LOCUS       NM_001458               9159 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens filamin C (FLNC), transcript variant 1, mRNA.
ACCESSION   NM_001458
VERSION     NM_001458.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9159)
  AUTHORS   Goliusova,D.V., Sharikova,M.Y., Lavrenteva,K.A., Lebedeva,O.S.,
            Muranova,L.K., Gusev,N.B., Bogomazova,A.N. and Lagarkova,M.A.
  TITLE     Role of Filamin C in Muscle Cells
  JOURNAL   Biochemistry (Mosc) 89 (9), 1546-1557 (2024)
   PUBMED   39418514
  REMARK    GeneRIF: Role of Filamin C in Muscle Cells.
            Review article
REFERENCE   2  (bases 1 to 9159)
  AUTHORS   Ohiri,J.C., Dellefave-Castillo,L., Tomar,G., Wilsbacher,L.,
            Choudhury,L., Barefield,D.Y., Fullenkamp,D., Gacita,A.M.,
            Monroe,T.O., Pesce,L., Blancard,M., Vaught,L., George,A.L. Jr.,
            Demonbreun,A.R., Puckelwartz,M.J. and McNally,E.M.
  TITLE     Reduction of Filamin C Results in Altered Proteostasis,
            Cardiomyopathy, and Arrhythmias
  JOURNAL   J Am Heart Assoc 13 (10), e030467 (2024)
   PUBMED   38761081
  REMARK    GeneRIF: Reduction of Filamin C Results in Altered Proteostasis,
            Cardiomyopathy, and Arrhythmias.
REFERENCE   3  (bases 1 to 9159)
  AUTHORS   Muranova,L.K., Vostrikova,V.M., Shatov,V.M., Sluchanko,N.N. and
            Gusev,N.B.
  TITLE     Interaction of the C-terminal immunoglobulin-like domains (Ig
            22-24) of filamin C with human small heat shock proteins
  JOURNAL   Biochimie 219, 146-154 (2024)
   PUBMED   38016530
  REMARK    GeneRIF: Interaction of the C-terminal immunoglobulin-like domains
            (Ig 22-24) of filamin C with human small heat shock proteins.
REFERENCE   4  (bases 1 to 9159)
  AUTHORS   Gao,S., He,L., Lam,C.K., Taylor,M.R.G., Mestroni,L., Lombardi,R.
            and Chen,S.N.
  TITLE     Filamin C Deficiency Impairs Sarcomere Stability and Activates
            Focal Adhesion Kinase through PDGFRA Signaling in Induced
            Pluripotent Stem Cell-Derived Cardiomyocytes
  JOURNAL   Cells 13 (3), 278 (2024)
   PUBMED   38334670
  REMARK    GeneRIF: Filamin C Deficiency Impairs Sarcomere Stability and
            Activates Focal Adhesion Kinase through PDGFRA Signaling in Induced
            Pluripotent Stem Cell-Derived Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9159)
  AUTHORS   Inoue,S. and Morita,H.
  TITLE     Characteristic Imaging Phenotype of Arrhythmogenic Cardiomyopathy
            With Filamin C Gene Variant
  JOURNAL   Circ J 87 (10), 1404-1405 (2023)
   PUBMED   37673657
  REMARK    GeneRIF: Characteristic Imaging Phenotype of Arrhythmogenic
            Cardiomyopathy With Filamin C Gene Variant.
REFERENCE   6  (bases 1 to 9159)
  AUTHORS   Marti,A., Luo,Z., Cunningham,C., Ohta,Y., Hartwig,J., Stossel,T.P.,
            Kyriakis,J.M. and Avruch,J.
  TITLE     Actin-binding protein-280 binds the stress-activated protein kinase
            (SAPK) activator SEK-1 and is required for tumor necrosis
            factor-alpha activation of SAPK in melanoma cells
  JOURNAL   J Biol Chem 272 (5), 2620-2628 (1997)
   PUBMED   9006895
REFERENCE   7  (bases 1 to 9159)
  AUTHORS   Lanfranchi,G., Muraro,T., Caldara,F., Pacchioni,B., Pallavicini,A.,
            Pandolfo,D., Toppo,S., Trevisan,S., Scarso,S. and Valle,G.
