LOCUS       NM_013280               4170 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens fibronectin leucine rich transmembrane protein 1
            (FLRT1), transcript variant 1, mRNA.
ACCESSION   NM_013280 XM_005273861
VERSION     NM_013280.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4170)
  AUTHORS   Novarino,G., Fenstermaker,A.G., Zaki,M.S., Hofree,M., Silhavy,J.L.,
            Heiberg,A.D., Abdellateef,M., Rosti,B., Scott,E., Mansour,L.,
            Masri,A., Kayserili,H., Al-Aama,J.Y., Abdel-Salam,G.M.H.,
            Karminejad,A., Kara,M., Kara,B., Bozorgmehri,B., Ben-Omran,T.,
            Mojahedi,F., El Din Mahmoud,I.G., Bouslam,N., Bouhouche,A.,
            Benomar,A., Hanein,S., Raymond,L., Forlani,S., Mascaro,M.,
            Selim,L., Shehata,N., Al-Allawi,N., Bindu,P.S., Azam,M., Gunel,M.,
            Caglayan,A., Bilguvar,K., Tolun,A., Issa,M.Y., Schroth,J.,
            Spencer,E.G., Rosti,R.O., Akizu,N., Vaux,K.K., Johansen,A.,
            Koh,A.A., Megahed,H., Durr,A., Brice,A., Stevanin,G., Gabriel,S.B.,
            Ideker,T. and Gleeson,J.G.
  TITLE     Exome sequencing links corticospinal motor neuron disease to common
            neurodegenerative disorders
  JOURNAL   Science 343 (6170), 506-511 (2014)
   PUBMED   24482476
REFERENCE   2  (bases 1 to 4170)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   3  (bases 1 to 4170)
  AUTHORS   Wheldon,L.M., Haines,B.P., Rajappa,R., Mason,I., Rigby,P.W. and
            Heath,J.K.
  TITLE     Critical role of FLRT1 phosphorylation in the interdependent
            regulation of FLRT1 function and FGF receptor signalling
  JOURNAL   PLoS One 5 (4), e10264 (2010)
   PUBMED   20421966
  REMARK    GeneRIF: the phosphorylation state of FLRT1, which is itself FGFR1
            dependent, may play a critical role in the potentiation of FGFR1
            signalling and may also depend on a SFK-dependent phosphorylation
            mechanism acting via the FGFR
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4170)
  AUTHORS   Lacy,S.E., Bonnemann,C.G., Buzney,E.A. and Kunkel,L.M.
  TITLE     Identification of FLRT1, FLRT2, and FLRT3: a novel family of
            transmembrane leucine-rich repeat proteins
  JOURNAL   Genomics 62 (3), 417-426 (1999)
   PUBMED   10644439
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000721.5 and AP006333.1.
            
            On or before Jun 18, 2020 this sequence version replaced
            XM_005273861.2, NM_013280.4.
            
            Summary: This gene encodes a member of the fibronectin leucine rich
            transmembrane protein (FLRT) family. The family members may
            function in cell adhesion and/or receptor signalling. Their protein
            structures resemble small leucine-rich proteoglycans found in the
            extracellular matrix. The encoded protein shares sequence
            similarity with two other family members, FLRT2 and FLRT3. This
            gene is expressed in kidney and brain. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.203309.1,
                                           SRR14038193.1376550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682287.1/ ENSP00000507207.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               AP000721.5         78017-78245
            230-1217            AP006333.1         23584-24571
            1218-4170           AP006333.1         36609-39561
FEATURES             Location/Qualifiers
     source          1..4170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..4170
                     /gene="FLRT1"
                     /gene_synonym="SPG68"
                     /note="fibronectin leucine rich transmembrane protein 1"
                     /db_xref="GeneID:23769"
                     /db_xref="HGNC:HGNC:3760"
                     /db_xref="MIM:604806"
