LOCUS       NM_004475               2668 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens flotillin 2 (FLOT2), transcript variant 1, mRNA.
ACCESSION   NM_004475
VERSION     NM_004475.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2668)
  AUTHORS   Zhang,Y., Chen,Y., Guo,Q., Zhang,Y. and Liu,A.
  TITLE     Fat mass and obesity-associated protein (FTO)-induced upregulation
            of flotillin-2 (FLOT2) contributes to cancer aggressiveness in
            diffuse large B-cell lymphoma (DLBCL) via activating the
            PI3K/Akt/mTOR signal pathway
  JOURNAL   Arch Biochem Biophys 758, 110072 (2024)
   PUBMED   38914215
  REMARK    GeneRIF: Fat mass and obesity-associated protein (FTO)-induced
            upregulation of flotillin-2 (FLOT2) contributes to cancer
            aggressiveness in diffuse large B-cell lymphoma (DLBCL) via
            activating the PI3K/Akt/mTOR signal pathway.
REFERENCE   2  (bases 1 to 2668)
  AUTHORS   Luo,C., Wen,B., Liu,J. and Yang,W.
  TITLE     HDAC6-mediated deacetylation of FLOT2 maintains stability and
            tumorigenic function of FLOT2 in nasopharyngeal carcinoma
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 49 (5), 687-697 (2024)
   PUBMED   39174882
  REMARK    GeneRIF: HDAC6-mediated deacetylation of FLOT2 maintains stability
            and tumorigenic function of FLOT2 in nasopharyngeal carcinoma.
REFERENCE   3  (bases 1 to 2668)
  AUTHORS   Zhang,Y., Chen,Y., Guo,Q., Zhang,Y. and Liu,A.
  TITLE     Analysis and Investigation of Bioinformatics and Epigenetics Reveal
            the Underlying Mechanisms by which FLOT2 Modulates the Progression
            of Diffuse Large B-cell Lymphoma
  JOURNAL   Discov Med 36 (182), 621-631 (2024)
   PUBMED   38531803
  REMARK    GeneRIF: Analysis and Investigation of Bioinformatics and
            Epigenetics Reveal the Underlying Mechanisms by which FLOT2
            Modulates the Progression of Diffuse Large B-cell Lymphoma.
REFERENCE   4  (bases 1 to 2668)
  AUTHORS   Trybus,M., Hryniewicz-Jankowska,A., Wojtowicz,K., Trombik,T.,
            Czogalla,A. and Sikorski,A.F.
  TITLE     EFR3A: a new raft domain organizing protein?
  JOURNAL   Cell Mol Biol Lett 28 (1), 86 (2023)
   PUBMED   37880612
  REMARK    GeneRIF: EFR3A: a new raft domain organizing protein?
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2668)
  AUTHORS   Wisniewski,D.J., Liyasova,M.S., Korrapati,S., Zhang,X.,
            Ratnayake,S., Chen,Q., Gilbert,S.F., Catalano,A., Voeller,D.,
            Meerzaman,D., Guha,U., Porat-Shliom,N., Annunziata,C.M. and
            Lipkowitz,S.
  TITLE     Flotillin-2 regulates epidermal growth factor receptor activation,
            degradation by Cbl-mediated ubiquitination, and cancer growth
  JOURNAL   J Biol Chem 299 (1), 102766 (2023)
   PUBMED   36470425
  REMARK    GeneRIF: Flotillin-2 regulates epidermal growth factor receptor
            activation, degradation by Cbl-mediated ubiquitination, and cancer
            growth.
REFERENCE   6  (bases 1 to 2668)
  AUTHORS   Salzer,U. and Prohaska,R.
  TITLE     Stomatin, flotillin-1, and flotillin-2 are major integral proteins
            of erythrocyte lipid rafts
  JOURNAL   Blood 97 (4), 1141-1143 (2001)
   PUBMED   11159550
REFERENCE   7  (bases 1 to 2668)
  AUTHORS   Hazarika,P., Dham,N., Patel,P., Cho,M., Weidner,D., Goldsmith,L.
            and Duvic,M.
