LOCUS       NM_013231              33681 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens fibronectin leucine rich transmembrane protein 2
            (FLRT2), transcript variant 3, mRNA.
ACCESSION   NM_013231
VERSION     NM_013231.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 33681)
  AUTHORS   Hwang,H.J., Kang,D., Kim,J.R., Choi,J.H., Ryu,J.K., Herman,A.B.,
            Ko,Y.G., Park,H.J., Gorospe,M. and Lee,J.S.
  TITLE     FLRT2 prevents endothelial cell senescence and vascular aging by
            regulating the ITGB4/mTORC2/p53 signaling pathway
  JOURNAL   JCI Insight 9 (7), e172678 (2024)
   PUBMED   38587072
  REMARK    GeneRIF: FLRT2 prevents endothelial cell senescence and vascular
            aging by regulating the ITGB4/mTORC2/p53 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33681)
  AUTHORS   Jiang,P., Ning,J., Yu,W., Rao,T., Ruan,Y. and Cheng,F.
  TITLE     FLRT2 suppresses bladder cancer progression through inducing
            ferroptosis
  JOURNAL   J Cell Mol Med 28 (5), e17855 (2024)
   PUBMED   37480224
  REMARK    GeneRIF: FLRT2 suppresses bladder cancer progression through
            inducing ferroptosis.
REFERENCE   3  (bases 1 to 33681)
  AUTHORS   Bae,H., Kim,B., Lee,H., Lee,S., Kang,H.S. and Kim,S.J.
  TITLE     Epigenetically regulated Fibronectin leucine rich transmembrane
            protein 2 (FLRT2) shows tumor suppressor activity in breast cancer
            cells
  JOURNAL   Sci Rep 7 (1), 272 (2017)
   PUBMED   28325946
  REMARK    GeneRIF: Taken together, these results provide insights into the
            role of FLRT2 as a novel tumor suppressor in the breast, which is
            inactivated by hypermethylation during tumor development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 33681)
  AUTHORS   Jackson,V.A., Mehmood,S., Chavent,M., Roversi,P., Carrasquero,M.,
            Del Toro,D., Seyit-Bremer,G., Ranaivoson,F.M., Comoletti,D.,
            Sansom,M.S., Robinson,C.V., Klein,R. and Seiradake,E.
  TITLE     Super-complexes of adhesion GPCRs and neural guidance receptors
  JOURNAL   Nat Commun 7, 11184 (2016)
   PUBMED   27091502
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 33681)
  AUTHORS   Wu,Y., Davison,J., Qu,X., Morrissey,C., Storer,B., Brown,L.,
            Vessella,R., Nelson,P. and Fang,M.
  TITLE     Methylation profiling identified novel differentially methylated
            markers including OPCML and FLRT2 in prostate cancer
  JOURNAL   Epigenetics 11 (4), 247-258 (2016)
   PUBMED   26890304
  REMARK    GeneRIF: OPCML and FLRT2 were further validated in an independent
            cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We
            then compared patients with biochemical recurrence (n=70) vs. those
            without (n=86) in a third cohort, and they showed no difference in
            methylation at these DMR loci
REFERENCE   6  (bases 1 to 33681)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   7  (bases 1 to 33681)
  AUTHORS   Wheeler,H.E., Metter,E.J., Tanaka,T., Absher,D., Higgins,J.,
            Zahn,J.M., Wilhelmy,J., Davis,R.W., Singleton,A., Myers,R.M.,
            Ferrucci,L. and Kim,S.K.
  TITLE     Sequential use of transcriptional profiling, expression
            quantitative trait mapping, and gene association implicates MMP20
            in human kidney aging
  JOURNAL   PLoS Genet 5 (10), e1000685 (2009)
   PUBMED   19834535
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 33681)
  AUTHORS   Haines,B.P., Wheldon,L.M., Summerbell,D., Heath,J.K. and Rigby,P.W.
  TITLE     Regulated expression of FLRT genes implies a functional role in the
            regulation of FGF signalling during mouse development
  JOURNAL   Dev Biol 297 (1), 14-25 (2006)
   PUBMED   16872596
REFERENCE   9  (bases 1 to 33681)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   10 (bases 1 to 33681)
  AUTHORS   Lacy,S.E., Bonnemann,C.G., Buzney,E.A. and Kunkel,L.M.
  TITLE     Identification of FLRT1, FLRT2, and FLRT3: a novel family of
            transmembrane leucine-rich repeat proteins
  JOURNAL   Genomics 62 (3), 417-426 (1999)
   PUBMED   10644439
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049775.2 and AL132641.3.
            
            On Jun 3, 2019 this sequence version replaced NM_013231.5.
            
            Summary: This gene encodes a member of the fibronectin leucine rich
            transmembrane (FLRT) family of cell adhesion molecules, which
            regulate early embryonic vascular and neural development. The
            encoded type I transmembrane protein has an extracellular region
            consisting of an N-terminal leucine-rich repeat domain and a type 3
            fibronectin domain, followed by a transmembrane domain and a short
            C-terminal cytoplasmic tail domain. It functions as both a
            homophilic cell adhesion molecule and a heterophilic chemorepellent
            through its interaction with members of the uncoordinated-5
            receptor family. Proteolytic removal of the extracellular region
            controls the migration of neurons in the developing cortex.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (3) uses an alternate exon in the
            5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode
            the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.115782.1, AK056649.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330753.6/ ENSP00000332879.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               AL049775.2         95847-96237
            392-33681           AL132641.3         80724-114013        c
FEATURES             Location/Qualifiers
     source          1..33681
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31.3"
     gene            1..33681
                     /gene="FLRT2"
                     /note="fibronectin leucine rich transmembrane protein 2"
                     /db_xref="GeneID:23768"
                     /db_xref="HGNC:HGNC:3761"
                     /db_xref="MIM:604807"
     exon            1..391
                     /gene="FLRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..33681
                     /gene="FLRT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             768..2750
                     /gene="FLRT2"
                     /note="leucine-rich repeat transmembrane protein FLRT2;
                     fibronectin-like domain-containing leucine-rich