  TITLE     Identification of 4370 expressed sequence tags from a
            3'-end-specific cDNA library of human skeletal muscle by DNA
            sequencing and filter hybridization
  JOURNAL   Genome Res 6 (1), 35-42 (1996)
   PUBMED   8681137
REFERENCE   8  (bases 1 to 9159)
  AUTHORS   Gariboldi,M., Maestrini,E., Canzian,F., Manenti,G., De Gregorio,L.,
            Rivella,S., Chatterjee,A., Herman,G.E., Archidiacono,N.,
            Antonacci,R. et al.
  TITLE     Comparative mapping of the actin-binding protein 280 genes in human
            and mouse
  JOURNAL   Genomics 21 (2), 428-430 (1994)
   PUBMED   8088838
REFERENCE   9  (bases 1 to 9159)
  AUTHORS   Maestrini,E., Patrosso,C., Mancini,M., Rivella,S., Rocchi,M.,
            Repetto,M., Villa,A., Frattini,A., Zoppe,M., Vezzoni,P. et al.
  TITLE     Mapping of two genes encoding isoforms of the actin binding protein
            ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7
  JOURNAL   Hum Mol Genet 2 (6), 761-766 (1993)
   PUBMED   7689010
REFERENCE   10 (bases 1 to 9159)
  AUTHORS   Selcen,D. and Engel,A.G.
  TITLE     Myofibrillar Myopathy - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301672
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025594.5.
            
            On May 20, 2020 this sequence version replaced NM_001458.4.
            
            Summary: This gene encodes one of three related filamin genes,
            specifically gamma filamin. These filamin proteins crosslink actin
            filaments into orthogonal networks in cortical cytoplasm and
            participate in the anchoring of membrane proteins for the actin
            cytoskeleton. Three functional domains exist in filamin: an
            N-terminal filamentous actin-binding domain, a C-terminal
            self-association domain, and a membrane glycoprotein-binding
            domain. Mutations in this gene are a cause of cardiopathy. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, May 2022].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB371585.1, AF089841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325888.13/ ENSP00000327145.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-584               AC025594.5         19557-20140
            585-833             AC025594.5         24477-24725
            834-931             AC025594.5         26311-26408
            932-1082            AC025594.5         26549-26699
            1083-1201           AC025594.5         26788-26906
            1202-1279           AC025594.5         27138-27215
            1280-1442           AC025594.5         27418-27580
            1443-1643           AC025594.5         27754-27954
            1644-1781           AC025594.5         29174-29311
            1782-1908           AC025594.5         29699-29825
            1909-2045           AC025594.5         29985-30121
            2046-2239           AC025594.5         30321-30514
            2240-2353           AC025594.5         30605-30718
            2354-2497           AC025594.5         31382-31525
            2498-2621           AC025594.5         31726-31849
            2622-2782           AC025594.5         31945-32105
            2783-2873           AC025594.5         32380-32470
            2874-3043           AC025594.5         32559-32728
            3044-3161           AC025594.5         32947-33064
            3162-3424           AC025594.5         33155-33417
            3425-4022           AC025594.5         33809-34406
            4023-4196           AC025594.5         35141-35314
            4197-4359           AC025594.5         35452-35614
            4360-4520           AC025594.5         35896-36056
            4521-4688           AC025594.5         36848-37015
            4689-4812           AC025594.5         37096-37219
            4813-4969           AC025594.5         37712-37868
            4970-5159           AC025594.5         37944-38133
            5160-5183           AC025594.5         38332-38355
            5184-5431           AC025594.5         38482-38729
            5432-5530           AC025594.5         39127-39225
            5531-5630           AC025594.5         39535-39634
