LOCUS       NM_001110556            8507 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens filamin A (FLNA), transcript variant 2, mRNA.
ACCESSION   NM_001110556
VERSION     NM_001110556.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8507)
  AUTHORS   Wade,E.M., Morgan,T., Gimenez,G., Jenkins,Z.A., Titheradge,H.,
            O'Donnell,M., Skidmore,D., Suri,M. and Robertson,S.P.
  TITLE     Pathogenic FLNA variants affecting the hinge region of filamin A
            are associated with male survival
  JOURNAL   Am J Med Genet A 194 (10), e63779 (2024)
   PUBMED   38853608
  REMARK    GeneRIF: Pathogenic FLNA variants affecting the hinge region of
            filamin A are associated with male survival.
REFERENCE   2  (bases 1 to 8507)
  AUTHORS   van der Flier,A. and Sonnenberg,A.
  TITLE     Structural and functional aspects of filamins
  JOURNAL   Biochim Biophys Acta 1538 (2-3), 99-117 (2001)
   PUBMED   11336782
  REMARK    Review article
REFERENCE   3  (bases 1 to 8507)
  AUTHORS   Chakarova,C., Wehnert,M.S., Uhl,K., Sakthivel,S., Vosberg,H.P., van
            der Ven,P.F. and Furst,D.O.
  TITLE     Genomic structure and fine mapping of the two human filamin gene
            paralogues FLNB and FLNC and comparative analysis of the filamin
            gene family
  JOURNAL   Hum Genet 107 (6), 597-611 (2000)
   PUBMED   11153914
REFERENCE   4  (bases 1 to 8507)
  AUTHORS   Patrosso,M.C., Repetto,M., Villa,A., Milanesi,L., Frattini,A.,
            Faranda,S., Mancini,M., Maestrini,E., Toniolo,D. and Vezzoni,P.
  TITLE     The exon-intron organization of the human X-linked gene (FLN1)
            encoding actin-binding protein 280
  JOURNAL   Genomics 21 (1), 71-76 (1994)
   PUBMED   8088819
REFERENCE   5  (bases 1 to 8507)
  AUTHORS   Maestrini,E., Patrosso,C., Mancini,M., Rivella,S., Rocchi,M.,
            Repetto,M., Villa,A., Frattini,A., Zoppe,M., Vezzoni,P. et al.
  TITLE     Mapping of two genes encoding isoforms of the actin binding protein
            ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7
  JOURNAL   Hum Mol Genet 2 (6), 761-766 (1993)
   PUBMED   7689010
REFERENCE   6  (bases 1 to 8507)
  AUTHORS   Robertson,S.
  TITLE     X-Linked Otopalatodigital Spectrum Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301567
REFERENCE   7  (bases 1 to 8507)
  AUTHORS   Chen,M.H. and Walsh,C.A.
  TITLE     FLNA Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301392
REFERENCE   8  (bases 1 to 8507)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
REFERENCE   9  (bases 1 to 8507)
  AUTHORS   Hoar,D.I., Field,L.L., Beards,F., Hoganson,G., Rollnick,B. and
            Hoo,J.J.
  TITLE     Tentative assignment of gene for oto-palato-digital syndrome to
            distal Xq (Xq26-q28)
  JOURNAL   Am J Med Genet 42 (2), 170-172 (1992)
   PUBMED   1733165
REFERENCE   10 (bases 1 to 8507)
  AUTHORS   Hock,R.S., Davis,G. and Speicher,D.W.
  TITLE     Purification of human smooth muscle filamin and characterization of
            structural domains and functional sites
  JOURNAL   Biochemistry 29 (40), 9441-9451 (1990)
   PUBMED   2248958
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP235228.1, X53416.1,
            AB191260.1 and AL050396.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 20, 2018 this sequence version replaced NM_001110556.1.
