LOCUS       NM_002017               3825 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens Fli-1 proto-oncogene, ETS transcription factor (FLI1),
            transcript variant 1, mRNA.
ACCESSION   NM_002017
VERSION     NM_002017.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3825)
  AUTHORS   Dunstan-Harrison,C., Morison,I.M. and Ledgerwood,E.C.
  TITLE     Inherited thrombocytopenia associated with a variant in the FLI1
            binding site in the 5' UTR of ANKRD26
  JOURNAL   Clin Genet 106 (3), 315-320 (2024)
   PUBMED   38757516
  REMARK    GeneRIF: Inherited thrombocytopenia associated with a variant in
            the FLI1 binding site in the 5' UTR of ANKRD26.
REFERENCE   2  (bases 1 to 3825)
  AUTHORS   Zhang,L., Ge,T. and Cui,J.
  TITLE     FLI-1-driven regulation of endothelial cells in human diseases
  JOURNAL   J Transl Med 22 (1), 740 (2024)
   PUBMED   39107790
  REMARK    GeneRIF: FLI-1-driven regulation of endothelial cells in human
            diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3825)
  AUTHORS   Tanaka,Y., Nakanishi,Y., Furuhata,E., Nakada,K.I., Maruyama,R.,
            Suzuki,H. and Suzuki,T.
  TITLE     FLI1 is associated with regulation of DNA methylation and
            megakaryocytic differentiation in FPDMM caused by a RUNX1
            transactivation domain mutation
  JOURNAL   Sci Rep 14 (1), 14080 (2024)
   PUBMED   38890442
  REMARK    GeneRIF: FLI1 is associated with regulation of DNA methylation and
            megakaryocytic differentiation in FPDMM caused by a RUNX1
            transactivation domain mutation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3825)
  AUTHORS   Chen,E., Wu,J., Huang,J., Zhu,W., Sun,H., Wang,X., Lin,D., Li,X.,
            Shi,D., Liu,Z., Huang,J., Chen,M., Xie,F. and Deng,W.
  TITLE     FLI1 promotes IFN-gamma-induced kynurenine production to impair
            anti-tumor immunity
  JOURNAL   Nat Commun 15 (1), 4590 (2024)
   PUBMED   38816360
  REMARK    GeneRIF: FLI1 promotes IFN-gamma-induced kynurenine production to
            impair anti-tumor immunity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3825)
  AUTHORS   Bhagirath,T., Abe,S., Nojima,T. and Yoshida,M.C.
  TITLE     Molecular analysis of a t(11;22) translocation junction in a case
            of Ewing's sarcoma
  JOURNAL   Genes Chromosomes Cancer 13 (2), 126-132 (1995)
   PUBMED   7542907
REFERENCE   6  (bases 1 to 3825)
  AUTHORS   Prasad,D.D., Rao,V.N. and Reddy,E.S.
  TITLE     Structure and expression of human Fli-1 gene
  JOURNAL   Cancer Res 52 (20), 5833-5837 (1992)
   PUBMED   1394211
REFERENCE   7  (bases 1 to 3825)
  AUTHORS   Watson,D.K., Smyth,F.E., Thompson,D.M., Cheng,J.Q., Testa,J.R.,
            Papas,T.S. and Seth,A.
  TITLE     The ERGB/Fli-1 gene: isolation and characterization of a new member
            of the family of human ETS transcription factors
  JOURNAL   Cell Growth Differ 3 (10), 705-713 (1992)
   PUBMED   1445800
REFERENCE   8  (bases 1 to 3825)
  AUTHORS   Delattre,O., Zucman,J., Plougastel,B., Desmaze,C., Melot,T.,
            Peter,M., Kovar,H., Joubert,I., de Jong,P., Rouleau,G. et al.
  TITLE     Gene fusion with an ETS DNA-binding domain caused by chromosome
            translocation in human tumours
  JOURNAL   Nature 359 (6391), 162-165 (1992)
   PUBMED   1522903
REFERENCE   9  (bases 1 to 3825)
  AUTHORS   Baud,V., Lipinski,M., Rassart,E., Poliquin,L. and Bergeron,D.
  TITLE     The human homolog of the mouse common viral integration region,
            FLI1, maps to 11q23-q24
  JOURNAL   Genomics 11 (1), 223-224 (1991)
   PUBMED   1765382
REFERENCE   10 (bases 1 to 3825)
  AUTHORS   Bergeron,D., Poliquin,L., Kozak,C.A. and Rassart,E.
  TITLE     Identification of a common viral integration region in Cas-Br-E
            murine leukemia virus-induced non-T-, non-B-cell lymphomas
  JOURNAL   J Virol 65 (1), 7-15 (1991)
   PUBMED   1845910
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313370.1, AP001122.5 and
            AI354789.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002017.4.