            5631-5771           AC025594.5         39954-40094
            5772-5900           AC025594.5         40383-40511
            5901-6074           AC025594.5         40606-40779
            6075-6236           AC025594.5         41742-41903
            6237-6440           AC025594.5         41979-42182
            6441-6593           AC025594.5         42620-42772
            6594-6716           AC025594.5         42866-42988
            6717-6959           AC025594.5         43125-43367
            6960-7229           AC025594.5         43564-43833
            7230-7367           AC025594.5         43926-44063
            7368-7483           AC025594.5         44350-44465
            7484-7616           AC025594.5         45669-45801
            7617-7793           AC025594.5         45896-46072
            7794-8012           AC025594.5         46269-46487
            8013-8222           AC025594.5         47159-47368
            8223-9159           AC025594.5         47487-48423
FEATURES             Location/Qualifiers
     source          1..9159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..9159
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /note="filamin C"
                     /db_xref="GeneID:2318"
                     /db_xref="HGNC:HGNC:3756"
                     /db_xref="MIM:102565"
     exon            1..584
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..8410
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /note="isoform a is encoded by transcript variant 1; actin
                     binding protein 280; filamin C, gamma; ABP-L, gamma
                     filamin; filamin-2; ABP-280-like protein"
                     /codon_start=1
                     /product="filamin-C isoform a"
                     /protein_id="NP_001449.3"
                     /db_xref="CCDS:CCDS43644.1"
                     /db_xref="GeneID:2318"
                     /db_xref="HGNC:HGNC:3756"
                     /db_xref="MIM:102565"
                     /translation="MMNNSGYSDAGLGLGDETDEMPSTEKDLAEDAPWKKIQQNTFTR
                     WCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSV
                     ALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQT
                     PKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVENA
                     REAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPK
                     KAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKDR
                     TYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVA
                     NKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPAMEGPHTV
                     HVAFAGAPITRSPFPVHVSEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGE
                     LKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVS
                     PEAGVQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDG
                     SCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKVKAFGPGLEPTGC
                     IVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTI
                     IISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGD
                     VSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASP
                     FHIKVDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFAGTAKGEV
                     VRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKIKVQ
                     GLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMP
                     PEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTK
                     GAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFK
                     ATIRPVFDPSKVRASGPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLI
                     HNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEP
                     HGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYE
                     EGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGA
                     GTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVP
                     VKDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVR
                     DNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNAS
                     GIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRY
                     TITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGQETVITV
                     DAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIP
                     NSPFHVLACDPLPHEEEPSEVPQLRQPYAPPRPGARPTHWATEEPVVPVEPMESMLRP
                     FNLVIPFAVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDG
                     NHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPS
                     KAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLN
                     VGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVS
                     VRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGL
                     GLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEG
                     RMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTER
                     TEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQ
                     DMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTV
                     GPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDR
                     KDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLK
                     VNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDV
                     KFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGAL
                     SVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPR
                     LSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKN
                     SFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGD
                     ESVPGSPFKVKVP"
     exon            585..833
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            834..931
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1082
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1201
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1279
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1442
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1643
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1781
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1908
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2045
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2239
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2353
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2497
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2621
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2782
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2873
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3043
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3161
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3424
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..4022
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            4023..4196
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            4197..4359
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            4360..4520
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            4521..4688
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            4689..4812
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            4813..4969
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            4970..5159
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            5160..5183
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            5184..5431
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            5432..5530
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            5531..5630
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            5631..5771
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            5772..5900
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            5901..6074
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            6075..6236
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            6237..6440
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            6441..6593
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            6594..6716
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            6717..6959
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            6960..7229
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            7230..7367
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            7368..7483
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            7484..7616
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            7617..7793
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            7794..8012
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            8013..8222
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     exon            8223..9159
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9140..9145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /note="hexamer: AATAAA"
     polyA_site      9159
                     /gene="FLNC"
                     /gene_synonym="ABP-280; ABP280A; ABPA; ABPL; ARVC15;
                     CMH26; FLN2; MFM5; MPD4; RCM5"
                     /note="major polyA site"
ORIGIN      
        1 gcccttcccg agcaccgctc cggccctgga gggagagaga gccagagagc ggccgagcgc
       61 ctaggaggcc cgccgagcct cgccgagccc cgccagcccc ggcgcgagag aagttggaga
      121 ggagagcagc gcagcgcagc gagtcccgtg gtcgcgcccc aacagcgccc gacagccccc
      181 gatagcccaa accgcggccc tagccccggc cgcaccccca gcccgcgcca gcatgatgaa
      241 caacagcggc tactcagacg ccggcctcgg cctgggcgat gagacagacg agatgccgtc
      301 cacggagaag gacctggcgg aggacgcgcc gtggaagaag atccagcaga acacattcac
      361 gcgctggtgc aatgagcacc tcaagtgcgt gggcaagcgc ctgaccgacc tgcagcgcga
      421 cctcagcgac gggctccggc tcatcgcgct gctcgaggtg ctcagccaga agcgcatgta
      481 ccgcaagttc catccgcgcc ccaacttccg ccaaatgaag ctggagaacg tgtccgtggc
      541 cctcgagttc ctcgagcgcg agcacatcaa gctcgtgtcc atagacagca aggccatcgt
      601 ggatgggaac ctgaagctga tcctgggcct gatctggacg ctgatcctgc actactccat
      661 ctccatgccc atgtgggagg atgaagatga tgaggatgcc cgcaaacaga cgcccaagca
      721 gcggctgctt ggctggatcc agaacaaggt gccccagctg cccatcacca acttcaaccg
      781 tgactggcag gacggcaaag ctctgggcgc cctggtggac aactgcgccc ccggtctctg
      841 ccccgactgg gaggcctggg accccaacca gcccgtggag aacgcccggg aggccatgca
      901 gcaggccgac gactggcttg gggtgcccca ggtcattgcc cctgaggaga ttgtggaccc
      961 caacgtggat gagcattctg ttatgaccta cctgtcccag ttccccaagg ccaagctcaa
     1021 acctggtgcc cctgttcgat ccaagcagct gaaccccaag aaagccatcg cctatgggcc
     1081 tggcatcgag ccacagggca acaccgtgct gcagcctgcc cacttcaccg tgcagacggt
     1141 ggacgcgggc gtgggcgagg tgctggtcta catcgaggac cctgaaggcc acaccgagga
     1201 ggctaaggtg gttcccaaca atgacaagga tcgcacctat gctgtctcct atgtgcccaa
     1261 ggtcgctggg ttacacaagg tgaccgtgct ctttgctggc cagaacattg aacgcagtcc
     1321 ctttgaggtg aacgtgggca tggccctggg agatgccaac aaggtgtcag cccgtggccc
     1381 tggcctggaa cctgtgggca atgtggccaa caaacccacc tactttgaca tctacactgc
     1441 gggggccggc actggcgatg ttgctgtggt gatcgtggac ccacagggcc ggcgggacac
     1501 agtggaggtg gccctggagg acaagggtga cagcacgttc cgctgcacat acagacctgc
     1561 catggagggg ccacataccg tgcatgtggc ctttgcgggt gcccccatca cccgcagtcc
     1621 cttccctgtc catgtgtcgg aagcctgtaa ccccaacgcc tgccgcgcct ctgggcgagg
     1681 cctgcagccc aagggtgttc gcgtgaaaga ggtggctgac ttcaaggtgt ttaccaaggg
     1741 tgccggcagc ggggagctca aggtcacggt caaggggcca aagggcacag aggagccagt
     1801 gaaggtgcgg gaggctgggg atggtgtgtt cgagtgcgag tactacccgg tggtgcctgg
     1861 gaagtatgtg gtgaccatca cgtggggcgg ctacgccatc cctcgcagcc cctttgaggt
     1921 acaggtgagc ccagaggcag gagtgcaaaa ggtccgggcc tggggtcctg gtttggagac
     1981 tggccaggtg ggcaagtcag ccgattttgt ggtggaagcc attggcaccg aggtggggac
     2041 actgggcttc tccatcgagg ggccctcaca agccaagatc gaatgtgacg acaaggggga
     2101 tggctcctgc gatgtgcggt actggcccac ggagcctggg gagtacgctg tgcacgtcat
     2161 ctgtgacgat gaggacatcc gagactcacc cttcattgcc cacatcctgc ccgccccacc
     2221 tgactgcttc ccagataagg tgaaggcctt tgggcctggc ctggagccta ccggctgcat
     2281 cgtggacaag cccgctgagt tcaccattga tgctcgtgca gctggcaagg gagacctgaa
     2341 gctctatgcc caggacgccg acggctgtcc catcgacatc aaggtgatcc ccaacggcga
     2401 cggcaccttc cgctgctcct acgtgcccac caagcccatt aagcacacca tcatcatctc
     2461 ctggggaggc gtaaacgtgc ccaagagccc cttccgggtg aacgtgggcg agggcagcca
