LOCUS       NM_004119               3826 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens fms related receptor tyrosine kinase 3 (FLT3),
            transcript variant 1, mRNA.
ACCESSION   NM_004119
VERSION     NM_004119.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3826)
  AUTHORS   Travaglini,S., Gurnari,C., Ottone,T. and Voso,M.T.
  TITLE     Advances in the pathogenesis of FLT3 -mutated acute myeloid
            leukemia and targeted treatments
  JOURNAL   Curr Opin Oncol 36 (6), 569-576 (2024)
   PUBMED   39246183
  REMARK    GeneRIF: Advances in the pathogenesis of FLT3 -mutated acute
            myeloid leukemia and targeted treatments.
            Review article
REFERENCE   2  (bases 1 to 3826)
  AUTHORS   Zhu,R., Shirley,C.M., Chu,S.H., Li,L., Nguyen,B.H., Seo,J., Wu,M.,
            Seale,T., Duffield,A.S., Staudt,L.M., Levis,M., Hu,Y. and Small,D.
  TITLE     Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia
            cells to FLT3 tyrosine kinase inhibition
  JOURNAL   Leukemia 38 (7), 1581-1591 (2024)
   PUBMED   38811818
  REMARK    GeneRIF: Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid
            leukemia cells to FLT3 tyrosine kinase inhibition.
REFERENCE   3  (bases 1 to 3826)
  AUTHORS   Turos-Cabal,M., Sanchez-Sanchez,A.M., Puente-Moncada,N.,
            Herrera,F., Antolin,I., Rodriguez,C. and Martin,V.
  TITLE     FLT3-ITD regulation of the endoplasmic reticulum functions in acute
            myeloid leukemia
  JOURNAL   Hematol Oncol 42 (3), e3281 (2024)
   PUBMED   38775115
  REMARK    GeneRIF: FLT3-ITD regulation of the endoplasmic reticulum functions
            in acute myeloid leukemia.
REFERENCE   4  (bases 1 to 3826)
  AUTHORS   Maceckova,D., Vankova,L., Holubova,M., Jindra,P., Klieber,R.,
            Jandova,E. and Pitule,P.
  TITLE     Current knowledge about FLT3 gene mutations, exploring the
            isoforms, and protein importance in AML
  JOURNAL   Mol Biol Rep 51 (1), 521 (2024)
   PUBMED   38625438
  REMARK    GeneRIF: Current knowledge about FLT3 gene mutations, exploring the
            isoforms, and protein importance in AML.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3826)
  AUTHORS   Langdon,W.Y.
  TITLE     FLT3 signaling and the development of inhibitors that target FLT3
            kinase activity
  JOURNAL   Crit Rev Oncog 17 (2), 199-209 (2012)
   PUBMED   22471708
  REMARK    Review article
REFERENCE   6  (bases 1 to 3826)
  AUTHORS   Parcells,B.W., Ikeda,A.K., Simms-Waldrip,T., Moore,T.B. and
            Sakamoto,K.M.
  TITLE     FMS-like tyrosine kinase 3 in normal hematopoiesis and acute
            myeloid leukemia
  JOURNAL   Stem Cells 24 (5), 1174-1184 (2006)
   PUBMED   16410383
  REMARK    Review article
REFERENCE   7  (bases 1 to 3826)
  AUTHORS   Carow,C.E., Kim,E., Hawkins,A.L., Webb,H.D., Griffin,C.A.,
            Jabs,E.W., Civin,C.I. and Small,D.
  TITLE     Localization of the human stem cell tyrosine kinase-1 gene (FLT3)
            to 13q12-->q13
  JOURNAL   Cytogenet Cell Genet 70 (3-4), 255-257 (1995)
   PUBMED   7789184
REFERENCE   8  (bases 1 to 3826)
  AUTHORS   Small,D., Levenstein,M., Kim,E., Carow,C., Amin,S., Rockwell,P.,
            Witte,L., Burrow,C., Ratajczak,M.Z., Gewirtz,A.M. et al.
  TITLE     STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed
            in CD34+ human bone marrow cells and is involved in the
            proliferation of early progenitor/stem cells
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 459-463 (1994)
   PUBMED   7507245
REFERENCE   9  (bases 1 to 3826)
  AUTHORS   Dosil,M., Wang,S. and Lemischka,I.R.
  TITLE     Mitogenic signalling and substrate specificity of the Flk2/Flt3
            receptor tyrosine kinase in fibroblasts and interleukin 3-dependent
            hematopoietic cells
  JOURNAL   Mol Cell Biol 13 (10), 6572-6585 (1993)
   PUBMED   7692230
REFERENCE   10 (bases 1 to 3826)
  AUTHORS   Rosnet,O., Mattei,M.G., Marchetto,S. and Birnbaum,D.
  TITLE     Isolation and chromosomal localization of a novel FMS-like tyrosine
            kinase gene
  JOURNAL   Genomics 9 (2), 380-385 (1991)
   PUBMED   2004790
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI461248.1, Z26652.1,
            AL356915.19, U02687.1, AL591024.14 and AW057705.1.
