LOCUS       NM_001457               9441 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens filamin B (FLNB), transcript variant 2, mRNA.
ACCESSION   NM_001457
VERSION     NM_001457.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9441)
  AUTHORS   Wang,F., Huang,J., Zeng,S., Pan,Y. and Zhou,H.
  TITLE     ETS homologous factor, controlled by lysine-specific demethylase
            5B, suppresses clear cell renal cell carcinoma by inducing
            Filamin-B
  JOURNAL   Gene 927, 148702 (2024)
   PUBMED   38880187
  REMARK    GeneRIF: ETS homologous factor, controlled by lysine-specific
            demethylase 5B, suppresses clear cell renal cell carcinoma by
            inducing Filamin-B.
REFERENCE   2  (bases 1 to 9441)
  AUTHORS   Qasim,H., Khan,H., Zeb,H., Ahmad,A., Ilyas,M., Zahoor,M.,
            Umar,M.N., Ullah,R. and Ali,E.A.
  TITLE     A novel variant in the FLNB gene associated with
            spondylocarpotarsal synostosis syndrome
  JOURNAL   J Basic Clin Physiol Pharmacol 35 (3), 181-187 (2024)
   PUBMED   38743867
  REMARK    GeneRIF: A novel variant in the FLNB gene associated with
            spondylocarpotarsal synostosis syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9441)
  AUTHORS   Sawyer,G.M., Clark,A.R., Robertson,S.P. and Sutherland-Smith,A.J.
  TITLE     Disease-associated substitutions in the filamin B actin binding
            domain confer enhanced actin binding affinity in the absence of
            major structural disturbance: Insights from the crystal structures
            of filamin B actin binding domains
  JOURNAL   J Mol Biol 390 (5), 1030-1047 (2009)
   PUBMED   19505475
  REMARK    GeneRIF: High-resolution X-ray crystal structures of the human
            filamin B wild type actin-binding domain, plus W148R and M202V
            mutants.
REFERENCE   4  (bases 1 to 9441)
  AUTHORS   van der Flier,A. and Sonnenberg,A.
  TITLE     Structural and functional aspects of filamins
  JOURNAL   Biochim Biophys Acta 1538 (2-3), 99-117 (2001)
   PUBMED   11336782
  REMARK    Review article
REFERENCE   5  (bases 1 to 9441)
  AUTHORS   Chakarova,C., Wehnert,M.S., Uhl,K., Sakthivel,S., Vosberg,H.P., van
            der Ven,P.F. and Furst,D.O.
  TITLE     Genomic structure and fine mapping of the two human filamin gene
            paralogues FLNB and FLNC and comparative analysis of the filamin
            gene family
  JOURNAL   Hum Genet 107 (6), 597-611 (2000)
   PUBMED   11153914
REFERENCE   6  (bases 1 to 9441)
  AUTHORS   Brocker,F., Bardenheuer,W., Vieten,L., Julicher,K., Werner,N.,
            Marquitan,G., Michael,D., Opalka,B. and Schutte,J.
  TITLE     Assignment of human filamin gene FLNB to human chromosome band
            3p14.3 and identification of YACs containing the complete FLNB
            transcribed region
  JOURNAL   Cytogenet Cell Genet 85 (3-4), 267-268 (1999)
   PUBMED   10449914
REFERENCE   7  (bases 1 to 9441)
  AUTHORS   Takafuta,T., Wu,G., Murphy,G.F. and Shapiro,S.S.
  TITLE     Human beta-filamin is a new protein that interacts with the
            cytoplasmic tail of glycoprotein Ibalpha
  JOURNAL   J Biol Chem 273 (28), 17531-17538 (1998)
   PUBMED   9651345
REFERENCE   8  (bases 1 to 9441)
  AUTHORS   Vujic,M., Hallstensson,K., Wahlstrom,J., Lundberg,A., Langmaack,C.
            and Martinson,T.
