LOCUS       NM_002018               4181 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens FLII actin remodeling protein (FLII), transcript
            variant 1, mRNA.
ACCESSION   NM_002018
VERSION     NM_002018.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4181)
  AUTHORS   Kuwabara,Y., York,A.J., Lin,S.C., Sargent,M.A., Grimes,K.M.,
            Pirruccello,J.P. and Molkentin,J.D.
  TITLE     A human FLII gene variant alters sarcomeric actin thin filament
            length and predisposes to cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 120 (19), e2213696120 (2023)
   PUBMED   37126682
  REMARK    GeneRIF: A human FLII gene variant alters sarcomeric actin thin
            filament length and predisposes to cardiomyopathy.
REFERENCE   2  (bases 1 to 4181)
  AUTHORS   Yang,G.N., Strudwick,X.L., Bonder,C.S., Kopecki,Z. and Cowin,A.J.
  TITLE     Increased Expression of Flightless I in Cutaneous Squamous Cell
            Carcinoma Affects Wnt/beta-Catenin Signaling Pathway
  JOURNAL   Int J Mol Sci 22 (24), 13203 (2021)
   PUBMED   34948000
  REMARK    GeneRIF: Increased Expression of Flightless I in Cutaneous Squamous
            Cell Carcinoma Affects Wnt/beta-Catenin Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4181)
  AUTHORS   Jeong,K.W.
  TITLE     FLII and MLL1 Cooperatively Regulate Aryl Hydrocarbon
            Receptor-Mediated Transcription in ARPE-19 Cells
  JOURNAL   Curr Issues Mol Biol 43 (3), 1623-1631 (2021)
   PUBMED   34698116
  REMARK    GeneRIF: FLII and MLL1 Cooperatively Regulate Aryl Hydrocarbon
            Receptor-Mediated Transcription in ARPE-19 Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4181)
  AUTHORS   Ruan,H., Bao,L., Tao,Z. and Chen,K.
  TITLE     Flightless I Homolog Reverses Enzalutamide Resistance through
            PD-L1-Mediated Immune Evasion in Prostate Cancer
  JOURNAL   Cancer Immunol Res 9 (7), 838-852 (2021)
   PUBMED   34011528
  REMARK    GeneRIF: Flightless I Homolog Reverses Enzalutamide Resistance
            through PD-L1-Mediated Immune Evasion in Prostate Cancer.
REFERENCE   5  (bases 1 to 4181)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4181)
  AUTHORS   Wilson,S.A., Brown,E.C., Kingsman,A.J. and Kingsman,S.M.
  TITLE     TRIP: a novel double stranded RNA binding protein which interacts
            with the leucine rich repeat of flightless I
  JOURNAL   Nucleic Acids Res 26 (15), 3460-3467 (1998)
   PUBMED   9671805
REFERENCE   7  (bases 1 to 4181)
  AUTHORS   Liu,Y.T. and Yin,H.L.
  TITLE     Identification of the binding partners for flightless I, A novel
            protein bridging the leucine-rich repeat and the gelsolin
            superfamilies
  JOURNAL   J Biol Chem 273 (14), 7920-7927 (1998)
   PUBMED   9525888
REFERENCE   8  (bases 1 to 4181)
  AUTHORS   Campbell,H.D., Fountain,S., Young,I.G., Claudianos,C.,
            Hoheisel,J.D., Chen,K.S. and Lupski,J.R.
  TITLE     Genomic structure, evolution, and expression of human FLII, a
            gelsolin and leucine-rich-repeat family member: overlap with LLGL
  JOURNAL   Genomics 42 (1), 46-54 (1997)
   PUBMED   9177775
REFERENCE   9  (bases 1 to 4181)
  AUTHORS   Chen,K.S., Gunaratne,P.H., Hoheisel,J.D., Young,I.G., Miklos,G.L.,
            Greenberg,F., Shaffer,L.G., Campbell,H.D. and Lupski,J.R.