            
            Summary: The protein encoded by this gene is an actin-binding
            protein that crosslinks actin filaments and links actin filaments
            to membrane glycoproteins. The encoded protein is involved in
            remodeling the cytoskeleton to effect changes in cell shape and
            migration. This protein interacts with integrins, transmembrane
            receptor complexes, and second messengers. Defects in this gene are
            a cause of several syndromes, including periventricular nodular
            heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1,
            OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome
            (MNS), and X-linked congenital idiopathic intestinal
            pseudoobstruction (CIIPX). Two transcript variants encoding
            different isoforms have been found for this gene.[provided by
            RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2) includes an alternate in-frame
            exon and encodes a slightly longer protein isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GU727643.1, X53416.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369850.10/ ENSP00000358866.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BP235228.1         5-77
            74-1072             X53416.1           1-999
            1073-6094           AB191260.1         805-5826
            6095-6886           X53416.1           6022-6813
            6887-8272           AB191260.1         6619-8004
            8273-8507           AL050396.1         3747-3981
FEATURES             Location/Qualifiers
     source          1..8507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..8507
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /note="filamin A"
                     /db_xref="GeneID:2316"
                     /db_xref="HGNC:HGNC:3754"
                     /db_xref="MIM:300017"
     exon            1..129
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            130..618
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..8189
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /note="isoform 2 is encoded by transcript variant 2; actin
                     binding protein 280; endothelial actin-binding protein;
                     non-muscle filamin; filamin A, alpha; filamin-1;
                     alpha-filamin; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="filamin-A isoform 2"
                     /protein_id="NP_001104026.1"
                     /db_xref="CCDS:CCDS48194.1"
                     /db_xref="GeneID:2316"
                     /db_xref="HGNC:HGNC:3754"
                     /db_xref="MIM:300017"
                     /translation="MSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKI
                     QQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQM
                     QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEED
                     EEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDA
                     SKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLR
                     PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTA
                     NNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLE
                     PSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQPTM
                     EGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYTK
                     GAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPF
                     EVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECD
                     DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGL
                     EKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKP
                     VKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAE
                     AGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQA
                     TPTSPIRVKVEPSHDASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGL
                     TKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLS
                     KIKVSGLGEKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSV
                     VRFLPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGSAGSPARF
                     TIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIP
                     GSPFKAHVVPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLP
                     AEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYG
                     PGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVE
                     YTPYEEGLHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTV
                     ETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGS
                     PFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLV
                     EPVDVVDNADGTQTVNYVPSREGPYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASG
                     PGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVP
                     DVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGE
                     ETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRF
                     GGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLD
                     VTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEM
                     DIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSL
                     AIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSM
                     RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET
                     GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRD
                     AGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSV
                     KVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEI
                     VEGENHTYCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL
                     ERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE
                     VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAI
                     DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGE
                     PGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECP
                     EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSL
                     TKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHG
                     PRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVVVP"
     exon            619..867
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            868..965
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1113
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1232
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1310
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1473
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1674
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1812
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1936
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2073
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2267
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2381
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2525
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2649
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2810
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2901
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3071
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3189
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3452
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..4050
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            4051..4224
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4387
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            4388..4548
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            4549..4719
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            4720..4843
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            4844..5000
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            5001..5190
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            5191..5214
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            5215..5462
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            5463..5558
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            5559..5661
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            5662..5802
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            5803..5931
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            5932..6105
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            6106..6267
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            6268..6471
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            6472..6624
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            6625..6747
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            6748..7014
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            7015..7152
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            7153..7268
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            7269..7401
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            7402..7578
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            7579..7797
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            7798..8001
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     exon            8002..8507
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8487..8492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /note="hexamer: AATAAA"
     polyA_site      8507
                     /gene="FLNA"
                     /gene_synonym="ABP-280; ABPX; CSBS; CVD1; FGS2; FLN;
                     FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD"
                     /note="major polyA site"
ORIGIN      
        1 gcgtggaggc gcgtcgcgcg cagcggacgc cgacagaatc cccgaggcgc ctggcgcggg
       61 cgcgggcgcg aaggcgatcc gggcgccacc ccgcggtcat cggtcaccgg tcgctctcag
      121 gaacagcagc gcaacctctg ctccctgcct cgcctcccgc gcgcctaggt gcctgcgact
      181 ttaattaaag ggccgtcccc tcgccgaggc tgcagcaccg cccccccggc ttctcgcgcc
      241 tcaaaatgag tagctcccac tctcgggcgg gccagagcgc agcaggcgcg gctccgggcg
      301 gcggcgtcga cacgcgggac gccgagatgc cggccaccga gaaggacctg gcggaggacg
      361 cgccgtggaa gaagatccag cagaacactt tcacgcgctg gtgcaacgag cacctgaagt
      421 gcgtgagcaa gcgcatcgcc aacctgcaga cggacctgag cgacgggctg cggcttatcg
      481 cgctgttgga ggtgctcagc cagaagaaga tgcaccgcaa gcacaaccag cggcccactt
      541 tccgccaaat gcagcttgag aacgtgtcgg tggcgctcga gttcctggac cgcgagagca
      601 tcaaactggt gtccatcgac agcaaggcca tcgtggacgg gaacctgaag ctgatcctgg
      661 gcctcatctg gaccctgatc ctgcactact ccatctccat gcccatgtgg gacgaggagg
      721 aggatgagga ggccaagaag cagaccccca agcagaggct cctgggctgg atccagaaca
      781 agctgccgca gctgcccatc accaacttca gccgggactg gcagagcggc cgggccctgg
      841 gcgccctggt ggacagctgt gccccgggcc tgtgtcctga ctgggactct tgggacgcca
      901 gcaagcccgt taccaatgcg cgagaggcca tgcagcaggc ggatgactgg ctgggcatcc
      961 cccaggtgat cacccccgag gagattgtgg accccaacgt ggacgagcac tctgtcatga
     1021 cctacctgtc ccagttcccc aaggccaagc tgaagccagg ggctcccttg cggcccaaac
     1081 tgaacccgaa gaaagcccgt gcctacgggc caggcatcga gcccacaggc aacatggtga
     1141 agaagcgggc agagttcact gtggagacca gaagtgctgg ccagggagag gtgctggtgt
     1201 acgtggagga cccggccgga caccaggagg aggcaaaagt gaccgccaat aacgacaaga
     1261 accgcacctt ctccgtctgg tacgtccccg aggtgacggg gactcataag gttactgtgc
     1321 tctttgctgg ccagcacatc gccaagagcc ccttcgaggt gtacgtggat aagtcacagg
     1381 gtgacgccag caaagtgaca gcccaaggtc ccggcctgga gcccagtggc aacatcgcca
     1441 acaagaccac ctactttgag atctttacgg caggagctgg cacgggcgag gtcgaggttg
     1501 tgatccagga ccccatggga cagaagggca cggtagagcc tcagctggag gcccggggcg
     1561 acagcacata ccgctgcagc taccagccca ccatggaggg cgtccacacc gtgcacgtca
     1621 cgtttgccgg cgtgcccatc cctcgcagcc cctacactgt cactgttggc caagcctgta
     1681 acccgagtgc ctgccgggcg gttggccggg gcctccagcc caagggtgtg cgggtgaagg
     1741 agacagctga cttcaaggtg tacacaaagg gcgctggcag tggggagctg aaggtcaccg
     1801 tgaagggccc caagggagag gagcgcgtga agcagaagga cctgggggat ggcgtgtatg
     1861 gcttcgagta ttaccccatg gtccctggaa cctatatcgt caccatcacg tggggtggtc
     1921 agaacatcgg gcgcagtccc ttcgaagtga aggtgggcac cgagtgtggc aatcagaagg