                     transmembrane protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane protein FLRT2
                     precursor"
                     /protein_id="NP_037363.1"
                     /db_xref="CCDS:CCDS9877.1"
                     /db_xref="GeneID:23768"
                     /db_xref="HGNC:HGNC:3761"
                     /db_xref="MIM:604807"
                     /translation="MGLQTTKWPSHGAFFLKSWLIISLGLYSQVSKLLACPSVCRCDR
                     NFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDE
                     FPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAIS
                     LKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTN
                     KGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLR
                     KLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNV
                     RGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPS
                     RSYTPPTPTTSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAY
                     KLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTI
                     CSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFCWHM
                     HKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRL
                     QPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT"
     regulatory      7152..7157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLRT2"
                     /note="hexamer: AGTAAA"
     polyA_site      7176
                     /gene="FLRT2"
                     /note="major polyA site"
     regulatory      14008..14013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLRT2"
                     /note="hexamer: AATAAA"
     polyA_site      14033
                     /gene="FLRT2"
     regulatory      20931..20936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLRT2"
                     /note="hexamer: AATAAT"
     polyA_site      20950
                     /gene="FLRT2"
     regulatory      22176..22181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLRT2"
                     /note="hexamer: AATAAA"
     polyA_site      22197
                     /gene="FLRT2"
     regulatory      31143..31148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLRT2"
                     /note="hexamer: AATAAA"
     polyA_site      31164
                     /gene="FLRT2"
     regulatory      33577..33582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLRT2"
                     /note="hexamer: AATAAA"
     polyA_site      33602
                     /gene="FLRT2"
     regulatory      33651..33656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLRT2"
                     /note="hexamer: AATAAA"
     polyA_site      33681
                     /gene="FLRT2"
ORIGIN      
        1 agttgtacgt tcgaaacctg tcgccgtcac ttgcgcgttt ggcattatcc attgtcaccg
       61 cggaggaacg agcgctcgag atatcatcag tgcccgcaaa tctccgcgcc aaggcgctga
      121 gctactcctt tccgaggtgc gcctctggtc ctccgtccct ggtgcccagc agcggcgagg
      181 cggcatctcc gctcccgccg ccgtgtccac cgagccctgg gatcagggtg gcagttctca
      241 acgatgggca ggagggacct cggcggcgac ccctaaaaca ataccatgcc ccgggatccc
      301 cgctgctgcc gcgccagcgt cttccctttc cacctccctg accctgtcgg attcggatga
      361 gcccattgca aggagaagac gcagccgtca gattgcagat tgagcttaac caagaagttc
      421 gtaggctaat caaggctggc ttgacctaca aaagaagaag agagttctgc ctgcccactt
      481 gggcttgtgt tgacacggct gataacttgc catcacctgt tgccagtgtg gaaaaattct
      541 ccctgttgaa ttttttgcac atggaggaca gcagcaaaga gggcaacaca ggctgataag
      601 accagagaca gcagggagat tattttacca tacgccctca ggacgttccc tctagctgga
      661 gttctggact tcaacagaac cccatccagt cattttgatt ttgctgttta tttttttttt
      721 ctttttcttt ttcccaccac attgtatttt atttccgtac ttcagaaatg ggcctacaga
      781 ccacaaagtg gcccagccat ggggcttttt tcctgaagtc ttggcttatc atttccctgg
      841 ggctctactc acaggtgtcc aaactcctgg cctgccctag tgtgtgccgc tgcgacagga
      901 actttgtcta ctgtaatgag cgaagcttga cctcagtgcc tcttgggatc ccggagggcg
      961 taactgtact ctacctccac aacaaccaaa ttaataatgc tggatttcct gcagaactgc
     1021 acaatgtaca gtcggtgcac acggtctacc tgtatggcaa ccaactggac gaattcccca
     1081 tgaaccttcc caagaatgtc agagttctcc atttgcagga aaacaatatt cagaccattt
     1141 cacgggctgc tcttgcccag ctcttgaagc ttgaagagct gcacctggat gacaactcca
     1201 tatccacagt gggggtggaa gacggggcct tccgggaggc tattagcctc aaattgttgt
     1261 ttttgtctaa gaatcacctg agcagtgtgc ctgttgggct tcctgtggac ttgcaagagc
     1321 tgagagtgga tgaaaatcga attgctgtca tatccgacat ggccttccag aatctcacga
     1381 gcttggagcg tcttattgtg gacgggaacc tcctgaccaa caagggtatc gccgagggca
     1441 ccttcagcca tctcaccaag ctcaaggaat tttcaattgt acgtaattcg ctgtcccacc
     1501 ctcctcccga tctcccaggt acgcatctga tcaggctcta tttgcaggac aaccagataa
     1561 accacattcc tttgacagcc ttctcaaatc tgcgtaagct ggaacggctg gatatatcca
     1621 acaaccaact gcggatgctg actcaagggg tttttgataa tctctccaac ctgaagcagc
     1681 tcactgctcg gaataaccct tggttttgtg actgcagtat taaatgggtc acagaatggc
     1741 tcaaatatat cccttcatct ctcaacgtgc ggggtttcat gtgccaaggt cctgaacaag
     1801 tccgggggat ggccgtcagg gaattaaata tgaatctttt gtcctgtccc accacgaccc
     1861 ccggcctgcc tctcttcacc ccagccccaa gtacagcttc tccgaccact cagcctccca
     1921 ccctctctat tccaaaccct agcagaagct acacgcctcc aactcctacc acatcgaaac
     1981 ttcccacgat tcctgactgg gatggcagag aaagagtgac cccacctatt tctgaacgga
     2041 tccagctctc tatccatttt gtgaatgata cttccattca agtcagctgg ctctctctct
     2101 tcaccgtgat ggcatacaaa ctcacatggg tgaaaatggg ccacagttta gtagggggca
     2161 tcgttcagga gcgcatagtc agcggtgaga agcaacacct gagcctggtt aacttagagc
     2221 cccgatccac ctatcggatt tgtttagtgc cactggatgc ttttaactac cgcgcggtag
     2281 aagacaccat ttgttcagag gccaccaccc atgcctccta tctgaacaac ggcagcaaca
     2341 cagcgtccag ccatgagcag acgacgtccc acagcatggg ctcccccttt ctgctggcgg
     2401 gcttgatcgg gggcgcggtg atatttgtgc tggtggtctt gctcagcgtc ttttgctggc
     2461 atatgcacaa aaaggggcgc tacacctccc agaagtggaa atacaaccgg ggccggcgga
     2521 aagatgatta ttgcgaggca ggcaccaaga aggacaactc catcctggag atgacagaaa
     2581 ccagttttca gatcgtctcc ttaaataacg atcaactcct taaaggagat ttcagactgc
     2641 agcccattta caccccaaat gggggcatta attacacaga ctgccatatc cccaacaaca
     2701 tgcgatactg caacagcagc gtgccagacc tggagcactg ccatacgtga cagccagagg
     2761 cccagcgtta tcaaggcgga caattagact cttgagaaca cactcgtgtg tgcacataaa
     2821 gacacgcaga ttacatttga taaatgttac acagatgcat ttgtgcattt gaatactctg
     2881 taatttatac ggtgtactat ataatgggat ttaaaaaaag tgctatcttt tctatttcaa
