LOCUS       NM_001459               1050 bp    mRNA    linear   PRI 29-AUG-2024
DEFINITION  Homo sapiens fms related receptor tyrosine kinase 3 ligand
            (FLT3LG), transcript variant 3, mRNA.
ACCESSION   NM_001459 XM_005258679
VERSION     NM_001459.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1050)
  AUTHORS   Momenilandi,M., Levy,R., Sobrino,S., Li,J., Lagresle-Peyrou,C.,
            Esmaeilzadeh,H., Fayand,A., Le Floc'h,C., Guerin,A., Della Mina,E.,
            Shearer,D., Delmonte,O.M., Yatim,A., Mulder,K., Mancini,M.,
            Rinchai,D., Denis,A., Neehus,A.L., Balogh,K., Brendle,S.,
            Rokni-Zadeh,H., Changi-Ashtiani,M., Seeleuthner,Y., Deswarte,C.,
            Bessot,B., Cremades,C., Materna,M., Cederholm,A., Ogishi,M.,
            Philippot,Q., Beganovic,O., Ackermann,M., Wuyts,M., Khan,T.,
            Fouere,S., Herms,F., Chanal,J., Palterer,B., Bruneau,J.,
            Molina,T.J., Leclerc-Mercier,S., Pretet,J.L., Youssefian,L.,
            Vahidnezhad,H., Parvaneh,N., Claeys,K.G., Schrijvers,R., Luka,M.,
            Perot,P., Fourgeaud,J., Nourrisson,C., Poirier,P., Jouanguy,E.,
            Boisson-Dupuis,S., Bustamante,J., Notarangelo,L.D., Christensen,N.,
            Landegren,N., Abel,L., Marr,N., Six,E., Langlais,D., Waterboer,T.,
            Ginhoux,F., Ma,C.S., Tangye,S.G., Meyts,I., Lachmann,N., Hu,J.,
            Shahrooei,M., Bossuyt,X., Casanova,J.L. and Beziat,V.
  TITLE     FLT3L governs the development of partially overlapping
            hematopoietic lineages in humans and mice
  JOURNAL   Cell 187 (11), 2817-2837 (2024)
   PUBMED   38701783
  REMARK    GeneRIF: FLT3L governs the development of partially overlapping
            hematopoietic lineages in humans and mice.
REFERENCE   2  (bases 1 to 1050)
  AUTHORS   Cui,T.X., Brady,A.E., Zhang,Y.J., Fulton,C.T., Goldsmith,A.M. and
            Popova,A.P.
  TITLE     Early-life hyperoxia-induced Flt3L drives neonatal lung dendritic
            cell expansion and proinflammatory responses
  JOURNAL   Front Immunol 14, 1116675 (2023)
   PUBMED   36845082
  REMARK    GeneRIF: Early-life hyperoxia-induced Flt3L drives neonatal lung
            dendritic cell expansion and proinflammatory responses.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1050)
  AUTHORS   Chen,H., Wu,M., Xia,H., Du,S., Zhou,G., Long,G., Zhu,Y., Huang,X.
            and Yang,D.
  TITLE     FLT3LG and IFITM3P6 consolidate T cell activity in the bone marrow
            microenvironment and are prognostic factors in acute myelocytic
            leukemia
  JOURNAL   Front Immunol 13, 980911 (2022)
   PUBMED   36081495
  REMARK    GeneRIF: FLT3LG and IFITM3P6 consolidate T cell activity in the
            bone marrow microenvironment and are prognostic factors in acute
            myelocytic leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1050)
  AUTHORS   Zhang,J., Li,Z., Chandrasekar,A., Li,S., Ludolph,A., Boeckers,T.M.,
            Huber-Lang,M., Roselli,F. and Olde Heuvel,F.
  TITLE     Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated
            With FLT3/FLT3L Signaling
  JOURNAL   Front Immunol 13, 824459 (2022)
   PUBMED   35281004
  REMARK    GeneRIF: Fast Maturation of Splenic Dendritic Cells Upon TBI Is
            Associated With FLT3/FLT3L Signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1050)
  AUTHORS   Peterlin,P., Gaschet,J., Guillaume,T., Garnier,A., Eveillard,M., Le
            Bourgeois,A., Cherel,M., Debord,C., Le Bris,Y., Theisen,O.,
            Godon,C., Mahe,B., Dubruille,V., Wuilleme,S., Touzeau,C.,
            Gastinne,T., Blin,N., Lok,A., Tessoulin,B., Le Gouill,S.,
            Moreau,P., Bene,M.C. and Chevallier,P.
  TITLE     A new cytokine-based dynamic stratification during induction is
            highly predictive of survivals in acute myeloid leukemia
  JOURNAL   Cancer Med 10 (2), 642-648 (2021)
   PUBMED   33369136
  REMARK    GeneRIF: A new cytokine-based dynamic stratification during
            induction is highly predictive of survivals in acute myeloid
            leukemia.
REFERENCE   6  (bases 1 to 1050)
  AUTHORS   Lyman,S.D., Stocking,K., Davison,B., Fletcher,F., Johnson,L. and
            Escobar,S.
  TITLE     Structural analysis of human and murine flt3 ligand genomic loci
  JOURNAL   Oncogene 11 (6), 1165-1172 (1995)
   PUBMED   7566977
REFERENCE   7  (bases 1 to 1050)
  AUTHORS   Lyman,S.D., James,L., Escobar,S., Downey,H., de Vries,P.,
            Brasel,K., Stocking,K., Beckmann,M.P., Copeland,N.G.,
            Cleveland,L.S. et al.