  TITLE     The human homologue of the Drosophila melanogaster flightless-I
            gene (flil) maps within the Smith-Magenis microdeletion critical
            region in 17p11.2
  JOURNAL   Am J Hum Genet 56 (1), 175-182 (1995)
   PUBMED   7825574
REFERENCE   10 (bases 1 to 4181)
  AUTHORS   Campbell,H.D., Schimansky,T., Claudianos,C., Ozsarac,N.,
            Kasprzak,A.B., Cotsell,J.N., Young,I.G., de Couet,H.G. and
            Miklos,G.L.
  TITLE     The Drosophila melanogaster flightless-I gene involved in
            gastrulation and muscle degeneration encodes gelsolin-like and
            leucine-rich repeat domains and is conserved in Caenorhabditis
            elegans and humans
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11386-11390 (1993)
   PUBMED   8248259
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC025300.1 and BM930929.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002018.3.
            
            Summary: This gene encodes a protein with a gelsolin-like actin
            binding domain and an N-terminal leucine-rich repeat-protein
            protein interaction domain. The protein is similar to a Drosophila
            protein involved in early embryogenesis and the structural
            organization of indirect flight muscle. The gene is located within
            the Smith-Magenis syndrome region on chromosome 17. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025300.1, SRR1803612.118651.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327031.9/ ENSP00000324573.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4160              BC025300.1         4-4163
            4161-4181           BM930929.1         313-333
FEATURES             Location/Qualifiers
     source          1..4181
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..4181
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /note="FLII actin remodeling protein"
                     /db_xref="GeneID:2314"
                     /db_xref="HGNC:HGNC:3750"
                     /db_xref="MIM:600362"
     exon            1..111
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..3858
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein flightless-1 homolog; flightless I homolog;
                     flightless I actin binding protein"
                     /codon_start=1
                     /product="protein flightless-1 homolog isoform 1"
                     /protein_id="NP_002009.1"
                     /db_xref="CCDS:CCDS11192.1"
                     /db_xref="GeneID:2314"
                     /db_xref="HGNC:HGNC:3750"
                     /db_xref="MIM:600362"
                     /translation="MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTG
                     LCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFK
                     LDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSE
                     NRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTS
                     LEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNL
                     SRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPE
                     SLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPADRAAEWYNI
                     DFSLQNQLRLAGASPATVAAAAAAGSGPKDPMARKMRLRRRKDSAQDDQAKQVLKGMS
                     DVAQEKNKKQEESADARAPSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIEN
                     FVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAV
                     NLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRV
                     YGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKN
                     ERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPEDFWPPQPKLYKVGLGLGYLEL
                     PQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRA
                     AALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQS
                     PGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDLDGMEGFVLEG
                     KKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAE
                     EKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKF
                     LSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSEFCFIL
                     KVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWV
                     GIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEV
                     YMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWS
                     AFCKALA"
     exon            112..222
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            223..294
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            295..375
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            376..461
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            462..623
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            624..727
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            728..903
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1061
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1146
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1294
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1431
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1644
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1824
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1907
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1982
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2066
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2238
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2343
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2535
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2724
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2864
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3099
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3254
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3315
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3444
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3551
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3657
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..3723
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     exon            3724..4181
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4131..4136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /note="hexamer: ATTAAA"
     regulatory      4153..4158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /note="hexamer: ATTAAA"
     polyA_site      4160
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
                     /note="major polyA site"
     polyA_site      4181
                     /gene="FLII"
                     /gene_synonym="CMD2J; FLI; Fli1; FLIL"
ORIGIN      
        1 gccccggcgc tccctagccc ggcgcggccc ggcagcgaga gcggcgccat ggaggccacc
       61 ggggtgctgc cgttcgtgcg tggcgtggac ctcagcggca acgacttcaa gggcggctac
      121 ttccctgaga atgtcaaggc catgaccagc ctgcggtggc tgaagctgaa ccgcactggc
      181 ctctgctacc tgcccgagga gctggccgcc ctgcagaagc tggaacactt gtctgtgagc
      241 cacaacaacc tgaccacgct tcatggggag ctgtccagcc tgccatcgct gcgcgccatc
      301 gtggcccgag ccaacagtct gaagaattcc ggagtccccg atgacatctt caagctagat
      361 gatctctcag tcctggactt gagccacaac cagctgacag agtgcccgcg ggagctggag
      421 aacgccaaga acatgctggt gctgaacctc agccacaaca gcatcgacac catccccaac
      481 cagctcttca tcaacctcac tgacctacta tacctggacc tcagcgagaa ccgcctggag
      541 agcctgcccc cgcagatgcg ccgcctggtg cacctgcaga cgctcgtgct caatggaaac
      601 cccctgctgc atgcacagct ccggcagctc ccagcgatga cggccctgca gaccctgcac
      661 ctgcggagca cccagcgcac ccagagcaac ctgcccacca gcctggaggg tctgagcaac
      721 ctcgcagacg tggatctgtc ctgcaatgac ctgacacggg tgcccgagtg tctgtacacc
      781 ctccccagcc tgcgccgcct caacctcagc agcaaccaga tcacggagct gtccctgtgc
      841 atagaccagt gggtgcacgt ggaaactctg aacctgtccc gaaatcagct cacctcactg
      901 ccctcagcca tttgcaagct gagcaagctg aagaagctgt acctgaattc caacaagctg
      961 gactttgacg ggctgccctc aggcattggc aagctcacca acctggaaga gttcatggct