  TITLE     Localization of a gene for autosomal dominant Larsen syndrome to
            chromosome region 3p21.1-14.1 in the proximity of, but distinct
            from, the COL7A1 locus
  JOURNAL   Am J Hum Genet 57 (5), 1104-1113 (1995)
   PUBMED   7485161
REFERENCE   9  (bases 1 to 9441)
  AUTHORS   Leedman,P.J., Faulkner-Jones,B., Cram,D.S., Harrison,P.J., West,J.,
            O'Brien,E., Simpson,R., Coppel,R.L. and Harrison,L.C.
  TITLE     Cloning from the thyroid of a protein related to actin binding
            protein that is recognized by Graves disease immunoglobulins
  JOURNAL   Proc Natl Acad Sci U S A 90 (13), 5994-5998 (1993)
   PUBMED   8327473
REFERENCE   10 (bases 1 to 9441)
  AUTHORS   Robertson,S.
  TITLE     FLNB Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301736
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF043045.1, AB371582.1,
            AB209889.1 and AC137936.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001457.3.
            
            Summary: This gene encodes a member of the filamin family. The
            encoded protein interacts with glycoprotein Ib alpha as part of the
            process to repair vascular injuries. The platelet glycoprotein Ib
            complex includes glycoprotein Ib alpha, and it binds the actin
            cytoskeleton. Mutations in this gene have been found in several
            conditions: atelosteogenesis type 1 and type 3; boomerang
            dysplasia; autosomal dominant Larsen syndrome; and
            spondylocarpotarsal synostosis syndrome. Multiple alternatively
            spliced transcript variants that encode different protein isoforms
            have been described for this gene. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region compared to variant 1. The resulting
            protein (isoform 2) is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF043045.1, AF042166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295956.9/ ENSP00000295956.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AF043045.1         24-100
            78-4315             AB371582.1         78-4315
            4316-8272           AB209889.1         1207-5163
            8273-9441           AC137936.3         117057-118225
FEATURES             Location/Qualifiers
     source          1..9441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..9441
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /note="filamin B"
                     /db_xref="GeneID:2317"
                     /db_xref="HGNC:HGNC:3755"
                     /db_xref="MIM:603381"
     exon            1..435
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..7952
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /note="isoform 2 is encoded by transcript variant 2; actin
                     binding protein 278; Larsen syndrome 1 (autosomal
                     dominant); thyroid autoantigen; filamin B, beta;
                     filamin-3; beta-filamin; ABP-280 homolog; filamin homolog
                     1; actin-binding-like protein"
                     /codon_start=1
                     /product="filamin-B isoform 2"
                     /protein_id="NP_001448.2"
                     /db_xref="CCDS:CCDS2885.1"
                     /db_xref="GeneID:2317"
                     /db_xref="HGNC:HGNC:3755"
                     /db_xref="MIM:603381"
                     /translation="MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDL
                     SDGLRLIALLEVLSQKRMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAI
                     VDGNLKLILGLVWTLILHYSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITN
                     FNQNWQDGKALGALVDSCAPGLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPE
                     EIIHPDVDEHSVMTYLSQFPKAKLKPGAPLKPKLNPKKARAYGRGIEPTGNMVKQPAK
                     FTVDTISAGQGDVMVFVEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFA
                     GQHISKSPFEVSVDKAQGDASKVTAKGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVE
                     VEDPQGKNTVELLVEDKGNQVYRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGEAC
                     NPNACRASGRGLQPKGVRIRETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLD
                     GVYAFEYYPSTPGRYSIAITWGGHHIPKSPFEVQVGPEAGMQKVRAWGPGLHGGIVGR
                     SADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGSCDVKYWPKEPGEYAVHIMCDD
                     EDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKI
                     FAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIAVVWGGVNIPHSPYRVNIGQGS
                     HPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSEDEEDVDFD
                     IIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVDPSHDASKVKAEGPGLS
                     KAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIIDNYDYSHTVKYTPTQ
                     QGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLENRVEVGKDQEFTVDTRGAG
                     GQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVTYDGHPVPGSPY
                     TVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECS
                     DNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHG
                     KVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTL
                     TMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQVG
                     GDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKV
                     AVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDN
                     KDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGPGLGSGVR
                     ARVLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVS
                     VKYADEEIPRSPFKVKVLPTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLL
                     AVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQ
                     TGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENE
                     DGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVTAVEEAPVNACPPGFRP
                     WVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDGTV
                     TVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATF
                     TIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIP
                     GSPFTAKITDDSRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLP
                     NNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGR
                     TFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTK
                     FADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEINSSDMSAH
                     VTSPSGRVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGE
                     GGAHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSC
                     GVSYIAQEPGNYEVSIKFNDEHIPESPYLVPVIAPSDDARRLTVMSLQESGLKVNQPA
                     SFAIRLNGAKGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGS
                     HVVGSPFKVRVGEPGQAGNPALVSAYGTGLEGGTTGIQSEFFINTTRAGPGTLSVTIE
                     GPSKVKMDCQETPEGYKVMYTPMAPGNYLISVKYGGPNHIVGSPFKAKVTGQRLVSPG
                     SANETSSILVESVTRSSTETCYSAIPKASSDASKVTSKGAGLSKAFVGQKSSFLVDCS
                     KAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSP
                     FHVTVP"
     exon            436..684
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            685..782
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            783..930