     1981 tacgggcctg gggccctggg ctggagggcg gcgtcgttgg caagtcagca gactttgtgg
     2041 tggaggctat cggggacgac gtgggcacgc tgggcttctc ggtggaaggg ccatcgcagg
     2101 ctaagatcga atgtgacgac aagggcgacg gctcctgtga tgtgcgctac tggccgcagg
     2161 aggctggcga gtatgccgtt cacgtgctgt gcaacagcga agacatccgc ctcagcccct
     2221 tcatggctga catccgtgac gcgccccagg acttccaccc agacagggtg aaggcacgtg
     2281 ggcctggatt ggagaagaca ggtgtggccg tcaacaagcc agcagagttc acagtggatg
     2341 ccaagcacgg tggcaaggcc ccacttcggg tccaagtcca ggacaatgaa ggctgccctg
     2401 tggaggcgtt ggtcaaggac aacggcaatg gcacttacag ctgctcctac gtgcccagga
     2461 agccggtgaa gcacacagcc atggtgtcct ggggaggcgt cagcatcccc aacagcccct
     2521 tcagggtgaa tgtgggagct ggcagccacc ccaacaaggt caaagtatac ggccccggag
     2581 tagccaagac agggctcaag gcccacgagc ccacctactt cactgtggac tgcgccgagg
     2641 ctggccaggg ggacgtcagc atcggcatca agtgtgcccc tggagtggta ggccccgccg
     2701 aagctgacat cgacttcgac atcatccgca atgacaatga caccttcacg gtcaagtaca
     2761 cgccccgggg ggctggcagc tacaccatta tggtcctctt tgctgaccag gccacgccca
     2821 ccagccccat ccgagtcaag gtggagccct ctcatgacgc cagtaaggtg aaggccgagg
     2881 gccctggcct cagtcgcact ggtgtcgagc ttggcaagcc cacccacttc acagtaaatg
     2941 ccaaagctgc tggcaaaggc aagctggacg tccagttctc aggactcacc aagggggatg
     3001 cagtgcgaga tgtggacatc atcgaccacc atgacaacac ctacacagtc aagtacacgc
     3061 ctgtccagca gggtccagta ggcgtcaatg tcacttatgg aggggatccc atccctaaga
     3121 gccctttctc agtggcagta tctccaagcc tggacctcag caagatcaag gtgtctggcc
     3181 tgggagagaa ggtggacgtt ggcaaagacc aggagttcac agtcaaatca aagggtgctg
     3241 gtggtcaagg caaagtggca tccaagattg tgggcccctc gggtgcagcg gtgccctgca
     3301 aggtggagcc aggcctgggg gctgacaaca gtgtggtgcg cttcctgccc cgtgaggaag
     3361 ggccctatga ggtggaggtg acctatgacg gcgtgcccgt gcctggcagc ccctttcctc
     3421 tggaagctgt ggcccccacc aagcctagca aggtgaaggc gtttgggccg gggctgcagg
     3481 gaggcagtgc gggctccccc gcccgcttca ccatcgacac caagggcgcc ggcacaggtg
     3541 gcctgggcct gacggtggag ggcccctgtg aggcgcagct cgagtgcttg gacaatgggg
     3601 atggcacatg ttccgtgtcc tacgtgccca ccgagcccgg ggactacaac atcaacatcc
     3661 tcttcgctga cacccacatc cctggctccc cattcaaggc ccacgtggtt ccctgctttg
     3721 acgcatccaa agtcaagtgc tcaggccccg ggctggagcg ggccaccgct ggggaggtgg
     3781 gccaattcca agtggactgc tcgagcgcgg gcagcgcgga gctgaccatt gagatctgct
     3841 cggaggcggg gcttccggcc gaggtgtaca tccaggacca cggtgatggc acgcacacca
     3901 ttacctacat tcccctctgc cccggggcct acaccgtcac catcaagtac ggcggccagc
     3961 ccgtgcccaa cttccccagc aagctgcagg tggaacctgc ggtggacact tccggtgtcc
     4021 agtgctatgg gcctggtatt gagggccagg gtgtcttccg tgaggccacc actgagttca
     4081 gtgtggacgc ccgggctctg acacagaccg gagggccgca cgtcaaggcc cgtgtggcca
     4141 acccctcagg caacctgacg gagacctacg ttcaggaccg tggcgatggc atgtacaaag
     4201 tggagtacac gccttacgag gagggactgc actccgtgga cgtgacctat gacggcagtc
     4261 ccgtgcccag cagccccttc caggtgcccg tgaccgaggg ctgcgacccc tcccgggtgc
     4321 gtgtccacgg gccaggcatc caaagtggca ccaccaacaa gcccaacaag ttcactgtgg
     4381 agaccagggg agctggcacg ggcggcctgg gcctggctgt agagggcccc tccgaggcca
     4441 agatgtcctg catggataac aaggacggca gctgctcggt cgagtacatc ccttatgagg
     4501 ctggcaccta cagcctcaac gtcacctatg gtggccatca agtgccaggc agtcctttca
     4561 aggtccctgt gcatgatgtg acagatgcgt ccaaggtcaa gtgctctggg cccggcctga
     4621 gcccaggcat ggttcgtgcc aacctccctc agtccttcca ggtggacaca agcaaggctg
     4681 gtgtggcccc attgcaggtc aaagtgcaag ggcccaaagg cctggtggag ccagtggacg
     4741 tggtagacaa cgctgatggc acccagaccg tcaattatgt gcccagccga gaagggccct
     4801 acagcatctc agtactgtat ggagatgaag aggtaccccg gagccccttc aaggtcaagg
     4861 tgctgcctac tcatgatgcc agcaaggtga aggccagtgg ccccgggctc aacaccactg
     4921 gcgtgcctgc cagcctgccc gtggagttca ccatcgatgc aaaggacgcc ggggagggcc
     4981 tgctggctgt ccagatcacg gatcccgaag gcaagccgaa gaagacacac atccaagaca
     5041 accatgacgg cacgtataca gtggcctacg tgccagacgt gacaggtcgc tacaccatcc
     5101 tcatcaagta cggtggtgac gagatcccct tctccccgta ccgcgtgcgt gccgtgccca
     5161 ccggggacgc cagcaagtgc actgtcacag tgtcaatcgg aggtcacggg ctaggtgctg
