctcccaa gccgtgaacc
     5101 agctcatgag agatgaacac tgtgggatcc actcaggaag gctcggggct ggcacaaagg
     5161 accacccagc attgccctgt gccacccagc actcagtgga cattctgggg acctgccttc
     5221 agccttttcc tgccctgtgc ctgacatcag caccctggct ggtcagaatg ccgccctccc
     5281 agaggagcag ccgagagatc ccctgaaggc tggaggcatt ctgctcagga cccctatccc
     5341 agctcacagt gcccaaccat ctcaccagga gaaagagcca catccccacg ttaggaccac
     5401 ggagactgac caccaccctg accccccaaa cccacgcacc agacgcttgc aggacaggcg
     5461 ccgcgcagcg ggcaggggct tgcccggccg accctcccct ccccacctcc cccactgcgc
     5521 gttactccag gatatgccga gtgcacgtat aaggtcatct tcgtcgtccc cgtggacctc
     5581 ccccttcctc tgcacgtcgt ccaacgtggg actggcgtgt caggcttccc tgggaggatc
     5641 tggaggttgt tctctgcaga gaaccagcct ggctcctggc gcgcacctct gctcccttct
     5701 cctcactacc cacccacgca tgtaccggga aaaaaactac tatgcccttc tagaccatgt
     5761 tctgagaaaa gatcgaaaat atttaacaag agataataat aaatctgatg ccggtctttg
     5821 tgtgtgttgc gga
//