     exon            1..229
                     /gene="FLRT1"
                     /gene_synonym="SPG68"
                     /inference="alignment:Splign:2.1.0"
     exon            230..1217
                     /gene="FLRT1"
                     /gene_synonym="SPG68"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..4170
                     /gene="FLRT1"
                     /gene_synonym="SPG68"
                     /inference="alignment:Splign:2.1.0"
     CDS             1267..3291
                     /gene="FLRT1"
                     /gene_synonym="SPG68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat transmembrane protein FLRT1;
                     fibronectin-like domain-containing leucine-rich
                     transmembrane protein 1"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane protein FLRT1
                     isoform 1"
                     /protein_id="NP_037412.2"
                     /db_xref="CCDS:CCDS8057.1"
                     /db_xref="GeneID:23769"
                     /db_xref="HGNC:HGNC:3760"
                     /db_xref="MIM:604806"
                     /translation="MVVAHPTATATTTPTATVTATVVMTTATMDLRDWLFLCYGLIAF
                     LTEVIDSTTCPSVCRCDNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDL
                     KTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDD
                     NSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAF
                     KGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLY
                     LQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGC
                     NLMWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFETGPQGGVANAAA
                     KTTASNHASATTPQGSLFTLKAKRPGLRLPDSNIDYPMATGDGAKTLAIHVKALTADS
                     IRITWKATLPASSFRLSWLRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYIICMV
                     TMETSNAYVADETPVCAKAETADSYGPTTTLNQEQNAGPMASLPLAGIIGGAVALVFL
                     FLVLGAICWYVHQAGELLTRERAYNRGSRKKDDYMESGTKKDNSILEIRGPGLQMLPI
                     NPYRAKEEYVVHTIFPSNGSSLCKATHTIGYGTTRGYRDGGIPDIDYSYT"
     regulatory      4153..4158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLRT1"
                     /gene_synonym="SPG68"
                     /note="hexamer: AATAGA"
     polyA_site      4170
                     /gene="FLRT1"
                     /gene_synonym="SPG68"
                     /note="major polyA site"
ORIGIN      
        1 gcactcctcc cgcggctccg ccgggcgccc gagccgggca gatgcgccgc cgcgcgcccc
       61 ccgctccggg cccgccaccg tgctctgccg cgcgccgggg gctcctctcc cgggcccccc
      121 tgggcgccct ccggctctgg ttcccgcccg ctccttggaa taacccctga ggctccagcc
      181 gtcaccgcaa agtttcccga ggagacccgc ctccccggcc gctgcgcagg tgaggaagca
      241 ggcagtgggc gagaagatgg attccttttt ggacagacaa gaccagagag tgaagcggga
      301 ataactcatc ctccctacct ccccagcaag gaaacctcta caaacaggag cagccaagca
      361 ggactgaggc ccttgccccc caagcatctt ctcaaagaag ggcatgtggg ggcctgacag
      421 ctcagctgca tgtgtcagca gctccagccc caccatgaac atctgaactc ctcagcgggg
      481 taatggaccc cctcctttcc cccggagaca cagcctgagt ggcaggaata cagagccttt
      541 ggagagtggc tccctctcag ctccgtcatg caagaacact ctctgcaccc agcccattct
      601 gccaagtgac ttaaaggaat taaaaaaaaa aaaagccttg gtaaacaaaa agggggtaaa
      661 agccacgcag aggcccttca gaagaggtgg cgggctgcag acaaaagggc aagagttgaa
      721 aagggctgtg gaggtagcaa gcagcagagg ccaccctgct cagggctggg tgccaggcca
      781 cagggcatgc ccgacgaaca gggagtcgga accccctcag gccaccctcg ggagtcctgg
      841 ggtccagagg ggtgtccctg taccccttgc acacaggacc ctcactctgc agggataagc
      901 cagctgcgcc tgcagcctag ggtgccaagg aggctgctga ttgtggccca cagcctcatc
      961 tgaacgccag gagaccagga taccgaggca ccggatcccc tctctgtgcc ctggggagcc
     1021 ccagtgctgc ccagtcaccc cagggctgag gtctgcgtcc ctagtggtgc aaggcctggt
     1081 aggaccacgg ggcagggaat gtgagcgcca tctgagctca cggtgtcctg agtcgcggct