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1049
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1127
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1290
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1488
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1626
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1753
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1890
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2084
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2198
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2342
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2466
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2627
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2718
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2888
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3006
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3269
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3867
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3868..4041
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4042..4204
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4205..4365
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4366..4533
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4534..4657
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4658..4814
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4815..5004
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5005..5252
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5253..5324
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5325..5427
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5428..5568
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5569..5697
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5698..5871
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5872..6030
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            6031..6234
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            6235..6387
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            6388..6510
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            6511..6777
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            6778..6915
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            6916..7031
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7032..7164
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7165..7341
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7342..7560
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7561..7764
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7765..9441
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9420..9425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /note="hexamer: AATAAA"
     polyA_site      9441
                     /gene="FLNB"
                     /gene_synonym="ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L;
                     LRS1; SCT; TABP; TAP"
                     /note="major polyA site"
ORIGIN      
        1 agagcagcac cggccgtggc tccggtagca gcaagttcga accccgctcc cgctccgctt
       61 cggttctcgc tccttcggcc cttgggcctc caaacaccag tccccggcag ctcgttgcgc
      121 attgcgctct ccccgccacc aggatgccgg taaccgagaa ggatctagct gaggacgcgc
      181 cttggaagaa gatccagcag aacacgttca cacgctggtg caacgagcac ctcaagtgcg
      241 tgaacaaacg catcggcaac ctgcagaccg acctgagcga cgggctgcgg ctcatcgcgc
      301 tgctcgaggt gctcagccag aagcgcatgt accgcaagta ccatcagcgg cccacctttc
      361 gccagatgca gctcgagaat gtgtccgtgg cgctcgagtt cctggaccgt gagagcatca
      421 agctcgtgtc catcgatagc aaagccattg tggatgggaa cctgaagctc atcttgggtc
      481 tggtgtggac gctgatcctc cactactcca tctccatgcc cgtgtgggag gatgaagggg