  TITLE     Identification of soluble and membrane-bound isoforms of the murine
            flt3 ligand generated by alternative splicing of mRNAs
  JOURNAL   Oncogene 10 (1), 149-157 (1995)
   PUBMED   7824267
REFERENCE   8  (bases 1 to 1050)
  AUTHORS   Lyman,S.D., James,L., Johnson,L., Brasel,K., de Vries,P.,
            Escobar,S.S., Downey,H., Splett,R.R., Beckmann,M.P. and
            McKenna,H.J.
  TITLE     Cloning of the human homologue of the murine flt3 ligand: a growth
            factor for early hematopoietic progenitor cells
  JOURNAL   Blood 83 (10), 2795-2801 (1994)
   PUBMED   8180375
REFERENCE   9  (bases 1 to 1050)
  AUTHORS   Hannum,C., Culpepper,J., Campbell,D., McClanahan,T., Zurawski,S.,
            Bazan,J.F., Kastelein,R., Hudak,S., Wagner,J., Mattson,J. et al.
  TITLE     Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of
            haematopoietic stem cells and is encoded by variant RNAs
  JOURNAL   Nature 368 (6472), 643-648 (1994)
   PUBMED   8145851
REFERENCE   10 (bases 1 to 1050)
  AUTHORS   Lyman,S.D., James,L., Vanden Bos,T., de Vries,P., Brasel,K.,
            Gliniak,B., Hollingsworth,L.T., Picha,K.S., McKenna,H.J.,
            Splett,R.R. et al.
  TITLE     Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase
            receptor: a proliferative factor for primitive hematopoietic cells
  JOURNAL   Cell 75 (6), 1157-1167 (1993)
   PUBMED   7505204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB490139.2, BC136464.1 and BC006331.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001459.3.
            
            Summary: Dendritic cells (DCs) provide the key link between innate
            and adaptive immunity by recognizing pathogens and priming
            pathogen-specific immune responses. FLT3LG controls the development
            of DCs and is particularly important for plasmacytoid DCs and CD8
            (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM
            604682)-positive tissue counterparts (summary by Sathaliyawala et
            al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011].
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126293.1, U04806.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000597551.6/ ENSP00000468977.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                DB490139.2         10-46
            38-970              BC136464.1         1-933
            971-1050            BC006331.2         967-1046
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1050
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /note="fms related receptor tyrosine kinase 3 ligand"
                     /db_xref="GeneID:2323"
                     /db_xref="HGNC:HGNC:3766"
                     /db_xref="MIM:600007"
     exon            1..67
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /inference="alignment:Splign:2.1.0"
     exon            68..137
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..812
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; flt3 ligand; fms related tyrosine kinase 3
                     ligand"
                     /codon_start=1
                     /product="fms-related tyrosine kinase 3 ligand isoform 1
                     precursor"
                     /protein_id="NP_001450.2"
                     /db_xref="CCDS:CCDS12767.1"
                     /db_xref="GeneID:2323"
                     /db_xref="HGNC:HGNC:3766"
                     /db_xref="MIM:600007"
                     /translation="MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVK
                     IRELSDYLLQDYPVTVASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVN
                     TEIHFVTKCAFQPPPSCLRFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQP
                     DSSTLPPPWSPRPLEATAPTAPQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPG
                     EQVPPVPSPQDLLLVEH"
     exon            138..248
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /inference="alignment:Splign:2.1.0"
     exon            249..302
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /inference="alignment:Splign:2.1.0"
     exon            303..446
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /inference="alignment:Splign:2.1.0"
     exon            447..585
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /inference="alignment:Splign:2.1.0"
     exon            586..764
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /inference="alignment:Splign:2.1.0"
     exon            765..833
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1050
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1029..1034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /note="hexamer: TATAAA"
     polyA_site      1050
                     /gene="FLT3LG"
                     /gene_synonym="FL; FLG3L; FLT3L; IMD125"
                     /note="major polyA site"
ORIGIN      
        1 cctttcactt tcggtctctg gctgtcaccc ggcttggccc cttccacacc caactggggc
       61 aagcctgacc cggcgacagg aggcatgagg ggcccccggc cgaaatgaca gtgctggcgc
      121 cagcctggag cccaacaacc tatctcctcc tgctgctgct gctgagctcg ggactcagtg
      181 ggacccagga ctgctccttc caacacagcc ccatctcctc cgacttcgct gtcaaaatcc
      241 gtgagctgtc tgactacctg cttcaagatt acccagtcac cgtggcctcc aacctgcagg
      301 acgaggagct ctgcgggggc ctctggcggc tggtcctggc acagcgctgg atggagcggc
      361 tcaagactgt cgctgggtcc aagatgcaag gcttgctgga gcgcgtgaac acggagatac
      421 actttgtcac caaatgtgcc tttcagcccc cccccagctg tcttcgcttc gtccagacca
      481 acatctcccg cctcctgcag gagacctccg agcagctggt ggcgctgaag ccctggatca
      541 ctcgccagaa cttctcccgg tgcctggagc tgcagtgtca gcccgactcc tcaaccctgc
      601 cacccccatg gagtccccgg cccctggagg ccacagcccc gacagccccg cagccccctc
      661 tgctcctcct actgctgctg cccgtgggcc tcctgctgct ggccgctgcc tggtgcctgc
      721 actggcagag gacgcggcgg aggacacccc gccctgggga gcaggtgccc cccgtcccca
      781 gtccccagga cctgctgctt gtggagcact gacctggcca aggcctcatc ctggggagga
      841 tactgaggca cacagagggg agtcaccagc cagaggatgc atagcctgga cacagaggaa
      901 gttggctaga ggccggtccc ttccttgggc ccctctcatt ccctccccag aatggaggca
      961 acgccagaat ccagcaccgg ccccatttac ccaactctgt acaaagccct tgtccccatg
     1021 aaattgtata taaatcatcc ttttctacca
//
