LOCUS       NM_005803               1866 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens flotillin 1 (FLOT1), transcript variant 1, mRNA.
ACCESSION   NM_005803
VERSION     NM_005803.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1866)
  AUTHORS   Tian,J., Hu,X. and Zhang,X.
  TITLE     Circ_0003855 involvement of esophageal cancer progression through
            miR-622/FLOT1
  JOURNAL   Oncol Res 32 (5), 925-931 (2024)
   PUBMED   38686057
  REMARK    GeneRIF: Circ_0003855 involvement of esophageal cancer progression
            through miR-622/FLOT1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1866)
  AUTHORS   McClellan,B., Wilson,C.N., Brenner,A.J., Jolly,C.A. and
            deGraffenried,L.
  TITLE     Flotillin-1 palmitoylation is essential for its stability and
            subsequent tumor promoting capabilities
  JOURNAL   Oncogene 43 (14), 1063-1074 (2024)
   PUBMED   38374406
  REMARK    GeneRIF: Flotillin-1 palmitoylation is essential for its stability
            and subsequent tumor promoting capabilities.
REFERENCE   3  (bases 1 to 1866)
  AUTHORS   Zhan,Z., Ye,M. and Jin,X.
  TITLE     The roles of FLOT1 in human diseases (Review)
  JOURNAL   Mol Med Rep 28 (5) (2023)
   PUBMED   37772385
  REMARK    GeneRIF: The roles of FLOT1 in human diseases (Review).
            Review article
REFERENCE   4  (bases 1 to 1866)
  AUTHORS   Wang,R., Huang,W., Cai,K., Xiao,S., Zhang,W., Hu,X., Guo,J.,
            Mao,L., Yuan,W., Xu,Y., Chen,Z., Chen,Z. and Lai,C.
  TITLE     FLOT1 promotes gastric cancer progression and metastasis through
            BCAR1/ERK signaling
  JOURNAL   Int J Biol Sci 19 (16), 5104-5119 (2023)
   PUBMED   37928269
  REMARK    GeneRIF: FLOT1 promotes gastric cancer progression and metastasis
            through BCAR1/ERK signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1866)
  AUTHORS   Yu,W., Liang,J., Fang,T., Jiang,J., Zhao,R., Li,R., Han,J. and
            Tian,H.
  TITLE     EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to
            Influence the Development of Lung Adenocarcinoma
  JOURNAL   Mol Cancer Res 21 (7), 713-725 (2023)
   PUBMED   37011005
  REMARK    GeneRIF: EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through
            FLOT1 to Influence the Development of Lung Adenocarcinoma.
REFERENCE   6  (bases 1 to 1866)
  AUTHORS   Salzer,U. and Prohaska,R.
  TITLE     Stomatin, flotillin-1, and flotillin-2 are major integral proteins
            of erythrocyte lipid rafts
  JOURNAL   Blood 97 (4), 1141-1143 (2001)
   PUBMED   11159550
REFERENCE   7  (bases 1 to 1866)
  AUTHORS   Baumann,C.A., Ribon,V., Kanzaki,M., Thurmond,D.C., Mora,S.,
            Shigematsu,S., Bickel,P.E., Pessin,J.E. and Saltiel,A.R.
  TITLE     CAP defines a second signalling pathway required for
            insulin-stimulated glucose transport
  JOURNAL   Nature 407 (6801), 202-207 (2000)
   PUBMED   11001060
REFERENCE   8  (bases 1 to 1866)
  AUTHORS   Hazarika,P., Dham,N., Patel,P., Cho,M., Weidner,D., Goldsmith,L.
            and Duvic,M.
  TITLE     Flotillin 2 is distinct from epidermal surface antigen (ESA) and is
            associated with filopodia formation
  JOURNAL   J Cell Biochem 75 (1), 147-159 (1999)
   PUBMED   10462713
REFERENCE   9  (bases 1 to 1866)
  AUTHORS   Volonte,D., Galbiati,F., Li,S., Nishiyama,K., Okamoto,T. and
            Lisanti,M.P.
  TITLE     Flotillins/cavatellins are differentially expressed in cells and
            tissues and form a hetero-oligomeric complex with caveolins in
            vivo. Characterization and epitope-mapping of a novel flotillin-1
            monoclonal antibody probe
  JOURNAL   J Biol Chem 274 (18), 12702-12709 (1999)
   PUBMED   10212252
REFERENCE   10 (bases 1 to 1866)
  AUTHORS   Bickel,P.E., Scherer,P.E., Schnitzer,J.E., Oh,P., Lisanti,M.P. and
            Lodish,H.F.
  TITLE     Flotillin and epidermal surface antigen define a new family of
            caveolae-associated integral membrane proteins
  JOURNAL   J Biol Chem 272 (21), 13793-13802 (1997)
   PUBMED   9153235
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY101236.1, AF089750.2 and
            AF117234.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005803.3.
