LOCUS       NM_198391               4977 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens fibronectin leucine rich transmembrane protein 3
            (FLRT3), transcript variant 2, mRNA.
ACCESSION   NM_198391
VERSION     NM_198391.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4977)
  AUTHORS   Pang,Y., Xu,Y., Chen,Q., Cheng,K., Ling,Y., Jang,J., Ge,J. and
            Zhu,W.
  TITLE     FLRT3 and TGF-beta/SMAD4 signalling: Impacts on apoptosis,
            autophagy and ion channels in supraventricular tachycardia
  JOURNAL   J Cell Mol Med 28 (7), e18237 (2024)
   PUBMED   38509727
  REMARK    GeneRIF: FLRT3 and TGF-beta/SMAD4 signalling: Impacts on apoptosis,
            autophagy and ion channels in supraventricular tachycardia.
REFERENCE   2  (bases 1 to 4977)
  AUTHORS   Yang,M., Li,D., Jiang,Z., Li,C., Ji,S., Sun,J., Chang,Y., Ruan,S.,
            Wang,Z., Liang,R., Dai,X., Li,B. and Zhao,H.
  TITLE     TGF-beta-Induced FLRT3 Attenuation Is Essential for
            Cancer-Associated Fibroblast-Mediated Epithelial-Mesenchymal
            Transition in Colorectal Cancer
  JOURNAL   Mol Cancer Res 20 (8), 1247-1259 (2022)
   PUBMED   35560224
  REMARK    GeneRIF: TGF-beta-Induced FLRT3 Attenuation Is Essential for
            Cancer-Associated Fibroblast-Mediated Epithelial-Mesenchymal
            Transition in Colorectal Cancer.
REFERENCE   3  (bases 1 to 4977)
  AUTHORS   Swierkowska,J., Karolak,J.A., Gambin,T., Rydzanicz,M.,
            Frajdenberg,A., Mrugacz,M., Podfigurna-Musielak,M., Stankiewicz,P.,
            Lupski,J.R. and Gajecka,M.
  TITLE     Variants in FLRT3 and SLC35E2B identified using exome sequencing in
            seven high myopia families from Central Europe
  JOURNAL   Adv Med Sci 66 (1), 192-198 (2021)
   PUBMED   33711669
  REMARK    GeneRIF: Variants in FLRT3 and SLC35E2B identified using exome
            sequencing in seven high myopia families from Central Europe.
REFERENCE   4  (bases 1 to 4977)
  AUTHORS   Diamond,J.M., Arcasoy,S., McDonnough,J.A., Sonett,J.R.,
            Bacchetta,M., D'Ovidio,F., Cantu,E. 3rd, Bermudez,C.A.,
            McBurnie,A., Rushefski,M., Kalman,L.H., Oyster,M., D'Errico,C.,
            Suzuki,Y., Giles,J.T., Ferrante,A., Lippel,M., Singh,G.,
            Lederer,D.J. and Christie,J.D.
  CONSRTM   Lung Transplant Body Composition Study
  TITLE     Adipose Gene Expression Profile Changes With Lung Allograft
            Reperfusion
  JOURNAL   Am J Transplant 17 (1), 239-245 (2017)
   PUBMED   27421969
  REMARK    GeneRIF: Low FLRT3 expression is associated with lung graft
            dysfunction.
REFERENCE   5  (bases 1 to 4977)
  AUTHORS   Lu,Y.C., Nazarko,O.V., Sando,R. 3rd, Salzman,G.S., Li,N.S.,
            Sudhof,T.C. and Arac,D.
  TITLE     Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell
            Adhesion
  JOURNAL   Structure 23 (9), 1678-1691 (2015)
   PUBMED   26235030
  REMARK    GeneRIF: Results suggest that UNC5 and LPHN3 can simultaneously
            bind to FLRT3, forming a trimeric complex, and that FLRT3 may form
            transsynaptic complexes with both LPHN3 and UNC5.