     2941 gttaattaca aacagttttg taactctttg ctttttaaat cttaaaaaaa aaaaagttgc
     3001 tgaagtactg tacagggttg tacaatgaga acccaatgcc aaggcaaaaa gaacgagtga
     3061 tttttcctta ggatacacat caaccacttt gctgttgaag ctgtcagaat aaattcctgg
     3121 tggtcagatg aaagggcaga ttaaatggac tcatcagggt aagaggaata atatgggtaa
     3181 aacaagaaat ggcccgatag tttcacacta ttcctatacc tccaggtccg gaagacaggt
     3241 aaaaaattct ataatgtaag aatggaggta gttaccctga tttgaccctg tgtgggaaat
     3301 gctgaaagca ccaggaggaa gccggttccc gtgagataag ttaacccggc ctgacagaat
     3361 caagaaaatt gagatgagat ttgaaaggac ccgaaaatgc aggggttggc tttctgactg
     3421 ggaacttaaa aatcactctt catgcttccc tggtcctatg tgataacaga gttagagact
     3481 tgagtctgat ttcagtcatc ttcagggacc agtctgatgt tgtagcaaga agactccctt
     3541 taaaagtgtt actgttcaaa tcatatatca ggttgaatca cattcaacag agatatattc
     3601 tagaatactt ttttagaaga ggctaataaa gggaagaatt atattgaatg gaattatttt
     3661 tgataatgag aattatttgg gtagattcac tgaggctatg tcaacatgat atttagacca
     3721 acaggtgatc aatgtttgga aaatacaaca atgacttatt taaaaattac ccttcctgct
     3781 atttagacaa aaacaactga tcagtggttc tgttatgtca gctgactttg ttagtatcat
     3841 gttgaaatag cttgaagtaa tatcttttat ccccttgcaa attcttgtct tccaatcatc
     3901 tcccatatat tttcataatt agttgtttat gacacctttg tttttctccc tctgttcagt
     3961 atttcaagga aaattatgga tgccagtctt ggctgcacaa gatatccatt acgtacttat
     4021 acattttaaa atgagtacta attttcactg ctaataattc tgtaaggaca catcaaagct
     4081 ggccaaaata atgaattttt tttaaaaagc aatacctggt ttccaccttg gactgacttt
     4141 gatcctgttc cacttttgaa attttatttg ttccttttcc atcgtggatg ttcctctact
     4201 ttggcaattg tggagggcta atcaatctta tgttagcagg acaacccatg aaaaacaagt
     4261 cagagagtga aggctttttc ccctaatcct ggcagagcag ggcgtagaaa agagaggatg
     4321 tccgtgctta attctagata cttttgagac aacaccttca gaaaacacat aatttaatct
     4381 ttgccatcct tagatagaga agggctatag atcacatacg ttatcaaaaa ctactccctt
     4441 ggaaaaaata tctttcgaaa atcaaattta aacatttcac tctgtgctgc atatttcttt
     4501 taccattgac cattattata gggacccatg aagtaaatgt cacaatcatc ttactagctc
     4561 tctctctctc agcaaaataa aactgtgatg tgtcttcttt gtaaaagttt aggtataaaa
     4621 tgctatgcaa ctttttcttt atagtaagag ctttattttc tttaataata tagcccaact
     4681 tatatgtttt aatctccctt gtccctcaga ataagcagaa aatataactg cagctgtatg
     4741 tcgtagacac aagaattgaa actgtgcagt cagtagagct gaacttagct atgaattaat
     4801 ttaaattaat tctaaagtga ctctggtttc cattttagtc tattagctag agggttttgg
     4861 ctgttgcttt ttttaaagtt aggtccacac agtgaaggga aaagagtctg tgaaggtgat
     4921 cagtgtagca gtaagacatc taaaatcaag acaatgacat gggggctttg tgtacttagc
     4981 tggataattc ccttctactg tcctcttccc cttggctgtg tagataaaat tgtgcattca
     5041 aatgatggta ctttgacttt tgagggtttt tatttctgtt attcacaaaa tactcattct
     5101 catttatgta tattgtatgt ttaaccccca gtgggatttc tggctgctga aaccactttg
     5161 ggccaggaag aacaaggatg aagaggttcc tgtcatttct tatggggttc acagaattat
     5221 ttggggctta aatggtacaa tggagacagt catgtgcaat gcttaagatg gtctgacagg
     5281 gtcccttttg ctggaggtgt tcctgaagag attgaaccta gtaacaggct ttattttcac
     5341 cttgtgtaca acatggcaaa gactgctaag attaaaatcc gtctcccatt tgttacagcc
     5401 tcacctgcac caggatagaa agcacgtgat ggaatctgtg atgtctaatg tgtcttatga
     5461 aaattgccaa acaactgtcc ctggggattc tgctttgatt ggcattttta gtcatgggaa
     5521 tgtatatttg ctgatatatc tgctctgtgt ttgggcctct cttgctgtca ttatgatgta
     5581 ttttgagatg attagtcaag agtcaaggtt gcgagtacag gccaagacca tgggaaaaaa
     5641 agccatgctc actggccaat aaagagcttg atgctgcctg gccaaatgag gtgactcaga
     5701 tagaatctga tcccattcag agcttggtaa atgtcactgt acagaagaca ttgaaaagga
     5761 agaggcatag tcatgatcaa aaggatatat tgacagttat ctatagccag ggtagttgtt
     5821 aatacctgct tgtttgggga gatatgtttg attatagaga gactctgggc caccctcaaa
     5881 caccgtcaga tgcattagca gcccactgca tgggacaatc gcaggcagat acgaggaatg
     5941 tatcccctgc ctattttcct tgtgtaacaa atggaaaaca ttctcccctg tgagaaataa
     6001 tgcaatttct aattatctgg atgttcgttg aaaatatatt agacattctc cctgaggtta
     6061 aaaacaaaaa gtacgtgacc agtctggtaa gaagtattaa tgaagtagct aatattacag
     6121 cttcattttc tactagcacc tatcataatg gtcttagtca tttcacacaa atcagaactt
     6181 ccttccccac cagggaggac aacatcttca tgctgtgatt gaagcatcca ttcagaacac
     6241 gaggcaatat tgcagtccac agggaatgga tgcttcactt gatctccgga ccttggctgc
     6301 agaggccatc gcagcttttg aaaagtgaag gggttaattc ccattggtgt ctttgcttat
     6361 agcatttttc tctaacctat aacaaggaga cattacattt tactttagaa catgagaata
     6421 gcagttttgc tcatgactta ccattccagc tgcatgggaa agcaaagcag aaaacagtgc
     6481 cccaaatgga aaaaagatac tcacacagaa caaaacagtt cttggtcttg ttcttggtct
     6541 tgtcaaacct tgcctgatgc tctttctaaa gtcaaaatat gaatgctaag aaggcataac
     6601 ctacatcctt ctctgatttc ttcagcaggg tcaaaagaca gttactagca atggggaatg
     6661 cttgtcactg tggagaaaga gttttgtata tgtctgatac cgttgttata acaaaacaaa
     6721 tttttttact atagtttttt gttttctacc tgcacaccca ccagaagagc acaaagcaag
     6781 gccattgcaa caggcattta aaaattatta tcaaacatgc acatgcttgt acacacacac
     6841 acacacacac acaaacaggg gcatttgtaa aggtgtccct ggaatgtaag atttataatg
     6901 tttaaggcaa ggtgaaggca ttgccaagtg tgtgtcgctc ataggactag tgtatattca
     6961 ctgaaagtta acctgatgat ttgttattgt ttgaaccata tgctgatttg cttctggttt
     7021 ctgtttagtg tgttctctct gataaggggc tgaaagattc tgcatcacac atcctctgag
     7081 acctaccatg tcgcacactt tgttaatgac aaacttcact ctacactata cagtaccttg
     7141 ttgatatatt cagtaaagtc ttattttaaa agaaaaccac attgtgttta tctgagtaag
     7201 ttcattggga tacagtcaat acttgtgctg ttaatgtaga agaaatgacg caggagggca
     7261 ggaataaaag aggtaatagg actttcgtat tctcctatca tgaatatgac ttgcatttct
     7321 aaaggccatt tgatcctttt tgtgtgagga gtttatatga aatcctcatg ttcttttaaa
     7381 tttcccaact aaattgtgtg ttcctacgaa taccttttag gtatgcacac atacacagag
     7441 catcttattt tatactggtg aaatctatgt tgtttaggat acagataatg tcattgtatt
     7501 tatcctatca gaataggctt ttcccctatt tcaaaataga tgctattggc tttatttttt
     7561 atttttaaat tttttttaaa cacggtctta ccatgttgcc caggctggtc tcaaactcct
     7621 agatgcaagc aatcatccca cctcgatcac ccaaagtgct gggagtacag gcagaggaca
     7681 ccatgcccag ccacgctatt ggttttaaat gtcagatttc tttaagaatt ctcatagtac
     7741 ttttctgccg cagaatttat agcacatctg tccatccttt caataggcac tcaaggaaat
     7801 gtatctattc atatgctcaa cttcaattga ttagtctcat atgatttttc agaacccctt
     7861 ttgctaaccc ctcttggcca tttcattaat aatgtatttg acagagattg aatcaggaaa
     7921 taaattcatg acatttcagt taactagtat tacctgtttg tagaatctct gttggaacat
     7981 tgactatgaa agacagtgct aacaagtaat tcatattact tttggggatt ttatgtaaag