      541 atgatgatgc caagaagcag acgccaaagc agaggctgct ggggtggatt cagaacaaga
      601 tcccctactt gcccatcacc aactttaacc agaactggca agacggcaaa gccctgggag
      661 ccctggtaga cagctgtgct ccaggtctgt gcccagactg ggaatcctgg gacccgcaga
      721 agcctgtgga taatgcacga gaagccatgc agcaggcaga tgactggctg ggtgtcccac
      781 aggtcatcac tcctgaagaa atcattcacc cggatgtgga cgagcactca gttatgactt
      841 acctgtccca gttccccaaa gccaagctca agccgggggc tcctctcaaa cccaaactca
      901 acccgaagaa agccagggcc tatggcagag gaatcgagcc cactggaaac atggtgaagc
      961 agccagccaa gttcactgtg gacaccatca gcgccgggca aggagacgtg atggtgtttg
     1021 ttgaggaccc agaagggaac aaagaggagg cacaagtgac ccctgacagt gacaagaaca
     1081 agacatactc tgtggagtat ctgcccaagg tcaccgggct acacaaagtc acagtcctct
     1141 ttgcaggaca gcacatctcc aagagcccat ttgaagtgag tgttgacaag gcccagggag
     1201 atgccagtaa agtcactgca aaaggtccag ggttggaagc tgtagggaac atcgccaata
     1261 agcccaccta ctttgacatc tatacggcag gagctggtgt gggtgacatt ggtgtggagg
     1321 tggaagatcc ccaggggaag aacaccgtgg agttgctcgt ggaagacaaa ggaaaccagg
     1381 tgtatcgatg tgtgtacaaa cccatgcagc ctggccctca cgtggtcaag atcttctttg
     1441 ctggggacac tattcctaag agtcccttcg ttgtgcaggt tggggaagcc tgcaatccaa
     1501 atgcctgccg ggccagtggc cgaggcctac aacccaaagg cgtccgtatc cgggagacca
     1561 cagatttcaa ggttgacacc aaagctgcag gaagtgggga gctcggtgta accatgaagg
     1621 gtcctaaggg tctggaggag ctggtgaagc agaaagactt tctggatggg gtctacgcat
     1681 tcgagtatta ccccagcacc ccggggagat acagcattgc catcacatgg gggggacacc
     1741 acattccaaa gagccccttt gaagttcaag ttggccctga agcgggtatg cagaaagtcc
     1801 gtgcttgggg ccctgggctc catggtggga ttgtcgggcg gtcagcggac ttcgtggtag
     1861 aatccattgg ctctgaagtg gggtctctgg ggtttgccat tgaaggcccc tctcaggcaa
     1921 agattgagta caacgaccag aatgatggat cgtgtgatgt caaatactgg cccaaggagc
     1981 ctggcgaata tgctgttcac atcatgtgtg acgacgaaga catcaaggac agcccgtaca
     2041 tggccttcat ccacccagcc acgggaggct acaaccctga tctggttcga gcatacgggc
     2101 caggtttgga gaaatctgga tgcattgtca acaacctggc cgagttcact gtggatccta
     2161 aggatgctgg aaaagctccc ttaaagatat ttgctcagga tggggaaggc caacgcattg
     2221 acatccagat gaagaaccgg atggacggca catatgcatg ctcatacacc ccggtgaagg
     2281 ccatcaagca caccattgct gtggtctggg gaggcgtgaa catcccgcac agcccctaca
     2341 gggtcaacat cgggcaaggt agccatcctc agaaggtcaa agtgtttggg ccaggtgtgg
     2401 agagaagtgg tctgaaggca aatgaaccta cacacttcac ggtggactgt actgaggctg
     2461 gggaaggtga tgtcagtgtt ggcattaagt gtgatgcccg ggtgttaagt gaagatgagg
     2521 aagacgtgga ttttgacatt attcacaatg ccaatgatac gttcacagtc aaatatgtgc
     2581 ctcctgctgc tgggcgatac actatcaaag ttctctttgc atctcaggaa atccccgcca
     2641 gccctttcag agtcaaagtt gacccttccc acgatgccag caaagtgaag gcagaaggcc
     2701 cagggctcag caaagcaggt gtggaaaatg ggaaaccgac ccacttcact gtctacacca
     2761 agggggctgg gaaagccccg ctcaacgtgc agttcaacag ccctcttcct ggcgatgcag
     2821 tgaaggattt ggatatcatc gataattatg actactctca cacggttaaa tatacaccca
     2881 cccaacaggg caacatgcag gttctggtga cttacggtgg cgatcccatc cctaaaagcc
     2941 ctttcactgt gggtgttgct gcaccgctgg atctgagcaa gataaaactc aatgggctgg
     3001 aaaacagggt ggaagttggg aaggatcagg agttcaccgt tgataccagg ggggcaggag
     3061 gccaggggaa gctggacgtg acaatcctca gcccctctcg gaaggtcgtg ccatgcctag
     3121 tgacacctgt gacaggccgg gagaacagca cggccaagtt catccctcgg gaggaggggc
     3181 tgtatgctgt agacgtgacc tacgatggac accctgtgcc cgggagcccc tacacagtgg
     3241 aggcctcgct gccaccagat cccagcaagg tgaaggccca cggtcccggc ctcgaaggtg
     3301 gtctcgtggg caagcctgcc gagttcacca tcgataccaa aggagctggt actggaggtc
     3361 tgggcttaac ggtggaaggt ccgtgcgagg ccaaaatcga gtgctccgac aatggtgatg
     3421 ggacctgctc cgtctcttac cttcccacaa aacccgggga gtacttcgtc aacatcctct
     3481 ttgaagaagt ccacatacct gggtctccct tcaaagctga cattgaaatg ccctttgacc