     2521 ccccgagcgg gtaaaggtgt acggccccgg agtggagaag acaggcctca aggccaatga
     2581 gcccacctac ttcacggtgg actgcagcga ggcggggcaa ggcgacgtga gcatcggcat
     2641 caagtgcgcc ccaggcgtgg tgggccctgc agaggctgac attgacttcg acatcatcaa
     2701 gaatgacaac gacaccttca ccgtcaagta cacgccacca ggggcgggcc gctacaccat
     2761 catggtgctg tttgccaacc aggagatccc cgccagcccc ttccacatca aggtggaccc
     2821 atcccacgat gccagcaaag tcaaggccga gggccctggg ctgaatcgca caggtgtgga
     2881 agtcgggaag cccacccact tcacggtgct gaccaaggga gccggcaagg ccaagctgga
     2941 tgtgcagttt gcagggacag ccaagggcga ggttgtgcgg gactttgaga tcatagacaa
     3001 ccatgactac tcctacactg tcaagtacac cgctgtccag cagggcaaca tggcagtgac
     3061 agtgacttat ggcggggacc ctgtccccaa gagccccttt gtggtgaatg tggcaccccc
     3121 gctggacctc agcaaaatca aagttcaggg ccttaatagc aaggtggctg tgggacagga
     3181 acaagcattc tctgtgaaca cacgaggggc tggcggtcag ggccaactgg atgtgcggat
     3241 gacttcgccc tctcgccggc ccatcccctg caagctggag ccaggcggtg gagcggaagc
     3301 ccaggctgtg cgctacatgc ccccggagga ggggccctac aaggtggata tcacctacga
     3361 tggtcacccg gtgcctggca gcccgtttgc tgtggagggt gtcctgcccc ctgatccctc
     3421 caaggtctgt gcttatggcc cgggtctcaa gggtggactg gtaggcaccc ccgcgccatt
     3481 ctccatcgac accaaggggg ctggcacagg tggcctgggg ctgaccgtag agggcccctg
     3541 cgaggccaag atcgagtgcc aggacaatgg tgatggctca tgtgctgtca gctacctgcc
     3601 cacggagcct ggcgagtaca ccatcaacat cctgtttgct gaggcccaca tccctggctc
     3661 gcccttcaaa gccaccattc ggcctgtgtt tgacccgagc aaggtgcggg ccagtggacc
     3721 gggcctggag cgcggcaagg tcggtgaggc agccaccttc actgtggact gctcagaggc
     3781 aggcgaggcg gagctgacca ttgagatcct gtcggatgcc ggggtcaagg ccgaggtgct
     3841 gatccacaac aacgcggatg gcacctacca catcacctac agccctgcct tccctggcac
     3901 ctacaccatt accatcaagt atggcgggca tcccgtgccc aaattcccca cccgtgtcca
     3961 tgtgcagcct gcggtcgata ccagtggcgt caaggtctca gggcctggtg ttgagccaca
     4021 cggtgtcctg cgggaggtga ccactgagtt cactgtggat gcaagatccc taacagccac
     4081 aggcggcaac cacgtgacgg ctcgtgtgct caacccctcg ggggccaaga cagacaccta
     4141 tgtgacagac aatggggacg gcacctaccg agtgcagtac accgcctacg aggagggcgt
     4201 gcatctggtg gaggtcctgt atgatgaggt cgctgtgccc aagagcccct tccgagtggg
     4261 cgtgaccgag ggctgtgatc ccacccgcgt ccgagccttc gggccaggcc tggagggtgg
     4321 cttggtcaac aaggccaacc gattcactgt ggagaccagg ggagcgggca ccgggggcct
     4381 tggcctagcc atcgagggtc cctcggaagc caagatgtcc tgcaaggaca acaaggatgg
     4441 tagctgcacc gtggagtaca tccccttcac tcctggagac tatgacgtca acatcacctt
     4501 cggggggcgg cccatcccag ggagcccgtt ccgcgtgcca gtgaaggatg tggtggaccc
     4561 tgggaaggtg aagtgctcag ggccagggct gggggctggt gtcagggccc gggttcctca
     4621 gaccttcaca gtggattgca gtcaagctgg ccgggcgccc ctgcaggtgg ctgtgctggg
     4681 ccccacaggt gtggccgagc ctgtggaggt gcgggacaat ggagatggca cccacactgt
     4741 ccactacacc ccagccactg acgggcccta cacggtagcc gtcaagtatg ctgaccagga
     4801 ggtgccacgc agccccttca agatcaaggt cctcccagct catgatgcca gcaaggtgcg
     4861 ggccagcggc ccaggcctca acgcctctgg catccctgcc agcctgcctg tggagttcac
     4921 catcgacgca cgggacgcgg gcgaggggtt gctcactgtc cagatcttgg accccgaggg
     4981 taagcccaag aaggccaaca tccgggacaa tggggatggc acgtacactg tgtcctacct
     5041 gccggacatg agtggccggt acaccatcac catcaagtat ggcggtgatg agatccccta
     5101 ctcgcccttc cgcatccatg ctctgcccac tggggatgcc agcaagtgcc tcgtcacagt
     5161 gtccattgga ggccatggcc tgggtgcctg cctgggccct cgaatccaga ttgggcagga
     5221 gacggtgatc acggtggatg ccaaggcagc cggtgagggg aaggtgacat gcacggtgtc
     5281 cacgccggat ggggcagagc tcgatgtgga tgtggttgag aaccatgacg gtacctttga
     5341 catctactac acagcgcccg agccgggcaa gtacgtcatc accatccgct tcgggggtga
     5401 gcacatcccc aacagcccct tccacgtgct ggcgtgtgac cccctgccgc acgaggagga
     5461 gccctctgaa gtgccacagc tgcgccagcc ctacgctcct ccccggcccg gcgcccgccc
     5521 cacacactgg gccacagagg agccagtggt gcctgtggag ccaatggagt ccatgctgag
     5581 gcccttcaac ctggtcatcc ccttcgcggt gcagaaaggg gagctcacag gagaggtgcg
     5641 gatgccctcg gggaagacgg cacggcccaa catcaccgac aacaaggacg gcaccatcac
     5701 ggtgaggtat gcacccactg agaaaggcct gcaccagatg gggatcaagt atgacggcaa
     5761 ccacatccct gggagcccct tacagttcta tgtggatgcc atcaacagcc gccatgtcag