     8041 taacatctat gctattcttg ggtacttttg ccaagagtta cagaccttat tctatacaga
     8101 ctaaaccatt agtcaaaaaa taccattcat tcaaaataat tcattaatgt cctcctactc
     8161 tgttccaaac actaggctga gttcagaggc ctcacagaat agtgaaatgc gttcttagcc
     8221 aaatcaggca aatcttctcc ctcactatgt ccctgaagaa atctcttcat ctgatatatt
     8281 tactattcat ctactttcta cagcactatg ttagggtctt ccggggattc agagaaaagt
     8341 gtctgtgagc cattaagaaa ctcacagatc aggtaataaa cactttttct aatgcattcc
     8401 agtgtctcag agcctgcata atcactttat actacttcat taaattgaca ggacatctaa
     8461 ggtgacaaaa gagatgtttc tacctgttgg taaggttgat gcaactgtca taattagatg
     8521 ttcttggttt ttaatagatg cagcaatgag agagtacatt gctaaagtca gaacttaatt
     8581 tgaattaaat tttcaagttt ccaccaagta tttgaaaact tagaaattgt atttcgtaat
     8641 tacacatgca gacatttaaa tttttattaa gcaccacgat ggaactcaat ctaaaggaat
     8701 aatggcacct gataattact aacaaccttt gtttatataa gaccttgtgc aaactgtgtg
     8761 ataacgtatg tttgcattct gtctttaaaa taaccctgta aggtgcgtta ttttaatttt
     8821 tagattttaa aacttagctt caagagaaat taagtgatta gtctatagct acaaatcctg
     8881 taaatggcag agtcaggaat taccactgag catgactcca tggactctta attgttttcc
     8941 tgcctcttaa taaattgacc atccttgaga ctgactagcc ttcagatttt tcatgatgga
     9001 gctatcataa cttctcagtg gatacatata ttatcattta tggcaaataa agggaacatt
     9061 ttagaagcct caaaattctt gtcttttaaa gcccttggtc atccattcct attttttata
     9121 aaaattcttt ttgtgattat ttgatggctg cacatttatc tgatttgaag gtttcagatg
     9181 gaatcaagat atgtctgtac ccatagggtg agctgaaaga gctactaaaa ggtcttcagt
     9241 tgggttattt ttaggaatga atttgtttcg tacttgagat gttgctctaa gtattttgta
     9301 gattccgctg aaaaagcacg tatgtcacaa tctattaggg cattagtaaa ctggcttctg
     9361 aatttatgct cttttttttt cccataacat agataaaaat gtgtgcttta ggggatatta
     9421 tataagcttt attttcactg gctctactga aagttaagga tacaaaagtt tttaatggta
     9481 ataacccaaa ctatatgtca ttttagcaca cacataccaa tgggtgatca tatctgtctt
     9541 tttttttttt tttttttttt ggtatgaagt ctaaactaga cgaaaacctc aatatatcct
     9601 taggggaatt cttattactt caatgacata ataaacctca gtattgggtc actcttttcc
     9661 taatataaaa aactatgctg gctcaaaaag tcttctaaac tccctagttg ggataggatg
     9721 ggcctttgtt ggtttagttt tgatttcatt cagcaaatat ttaccgaggc ctggtaagtt
     9781 ctggtgcaga ataagaatgt tttccaggag agttaaattt tgctcatcaa aaatctttct
     9841 tggaagctgc tggtttttaa ccgtcagcct gggctctttc tgcctctttg ctttttttga
     9901 gcagaatatg gccaggctgg tctcaaactc ctgatcttag gtgatccacc cacctaggcc
     9961 tcccaaagtg ctgggattac aggcatgagc cacaccactg catttaaata atcagcctag
    10021 gattctgcta gttccagcac cagagtggcc tctcaaatgt gttttctcct cttggttccc
    10081 tgactctgac ttggttaaga cccttccttt agtctttttc taatttagcc tttccaacac
    10141 attgaaggac aaagggtaat cataatctat aaggaatgcc tgagtacgat actgcagtgc
    10201 ttgcaaaaca tgcgttttta ttgcttgcaa gatagaattc aaactctttg tgtgacttat
    10261 gtatcctact acatgttgct ccctgacatt tcttaccaat attgcctcct ccttcattac
    10321 atgctctaga ttatatatat ataattacat atataatcta gattttatat atatatatat
    10381 atgaaatgag caaacaaaat gctttcagtt tatcttcctg ggatctcaag ttccttcaaa
    10441 ccactatata tgtgctcaag gtctttcatc ctgtgacatt cccctttgcc tgatgacata
    10501 tttgtccttt aagatacaag tcaaagacct ctcttccaaa gccgctggaa tcacacctgc
    10561 caattatctg accgctttgt gcggttaata taactttaaa atacatttat ttttagcacc
    10621 tatatattgt aattttttgt gagtctgctt catgcctata caatggggcc cctggaaaca
    10681 gaaaacatat tctgtaaatt gttgtacctc atccagtgtt aagagccatg cccaggccct
    10741 ggtgggtgcc cagctacagg ggaagagcca ctctgtcagt tgcttatggc cagatggctc
    10801 tttttttaat agccccagaa agagctgtgg agttctgact tgtgcaaaat tagccttgct
    10861 caaagaccac agtatgcgtt ttacaagaac aaacaaacat atatattttc cttaaaatct
    10921 cttgattact catcaacatt tttaaaagaa attttgtttt tatgattatt tggtggccat
    10981 gcatctgatt tgaaagcttt agatggaatc agtatgtcta cattcatagg atgtgctgag
    11041 ataacaatta aaaagacctg aagaacatct ttttatttta tttatttatt tttttttgag
    11101 ttggagtctc actctgtcac cagattggag tgcagtggca caagctcggc tcactgcaac
    11161 ctccgcctcc cgggttcaag caattctcct gcctcagcct cctgcgtagc tgggactaca
    11221 ggcgtgcacc accatgcctg gctaattttt tgtattttta gtagagatgg gttttgccac
    11281 attggccagg ctagtctcga actcctgacc tcaggtgatc cccccaccta ggcctcccaa
    11341 agtgctggga ttacaggtgt gagccactgc gcccagccaa gaacatcctt tttatatatt
    11401 acagacaaac tcaaaactga accagcttgc agaaaagcat acaaagaggt atctttaaaa
    11461 atcaccttaa tcccagcact ttgggaggcc gaggtgggca gatcacgagg tcaagaaatc
    11521 aagaccatcc tggccaacat ggtgaaaccc tgtctctact aaaaatacaa aaaatttagc
    11581 cgggcttggt ggtgcgtgcc tgtagtccca gctactcagg aggctgaggc aggagaattg
    11641 cttgaaccta ggaggtggag gttgcagtga gccaagatca tgccattgca ctccagcctg
    11701 gtgacagagt gagactcaaa aaaaaaaaaa aaaaaatcac cttgcaacaa aatatcgcca
    11761 tcatgaaaag tccacaaagc acaagtagac acaaagttaa acatttcgac agtcggctag
    11821 tcaaaatgaa ttctttgcat gtgaaaagca gagatttttt ttttttcatc ttcatcagca
    11881 aaattaaaaa agacagtcat tattcactat gtcatatccc atataaaaat acagcatata
    11941 tcatttaaag gttcacattg tgttatcttg gttattgcca tgagaatagt ctttcctaga
    12001 aatgatatgc ttgtaaagaa gggagtggag agtggtagtt attaagaaat cagtttgaaa
    12061 tcaagctgac ttactttgga atcctgcttc aaccactgac ctgccaattt gccttggcaa
    12121 taacttgcac tttagggtta tcagtgtact tttcctaaaa tggggacaat gatgtctaac
    12181 acatatggtg gttgtcagaa ttaaaggcat atatagtagt tgacagagta tctggtactg
    12241 agtatacatt gaataaatga catgaagcac catgtatttt tcatgcagat gtaattcaca
    12301 agcacatggt gacaaattgc cagcttttta tgatgaaaat caaatttctt gtgtattggg
    12361 gtaagaatta catgtagaga tgatctattt aaaggtaatt agcattcaaa attcctcaaa
    12421 acactcaata atttgcacag ctattatcaa gatgggtctg tcagaaaggt tttcattatt
    12481 ctgtattctt tctgggggaa aaaaattggg aagatgaggt gccatgggat aacacacaac
    12541 catggcaggc cttttttctc atggtgtgtg ggatcattga acaacatggt tgaacagaaa
    12601 gagaacagac ttctttataa tgtagcatat attctatctg gttgctagag tacacataga
    12661 tgtagttatt gctgaaaatt aattcagaat atgtgggtgt caaaagagcc ccaggaatga
    12721 gcattcagaa ggcattggaa atcaaaatac taaaaacaaa atcaagataa gctgagcaca
    12781 gtggctcatg cctataatcg cagtactttg ggaggccaag gtgggaggat tgcttgaggt
    12841 caggatttcc agaccagcct gggcaatgca gtgagaccct atctctaaaa aaaaaaaaaa
    12901 aaattagcca ggagtggtgg catgtgccta tagtcccagc tacttgggag gttgaagcag
    12961 gagggtcact tgagcccagg agatcaagat tacattgagc tctgattgtg ccactgcact
    13021 ccagcttagg caactgagca agaccctgtc tcaaaaaaaa aaaaaaagta ataaatttct
    13081 gatattgttt caaaaatcta taatttctag taagacatag ttttatttga tgctagtaca
    13141 ccaccaatta cggcatttaa atccacactg ggtttgctga tagtggggat ggtagcagtc