REFERENCE   6  (bases 1 to 4977)
  AUTHORS   O'Sullivan,M.L., de Wit,J., Savas,J.N., Comoletti,D., Otto-Hitt,S.,
            Yates,J.R. 3rd and Ghosh,A.
  TITLE     FLRT proteins are endogenous latrophilin ligands and regulate
            excitatory synapse development
  JOURNAL   Neuron 73 (5), 903-910 (2012)
   PUBMED   22405201
  REMARK    GeneRIF: This study demonistrated that LPHN3 and its ligand FLRT3
            play an important role in glutamatergic synapse development.
REFERENCE   7  (bases 1 to 4977)
  AUTHORS   Kuniba,H., Tsuda,M., Nakashima,M., Miura,S., Miyake,N., Kondoh,T.,
            Matsumoto,T., Moriuchi,H., Ohashi,H., Kurosawa,K., Tonoki,H.,
            Nagai,T., Okamoto,N., Kato,M., Fukushima,Y., Naritomi,K.,
            Matsumoto,N., Kinoshita,A., Yoshiura,K.I. and Niikawa,N.
  TITLE     Lack of C20orf133 and FLRT3 mutations in 43 patients with Kabuki
            syndrome in Japan
  JOURNAL   J Med Genet 45 (7), 479-480 (2008)
   PUBMED   18593871
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4977)
  AUTHORS   Tsuji,L., Yamashita,T., Kubo,T., Madura,T., Tanaka,H., Hosokawa,K.
            and Tohyama,M.
  TITLE     FLRT3, a cell surface molecule containing LRR repeats and a FNIII
            domain, promotes neurite outgrowth
  JOURNAL   Biochem Biophys Res Commun 313 (4), 1086-1091 (2004)
   PUBMED   14706654
REFERENCE   9  (bases 1 to 4977)
  AUTHORS   Lacy,S.E., Bonnemann,C.G., Buzney,E.A. and Kunkel,L.M.
  TITLE     Identification of FLRT1, FLRT2, and FLRT3: a novel family of
            transmembrane leucine-rich repeat proteins
  JOURNAL   Genomics 62 (3), 417-426 (1999)
   PUBMED   10644439
REFERENCE   10 (bases 1 to 4977)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL529481.3, BC020870.1,
            AB040902.1 and AL132826.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_198391.2.
            
            Summary: This gene encodes a member of the fibronectin leucine rich
            transmembrane protein (FLRT) family. FLRTs may function in cell
            adhesion and/or receptor signalling. Their protein structures
            resemble small leucine-rich proteoglycans found in the
            extracellular matrix. This gene is expressed in many tissues. Two
            alternatively spliced transcript variants encoding the same protein
            have been described for this gene. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (2) is the longer transcript.
            Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.192808.1,
                                           SRR1660809.68051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341420.5/ ENSP00000339912.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               AL529481.3         13-479
            468-2538            BC020870.1         236-2306
            2539-3969           AB040902.1         2288-3718
            3970-4977           AL132826.18        63829-64836         c
FEATURES             Location/Qualifiers
     source          1..4977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.1"
     gene            1..4977
                     /gene="FLRT3"
                     /gene_synonym="HH21"
                     /note="fibronectin leucine rich transmembrane protein 3"
                     /db_xref="GeneID:23767"
                     /db_xref="HGNC:HGNC:3762"
                     /db_xref="MIM:604808"
     exon            1..209
                     /gene="FLRT3"
                     /gene_synonym="HH21"
                     /inference="alignment:Splign:2.1.0"
     exon            210..403
                     /gene="FLRT3"
                     /gene_synonym="HH21"
                     /inference="alignment:Splign:2.1.0"
     exon            404..4977
                     /gene="FLRT3"
                     /gene_synonym="HH21"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..2405
                     /gene="FLRT3"
                     /gene_synonym="HH21"
                     /note="leucine-rich repeat transmembrane protein FLRT3;
                     fibronectin-like domain-containing leucine-rich
                     transmembrane protein 3"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane protein FLRT3
                     precursor"
                     /protein_id="NP_938205.1"
                     /db_xref="CCDS:CCDS13121.1"
                     /db_xref="GeneID:23767"
                     /db_xref="HGNC:HGNC:3762"
                     /db_xref="MIM:604808"
                     /translation="MISAAWSIFLIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGFIYC
                     NDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNL
                     PKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLF
                     LSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGD
                     KVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRL
                     DMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMC
                     QAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTAIPNTVYPAQGQWPAPVTKQPDIK
                     NPKLTKDHQTTGSPSRKTITITVKSVTSDTIHISWKLALPMTALRLSWLKLGHSPAFG
                     SITETIVTGERSEYLVTALEPDSPYKVCMVPMETSNLYLFDETPVCIETETAPLRMYN
                     PTTTLNREQEKEPYKNPNLPLAAIIGGAVALVTIALLALVCWYVHRNGSLFSRNCAYS
                     KGRRRKDDYAEAGTKKDNSILEIRETSFQMLPISNEPISKEEFVIHTIFPPNGMNLYK
                     NNHSESSSNRSYRDSGIPDSDHSHS"
     regulatory      3811..3816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLRT3"
                     /gene_synonym="HH21"
                     /note="hexamer: AATAAA"
     polyA_site      3830
                     /gene="FLRT3"
                     /gene_synonym="HH21"
                     /note="major polyA site"
     regulatory      3935..3940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLRT3"
                     /gene_synonym="HH21"
                     /note="hexamer: AATAAA"