  TITLE     Flotillin 2 is distinct from epidermal surface antigen (ESA) and is
            associated with filopodia formation
  JOURNAL   J Cell Biochem 75 (1), 147-159 (1999)
   PUBMED   10462713
REFERENCE   8  (bases 1 to 2668)
  AUTHORS   Volonte,D., Galbiati,F., Li,S., Nishiyama,K., Okamoto,T. and
            Lisanti,M.P.
  TITLE     Flotillins/cavatellins are differentially expressed in cells and
            tissues and form a hetero-oligomeric complex with caveolins in
            vivo. Characterization and epitope-mapping of a novel flotillin-1
            monoclonal antibody probe
  JOURNAL   J Biol Chem 274 (18), 12702-12709 (1999)
   PUBMED   10212252
REFERENCE   9  (bases 1 to 2668)
  AUTHORS   Schroeder,W.T., Stewart-Galetka,S., Mandavilli,S., Parry,D.A.,
            Goldsmith,L. and Duvic,M.
  TITLE     Cloning and characterization of a novel epidermal cell surface
            antigen (ESA)
  JOURNAL   J Biol Chem 269 (31), 19983-19991 (1994)
   PUBMED   8051082
REFERENCE   10 (bases 1 to 2668)
  AUTHORS   Schroeder,W.T., Siciliano,M.J., Stewart-Galetka,S.L. and Duvic,M.
  TITLE     The human gene for an epidermal surface antigen (M17S1) is located
            at 17q11-12
  JOURNAL   Genomics 11 (2), 481-482 (1991)
   PUBMED   1769667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024267.18, CA390100.1,
            BC003683.1, BC017292.1 and M60922.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004475.2.
            
            Summary: Caveolae are small domains on the inner cell membrane
            involved in vesicular trafficking and signal transduction. This
            gene encodes a caveolae-associated, integral membrane protein,
            which is thought to function in neuronal signaling. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.12190.1,
                                           SRR14038197.828349.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394908.9/ ENSP00000378368.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC024267.18        90846-90881         c
            37-124              CA390100.1         1-88
            125-1140            BC003683.1         1-1016
            1141-1571           BC017292.1         927-1357
            1572-2667           M60922.1           1392-2487
            2668-2668           BC017292.1         2454-2454
FEATURES             Location/Qualifiers
     source          1..2668
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..2668
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /note="flotillin 2"
                     /db_xref="GeneID:2319"
                     /db_xref="HGNC:HGNC:3758"
                     /db_xref="MIM:131560"
     exon            1..208
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1446
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Flotillin 2 (epidermal surface antigen 1); membrane
                     component, chromosome 17, surface marker 1 (35kD protein
                     identified by monoclonal antibody ECS-1); membrane
                     component chromosome 17 surface marker 1"
                     /codon_start=1
                     /product="flotillin-2 isoform 1"
                     /protein_id="NP_004466.2"
                     /db_xref="CCDS:CCDS11245.2"
                     /db_xref="GeneID:2319"
                     /db_xref="HGNC:HGNC:3758"
                     /db_xref="MIM:131560"
                     /translation="MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQR
                     ISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNV
                     VLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDK
                     VDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRA
                     FELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL
                     RTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMG
                     KAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVT
                     SEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV"
     exon            209..290
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..381