    13201 aaatggaaga acattttaat gtctctacaa tgcaggtgca atagtctacc acctgtcatg
    13261 tggttacttt ttgcaatcga tatcattatt aagtttggaa gctggttgtt attaacaggc
    13321 atgcatcctc ttcagctgga tcacgttgtt ttctttctgt acactttgtg gtagttaata
    13381 gtctcaaagc aattcactca ctacggtctg tattagcatt attttccttt ctatttatgt
    13441 ctttccttgc ttaataaatg cagaagttca gacatttgat gaggggggaa atatactttt
    13501 tcagtccttg actgcatgat ttaattggtt tcaggacagt tatttggcaa gtagtatcaa
    13561 tgggtactgg cattcctgtg gtctgctgcc aatctctatt ctgtttggac tagtgtctgt
    13621 tttgactggt aggcctcagc tatcctattg ctaagtattt tacataactg ccctcattag
    13681 ttggaatata gcatgcttta ctagtgtatc tgaagtaagg aggaagcagg aagtgagctg
    13741 ttttgtaatg gaggccaatt atatctaaca gcaactgtgt ctataagact gtagcctatt
    13801 ggatgggaag ttatattatg aaaacatgat gaatctttta aattctgagt ccaatgctgt
    13861 ctacatctaa atttaaatcc tggctcatac taaccttggt ccttgggcat gtatatgctt
    13921 caattttctc atctgtacat gggttaataa caacactcac ctcaacagta accatactgc
    13981 acagtgcctg acacatataa agtgctcaat aaatgccagc tactttctga aaatatatgg
    14041 aattagtgtg caaaaagttg ggctatataa ctcaaatctc ctttgtatct tggataagac
    14101 cacttctctc tcgggcttgt ttcttatagt caaaagcgca ggaatttagt tgatctccca
    14161 agttactttg gaccttaaat tctgttttat ggttgttcat tttctatgta gtttagattt
    14221 ggttcattgg actgatttgt gttctgtgtg cttttaaaat tcaggaagat gtgactagga
    14281 tagataaagc aaacatataa acactcagtt tcattgactt aagtataaag actaacatgt
    14341 ttctcattag ttataataac cttaaacttg atatgttagg gaagcaacct gcataaccat
    14401 taaaatcagg agctacagaa tcacaaagaa ctgtgacttt gtatctgtgt gatattattt
    14461 aatgtcccta agcctcagtt tcctcatata tgaaatgagg tactaatact tttaaggatt
    14521 tgatgagata atttatatca tcttcacttc agtggttggc atatattcaa acccattatg
    14581 gctgaaaaat tacaaatgaa tagaaagaga agcaagtgaa aacaaaactc attagttcaa
    14641 ccacttctcc ctcaaaacaa ggaaatacaa actatattac taagtagact attaataaaa
    14701 cactttattt aagtcaaaat tatcaaagat agagtgtcgt acaataaaaa ttgtataaaa
    14761 aattgtttat taaaatatta aatattttat gttttcaagc cattatataa cagctattaa
    14821 accctaatat ttgacagaga aagaattatg agaatagcta gaaaatatta aataataaat
    14881 gtggtttatt tttgatggaa tagaacagat tttaaccctg atccctgcca cttttatctg
    14941 aaccttgaac aaacatacaa ttatggttta aaaaaaagaa agatgaaaac tttttagaat
    15001 aattaggaaa ttcttctttc ccagaccttc aatactttta taaaaccact acttagcagc
    15061 taacaatgaa atgttcattt caaaatgttt agtctttaaa gcggttacct aagaatatct
    15121 gccagtgaac actagcttta tttcatcaca tcatacacct gaatgtaatc aacattgctt
    15181 tattaaagat gtttatataa tttttatata atacacactt ccaataattg ataatagtct
    15241 aatgattgat attttaaatt aatggcttgt aattgtgtaa ttggaaagtg gtccttggga
    15301 ctcagattaa ggtatcatta cctgttcttt cataagctgt tatttatgct tctcattaat
    15361 tagttctttg ttatgaaatc tttaaaagtt cattaattct gtaaagggaa tttaataaaa
    15421 tgcaagcaga ttagtaaaat aatttgtttt aaagttagtt ttaaatatta tgctacctct
    15481 ataaaggacc aaaatagtat ttttaaaaga atttatcaaa gtaactataa taaaagtatt
    15541 taatggtatt tgtattgcaa acattgaaat tctacctggc agtttaaaga acatcactaa
    15601 cattgcctaa atgtaggaaa atcaaaggtg aagtcacctg cagaaaaaaa aaaaaaaaaa
    15661 acaaaaaaca ttcttattaa tcttaactaa ttttctttag tgacagaaat tcaaacttcg
    15721 agacatgttt gaaacatttt atttcagtaa atatagctgt cactatggaa gtaattactc
    15781 taaaggaaat ctgttttaaa aagccagtat aaactgaaaa gtaagcaaca aaacatcttc
    15841 aggaaaagaa aaagaaaggc aaataaaatg tttatatgaa attacgaaca ttctgggccg
    15901 ggtgtggtgg ctcatgcctg taatcccagc acttttggag gctgaggtgg gtgaattatt
    15961 tatttgaggt caggagtttg agactagctt ggccaacatg gtgaaagccc gcctttacta
    16021 aaaatacaaa aattagcagg gtatggtggc aggcgcctgt tatcccagct acttgggagg
    16081 ctgaggcagc agaattgctt gaacctggga ggcggaggtt gcagtgagct gagatagtgc
    16141 cactgcattc tagcctgggt gacagagcga tacttcgtct ccaaaaaaaa aaaaaaaaaa
    16201 aaaaaaagag agagactaac attctaacag acaaaacaaa aacaaaaaac aaaaaaacac
    16261 attttacaaa acaataatct aagtgggcaa gtaaatactg gtgtgacata catttttagg
    16321 gaaaaactag caacatgttt tgtggagata aatgtaaaca cattttacac atacaaatct
    16381 tttctggcat gggtacaaat gtaactaatc aagtgtaatt tataaactat aaaaaatttt
    16441 catctagaca aagaagttat taaaagcatt aacaagtagt tgaaaatatt atccctctaa
    16501 gtattagaaa gttaaactgc agtaattaaa agtcatataa gaatcaccat ggcatagaca
    16561 tggtaggaaa agcattagct ttggcgttca aatattgact cattcactta ccagctgtgt
    16621 tctccagtca aaaaacttca cctctttaat gtttggtttc atatttttta aaaggtataa
    16681 caaaaacacc taccacagtg ttggtgtgaa gactcattta aagttactag cacagtgtct
    16741 agtatataca gttgctttgt tacattaact ccattcaata ttctttcttt ccacaatcgt
    16801 ctgtcactcc cggtagaact aagtgatttt ccatgctcct gcaatgacag caaatttccc
    16861 ccagtctgct cttccatgaa tatctcagac agagaagggt gccttctcat gtgatcagga
    16921 gtgatgtagc tttgagggtg gacccaccat tcctgccata ttccttgggt aggctcatct
    16981 atcacttgtc ttaaaggaag atttgaaaca taatagtttc ctttgcgctt ctgtggatgt
    17041 ctctgaaaaa gctggcaggg cacacactct tgcaaatttt tcatgttgta atcacccacc
    17101 agtggtaata atagggttaa ttatatgaac ccatatagta gtgtcattta aagggaattt
    17161 aaattctctc ttgtccttac tctgctccac catcctccac tgtgcttgaa atgcctatca
    17221 ttatccttat tcttttgata ccaggcatca ctacaaaatg tatacacatt acctagattt
    17281 tcaagaagtg aaatgtttag taaccattat gatggaagct gggactaggt gacttattct
    17341 aaatgtaaca attaccggta gagaatggga taaaggacaa ctgagtgtgg atagagaaag
    17401 gagaaatgga agagtttgga gcacgggcca ttgcgatgga cagacgccac cgcagagagc
    17461 aaggtttacc tgtgtggttg gcattcttgg aagtgctctg gttctattgg cagagatcct
    17521 tgctgttagc ctcttgcctt tcgcccaggc tgaagacaga gtgctttccc atggttctgt
    17581 ctttttctcc aggcaacact tcctgatgac tgatcaatat tggggtagga agtcttagac
    17641 atcttactcc agctcagatc agctctgatg ggctgcaggc tcagtttagg cttcccttga
    17701 gatttcatca tggctttact tctccctcta ccagtcctgg ttcttcatag ccttccacag
    17761 gtgtcagctg caaaaaccct cccaagtaag cctcttgtat gctactctgt ctcagagtcc
    17821 atttccttgg gaacccaacc tgctacagcc tacttcacac ttcttctcaa ggctgtcttg
    17881 aattcctcca acaatagacc cgttattatg tgaaagtgtg aggctgggcc caagggattt
    17941 ctttacttat tgagcagagc gaagtaacat taatttgtgt tataaccact gaatgttcta
    18001 attccatgaa tttaaatgac gcacctgaac atatatgagg cctagatttt gctgcatgtc
    18061 cgcaaaccta ttttgatcaa ccagtactga acttttcccc ttctcttatg attgtcaaat
    18121 aaccttgtta tatgctaaaa ataaaagatt aaaaaacata cagtgcaaaa aagcaaacaa
    18181 aagttagcta ataatcaatt ctttgaacga agcccagtga aaccaagttt atcaactcta
    18241 tctgaaaata aaaatgtcca agaaaatgac aatcaaaacg attagtgcat taggataagt