     5221 gcatcggccc caccattcag attggggagg agacggtgat cactgtggac actaaggcgg
     5281 caggcaaagg caaagtgacg tgcaccgtgt gcacgcctga tggctcagag gtggatgtgg
     5341 acgtggtgga gaatgaggac ggcactttcg acatcttcta cacggccccc cagccgggca
     5401 aatacgtcat ctgtgtgcgc tttggtggcg agcacgtgcc caacagcccc ttccaagtga
     5461 cggctctggc tggggaccag ccctcggtgc agccccctct acggtctcag cagctggccc
     5521 cacagtacac ctacgcccag ggcggccagc agacttgggc cccggagagg cccctggtgg
     5581 gtgtcaatgg gctggatgtg accagcctga ggccctttga ccttgtcatc cccttcacca
     5641 tcaagaaggg cgagatcaca ggggaggttc ggatgccctc aggcaaggtg gcgcagccca
     5701 ccatcactga caacaaagac ggcaccgtga ccgtgcggta tgcacccagc gaggctggcc
     5761 tgcacgagat ggacatccgc tatgacaaca tgcacatccc aggaagcccc ttgcagttct
     5821 atgtggatta cgtcaactgt ggccatgtca ctgcctatgg gcctggcctc acccatggag
     5881 tagtgaacaa gcctgccacc ttcaccgtca acaccaagga tgcaggagag gggggcctgt
     5941 ctctggccat tgagggcccg tccaaagcag aaatcagctg cactgacaac caggatggga
     6001 catgcagcgt gtcctacctg cctgtgctgc cgggggacta cagcattcta gtcaagtaca
     6061 atgaacagca cgtcccaggc agccccttca ctgctcgggt cacaggtgac gactccatgc
     6121 gtatgtccca cctaaaggtc ggctctgctg ccgacatccc catcaacatc tcagagacgg
     6181 atctcagcct gctgacggcc actgtggtcc cgccctcggg ccgggaggag ccctgtttgc
     6241 tgaagcggct gcgtaatggc cacgtgggga tttcattcgt gcccaaggag acgggggagc
     6301 acctggtgca tgtgaagaaa aatggccagc acgtggccag cagccccatc ccggtggtga
     6361 tcagccagtc ggaaattggg gatgccagtc gtgttcgggt ctctggtcag ggccttcacg
     6421 aaggccacac ctttgagcct gcagagttta tcattgatac ccgcgatgca ggctatggtg
     6481 ggctcagcct gtccattgag ggccccagca aggtggacat caacacagag gacctggagg
     6541 acgggacgtg cagggtcacc tactgcccca cagagccagg caactacatc atcaacatca
     6601 agtttgccga ccagcacgtg cctggcagcc ccttctctgt gaaggtgaca ggcgagggcc
     6661 gggtgaaaga gagcatcacc cgcaggcgtc gggctccttc agtggccaac gttggtagtc
     6721 attgtgacct cagcctgaaa atccctgaaa ttagcatcca ggatatgaca gcccaggtga
     6781 ccagcccatc gggcaagacc catgaggccg agatcgtgga aggggagaac cacacctact
     6841 gcatccgctt tgttcccgct gagatgggca cacacacagt cagcgtgaag tacaagggcc
     6901 agcacgtgcc tgggagcccc ttccagttca ccgtggggcc cctaggggaa gggggagccc
     6961 acaaggtccg agctgggggc cctggcctgg agagagctga agctggagtg ccagccgaat
     7021 tcagtatctg gacccgggaa gctggtgctg gaggcctggc cattgctgtc gagggcccca
     7081 gcaaggctga gatctctttt gaggaccgca aggacggctc ctgtggtgtg gcttatgtgg
     7141 tccaggagcc aggtgactac gaagtctcag tcaagttcaa cgaggaacac attcccgaca
     7201 gccccttcgt ggtgcctgtg gcttctccgt ctggcgacgc ccgccgcctc actgtttcta
     7261 gccttcagga gtcagggcta aaggtcaacc agccagcctc ttttgcagtc agcctgaacg
     7321 gggccaaggg ggcgatcgat gccaaggtgc acagcccctc aggagccctg gaggagtgct
     7381 atgtcacaga aattgaccaa gataagtatg ctgtgcgctt catccctcgg gagaatggcg
     7441 tttacctgat tgacgtcaag ttcaacggca cccacatccc tggaagcccc ttcaagatcc
     7501 gagttgggga gcctgggcat ggaggggacc caggcttggt gtctgcttac ggagcaggtc
     7561 tggaaggcgg tgtcacaggg aacccagctg agttcgtcgt gaacacgagc aatgcgggag
     7621 ctggtgccct gtcggtgacc attgacggcc cctccaaggt gaagatggat tgccaggagt
     7681 gccctgaggg ctaccgcgtc acctataccc ccatggcacc tggcagctac ctcatctcca
     7741 tcaagtacgg cggcccctac cacattgggg gcagcccctt caaggccaaa gtcacaggcc
     7801 cccgtctcgt cagcaaccac agcctccacg agacatcatc agtgtttgta gactctctga
     7861 ccaaggccac ctgtgccccc cagcatgggg ccccgggtcc tgggcctgct gacgccagca
     7921 aggtggtggc caagggcctg gggctgagca aggcctacgt aggccagaag agcagcttca
     7981 cagtagactg cagcaaagca ggcaacaaca tgctgctggt gggggttcat ggcccaagga
     8041 ccccctgcga ggagatcctg gtgaagcacg tgggcagccg gctctacagc gtgtcctacc
     8101 tgctcaagga caagggggag tacacactgg tggtcaaatg gggggacgag cacatcccag
     8161 gcagccccta ccgcgttgtg gtgccctgag tctggggccc gtgccagccg gcagccccca
     8221 agcctgcccc gctacccaag cagccccgcc ctcttcccct caaccccggc ccaggccgcc
     8281 ctggccgccc gcctgtcact gcagccgccc ctgccctgtg ccgtgctgcg ctcacctgcc
     8341 tccccagcca gccgctgacc tctcggcttt cacttgggca gagggagcca tttggtggcg
     8401 ctgcttgtct tctttggttc tgggaggggt gagggatggg ggtcctgtac acaaccaccc
     8461 actagttctc ttctccagcc aagaggaata aagttttgct tccattc
//