     1021 gccaacaaca acctggagct ggtccctgaa agtctctgca ggtgcccaaa gctgaggaaa
     1081 cttgtcctga acaagaacca cctggtgacc ctcccagaag ccatccattt cctgacggag
     1141 atcgaggtcc tggatgtgcg ggagaacccc aacctggtca tgccgcccaa gcccgcagac
     1201 cgtgccgctg agtggtacaa catcgacttc tcgctgcaga accagctgcg gctagcgggt
     1261 gcctctcctg ctaccgtggc tgcagctgca gctgcaggga gtgggcccaa ggaccctatg
     1321 gctcgcaaga tgcgactgcg gaggcgcaag gattcagccc aggatgacca ggccaagcag
     1381 gtgctgaagg gcatgtcaga tgttgcccag gagaagaaca aaaagcagga ggagagcgca
     1441 gatgcccggg cccccagcgg gaaggtgcgg cgttgggacc agggcctgga gaagccccgc
     1501 cttgactact ccgagttctt cacggaggac gtgggccagc tgcccggact gaccatctgg
     1561 cagatagaga acttcgtgcc tgtgctggtg gaggaagcct tccacggcaa gttctacgag
     1621 gctgactgct acattgtgct caagaccttt ctggatgaca gcggctccct caactgggag
     1681 atctactact ggattggcgg ggaggccaca ctcgacaaga aagcttgctc tgccatccac
     1741 gctgtcaact tgcgcaacta cctgggtgct gagtgccgca ctgtccggga ggagatgggc
     1801 gatgagagcg aggagttcct gcaggtgttt gacaacgaca tctcctacat tgagggtgga
     1861 acagccagtg gcttctacac tgtggaagac acacactatg tcaccaggat gtatcgtgtg
     1921 tatgggaaaa agaacatcaa gttggagcct gtgcccctca aggggacctc tctggaccca
     1981 aggtttgttt tcctgctgga ccgagggcta gacatctacg tatggcgggg ggcccaggcc
     2041 acactgagca gcaccaccaa ggccaggctc tttgcagaga aaattaacaa gaatgagcgg
     2101 aaagggaagg ctgagatcac actgctggtg cagggccagg agctcccaga gttctgggag
     2161 gcactgggtg gggagccctc tgagatcaag aagcacgtgc ctgaagactt ctggccgccg
     2221 cagcccaagc tgtacaaggt gggcctgggc ttgggctacc tggagctgcc acagatcaac
     2281 tacaagctct ccgtggaaca taagcagcgt cccaaggtgg agctgatgcc aagaatgcgg
     2341 ctgctgcaga gtctgctgga cacgcgctgc gtgtacattc tggactgttg gtccgacgtg
     2401 ttcatctggc tcggccgcaa gtccccgcgc ctggtgcgcg ctgccgccct caagctgggt
     2461 caggagctgt gcgggatgct gcaccggcca cgccatgcca cggtcagccg cagcctcgag
     2521 ggcaccgagg cgcaggtgtt caaggccaag ttcaagaatt gggacgatgt gttgacggtg
     2581 gactacacac gcaatgcgga ggccgtgctg cagagcccgg gtctctccgg gaaggtgaaa
     2641 cgcgacgccg agaagaaaga ccagatgaag gctgacctca ctgcgctttt cctgccgcgg
     2701 cagccgccca tgtcgctggc cgaggcggag cagctgatgg aggagtggaa cgaagaccta
     2761 gacggcatgg agggtttcgt gctggagggc aagaagtttg cgcggctgcc ggaagaggag
     2821 tttggccact tctacacgca ggactgctac gtcttcctct gcaggtactg ggtgcctgtg
     2881 gagtacgagg aggaggaaaa gaaggaagac aaggaggaga aggccgaggg caaagaaggc
     2941 gaggaagcaa ccgctgaggc agaggagaag cagccagagg aggacttcca gtgcatcgtg
     3001 tacttctggc agggccgtga agcctccaat atgggctggc tcaccttcac cttcagcctg
     3061 caaaagaagt tcgagagcct cttccctggg aagctggagg tggtacgcat gacgcagcag
     3121 caggagaacc ccaagttcct gtcccatttc aagaggaagt tcatcatcca ccggggcaag
     3181 aggaaggcgg tccagggcgc ccaacagccc agcctctacc agatccgcac caacggcagc
     3241 gccctctgca cccggtgcat ccagatcaac accgactcca gcctcctcaa ctccgagttc
     3301 tgcttcatcc tcaaggttcc ctttgagagt gaggacaacc agggcatcgt gtatgcctgg
     3361 gtgggccggg catcagaccc tgacgaagcc aagttggcag aagacatcct gaacaccatg
     3421 tttgacacct cctacagcaa gcaggttatc aacgaaggtg aggagcctga gaacttcttc
     3481 tgggtgggca ttggggcaca gaagccctat gatgacgatg ccgagtacat gaaacacaca
     3541 cgtctcttcc ggtgctccaa cgagaagggc tactttgcag tgactgagaa atgctccgac
     3601 ttttgccaag atgacctggc agatgatgac atcatgttgc tagacaatgg ccaagaggtc
     3661 tacatgtggg tggggaccca gactagccag gtggagatca agctgagcct gaaggcctgc
     3721 caggtatata tccagcacat gcggtccaag gaacatgagc ggccgcgccg gctgcgcctg
     3781 gtccgcaagg gcaatgagca gcacgccttt acccgctgct tccacgcctg gagcgccttc
     3841 tgcaaggccc tggcctaaga caggctggca cagccccagg cttggtgagg aagaggaagg
     3901 ggcctcatcc actgtctgct agcaaagaat gtactcaggt gacaccacct gctccagcca
     3961 cgtccagtgc cacagtcccc agtagcctca agcagcacca atggggatga ccctgacagg
     4021 tgccctcagg ggtctgggaa atccaactct ctccacagtg tgagtgcacg tgtgaagccc
     4081 cctcactctt ccgctaggga taaagcagat gtggatgccc tttaagagat attaaatgct
     4141 tttattttca atattaaaaa tcagtatttt taatattaaa a
//