    18301 gtcgtctctt gtagatagat aaaaactaaa ctgaaaccaa aagaatttcc agagcaggca
    18361 gtctctattc tgtaacaagg ttttctcatg atccagttat tttaaggata cctgcaggat
    18421 cccacaggtt ttctcaggga tttgctggaa gctgggaaag tgatgactct cattcactgt
    18481 tgccctgttt ccttttcctt gacaaattca gttaaccgga tggcaagttg tttatgagca
    18541 tgccttctcg ttaagttgac aaaatcttga caggagtaaa agataatcga attctctttg
    18601 tgaagtgatt tatggtttta aaataagcag cttttcttga aagtagttta ccgggttggg
    18661 caaaaagagg atgagtatta aaggtcatta ggcattcaag gtaccacatt tactttctac
    18721 aatgcaagta gaagaagggg ccccaccagt cattctgaga cgtgtttcca ttttctgcta
    18781 ctttttagtg agcccaaatg atggtagcaa tgattgattt atctcaatct tcttgtatag
    18841 ctgctgaatt ttctctcatg agtttggcta aaattagagt gtgtgttagt agaatttata
    18901 tttatagact attgatatta ttatgtgcat tacccatttt aaagatggaa acactgaagc
    18961 ccccagaaag gactggctaa gctcttacaa taagtgatgg aatgagcttt gaaaacacag
    19021 ggcttaggat ttcaaatcag gctgttttcc ctcaccgcac catggtgctt cactagcaga
    19081 aattctttat tttttttttt ttcctttttt tttttttttg agacagtgtc tcgctctgtc
    19141 ccccaggcca gagtgcagcg gcgtgatctc gactcactgc aagctccgcc ttccgagttc
    19201 acaccattct cctgcctcag tctcccgagt agctgggact acaggctcct gccaccacgc
    19261 ctggctaata ttttgtattt ttagtagaga cgaggtttca ccgtgttagc caggatggtc
    19321 tcgatttcct gacctcgtga tccgcccgcc tcggcctccc aaagtgctgg gattacaggc
    19381 gtgagccact gccccccacc cactagcaga aattcttaac agttattgtt atctaactac
    19441 ttgactagtg tagattctgc tgtgagcttg tggtggttcc ttctgcagat aaagcaaagg
    19501 aaatctggaa atggccaacc tgaatacttt atttccaaaa ctgtatattt tatcaggaca
    19561 gtaaggcaat cagtggagta atgatccttc caaactgctg actacatcta gaatcatgca
    19621 attattagtt tttaataaag atcgtgacca agctttcctt gggaagtaaa ctttggtcac
    19681 cacaatatac atagcaagta ttaaatatct tgagaggttt tctttaattg tttaattcat
    19741 aggaaagcca ctgggagcct tctgggagcc agaagcaaat taggagacac agaattattt
    19801 aataataatg gtaataatga ctaagttctc tcatcaaggt ctgtaccatg attgaactac
    19861 ttgctgccat aaatttttta ctattgaata aatatgcttt gtgaatattc catacatttg
    19921 ctaagttctc actggtcagg ttcagtcttt gctattagag tcgagcatct ctgcaaagag
    19981 atttgagccc cttgagtaga acataggcca catagtgtgg caaacacatc attagaaact
    20041 gcctcctatt cactctctta atagcttgag agaattgtac acaaacgttt ctaaaataca
    20101 gatcctacct taggcttttc ggctgcacag ctgaatcgcc tctgtgaaaa tcctgacctc
    20161 gctttcttct ggcctttctt ccccgtgacc ttgggcaagt tgcttaaact gtagccataa
    20221 tttcctcata gatttggtat gagttaaaat gcatagaaag catgtactac atctagtgca
    20281 tttctccata atgtgggtgg caattattct aatcccttcc acaaagtatt tagtctatga
    20341 cttatttctg cgaaaaccca cgaaagtgaa aactaacaat agagaagcct tttaaaaacc
    20401 taacagcctc caaagactga agaagagagc atggtgttta atgccagggt ggaaagctgt
    20461 gacagtcagc tttttccctg gatatggctt attggtattc attattccca attccttcta
    20521 tatgccttcc tttctggata gaatcgatca catttgctgg actccattat gtttggattc
    20581 tatgtataaa ttaggttcta ccaattacag gcacgtgtgc aggattttca aggtagaagt
    20641 gaagtggaaa ctctcttctt actaatgtca gtcttgggcc caagaggcca tcaggcacgg
    20701 tgcccataat cagtgtttta gtgtctggtc actatcttca gtggagtcag gtgatgtgaa
    20761 tagcagcagg agagacctga tttctggata aggactacag tagtacgtcc ttggacgcaa
    20821 cagtttaaga ggtagttcct gatttattcc cctccccttt ccaattcatt ccctgatttt
    20881 gtgcacacct aatacttata ttaaatacct ctcctgcttt gaataaatgg aataatttct
    20941 gtttcctgca ttttatcttg ttggattaag tatttgataa taaaactgat tgtgggtcta
    21001 cttacctaag ggtataaatt tgatattggt tacctaaact gtctgaattt gaaagtagag
    21061 acaatcttat tcatgcataa tggatcactg ataatttttg gcttgcaatg agaaaaaaaa
    21121 atcagcagct gaaattatta cctgagatca cctggaatga agagcctatt aaagccaagg
    21181 ctttggtgac caatgtgatt gcttcagaat tttatgatga gaatgtaaat ataataattg
    21241 tgaggtaggc tgaagcatgt atagaaagaa aacaacaaat tcagagtttt aaataactgg
    21301 ctcaaggcaa gtcagaggtc caaggagcat ctatgattat ctccgacact attttatttc
    21361 ttacagtttc aaggttgctg ttgacaaaaa aaaaaaaaaa gaaagaaaga aaaaaatggc
    21421 acacagtgtc tgatcttgtt tattgctgaa atataatttc agttgaatca caccctcatc
    21481 aggtcttctc tgtgaaaatt agggcattga gtgagaaata tcagaaaccc agagcattat
    21541 aatgggaatg ttaggtaggt ttaaattatt ctgactatac tgaaccccca agtccgatga
    21601 gccttctttg ccagtagaac tccttcatct ctgttatata aggttgattc tgcctttgtg
    21661 gggagaacta acttacctga ggtaactaat gtaaaatagc ttgttctgat cacctcactg
    21721 cctccaagtc tagagttaga gctcgttccc agtgtctcag tagggcttaa atatgaagta
    21781 taaactggga agaaaaggct aaaataacaa caaaaaaacg gcaatagttt gttatttttt
    21841 atcaggagaa atctgcggac tatgtatggc aacagactca aagggaggta caccaggtag
    21901 gaaaaatcat aaccagattg ggccatatta gccaatatgg gtacatatac tagagcctgc
    21961 atgcaatgag cttacccaac cagctcagag tgattataat tgttttgctt tctggattgg
    22021 ttgactgaaa tctggactca atggtgagtc acactaattg aagttgagat ggaagaaatt
    22081 ccttggcata ttgtagaatc tgaaatatag gttgtatatt tattagtcag tttggactgc
    22141 tgtaacaaaa ataccataga ctgagtggct taaacaataa acatttatta cttccaattc
    22201 ttgaggctgt gaagcccaag atcaagttgc ctgcagatct ggtgtctggt gatgctcctc
    22261 tttttgagtt gtaaacaact gccctcagaa ggctctctcc tgtctctttt tattaggtca
    22321 ttattctcaa catgagggct ccacccttat ggattaattg cctcccaaag gcctcatctt
    22381 caaacactat tccactcggg gctaggatgt caacatatga aatttagggg cacataaata
    22441 tacagtccat aacagggaga taggaacatt ggagtaaccc atcatatgat tcactttaat
    22501 gtctaaaaac atctcatgag agagttcaga gggtatttct tttttttctt tctttctttc
    22561 tttctttctt tctttctttc tttctttctt tctttctttc tttctttctt ccttccttcc
    22621 ttccttcctt tctttccttt ctcctttttc ttttttttgt tttgagacag gttctctctc
    22681 tgtcacccag gcaggaatgc agtggcgtga tctcagctca ctgcaacctc cgcctcctgg
    22741 gttcaagcga ttctcctgcc tcagcctcct gagtagctgg gactacaggc gtgcaccacc
    22801 acacctgact aatttttgtg tttttagtag agacggggtt tcaccatatt agccaggctg
    22861 ctctcaaact cctgacctca ggtgatccac ccgcctcagc ttcccaaatc gctgggttta
    22921 caggcgtgag ccattgcacc tggccagagg gtgtttcttt aaggcattta ttaatgcatt
    22981 gatgaggact ctcctctttt agatagagat gaaagtgtag atgctgccca caaaatgtgc
    23041 tccctgttta agtggggttg gtggaatcct ggagtgacag agaacaaacg acaacattta
    23101 gtccagttgc agcagagtgg ttgtggtttt tattataagc attaaaagta tagtagtagg
    23161 aaactgtgtt taacctgttt tcaagaatgg ataattgctc attatagctt catgaataat
    23221 atagatgttc agccaactta agttgtacct gaattgtgca aatgaaggaa agatgcaggt
    23281 ttggcaaatt gaagccagac taattatcac aatgtagtat cattaacact cacacaattc
    23341 ccagattcaa ggtgcagcag tggatatttc taagacgtcc tcatttaact tgattttttt
    23401 ttttaatcta tgaagtagtt ggctatgttt tggagaatat acaattaatg taagtttact