     polyA_site      3967
                     /gene="FLRT3"
                     /gene_synonym="HH21"
                     /note="major polyA site"
     regulatory      4648..4653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLRT3"
                     /gene_synonym="HH21"
                     /note="hexamer: AGTAAA"
     polyA_site      4667
                     /gene="FLRT3"
                     /gene_synonym="HH21"
     regulatory      4954..4959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLRT3"
                     /gene_synonym="HH21"
                     /note="hexamer: ATTAAA"
     polyA_site      4977
                     /gene="FLRT3"
                     /gene_synonym="HH21"
ORIGIN      
        1 gtgcagtaaa ctggaatgct ctccctcgct cactcctcag tgtaggagtg atctgaagca
       61 ggacaagctc agcctgcagc tgccgtgggc tttgtgtgga ctggacgcag agcttgggag
      121 acgggggagg gctattactc caattcactg tcaatggaat tacagctata gcggcagtgt
      181 atataggatt gctttttctc gtcttcctgg agatgctcag tcccagtata ttttaaggaa
      241 gagaaatata aaggaaattt agtatgcctc cttttcttta aatgaagaat ttagtttcct
      301 ttacttctta aaagagaata cctgttcttg tataacgtga ctgcaccaga cattctgaaa
      361 aatcagcaag aagcaaaagc tggaaatagc tatttcacag cagggttctg aagtaacgga
      421 agctaccttg tataaagacc tcaacactgc tgaccatgat cagcgcagcc tggagcatct
      481 tcctcatcgg gactaaaatt gggctgttcc ttcaagtagc acctctatca gttatggcta
      541 aatcctgtcc atctgtgtgt cgctgcgatg cgggtttcat ttactgtaat gatcgctttc
      601 tgacatccat tccaacagga ataccagagg atgctacaac tctctacctt cagaacaacc
      661 aaataaataa tgctgggatt ccttcagatt tgaaaaactt gctgaaagta gaaagaatat
      721 acctatacca caacagttta gatgaatttc ctaccaacct cccaaagtat gtaaaagagt
      781 tacatttgca agaaaataac ataaggacta tcacttatga ttcactttca aaaattccct
      841 atctggaaga attacattta gatgacaact ctgtctctgc agttagcata gaagagggag
      901 cattccgaga cagcaactat ctccgactgc ttttcctgtc ccgtaatcac cttagcacaa
      961 ttccctgggg tttgcccagg actatagaag aactacgctt ggatgataat cgcatatcca
     1021 ctatttcatc accatctctt caaggtctca ctagtctaaa acgcctggtt ctagatggaa
     1081 acctgttgaa caatcatggt ttaggtgaca aagttttctt caacctagtt aatttgacag
     1141 agctgtccct ggtgcggaat tccctgactg ctgcaccagt aaaccttcca ggcacaaacc
     1201 tgaggaagct ttatcttcaa gataaccaca tcaatcgggt gcccccaaat gctttttctt
     1261 atctaaggca gctctatcga ctggatatgt ccaataataa cctaagtaat ttacctcagg
     1321 gtatctttga tgatttggac aatataacac aactgattct tcgcaacaat ccctggtatt
     1381 gcgggtgcaa gatgaaatgg gtacgtgact ggttacaatc actacctgtg aaggtcaacg
     1441 tgcgtgggct catgtgccaa gccccagaaa aggttcgtgg gatggctatt aaggatctca
     1501 atgcagaact gtttgattgt aaggacagtg ggattgtaag caccattcag ataaccactg
     1561 caatacccaa cacagtgtat cctgcccaag gacagtggcc agctccagtg accaaacagc
     1621 cagatattaa gaaccccaag ctcactaagg atcaccaaac cacagggagt ccctcaagaa
     1681 aaacaattac aattactgtg aagtctgtca cctctgatac cattcatatc tcttggaaac
     1741 ttgctctacc tatgactgct ttgagactca gctggcttaa actgggccat agcccggcat
     1801 ttggatctat aacagaaaca attgtaacag gggaacgcag tgagtacttg gtcacagccc
     1861 tggagcctga ttcaccctat aaagtatgca tggttcccat ggaaaccagc aacctctacc
     1921 tatttgatga aactcctgtt tgtattgaga ctgaaactgc accccttcga atgtacaacc
     1981 ctacaaccac cctcaatcga gagcaagaga aagaacctta caaaaacccc aatttacctt
     2041 tggctgccat cattggtggg gctgtggccc tggttaccat tgcccttctt gctttagtgt
     2101 gttggtatgt tcataggaat ggatcgctct tctcaaggaa ctgtgcatat agcaaaggga
     2161 ggagaagaaa ggatgactat gcagaagctg gcactaagaa ggacaactct atcctggaaa