     3541 cctctaaagt cgtggcatcg gggccaggtc tcgagcacgg gaaggtgggt gaagctggcc
     3601 tccttagcgt cgactgctcg gaagcgggac cgggggccct gggcctggaa gctgtctcgg
     3661 actcgggaac aaaagccgaa gtcagtattc agaacaacaa agatggcacc tacgcggtga
     3721 cctacgtgcc cctgacggcc ggcatgtaca cgttgaccat gaagtatggt ggcgaactcg
     3781 tgccacactt ccccgcccgg gtcaaggtgg agcccgccgt ggacaccagc aggatcaaag
     3841 tctttggacc aggaatagaa gggaaagatg tgttccggga agctaccacc gactttacag
     3901 ttgactctcg gccgctgacc caggttgggg gtgaccacat caaggcccac attgccaacc
     3961 cctcaggggc ctccaccgag tgctttgtca cagacaatgc ggatgggacc taccaggtgg
     4021 aatacacacc ctttgagaaa ggtctccatg tagtggaggt gacatatgat gacgtgccta
     4081 tcccaaacag tcccttcaag gtggctgtca ctgaaggctg ccagccatct agggtgcaag
     4141 cccaaggacc tggattgaaa gaggccttta ccaacaagcc caatgtcttc accgtggtta
     4201 ccagaggcgc aggaattggt gggcttggca taactgttga gggaccatca gagtcgaaga
     4261 taaattgcag agacaacaag gatggcagct gcagtgctga gtacattcct ttcgcaccgg
     4321 gggattacga tgttaatatc acatatggag gagcccacat ccccggcagc cccttcaggg
     4381 ttcctgtgaa ggatgttgtg gaccccagca aggtcaagat tgccggcccc gggctgggct
     4441 caggcgtccg agcccgtgtc ctgcagtcct tcacggtgga cagcagcaag gctggcctgg
     4501 ctccgctgga agtgagggtt ctgggcccac gaggcttggt ggagccagtg aacgtggtgg
     4561 acaatggaga tggcacacac acagtaacct acaccccatc tcaggaggga ccttacatgg
     4621 tctcagttaa atatgctgat gaagagattc ctcgcagtcc cttcaaggtc aaggtccttc
     4681 ccacatatga tgccagcaaa gtgactgcca gtggccccgg ccttagttcc tatggtgtgc
     4741 ctgccagtct acctgtggac tttgcaattg atgcccgaga tgccggggaa ggcctgcttg
     4801 ctgttcaaat aacggaccaa gaaggaaaac ccaaaagagc cattgtccat gacaataaag
     4861 atggcacgta tgctgtcacc tacatccccg acaagactgg gcgctatatg attggagtca
     4921 cctacggggg tgacgacatc ccactttctc cttatcgcat ccgagccaca cagacgggtg
     4981 atgccagcaa gtgcctggcc acgggtcctg gaatcgcctc cactgtgaaa actggcgaag
     5041 aagtaggctt tgtggttgat gccaagactg ccgggaaggg taaagtgacc tgcacggttc
     5101 tgaccccaga tggcactgag gccgaggccg atgtcattga gaatgaagat ggaacctatg
     5161 acatcttcta cacagctgcc aagccgggca catatgtgat ctatgtgcgc ttcggtggtg
     5221 ttgatattcc taacagcccc ttcactgtca tggccacaga tggggaagtc acagccgtgg
     5281 aggaggcacc ggtaaatgca tgtccccctg gattcaggcc ctgggtgacc gaagaggcct
     5341 atgtcccagt gagtgacatg aacggcctgg gatttaagcc ttttgacctg gtcattccgt
     5401 ttgctgtcag gaaaggagaa atcactggag aggtccacat gccttctggg aagacagcca
     5461 cacctgagat tgtggacaac aaggacggca cggtcactgt tagatatgcc cccactgagg
     5521 tcgggctcca tgagatgcac atcaaataca tgggcagcca catccctgag agcccactcc
     5581 agttctacgt gaactacccc aacagtggaa gtgtttctgc atacggtcca ggcctcgtgt
     5641 atggagtggc caacaaaact gccaccttca ccatcgtcac agaggatgca ggagaaggtg
     5701 gtctggactt ggctattgag ggcccctcaa aagcagaaat cagctgcatt gacaataaag
     5761 atgggacatg cacagtgacc tacctgccga ctctgccagg cgactacagc attctggtca
     5821 agtacaatga caagcacatc cctggcagcc ccttcacagc caagatcaca gatgacagca
     5881 ggcggtgctc ccaggtgaag ttgggctcag ccgctgactt cctgctcgac atcagtgaga
     5941 ctgacctcag cagcctgacg gccagcatta aggccccatc tggccgagac gagccctgtc
     6001 tcctgaagag gctgcccaac aaccacattg gcatctcctt catcccccgg gaagtgggcg
     6061 aacatctggt cagcatcaag aaaaatggca accatgtggc caacagcccc gtgtctatca
     6121 tggtggtcca gtcggagatt ggtgacgccc gccgagccaa agtctatggc cgcggcctgt
     6181 cagaaggccg gactttcgag atgtctgact tcatcgtgga cacaagggat gcaggttatg
     6241 gtggcatatc cttggcggtg gaaggcccca gcaaagtgga catccagacg gaggacctgg
     6301 aagatggcac ctgcaaagtc tcctacttcc ctaccgtgcc tggggtttat atcgtctcca
     6361 ccaaattcgc tgacgagcac gtgcctggga gcccatttac cgtgaagatc agtggggagg
     6421 gaagagtcaa agagagcatc acccgcacca gtcgggcccc gtccgtggcc actgtcggga