    23461 caggtggtaa ttccagttgc tatggttgtg gaagatatgg tctctactta aacaaattca
    23521 actgagctat ggcatctcca atgcaactgt caatttagaa atttctttct ttttatctca
    23581 ataggcaaag aacactaaag tagtctgctt tcactttcat taacacgccc catggagata
    23641 tcatgaatta ctctcaggcc cttgattatc ttatcatacc agaggatgtc ccacaggtct
    23701 acagcttaat aacatcatgt gactgaagtg gaagaactgg aaggaaaaga taacctagaa
    23761 actcagtaat tcacatgcat tcaagaaggt agaagaaaat tctcactaaa actcagggac
    23821 atgccacctt ttgcaaattt ctgggagttt agtccggcat gtctggaaat cctttccaaa
    23881 gaaactgggc ctgttcttga tgggctccct ggatgtttga aggcaacata tactagtttt
    23941 agatgcgctg cttcgatact ttggattcaa tacttagtaa tccctaaagc tgtgaatttg
    24001 gagtttgttg ctgaggaaga gtagactctc tagcttttcc aggctgtggt ccaggctgct
    24061 gtctttgcta cttggttaca atgatccagc aaattcaacg gtgcataaaa tgtttcaggc
    24121 agatggtcat gcagtttgta aaactttgcc aatctcgtag gagattaata gcgtagagct
    24181 ctgtggttct gaagcaaaat catgctttct ttcttagatt attaatctcc ttgtgaggga
    24241 cagttcttgt cttgctaata gaaatagatg ccgaaagagg ctcaactgtt ggctattgga
    24301 tcccgagtag taatgcaact gaactgtaat catgagtttt gatcaaccaa ccataaagtt
    24361 gagcttgggc agcagaactc ctacatcaag taaaaagtat atatatacac acatatgtgt
    24421 gtatgtatat gtatacctat atatatgtat acatatgtat atatgtacac atgtgtatat
    24481 atgtatatac atatatgtat acatgtgtat atatgtatac atgtgtatat atgtatatac
    24541 atatatgtat atagaagtat atatacacat ataaatgtgt gcgtgtatat atatatgatt
    24601 ggctgagtgc tctatttgtt gcttgagcag gtgttcaccc tcccacataa attcatccta
    24661 cttaattggc actttttctt caacccatac ctgcttctca gagaaactat agagaagagg
    24721 aaacttccaa gtgagcaggt ctttgaatgg tacatctatt tgttcactct gcttggaaac
    24781 aaaggtttca ctaagcatgg atacaatttg gatcattggt aataaggaga cttagggaag
    24841 aaatacgtgt taaggattgt tcataagtgg cagaacctat gagaatattc atgccacatg
    24901 ttatttcttt tcagaagatc ttcctagttg aggaatcttt cagagattca gtagataagg
    24961 tgatctatta tatggatgtc aagctgtcct tttccccagc caccctcctc acgtcttgct
    25021 caatgacttc atgaatgaaa agtttatgat agcaaagatg ttggtaacat atgcattcaa
    25081 caacatagtt catttggtag agtcaatact gagtacctaa gagcccaatt ctgatactct
    25141 catattgcac tattcactag gaggttcagc aatctattta gtggcaggtg gtgacagtgg
    25201 atttcttctc ttatggaaag gacaactatc catattgaaa tagacaatta ctctgtatat
    25261 agatttgcct gccttgtaac catgcctttg catctgttta cttacttaat gggacattat
    25321 tatggtgacc catacaacat cacttttaaa cagtggattt atttatggca cagaggttaa
    25381 gaaaatgaac tcaggccggt aagagtcact gttatcattc accacaagtt gcctgaagca
    25441 accagccttt aaaatactat aatggactgt ggaaaaatca gttagagtgt cacttggatg
    25501 aagctgtaat tggaagttga ggacactgtc attcagaata agatgtatga tctgaattag
    25561 tggccaatac ctggcccttt ttgtctgtag ttaaatgtga tgtgaggaaa taccaaagct
    25621 catggtaatc tcagatgtca ttggacagag aagctcacag accaaattaa gatgctgaag
    25681 tcagatgact tatgaatcaa tttaaaacaa atcatgagaa ggaagggagg aaaggatgaa
    25741 gtaggtttgc agtcctctta gaagaaggta aaagtgggta gaatggacca tagtacttga
    25801 atcttgagtt cagaatcaga tattcttcct ccttggcctc ttctgtttca gggcttctcg
    25861 aatttttttt tcttttattt attttttgag atggagtctt gctctaccac ccaggctgga
    25921 gtgcagtggc acaatcttgg ctcaatgcaa cctccttctc ccaggttcaa ggaattctcc
    25981 tgccttagcc tctcgagtag atgagattgc aggtgcccac cactacaccc agctaatttt
    26041 tgtttttttt ggtagagatg gggtttcacc atgttggcca ggctggttct gcctcttgac
    26101 tttatcatcc ttcctctctg atggtatggt tatgtggacc agaactgaag tttaaggaag
    26161 gggcttaaga tatggaagtt gcctgggacc aacatactct gtccaagaga cacagtgaca
    26221 catacatgca cagctgacca aagctatagc ttcccaatta cttgatgaac agctatgaat
    26281 gttgtttctt tttcttagac aaagtgcata tctgctcaag atggatgtca ctaatgtgca
    26341 actgatccac aacctcatac aattttagta tctcatatgc ttcgtgtaca tgtcatgtat
    26401 gaaggtgcct gaggtacccc atgtatatat agcatgttat gaatgttagg catattttgg
    26461 tctttccttt ctatctatgt ttagtatgca caagacatac ttattttacc tttgcttaat
    26521 atgccttata gtttactaac ttacttaaca gaggagtttt gttttcttgt tatctgtagc
    26581 agaattgaat gttgcccagc aatataatat atgtaaatca taccaaatta tatgtgttta
    26641 aaactcaagg gatggaactg ggagagataa cactcatttt tcacctacgc atcactcaca
    26701 atatttagct ctccttccac atgatgttgg gatatgatgg cttagaagtc ttactagtca
    26761 atggaagaat gtttctcttc caagaggaca caacaatgat tcatttgaac tctatgattg
    26821 ccactgaata atttggtctt tccatgccta taagcaaaga agttacgtgt attaactgga
    26881 acaattggtc ctgattatta aggagagtaa gtttttccta caaagagatg tatgtatggg
    26941 acccagggaa ttttacagaa acatctctaa gaacttccat gcttttttgt caagttaaat
    27001 ggacaactat cgcaaccaca tacaggcaga accactaaga gtaaaaaccc ctcaggaatt
    27061 aggattcggg tcaccctgct tggcagagcc ctaattagtc acagtgctag gtgaggtcaa
    27121 aagtaatatg aaataggaag aggataaaca gtgtcataaa caactgtgat cttatggcca
    27181 gttgcagagt aagaaattaa taactactcc tgttctcttc tttgccttgt tatgcatgta
    27241 ctgacttttt acctctttct ttttccctac aattttataa aaatggtgat acatttgtaa
    27301 tttgtccctc aaattacaga ctatcagctt gaaactatga ttggaattga aggttaaaga
    27361 aaacccagct atagattcag tgactaacaa aatttgggga cagtgtaagc ctcattctaa
    27421 ttgcataagg aatagttact gtatgttagg caggtgcatg ttgttattgc tacttttttc
    27481 aagtctaagt tctaggtaca aagtgtacac tgtactggat ttagtatttg acatctattt
    27541 tcacatcctt ctaggagtca tcttgtacta aagaagctgt aagcccacat gtgcatttcc
    27601 cagagtccct tgttgctagg gggctgaatg cgaacgaggt ttcaccatta aatatactta
    27661 tacatttgga aaggcaaaaa tgaggcagag gccatctttg tgttgctggt ttgattagca
    27721 agtttgctaa gacatgagtg tcaagggaag ttgaggtgga gatggtggct atatggtgca
    27781 gctgttttcc tgattcccag agagcaatca ctcagatgtg ctcttgtact taatacttcc
    27841 actggcagtc ccttttcttt cctcttttag ttcttcctat aattttctaa gtgtataatt
    27901 gcccattttc cctaaatacc taggtaggtt ttatttccta aactggacct cttaccaaac
    27961 acagatgaga tgtactgtct gccaccctaa ctgcccatag gactccacca aggatgccaa
    28021 ctctaagtgg tcatttacct ctgtgattgt gtttttaatg cctgcctccc attaagttat
    28081 aagatccagg aatttaataa tttattttga taaggactta acacaatgct tggcacataa
    28141 gaggaattaa ataacatttt tctgaatgaa tagattttaa accatgtgtg agcagtcaca
    28201 gaattcactg atctattata atttaccaat tcctttgcat catagcaccc atgcaaaata
    28261 ttttggctac agggagtgct ccaattttga tactctccct gtcaatatgc ctattacccc
    28321 aatataattt aagattgaca gggagagcat cagtattctg cagtctgatt gcagaagcat
    28381 atatgtaaaa atataccttt tagaaatgat tttagaatct ggaaatttac aaactattaa
    28441 ttttcttttc tacagtttcc tccagaaagc ccctatgtat ttattccggt taacaatttt
    28501 acttgagtag aaatcacttg actcaaattt tgatgattta atagctcatt gaaagaacta