     2221 tcagggaaac ttcttttcag atgttaccaa taagcaatga acccatctcg aaggaggagt
     2281 ttgtaataca caccatattt cctcctaatg gaatgaatct gtacaaaaac aatcacagtg
     2341 aaagcagtag taaccgaagc tacagagaca gtggtattcc agactcagat cactcacact
     2401 catgatgctg aaggactcac agcagacttg tgttttgggt tttttaaacc taagggaggt
     2461 gatggtagga accctgttct actgcaaaac actggaaaaa gagactgaaa aaaagcaatg
     2521 tactgtacat ttgccatata atttatattt aagaactttt tattaaaagt ttcaaatttc
     2581 aggttactgc tgcgattgat gtagtggaga tgcctgaaca caattctata ttttagtatt
     2641 ttttagtaat ttgtactgta ttttccttgc aaatattgga gttataaacc atttactttg
     2701 tgttctactg agtaagatga cttgttgact gtgaaagtga attttcttgc tgtgtcgaac
     2761 aatcaggact gcattcatat gagatccttg tagtataagc acaggccatt tttcactttg
     2821 gtattaataa aatgtaaaaa aaaaaaactg gctgaatggc tgaatgagat aaaatttaat
     2881 tttaaaaaat ggttatgaaa taatgttcca attattaaat ttgtattatc ccagtggtat
     2941 tcaataaatc aaaatgtgtg aagtaatggg caatatcaaa cttcctgcat atctccattt
     3001 ttgctctagg caaattaatt atccttaaaa aagttaagca tatcttctga actgaataca
     3061 tcagctggca taaaaggagc atgaagtctg ttaaagccat tgtcagcaaa gctttgaaaa
     3121 taaaggactt cacaaaaacg gtaatgtaaa tgtgcttcca agttgggggg aaaatgtgta
     3181 cttaggaaaa catggaaact tagacttgta tagtgtaatg aacacaaata ccaaaactgc
     3241 attttggttt tgcctatacc atcctgattt ttgaaaagtg aattataaac acaaaattgt
     3301 tagtgtttat gatgttttta tcataaagga tgtcagagaa actttatgca tattaaaaat
     3361 gtaatgtaat tataagcgat tcccctcaac aatccagaga aagtagttct ttaaataaga
     3421 gataatttaa agaaaaataa atactagaca tcaaatttag atctggttta tgtcaaaggt
     3481 tttaacactg tacataaatg ttcaatttac ttttacaaag atcaagaata ctgcccatta
     3541 ctgtcacaat tttccagata ttatataatg aactcgtaat gtaacatttc cttctagctt
     3601 cctactgaat tgtgagctgt tacttgttga aaaaccatat cacttttctg ttgccatgat
     3661 tttttttttt tcaacaaaaa accaaagtgc attgtacgcc ctttggccag tcttgtatgt
     3721 gccttgatcc aacgctacat gtattcagct tttaaaactc cacaaatttt tcatactcct
     3781 taaatatgaa aaattatggt cttattgctg aataaaactt ttaaaaagta cagaataatt
     3841 gtgcttgctt tttcaggatt gtgttactat cactaagtag caaattgccc agcacattag
     3901 tcctaaacgt cccatgtatt tttctaggca taaaaataaa agttggctaa aaattttaaa
     3961 aaatcaacat cttgaggttg tgtatcattt tacttcaaag agttcagtgt ttcatgtata
     4021 aatgtatttc ctcttactta tacactgtat agatggaaaa tttaagaaat ggtttcaaag
     4081 cctttctctc ttaggcgcac tgctgccact gtcctgatac tttttaaggt ggtctttgaa
     4141 aaactgtttt tttaaaatag ccttttagta gagtgagttg gcatttgtga tactgtgaaa
     4201 tacacacttt ctctttgtcc ctgtttctgg catacaactc ctaaaatcct tgcaatcttc
     4261 aaagtgatat attttcatat gctaatgagt tcactgatag ctggcaggcc ctaggtagct
     4321 tcaagataaa gtctgatcat tgaaaagacc aagacatgat tatagggttg ggacttacaa
     4381 ccccaaaccc taacctccag agagggcgaa gtggatgaag attaagttga tcaccagtga
     4441 ccagtggttt aatcaagcat gcctatgtaa tcaagcctcc ataaaaaaac aaaaggtcaa
     4501 gatttggaga gcttccagat tgctgaacat gtggtggttc ctgcaggatg gcatgcctgg
     4561 agagggcatg gaagctctgt gcccacctag acctcacctt atgtttcctg ccatctggat
     4621 cctttgtaac atcctttata atacgtcagt aaatctgttt ccttgcattt tgtgagctgt
     4681 tgtagcaaat taatagaaca caaaaagggg atcctgggaa accaaacttg aagctgacta
     4741 gtcttgcaac tggtgtctga agaggaggca gttttgtggg aataagccct caacctgtgg
     4801 gatatgacac aatttccagg tagacagtgt tgggattaaa ctgaattgga ggacacccag
     4861 ctggtatctg ctgaagaact gattgcttgc gtggtgtatg gggcaaaact tgttaagaca
     4921 agtcttctat gttgattatt gttgaatgag agaattaaac acacatacac actttga
//