     1141 tcgtgacttt ggcaggggcc tccggaccag tgaccccagt caaacccaga gggtcttggg
     1201 cggcagcgac gaaggaggta ttcaggctcc aggccaggtg gggccggacg cccccagcca
     1261 tccaccatgg tggtggcaca ccccaccgcc actgccacca ccacgcccac tgccactgtc
     1321 acggccaccg ttgtgatgac cacggccacc atggacctgc gggactggct gttcctctgc
     1381 tacgggctca tcgccttcct gacggaggtc atcgacagca ccacctgccc ctcggtgtgc
     1441 cgctgcgaca acggcttcat ctactgcaac gaccggggac tcacatccat ccccgcagat
     1501 atccctgatg atgccaccac cctctacctg cagaacaacc agatcaacaa cgccggcatc
     1561 ccccaggacc tcaagaccaa ggtcaacgtg caggtcatct acctatacga gaatgacctg
     1621 gatgagttcc ccatcaacct gccccgctcc ctccgggagc tgcacctgca ggacaacaat
     1681 gtgcgcacca ttgccaggga ctcgctggcc cgcatcccgc tgctggagaa gctgcacctg
     1741 gatgacaact ccgtgtccac cgtcagcatt gaggaggacg ccttcgccga cagcaaacag
     1801 ctcaagctgc tcttcctgag ccggaaccac ctgagcagca tcccctcggg gctgccgcac
     1861 acgctggagg agctgcggct ggatgacaac cgcatctcca ccatcccgct gcatgccttc
     1921 aagggcctca acagcctgcg gcgcctggtg ctggacggta acctgctggc caaccagcgc
     1981 atcgccgacg acaccttcag ccgcctacag aacctcacag agctctcgct ggtgcgcaat
     2041 tcgctggccg cgccacccct caacctgccc agcgcccacc tgcagaagct ctacctgcag
     2101 gacaatgcca tcagccacat cccctacaac acgctggcca agatgcgtga gctggagcgg
     2161 ctggacctgt ccaacaacaa cctgaccacg ctgccccgcg gcctgttcga cgacctgggg
     2221 aacctggccc agctgctgct caggaacaac ccttggtttt gtggctgcaa cctcatgtgg
     2281 ctgcgggact gggtgaaggc acgggcggcc gtggtcaacg tgcggggcct catgtgccag
     2341 ggccctgaga aggtccgggg catggccatc aaggacatta ccagcgagat ggacgagtgt
     2401 tttgagacgg ggccgcaggg cggcgtggcc aatgcggctg ccaagaccac ggccagcaac
     2461 cacgcctctg ccaccacgcc ccagggttcc ctgtttaccc tcaaggccaa aaggccaggg
     2521 ctgcgcctcc ccgactccaa cattgactac cccatggcca cgggtgatgg cgccaagacc
     2581 ctggccatcc acgtgaaggc cctgacggca gactccatcc gcatcacgtg gaaggccacg
     2641 ctccccgcct cctctttccg gctcagttgg ctgcgcctgg gccacagccc agccgtgggc
     2701 tccatcacgg agaccttggt gcagggggac aagacagagt acctgctgac agccctggag
     2761 cccaagtcca cctacatcat ctgcatggtc accatggaga ccagcaatgc ctacgtagct
     2821 gatgagacac ccgtgtgtgc caaggcagag acagccgaca gctatggccc taccaccaca
     2881 ctcaaccagg agcagaacgc tggccccatg gcgagcctgc ccctggcggg catcatcggc
     2941 ggggcagtgg ctctggtctt cctcttcctg gtcctggggg ccatctgctg gtacgtgcac
     3001 caggctggcg agctgctgac ccgggagagg gcctacaacc ggggcagcag gaaaaaggat
     3061 gactatatgg agtcagggac caagaaggat aactccatcc tggaaatccg cggccctggg
     3121 ctgcagatgc tgcccatcaa cccgtaccgc gccaaagaag agtacgtggt ccacactatc
     3181 ttcccctcca acggcagcag cctctgcaag gccacacaca ccattggcta cggcaccacg
     3241 cggggctacc gggacggcgg catccccgac atagactact cctacacatg atgcccgccc
     3301 acccgggctg ccccgcctca gccccagctg ccctggcgtg gccatgtggc tttgcccagc
     3361 ctgctgcaat ccaagagagc aaggaagaga aattccatgg gtgactttcc tccgcagaaa
     3421 gcaaagtttg gggagggctg acgattttgt agaacacaac agtgacaatt ttttttaaaa
     3481 gaatagaagg caggaggggg aattcgacat tgttgaagac ataatttata ccaagttatg
     3541 ccagttgggg agggaaggac taaaaataat attgcaggca gggctgggtt gggttttttt
     3601 tttttccccc ctgaactgga aggatactac ctgtacaaca tctgtggaca cctcatgctc
     3661 tgttcaaggc catcacaaag gaaccgccag ggagaagcag ccggctctca aagctcccac
     3721 gcagctctcc cgccactggc cactcgctgg cgacccgatg gaaggttttc aggctcctca
     3781 caaaggagag agggaagaaa agatcttttg ccctggagat atggtcctga aatctctccc
     3841 ctggcttatt ccataccatt tcccttgcag atttgcagaa acatggcatc tttcactgca
     3901 ttctttgaac aatcatgtag tcgattaaaa aaaaaaaaca aacttttttt tcctaggctg
     3961 aagccctctt cagttccatg caccacgctc cgtagaagcc ccggcggaag ccgtagcttt
     4021 ccctgccacc tggaggtgca tctgtctgcc tgtctatccc tgtcgcggtg tctctaagta
     4081 cagatgggta gatagagcca catgcacggt ccttaccgtt cttcttgggt cagttcttac
     4141 catttcctga acaatagaat tgtgaaagtg
//