            
            On Aug 31, 2019 this sequence version replaced NM_004119.2.
            
            Summary: This gene encodes a class III receptor tyrosine kinase
            that regulates hematopoiesis. This receptor is activated by binding
            of the fms-related tyrosine kinase 3 ligand to the extracellular
            domain, which induces homodimer formation in the plasma membrane
            leading to autophosphorylation of the receptor. The activated
            receptor kinase subsequently phosphorylates and activates multiple
            cytoplasmic effector molecules in pathways involved in apoptosis,
            proliferation, and differentiation of hematopoietic cells in bone
            marrow. Mutations that result in the constitutive activation of
            this receptor result in acute myeloid leukemia and acute
            lymphoblastic leukemia. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z26652.1, U02687.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241453.12/ ENSP00000241453.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BI461248.1         22-87
            67-297              Z26652.1           1-231
            298-354             AL356915.19        22180-22236         c
            355-1102            U02687.1           346-1093
            1103-3479           Z26652.1           1037-3413
            3480-3598           AL591024.14        61478-61596         c
            3599-3826           AW057705.1         7-234               c
FEATURES             Location/Qualifiers
     source          1..3826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.2"
     gene            1..3826
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /note="fms related receptor tyrosine kinase 3"
                     /db_xref="GeneID:2322"
                     /db_xref="HGNC:HGNC:3765"
                     /db_xref="MIM:136351"
     exon            1..109
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..3048
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /EC_number="2.7.10.1"
                     /note="fetal liver kinase 2; growth factor receptor
                     tyrosine kinase type III; FL cytokine receptor; CD135
                     antigen; stem cell tyrosine kinase 1; receptor-type
                     tyrosine-protein kinase FLT3; fms-like tyrosine kinase 3;
                     fms related tyrosine kinase 3"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein kinase FLT3
                     precursor"
                     /protein_id="NP_004110.2"
                     /db_xref="CCDS:CCDS31953.1"
                     /db_xref="GeneID:2322"
                     /db_xref="HGNC:HGNC:3765"
                     /db_xref="MIM:136351"
                     /translation="MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNND
                     SSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNIS
                     CLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSI
                     RNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEE
                     KVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVH
                     VNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSK
                     HPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPC
                     EQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQA
                     SCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIK
                     GFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKY
                     KKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKV
                     MNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACT
                     LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGS
                     REVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKG
                     MEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMA
                     PESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYA
                     TEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNR
                     RPFSREMDLGLLSPQAQVEDS"
     exon            110..231
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            232..434
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..550
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..680
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..808
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..948
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1102
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1271
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1375
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1484
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1663
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1770
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1903
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2008
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2119
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2273
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2356
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2484
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2607
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2719
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2819
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2925