            
            Summary: This gene encodes an protein that localizes to the
            caveolae, which are small domains on the inner cell membranes. This
            protein plays a role in vesicle trafficking and cell morphology.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.633520.1,
                                           SRR3476690.834200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376389.8/ ENSP00000365569.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                HY101236.1         166-176
            12-1841             AF089750.2         1-1830
            1842-1866           AF117234.1         1464-1488
FEATURES             Location/Qualifiers
     source          1..1866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1866
                     /gene="FLOT1"
                     /note="flotillin 1"
                     /db_xref="GeneID:10211"
                     /db_xref="HGNC:HGNC:3757"
                     /db_xref="MIM:606998"
     exon            1..161
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..218
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1459
                     /gene="FLOT1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     integral membrane component of caveolae"
                     /codon_start=1
                     /product="flotillin-1 isoform 1"
                     /protein_id="NP_005794.1"
                     /db_xref="CCDS:CCDS4688.1"
                     /db_xref="GeneID:10211"
                     /db_xref="HGNC:HGNC:3757"
                     /db_xref="MIM:606998"
                     /translation="MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLN
                     TLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALE
                     TLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDY
                     LHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYEL
                     KKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARRE
                     KELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAE
                     AEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAK
                     VTGEVLDILTRLPESVERLTGVSISQVNHKPLRTA"
     exon            219..294
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..385
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..529
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..649
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..745
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..898
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1080
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1126
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1264
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1429
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1866
                     /gene="FLOT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1727..1732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLOT1"
                     /note="hexamer: ATTAAA"
     polyA_site      1745
                     /gene="FLOT1"
                     /note="major polyA site"
     regulatory      1816..1821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLOT1"
                     /note="hexamer: AATAAA"
     regulatory      1840..1845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLOT1"
                     /note="hexamer: AATAAA"
     polyA_site      1846
                     /gene="FLOT1"
     polyA_site      1866
                     /gene="FLOT1"
ORIGIN      
        1 gcgtctgccg cagcaacggg gtgcggcagg gtggggaacg cgggagcggg gccagctccc
       61 aggaaagctg gtctgcgagc ggcccctgcc cggctcccag gtccctgcgc gaccccgccc
      121 ttcccgagac cccagccggg ctgccgcccg cgtcccggaa gctccagcct gaaccatgtt
      181 tttcacttgt ggcccaaatg aggccatggt ggtctccggg ttctgccgaa gccccccagt
      241 catggtggct ggagggcgtg tctttgtcct gccctgcatc caacagatcc agaggatctc
      301 tctcaacaca ctgaccctca atgtcaagag tgaaaaggtt tacactcgcc atggggtccc
      361 catctcagtc actggcattg cccaggtaaa aatccagggg cagaacaagg agatgttggc
      421 ggccgcctgt cagatgttcc tggggaagac ggaggctgag attgcccaca ttgccctgga
      481 gacgttagag ggccaccaga gggccatcat ggcccacatg actgtggagg agatctataa
      541 ggacaggcag aaattctcag aacaggtttt caaagtggcc tcctcagacc tggtcaacat
      601 gggcatcagt gtggttagct acactctgaa ggacattcac gatgaccagg actatttgca
      661 ctctttgggg aaggctcgaa cagctcaagt ccaaaaagat gcacggattg gagaagcaga
      721 ggccaagaga gatgctggga tccgggaagc taaagccaag caggaaaagg tgtctgctca
      781 gtacctgagt gagatcgaga tggccaaggc acagagagat tacgaactga agaaggccgc
      841 ctatgacatc gaggtcaaca cccgccgagc acaggctgac ctggcctatc agcttcaggt
      901 ggccaagact aagcagcaga ttgaggagca gcgggtgcag gtgcaggtgg tggagcgggc
      961 ccagcaggtg gcagtgcagg agcaggagat cgcccggcgg gagaaggagc tggaggcccg
     1021 ggtgcggaag ccagcggaag cggagcgcta caagctggag cgcctagccg aggcagagaa
     1081 gtcccaacta attatgcagg cggaggcaga agccgcgtct gtgcggatgc gtggggaagc
     1141 tgaggccttt gccatagggg cccgagcccg agccgaggct gagcagatgg ccaagaaggc
     1201 agaagccttc cagctgtacc aagaggctgc tcagctggac atgctgctag agaagctgcc
     1261 ccaggtggca gaggagatca gtggtccctt gacttcagcc aataagatca cactggtgtc
     1321 cagcggcagt gggaccatgg gggcagccaa agtgactggg gaagtactgg acattctaac
     1381 tcgcctgcca gagagtgtgg aaagactcac aggcgtgagc atctcccagg tgaatcacaa
     1441 gcctttgaga acagcctgag ccttcagccc tcacagatgc ccagcctcat agctgaagtt
     1501 gcctgaatga tcctcctgtt gcatgtaacc cactggcctc cctgagcatg tccattgaca
     1561 gtgaggtccc acccctcatc tctccttgcc aaatagtttg tgccttgtct tgaagggggt
     1621 tgctcccctt gccaacctca cactgctatg attgccaact ccagcggtcc catgtcagcc
     1681 ttctgatgat cccactccac cccacctcaa cttatttaac ttcctaatta aatcagactg
     1741 tttgagcctg ttgtctagaa tattttcctg accaagactg agggatgggc tggaggtttt
     1801 caactttgct acccaaataa attgctgtaa gtaagtacta ataaaacaga agcaactgga
     1861 aattaa
//