            
            Summary: This gene encodes a transcription factor containing an ETS
            DNA-binding domain. The gene can undergo a t(11;22)(q24;q12)
            translocation with the Ewing sarcoma gene on chromosome 22, which
            results in a fusion gene that is present in the majority of Ewing
            sarcoma cases. An acute lymphoblastic leukemia-associated
            t(4;11)(q21;q23) translocation involving this gene has also been
            identified. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.81592.1,
                                           SRR1660809.226136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000527786.7/ ENSP00000433488.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1546              AK313370.1         11-1556
            1547-3388           AP001122.5         162455-164296
            3389-3825           AI354789.1         15-451              c
FEATURES             Location/Qualifiers
     source          1..3825
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..3825
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /note="Fli-1 proto-oncogene, ETS transcription factor"
                     /db_xref="GeneID:2313"
                     /db_xref="HGNC:HGNC:3749"
                     /db_xref="MIM:193067"
     exon            1..205
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1546
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor ERGB; Ewing sarcoma breakpoint region
                     2; Friend leukemia virus integration 1"
                     /codon_start=1
                     /product="Friend leukemia integration 1 transcription
                     factor isoform 1"
                     /protein_id="NP_002008.2"
                     /db_xref="CCDS:CCDS44768.1"
                     /db_xref="GeneID:2313"
                     /db_xref="HGNC:HGNC:3749"
                     /db_xref="MIM:193067"
                     /translation="MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQ
                     PHKINPLPPQQEWINQPVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNY
                     NSYMDEKNGPPPPNMTTNERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQ
                     NMDGKELCKMNKEDFLRATTLYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLSVKE
                     DPSYDSVRRGAWGNNMNSGLNKSPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANP
                     GSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDK
                     LSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTESSMYKYPSDISYMPSYH
                     AHQQKVNFVPPHPSSMPVTSSSFFGAASQYWTSPTGGIYPNPNVPRHPNTHVPSHLGS
                     YY"
     exon            206..417
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..572
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..776
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..842
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..908
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..968
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1016
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..3825
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2954..2959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /note="hexamer: AATAAA"
     polyA_site      2974
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /note="major polyA site"
     regulatory      3803..3808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
                     /note="hexamer: AATAAA"
     polyA_site      3825
                     /gene="FLI1"
                     /gene_synonym="BDPLT21; EWSR2; FLI-1; SIC-1"
ORIGIN      
        1 ctctttcgct ccgctacaac aacaaacgtg cacaggggag tgagggcagg gcgctcgcag
       61 ggggcacgca gggagggccc agggcgccag ggaggccgcg ccgggctaat ccgaaggggc
      121 tgcgaggtca ggctgtaacc gggtcaatgt gtggaatatt ggggggctcg gctgcagact
      181 tggccaaatg gacgggacta ttaaggaggc tctgtcggtg gtgagcgacg accagtccct
      241 ctttgactca gcgtacggag cggcagccca tctccccaag gccgacatga ctgcctcggg
      301 gagtcctgac tacgggcagc cccacaagat caaccccctc ccaccacagc aggagtggat
      361 caatcagcca gtgagggtca acgtcaagcg ggagtatgac cacatgaatg gatccaggga