    28561 gcctgaagca gataaaatat gttgcagatg ctgtaactct tatttgcatc cattggtctt
    28621 ttggtttatg tgctttaata atttgaaaaa caagaagata atcaggaacc aagatggata
    28681 tgtgtgtctt gaggcagaac ttaattcaaa attgttcagt gttttgtcag atgaactcct
    28741 taaccacatt tgttatcagt agcacacaat atattggatt aagtttttga atgatgtgca
    28801 aagatgatgc cagattgatc ctaacaaaca taaagctcag aatcaaaacc agaatgttgt
    28861 tttgatcata ctggttttag gcaaaggatt ttaagataaa ttctttcata ctggaatttg
    28921 tgatactatc cacacttttc ctcactataa aatttaatga accttatatc attaatattt
    28981 ttgtgtcaat ggtgagttct tcttttttct ttacctgagt tgtatcaaca gtttcaaagg
    29041 agagagagtg tttttggtaa aggcaataaa ttatttttta atgtacatct tatacacata
    29101 aaatactttc tcatattctg aagaatgaag catttctgtc ctaggtgatt ataaagtttg
    29161 ttgctatagt atttcattat tttttattag aaaatatttt aataacacaa gaaagtaaag
    29221 aaagtaatac aaggaacact catgtacaca tcaaccagct ttgtctgaaa ttaatatcat
    29281 cctaaatttg cttcattgct tttattcatt aaaaattaca aatacaattg aagcccttga
    29341 acccctcacc tgtcacacta tcctctttgc tttgtcaaat acttactacg ttcatatgta
    29401 ttgatgtaca gtatagcctt attttacgtg ttttaaattt atacataaac aatttcaaac
    29461 tctatgaatc attctacatt ttgctatttt gtgttcaata tcctgttgtc gaaacatttc
    29521 catgttcctt taattcattc attggcaata cagtataata tgttattgta tagatacata
    29581 tatatttaaa atatataggt attttaattt tactgtatta tattgttgaa catttccact
    29641 gttttacatt ttttagtatc ataaactatc cttcaatgaa cactctttta atgtcatctg
    29701 gtgtcaggta tgagagttcc taaacacaca cagtgtatct agaatttgaa ttgctaaaat
    29761 tgaacattca attttcattt ttaactttac taaatactgt aaaattgttc tctgtgtgcc
    29821 aattttcttt accactggta aaatgtgagt ttccactttc acatgcttgc catttcctat
    29881 tgcaaaacat ttaagtattt atgtttgtga taaaaatgga gtcttatttt gattttaatt
    29941 tgtacttccc cagttcctgt tgtgtttaag tttgtttttt atttatttat tatctgttca
    30001 tgattttctt cattttttct cttactggtt catattctct atacatgctg aatggtgtta
    30061 gctagctata ttctttgcaa taattattaa aattttcttt ttcttttctt tttttaagag
    30121 acaaggtctt accctgtcat ccaggctagg atgcagtagc acgatcttag cttactgtag
    30181 actccaactc ctgggctcaa gagatactct cctgccttgg tttcctaaag tgctgggatt
    30241 ataggcctga gccactggcc tgttttgttt ttcttaatat aaggctatac atttccctct
    30301 aagaactaat ttagctgcct ccctcaatct tttatatgta attttaagtt aatattcagc
    30361 tttaaacttt tctaattcaa ttatcttttt tgattaatca attgtttagg ataatgtctc
    30421 aaaacttttt tggtatatag atatctttaa ttacatattt ctaaattatt ttcatttaag
    30481 tcaaaggaca tagcctggaa agtattcgtt tgtttgtgtg tgtgtgtgtg tgtgtgtgtg
    30541 tgtatttgtt gtgatttgtt tttatgtttt agcaatttgg tcagttgctt taaattagag
    30601 attttgcctg attgttatct acagaattct atgcaactcc attacattaa gctaatatcg
    30661 cttcatttta tctctcatca cattttgttt ttgtttgttt gtgctgtgaa ttattgagat
    30721 aatgggttaa atgtatgtgc ctgtgtccat ttatttcaat aatatcttat actatgactc
    30781 tatattatta attgggaaga ttttagaata cttaacgtat gttttctaat taagcagtga
    30841 cccacttaat ttctcagaag tacattttgt tttattgctt taaactctat tttgattgtt
    30901 tttaatctga tcatacagac ttttattttg gctgatattt tcgttacttt tttcttattt
    30961 ttatcctttc tatgtcttta tgattaaatt gtgtgcctta caaggaggtt ttactttttc
    31021 cctcaatgga tttggaagat atatgttcta tttttatttc tgttgttggt ttcctgaaaa
    31081 tctcagcatg catatttgac ttaaattcta aaattaataa acactttctt aatttcctga
    31141 acaataaaag gaatttcaaa catattattg gtcatcatca cctgcctatt aaatatgctt
    31201 tcccactagg gctggggcta atggaaaata catcttaaaa agtcttctgt gtaaaacatg
    31261 ggactcaaaa caacactagg aaaatagcgt agatcagata attctcatta aatcagctgt
    31321 ttattaaaaa aagcaatgag caaggaacaa caaagtctcc ttaggaggca aaacaaagta
    31381 ttattaaaag tatgtttgat gttgctgaag attctttcat aaacatatta aagtcaatta
    31441 taattctgtt tttaatgacc ttattagctc agatgatgtt ttaatgattt gagtttatgt
    31501 attatttgaa gaatctctaa atagcactat taagtgctct gatatgcagt aatatttata
    31561 ttgagaagca acttttttaa ttgtttgggg aaagacttct atttcttatg acatgcttcc
    31621 ttttcattga ggaataccca agataccaag ttttctttca gaagtaattt gcattttcca
    31681 ccttgaagtt gtatttgcca ttttgtttgt tgccatagga aaattctttt ttgagaattt
    31741 ttttcttata acgttcttca tctgattaaa caaacaaaaa acccatcttt atttttagac
    31801 taaaagcctt tgaataaaat attatacaac tttaaataaa tttaagatga cattatgact
    31861 tattaggcca cagttaaata tgagcttcat ctattagtga gtcaatcata ggattttcac
    31921 acatggcttt tgttcacagt aagttatatc aattaagttg cttagaatga acatatagct
    31981 gaactaataa gcatgaaata ttttcactga tttataagaa tccagaaatt atcaatgagt
    32041 tttctttttc tattatttaa aaaagttttt gcttggcaaa tcttcccctc taggagatta
    32101 aagtattttt tgctcattaa tcaatgtaag aacaccttac tttacattca ttgaactctg
    32161 aggttataga actgtgaact tttcgatttg ttcggcttgg ggaatgtcat agttcattct
    32221 gtgagtggaa gttgccttta accacatgag aacaaataag ggaatattaa ggttttaact
    32281 caaggcagct gatatgcaat ggctgggata atggccatta cctaaaagaa agaaggcagc
    32341 aaatggttcc agacatttat aattatgcat ctgaagtcag aacacctttt ctttttaaac
    32401 attttcaatt tgtgatctgc ttgaggactt gtacatagat aggctcaaga tattttgagt
    32461 cacatatgta aatgaaatgt tttgagcaaa gttgtaaccc tgcccacaaa atagctttgc
    32521 tagggaacag atgtaacttg gagaagtacc aattttgtca ttctagatga gaaatcttct
    32581 ggtgccatca atgggatgca atttggctag tcacacctgg gtgaccaata tccggaggct
    32641 ctacgtcaag tcattgaaca tggatggatg ctccattaag tcatttaaaa taaacttcct
    32701 agcaagtgat ctctagcatc tcaatttaac tgtatccttt ggagatttaa ggaaaactga
    32761 caaagctaaa aatacctctg ctaggggatc tattagtatt ctccacattg ctactgaaac
    32821 ttgctgcctt ttcctagaag cacatgaaag aaaccctggt ccaagcgaac tgtctccttc
    32881 accaaagcca ccttggagag agcccacacg gagactggag atgtagacta ttaagagcac
    32941 tcagccacag agtcactttg gttgtgtcac ttaacctctg tgctcttcta agctccattc
    33001 ctggcttgtg ttgcagggat gttttgagga tatgttgatg tgtgtgactc cttctctgtg
    33061 tgttgctatt aaagacatta agaactgagc tgagtaacaa actttctaga aatgaatgaa
    33121 gaaaacatag caaaattata cctatttttt taaattgaag tacaaagaaa ctgtagctat
    33181 aattatcttt cttgacacta acagtacatg attcctaaat gctattgctc acctcaagtc
    33241 aatgtcactt tgtattaatg gatttagtgt catgtatggt cttgtttttt gaggtcgtct
    33301 gatgaaatca gaatgatttc acttaaggca aggcatatta aaatacaaat tcgtaaagat
    33361 aataccttga tgtttatgtc tatgccaaac ttgctctgct gagttcctgg tggaatgaaa
    33421 agactgtctt tttttaattg tgatttgttt atgactaaca gcatggattt gagacagtta
    33481 tgaaaatgcc atggtatcat tctgtaaata actttgtcta tgtaattgta gtgtatactt
    33541 attattgaca acttgaagaa agtacataaa gtacaaaata aaagttaccc atattcttat
    33601 cagccagatc taactaattt taccattttc atatctctgt gcatactctt aataaaaaat
    33661 ggtataatac atttaagcag a
//