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3826
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3466..3471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /note="hexamer: AATAAA"
     polyA_site      3486
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /note="major polyA site"
     regulatory      3803..3808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /note="hexamer: AATAAA"
     polyA_site      3826
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /note="major polyA site"
ORIGIN      
        1 gcgccgctcc aggcggcatc gcagggctgg gccggcgcgg cctggggacc ccgggctccg
       61 gaggccatgc cggcgttggc gcgcgacggc ggccagctgc cgctgctcgt tgttttttct
      121 gcaatgatat ttgggactat tacaaatcaa gatctgcctg tgatcaagtg tgttttaatc
      181 aatcataaga acaatgattc atcagtgggg aagtcatcat catatcccat ggtatcagaa
      241 tccccggaag acctcgggtg tgcgttgaga ccccagagct cagggacagt gtacgaagct
      301 gccgctgtgg aagtggatgt atctgcttcc atcacactgc aagtgctggt cgacgcccca
      361 gggaacattt cctgtctctg ggtctttaag cacagctccc tgaattgcca gccacatttt
      421 gatttacaaa acagaggagt tgtttccatg gtcattttga aaatgacaga aacccaagct
      481 ggagaatacc tactttttat tcagagtgaa gctaccaatt acacaatatt gtttacagtg
      541 agtataagaa ataccctgct ttacacatta agaagacctt actttagaaa aatggaaaac
      601 caggacgccc tggtctgcat atctgagagc gttccagagc cgatcgtgga atgggtgctt
      661 tgcgattcac agggggaaag ctgtaaagaa gaaagtccag ctgttgttaa aaaggaggaa
      721 aaagtgcttc atgaattatt tgggacggac ataaggtgct gtgccagaaa tgaactgggc
      781 agggaatgca ccaggctgtt cacaatagat ctaaatcaaa ctcctcagac cacattgcca
      841 caattatttc ttaaagtagg ggaaccctta tggataaggt gcaaagctgt tcatgtgaac
      901 catggattcg ggctcacctg ggaattagaa aacaaagcac tcgaggaggg caactacttt
      961 gagatgagta cctattcaac aaacagaact atgatacgga ttctgtttgc ttttgtatca
     1021 tcagtggcaa gaaacgacac cggatactac acttgttcct cttcaaagca tcccagtcaa
     1081 tcagctttgg ttaccatcgt agaaaaggga tttataaatg ctaccaattc aagtgaagat
     1141 tatgaaattg accaatatga agagttttgt ttttctgtca ggtttaaagc ctacccacaa
     1201 atcagatgta cgtggacctt ctctcgaaaa tcatttcctt gtgagcaaaa gggtcttgat
     1261 aacggataca gcatatccaa gttttgcaat cataagcacc agccaggaga atatatattc
     1321 catgcagaaa atgatgatgc ccaatttacc aaaatgttca cgctgaatat aagaaggaaa
     1381 cctcaagtgc tcgcagaagc atcggcaagt caggcgtcct gtttctcgga tggataccca
     1441 ttaccatctt ggacctggaa gaagtgttca gacaagtctc ccaactgcac agaagagatc
     1501 acagaaggag tctggaatag aaaggctaac agaaaagtgt ttggacagtg ggtgtcgagc
     1561 agtactctaa acatgagtga agccataaaa gggttcctgg tcaagtgctg tgcatacaat
     1621 tcccttggca catcttgtga gacgatcctt ttaaactctc caggcccctt ccctttcatc
     1681 caagacaaca tctcattcta tgcaacaatt ggtgtttgtc tcctcttcat tgtcgtttta
     1741 accctgctaa tttgtcacaa gtacaaaaag caatttaggt atgaaagcca gctacagatg
     1801 gtacaggtga ccggctcctc agataatgag tacttctacg ttgatttcag agaatatgaa
     1861 tatgatctca aatgggagtt tccaagagaa aatttagagt ttgggaaggt actaggatca
     1921 ggtgcttttg gaaaagtgat gaacgcaaca gcttatggaa ttagcaaaac aggagtctca
     1981 atccaggttg ccgtcaaaat gctgaaagaa aaagcagaca gctctgaaag agaggcactc
     2041 atgtcagaac tcaagatgat gacccagctg ggaagccacg agaatattgt gaacctgctg
     2101 ggggcgtgca cactgtcagg accaatttac ttgatttttg aatactgttg ctatggtgat
     2161 cttctcaact atctaagaag taaaagagaa aaatttcaca ggacttggac agagattttc
     2221 aaggaacaca atttcagttt ttaccccact ttccaatcac atccaaattc cagcatgcct
     2281 ggttcaagag aagttcagat acacccggac tcggatcaaa tctcagggct tcatgggaat
     2341 tcatttcact ctgaagatga aattgaatat gaaaaccaaa aaaggctgga agaagaggag
     2401 gacttgaatg tgcttacatt tgaagatctt ctttgctttg catatcaagt tgccaaagga
     2461 atggaatttc tggaatttaa gtcgtgtgtt cacagagacc tggccgccag gaacgtgctt
     2521 gtcacccacg ggaaagtggt gaagatatgt gactttggat tggctcgaga tatcatgagt
     2581 gattccaact atgttgtcag gggcaatgcc cgtctgcctg taaaatggat ggcccccgaa
     2641 agcctgtttg aaggcatcta caccattaag agtgatgtct ggtcatatgg aatattactg
     2701 tgggaaatct tctcacttgg tgtgaatcct taccctggca ttccggttga tgctaacttc
     2761 tacaaactga ttcaaaatgg atttaaaatg gatcagccat tttatgctac agaagaaata
     2821 tacattataa tgcaatcctg ctgggctttt gactcaagga aacggccatc cttccctaat
     2881 ttgacttcgt ttttaggatg tcagctggca gatgcagaag aagcgatgta tcagaatgtg
     2941 gatggccgtg tttcggaatg tcctcacacc taccaaaaca ggcgaccttt cagcagagag
     3001 atggatttgg ggctactctc tccgcaggct caggtcgaag attcgtagag gaacaattta
     3061 gttttaagga cttcatccct ccacctatcc ctaacaggct gtagattacc aaaacaagat
     3121 taatttcatc actaaaagaa aatctattat caactgctgc ttcaccagac ttttctctag
     3181 aagctgtctg cgtttactct tgttttcaaa gggacttttg taaaatcaaa tcatcctgtc
     3241 acaaggcagg aggagctgat aatgaacttt attggagcat tgatctgcat ccaaggcctt
     3301 ctcaggctgg cttgagtgaa ttgtgtacct gaagtacagt atattcttgt aaatacataa
     3361 aacaaaagca ttttgctaag gagaagctaa tatgattttt taagtctatg ttttaaaata
     3421 atatgtaaat ttttcagcta tttagtgata tattttatgg gtgggaataa aatttctact
     3481 acagaattgc ccattattga attatttaca tggtataatt agggcaagtc ttaactggag
     3541 ttcacgaacc ccctgaaatt gtgcacccat agccacctac acattccttc cagagcacgt
     3601 gtgcttttac cccaagatac aaggaatgtg taggcagcta tggttgtcac agcctaagat
     3661 ttctgcaaca acaggggttg tattggggga agtttataat gaataggtgt tctaccataa
     3721 agagtaatac atcacctaga cactttggcg gccttcccag actcagggcc agtcagaagt
     3781 aacatggagg attagtattt tcaataaagt tactcttgtc cccaca
//