     5821 tgcctatggg ccaggcctga gccatggcat ggtcaacaag ccagccacct tcactattgt
     5881 caccaaagat gctggagaag ggggtctgtc actggccgtg gagggcccat ccaaggcaga
     5941 gatcacctgt aaggacaaca aggatggcac ctgcaccgtg tcctatctgc cgactgcgcc
     6001 tggagactac agcatcatcg tgcgcttcga tgacaagcac atcccgggga gccccttcac
     6061 agccaagatc acaggtgatg actccatgag gacctcacag ctgaatgtgg gcacctccac
     6121 ggacgtgtca ctgaagatca ccgagagtga tctgagccag ctgaccgcca gcatccgtgc
     6181 cccctcgggc aacgaggagc cctgcctgct gaagcgcctg cccaaccggc acattgggat
     6241 ctccttcacc cccaaggagg tcggggagca cgtggtgagc gtgcgcaaga gtggcaagca
     6301 tgtcaccaac agccccttca agatcctggt ggggccatct gagatcgggg acgccagcaa
     6361 ggtgcgggtc tggggcaagg ggctttccga gggacacaca ttccaggtgg cagagttcat
     6421 cgtggacact cgcaatgcag gttatggggg cttggggctg agtattgaag gcccaagcaa
     6481 ggtggacatc aactgtgagg acatggagga cgggacatgc aaagtcacct actgccccac
     6541 cgagcccggc acctacatca tcaacatcaa gtttgctgac aagcacgtgc ctggaagccc
     6601 cttcactgtg aaggtgaccg gcgagggccg catgaaggag agcatcaccc ggcggagaca
     6661 ggcaccttcc atcgccacca tcggcagcac ctgtgacctc aacctcaaga tcccaggaaa
     6721 ctggttccag atggtgtctg cccaggagcg cctgacacgc accttcacac gcagcagcca
     6781 cacctacacc cgcacggagc gcacggagat cagcaagacg cggggcgggg agacaaagcg
     6841 cgaggtgcgg gtggaggagt ccacccaggt cggcggggac cccttccctg ctgtgtttgg
     6901 ggacttcctg ggccgggagc gcctgggatc cttcggcagc atcacccggc agcaggaggg
     6961 tgaggccagc tctcaggaca tgactgcaca ggtgaccagc ccatcgggca aggtggaagc
     7021 cgcagagatc gtcgagggcg aggacagcgc ctacagcgtg cgctttgtgc cccaggaaat
     7081 ggggccccat acggtcgctg tcaagtaccg tggccagcac gtgcccggca gcccctttca
     7141 gttcactgtg gggccgctgg gtgaaggtgg tgcccacaag gtgcgggccg gaggcacagg
     7201 gctggagcga ggtgtggccg gcgtgccagc cgagttcagc atctggaccc gggaggctgg
     7261 cgctgggggc ctgtccattg ctgtggaggg tcctagcaaa gcggagattg catttgagga
     7321 tcgcaaagat ggctcctgcg gcgtctccta tgtcgtccag gaaccaggtg actatgaggt
     7381 ctccatcaag ttcaatgatg agcacatccc agacagcccc tttgtggtgc ctgtggcctc
     7441 cctctcggat gacgctcgcc gtctcactgt caccagcctc caggagacgg ggctcaaggt
     7501 gaaccagcca gcgtcctttg ccgtgcagct gaacggtgcc cggggcgtga ttgatgcccg
     7561 ggtgcacaca ccctcggggg ctgtggagga gtgctacgtc tctgagctgg acagtgacaa
     7621 gcacaccatc cgcttcatcc cccacgagaa tggcgtccac tccatcgatg tcaagttcaa
     7681 cggtgcccac atccctggaa gtcccttcaa gatccgcgtt ggggagcaga gccaggctgg
     7741 ggacccaggc ttggtgtcag cctacggtcc tgggctcgag ggaggcacta ccggtgtgtc
     7801 atcagagttc atcgtgaaca ccctgaatgc cggctcgggg gccttgtctg tcaccattga
     7861 tggcccctcc aaggtgcagc tggactgtcg ggagtgtcct gagggccatg tggtcactta
     7921 tactcccatg gcccctggca actacctcat tgccatcaag tacggtggcc cccagcacat
     7981 cgtgggcagc cccttcaagg ccaaggtcac tggtccgagg ctgtccggag gccacagcct
     8041 tcacgaaaca tccacggttc tggtggagac tgtgaccaag tcctcctcaa gccggggctc
     8101 cagctacagc tccatcccca agttctcctc agatgccagc aaggtggtga ctcggggccc
     8161 tgggctgtcc caggccttcg tgggccagaa gaactccttc accgtggact gcagcaaagc
     8221 aggcaccaac atgatgatgg tgggcgtgca cggccccaag accccctgtg aggaggtgta
     8281 cgtgaagcac atggggaacc gggtgtacaa tgtcacctac actgtcaagg agaaagggga
     8341 ctacatcctc attgtcaagt ggggtgacga aagtgtccct ggaagcccct tcaaagtcaa
     8401 ggtcccttga atcccaaaag tgcctcccca gcctcagccc ccacctccag ccacacacac
     8461 attacacaca cacacacaca cacacaaatg tgccacaccc agacacgcac agaatcagac
     8521 actacaaaca cctgccttgg gggtgaagtg aaggcccagc ctccccaccc caccgcgccc
     8581 caggggttgg aggaccttgt ctgtgtcagg acagtgtccc tccctgggaa tgtgacatga
     8641 gggccgactg gggccaggct caggggcaga ggctgggaca caaggggctg gcgagggctg
     8701 cgaggccagg gaagccctga gtttctggcg gggctgagca gtgggggagc attgtgttgt
     8761 gggtgtctgt gtgtgaggtc accctcaaac tgcaccgccg gccagatacc ctcctgaccc
     8821 cgaggacttg gtctggtctc tctggtggct acaaccccag agttttaagg acttggaaag
     8881 gaaagcacaa tcagagaaga aaacagcccc cgaaccagca ggagtggcct ggcacatgga
     8941 ccggcctgag cgatgtgcac tccacccaag ccaggctccc agggggcctg atttctctct
     9001 cactgtctct ttttttaaaa tggttgcacg gctctgcccc atggggggcc ttttttacac
     9061 actgcgaggc ccagctttct aggggacttt tgcacatgtc atgcagctca gctgggagct
     9121 gcttaggtgg aaaactccaa ataaagtgcg gctgtcgca
//