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..505
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..624
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..738
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..858
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1073
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1257
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1407
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..2668
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2647..2652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /note="hexamer: AATAAA"
     polyA_site      2668
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /note="major polyA site"
ORIGIN      
        1 acacttccgg cggggctgcg accgcagagg ggcgcgggcg agcgagcggg cggccggccg
       61 ctgggggtgg cgggataggc tgggcgcggc cggcgctgca gacccgctgc tgttgtccgg
      121 gtctgtgcgg tcccgagggc cctccgtgcc gccggcgcca tgggcaattg ccacacggtg
      181 gggcccaacg aggcgctggt ggtttcaggg ggctgttgtg gttccgacta taaacagtac
      241 gtgtttggcg gctgggcctg ggcctggtgg tgtatctccg acactcagag gatttcccta
      301 gagattatga cgttgcagcc ccgctgcgag gacgtagaga cggccgaggg ggtagcttta
      361 actgtgacgg gtgtcgccca ggtgaagatc atgacggaga aggaactcct ggccgtggct
      421 tgtgagcagt ttctgggtaa gaatgtgcag gacatcaaaa acgtcgtcct gcagaccctg
      481 gagggacatc tgcgctccat cctcgggacc ctgacagtgg agcagattta tcaggaccgg
      541 gaccagtttg ccaagctggt gcgggaggtg gcagcccctg atgttggccg catgggcatt
      601 gagatcctca gcttcaccat caaggacgtg tatgacaaag tggactatct gagctccctg
      661 ggcaagacgc agactgccgt ggtgcagaga gatgctgaca ttggcgtggc cgaggctgaa
      721 cgggacgcag gcatccggga agctgagtgc aagaaggaga tgctggatgt gaagttcatg
      781 gcagacacca agattgctga ctctaagcga gccttcgagc tgcaaaagtc agccttcagt
      841 gaggaggtta acatcaagac agctgaggcc cagttggcct atgagctgca gggggcccgt
      901 gaacagcaga agatccggca ggaagagatt gagattgagg ttgtgcagcg caagaaacag
      961 attgccgtgg aggcacagga gatcctgcgt acggacaagg agctcatcgc tacagtgcgc
     1021 cggcctgccg aggccgaggc ccaccgcatc cagcagattg ccgagggtga aaaggtgaag
     1081 caggtcctct tggcacaggc agaggctgag aagatccgca aaatcgggga ggcggaagcg
     1141 gcagtcatcg aggcgatggg caaggcagag gctgagcgga tgaagctcaa ggcagaagcc
     1201 taccagaaat acggggatgc agccaagatg gccttggtgc tagaggccct gccccagatt
     1261 gctgccaaaa tcgctgcccc acttaccaag gtcgatgaga ttgtggtcct cagtggagac
     1321 aacagtaagg tcacatcaga agtgaaccga ctgctggccg agctgcctgc ctctgtgcat
     1381 gccctcacag gcgtggacct gtctaagata cccctgatca agaaggccac tggtgtgcag
     1441 gtgtgaggct cctgcaggcc cactctcttc agcagccacc cggccctccc tccagcaccc
     1501 gttttaatcc cacagaacaa cgggaacgtt actgactctg gtgccttatc tcgaagggac
     1561 cagaagtgct gcgtgttcag gccatctctg gctgtcttcc tgtctctcct gtctgtccac
     1621 ctcctcctct tcctctcctt taccccactt tcactgccac tttcatcagg tttgtgtctc
     1681 atctccctgc gtgtcttttc ctttgtctgt ctttttcttt cccccatgca catcatgtag
     1741 attaagctga agatgtttat tacaatcact ctctgtgggg ggtggccctg ctgctcctca
     1801 gaatcctggt gccttgaagt tctctgtgca tctgtccatc ctccctatgg ccctggccag
     1861 agctcagcat gggcaggggt tctgggtagg acggtcactg tcctctctcc tggactggtc
     1921 ttcccagccc taaaccctgc cccaggaagc ccacagcctc acctgctgct gcccctctag
     1981 gtctgggcag ccatgacctg cagggcccag agacactgtc cttcccctca tccacccaag
     2041 gccccagcca gcgctcatac cctgtccttt ctccctgacc ccaagggcac agaggcaagg
     2101 cctcctgtct acagcagctt cctcagtttc ctactgcctt aggaggcccc tgcttgtgct
     2161 cagggaaggc ctcttcatgg gcatgttcct gctggggcgg tgcggtttgg tcccaactct
     2221 gctaagtttt ctgagatgag ggtctagccc tgttggggac agaaaagtgt gtagaccttc
     2281 ttcctgctag ggctgcactg tcctgggtgt tgggcccttc tggtggacaa ggctgtgcca
     2341 accctgtaca gaatcgagtg ctgtagcctg gccagacccc agagcccttg tgccatcttt
     2401 cttcctggcc agagtgatgg ggttccagcc atggggaagc aacccaatcc tctgtctcct
     2461 tgctccaatg gaggcagaag agcccaggac ccaagcgtct tggcaggggt gctgtgaatg
     2521 tccagtggtc ccagctcccc accctggccc tgccccagcc tgtgtagctc ttcctgcatg
     2581 tggatgctgc atgtctggtc tggggcttgg atgttgcact gccccactgc ctgtcccttc
     2641 tggtaaaata aagaactctt aatgccca
//