     6481 gcatttgtga cctgaacctg aaaatcccag aaatcaacag cagtgatatg tcggcccacg
     6541 tcaccagccc ctctggccgt gtgactgagg cagagattgt gcccatgggg aagaactcac
     6601 actgcgtccg gtttgtgccc caggagatgg gcgtgcacac ggtcagcgtc aagtaccgtg
     6661 ggcagcacgt caccggcagc cccttccagt tcaccgtggg gccacttggt gaaggaggcg
     6721 cccacaaggt gcgggcagga ggccctggcc tggagagagg agaagcggga gtcccagctg
     6781 agttcagcat ttggacccgg gaagcaggcg ctggaggcct ctccatcgct gttgagggcc
     6841 ccagtaaggc cgagattaca ttcgatgacc ataaaaatgg gtcgtgcggt gtatcttata
     6901 ttgcccaaga gcctggtaac tacgaggtgt ccatcaagtt caatgatgag cacatcccgg
     6961 aaagccccta cctggtgccg gtcatcgcac cctccgacga cgcccgccgc ctcactgtta
     7021 tgagccttca ggaatcggga ttaaaagtta accagccagc atcctttgct ataaggttga
     7081 atggcgcaaa aggcaagatt gatgcaaagg tgcacagccc ctctggagcc gtggaggagt
     7141 gccacgtgtc tgagctggag ccagataagt atgctgttcg cttcatccct catgagaatg
     7201 gtgtccacac catcgatgtc aagttcaatg ggagccacgt ggttggaagc cccttcaaag
     7261 tgcgcgttgg ggagcctgga caagcgggga accctgccct ggtgtccgcc tatggcacgg
     7321 gactcgaagg gggcaccaca ggtatccagt cggaattctt tattaacacc acccgagcag
     7381 gtccagggac attatccgtc accatcgaag gcccatccaa ggttaaaatg gattgccagg
     7441 aaacacctga agggtacaaa gtcatgtaca cccccatggc tcctggtaac tacctgatca
     7501 gcgtcaaata cggtgggccc aaccacatcg tgggcagtcc cttcaaggcc aaggtgacag
     7561 gccagcgtct agttagccct ggctcagcca acgagacctc atccatcctg gtggagtcag
     7621 tgaccaggtc gtctacagag acctgctata gcgccattcc caaggcatcc tcggacgcca
     7681 gcaaggtgac ctctaagggg gcagggctct caaaggcctt tgtgggccag aagagttcct
     7741 tcctggtgga ctgcagcaaa gctggctcca acatgctgct gatcggggtc catgggccca
     7801 ccaccccctg cgaggaggtc tccatgaagc atgtaggcaa ccagcaatac aacgtcacat
     7861 acgtcgtcaa ggagaggggc gattatgtgc tggctgtgaa gtggggggag gaacacatcc
     7921 ctggcagccc ttttcatgtc acagtgcctt aaaacagttt tctcaaatcc tggagagagt
     7981 tcttgtggtt gcttttgttg cttgtttgta attcatttta tacaaagccc tccagcctgt
     8041 ttgtggggct gaaaccccat ccctaaaata ttgctgttgt aaaatgcctt cagaaataag
     8101 tcctagactg gactcttgag ggacatattg gagaatctta agaaatgcaa gcttgttcag
     8161 ggggctgaga agatcctgag tacactaggt gcaaaccaga actcttggtg gaacagacca
     8221 gccactgcag cagacagacc aggaacacaa tgagactgac atttcaaaaa aacaaaactg
     8281 gctagcctga gctgctggtt cactcttcag catttatgaa acaaggctag gggaagatgg
     8341 gcagagaaaa aggggacacc tagtttggtt gtcatttggc aaaggagatg acttaaaatc
     8401 cgcttaatct cttccagtgt ccgtgttaat gtatttggct attagatcac tagcactgct
     8461 ttaccgctcc tcatcgccaa cacccccatg ctctgtggcc ttcttacact tctcagaggg
     8521 cagagtggca gccgggcacc ctacagaaac tcagagggca gagtggcagc caggcccaca
     8581 tgtctctcaa gtacctgtcc cctcgctctg gtgattattt cttgcagaat caccacacga
     8641 gaccatcccg gcagtcatgg ttttgcttta gttttccaag tccgtttcag tcccttcctt
     8701 ggtctgaaga aattctgcag tggcgagcag tttcccactt gccaaagatc ccttttaacc
     8761 aacactagcc cttgttttta acacacgctc cagcccttca tcagcctggg cagtcttacc
     8821 aaaatgttta aagtgatctc agaggggccc atggattaac gccctcatcc caaggtccgt
     8881 cccatgacat aacactccac acccgcccca gccaacttca tgggtcactt tttctggaaa
     8941 ataatgatct gtacagacag gacagaatga aactcctgcg ggtctttggc ctgaaagttg
     9001 ggaatggttg ggggagagaa gggcagcagc ttattggtgg tcttttcacc attggcagaa
     9061 acagtgagag ctgtgtggtg cagaaatcca gaaatgaggt gtagggaatt ttgcctgcct
     9121 tcctgcagac ctgagctggc tttggaatga ggttaaagtg tcagggacgt tgcctgagcc
     9181 caaatgtgta gtgtggtctg ggcaggcaga cctttaggtt ttgctgctta gtcctgagga
     9241 agtggccact cttgtggcag gtgtagtatc tggggcgagt gttgggggta aaagcccacc
     9301 ctacagaaag tggaacagcc cggagcctga tgtgaaagga ccacgggtgt tgtaagctgg
     9361 gacacggaag ccaaactgga atcaaacgcc gactgtaaat tgtatcttat aacttattaa
     9421 ataaaacatt tgctccgtaa a
//