      421 gtctccggtg gactgcagcg ttagcaaatg cagcaagctg gtgggcggag gcgagtccaa
      481 ccccatgaac tacaacagct atatggacga gaagaatggc ccccctcctc ccaacatgac
      541 caccaacgag aggagagtca tcgtccccgc agaccccaca ctgtggacac aggagcatgt
      601 gaggcaatgg ctggagtggg ccataaagga gtacagcttg atggagatcg acacatcctt
      661 tttccagaac atggatggca aggaactgtg taaaatgaac aaggaggact tcctccgcgc
      721 caccaccctc tacaacacgg aagtgctgtt gtcacacctc agttacctca gggaaagttc
      781 actgctggcc tataatacaa cctcccacac cgaccaatcc tcacgattga gtgtcaaaga
      841 agacccttct tatgactcag tcagaagagg agcttggggc aataacatga attctggcct
      901 caacaaaagt cctccccttg gaggggcaca aacgatcagt aagaatacag agcaacggcc
      961 ccagccagat ccgtatcaga tcctgggccc gaccagcagt cgcctagcca accctggaag
     1021 cgggcagatc cagctgtggc aattcctcct ggagctgctc tccgacagcg ccaacgccag
     1081 ctgtatcacc tgggagggga ccaacgggga gttcaaaatg acggaccccg atgaggtggc
     1141 caggcgctgg ggcgagcgga aaagcaagcc caacatgaat tacgacaagc tgagccgggc
     1201 cctccgttat tactatgata aaaacattat gaccaaagtg cacggcaaaa gatatgctta
     1261 caaatttgac ttccacggca ttgcccaggc tctgcagcca catccgaccg agtcgtccat
     1321 gtacaagtac ccttctgaca tctcctacat gccttcctac catgcccacc agcagaaggt
     1381 gaactttgtc cctccccatc catcctccat gcctgtcact tcctccagct tctttggagc
     1441 cgcatcacaa tactggacct cccccacggg gggaatctac cccaacccca acgtcccccg
     1501 ccatcctaac acccacgtgc cttcacactt aggcagctac tactagaagc ttactcatca
     1561 gtggccttct agctgaagcc catcctgcac acttactgga tgctttggac tcaacaggac
     1621 atatgtggcc ttgaagggaa gacaaaactg gatgttcttt cttgttggat agaacctttg
     1681 tatttgttct ttaaaaacat tttttttaat gttggtaact tttgcttcct ctacctgaac
     1741 aaagagatga ataattccat gggccagtat gccagtttga attctcagtc tcctagcatc
     1801 ttgtgagttg catattaaga ttactggaat ggttaagtca tggttctgag aaagaagctg
     1861 tacgttttct ttatgttttt atgaccaaag cagtttcttg tcaatacacg gggttcagta
     1921 tgacacagaa tcatggactt aacccgtcat gttctggttt gagatttagt gacaaataga
     1981 ggtgggaagc ttataatcta attttaggag gaccaaattc agtggatggc aactggaaca
     2041 ttgattgtaa ggccagtgaa gttttcaccc aactggaatt tgatggaaag aaggtttgtg
     2101 tgtttaagac gccaagggca ttgcagaatc cctctcagtg gacagtatgc actcagctga
     2161 ccactctctc tagaaatagt caagatatga actaagaaat tttaatgcaa atacatacat
     2221 tcctgaaaga cggggaatta aattactaat tttttttttt ttttaaatga tgacagtggt
     2281 cccagaactt ggaaaagttg tagggatttc taaactcaag cagattcgca agtgctgtgc
     2341 gcttgtcaga ccatcagacc agggccaacc aatcagaagg caacttactg tataaattat
     2401 gcagagttat tttcctatat ctcacagtat taaaaataaa taattaaaaa ttaagaataa
     2461 ataaacgagt tgacctcggt cacaaaagca gttttactat cgaatcaatc gctgttattt
     2521 tttttaatgt aatttgtaca tcttttttca atctgtacat ttgggctgtc tgtatgtttt
     2581 tatagctggt ttttaaaaag cataatatgc ctatagctga aaaggaaaca gggctgttta
     2641 agtcactgac ttatgagaaa gcaaagcact ggtacagtta tttaacaggc atacacaagc
     2701 agggaaaaga taatccattt agatctttaa tgctttggaa atgcgtgtaa cagtactgca
     2761 ataatcacag ctctgggaaa aacaacgaaa ctttcccttg tggagaggag ggattttcct
     2821 gctctatata agcaacatat ttttagacat taaaatatat ataattttgc aggtaattgt
     2881 tgactttttt aactatatta agtgttaagc tgacaactgt caaagaagac catgttgtaa
     2941 aataatttga ctaaataaat ggttccttct ctcagtgctg aggacagttt tcttatttac
     3001 cgcccccgtt aggtcaaagg gttttccctg gggaactttc ctatttactt cttgcactat
     3061 caagaatttt tcgaatgtac ctactgcagt acagcagaag gtaaaaaatc agtgtggttt
     3121 ttcattgttg ttgatgatgt ttgtagtgtt tttgtgtgtg ttatttaaat cttcctccag
     3181 cctaaaaggg ttttataaaa cagcagctaa ggccatggat aaacctgtat gtaaggactg
     3241 gagcaaagcg agctggtcta tccagactgg tctgtgagat ttaactctgc agcctcccct
     3301 gggcacttca gacccagacg gccaccttct gccactccag caaagaataa gcgccctgct
     3361 tccttcaggt ctcagaccag gactttatgg ctcatgcaga tttttaaggt catttttctt
     3421 cccaaggaag aaacttgcct ccagttcctt cactgttagg tagcttattt tcattttctc
     3481 tattttacaa tgaaaagagt gagacctggg aagtccttga tttgcaagga attagactca
     3541 cagcattggt aaccctagaa ccttcttagg gtaacactaa gtaccttcta gacaacatgt
     3601 ctacctaaat gaaatgggat gtgtttcgga acatttgtct ccagtttttt tttaatcttg
     3661 caccctgcca tttaaaaaga tgtgtaaagc acatattctc aacatatgca cattgattta
     3721 taaatcatat atacaaactg ttacattatt cttcatatta gaaaacaaat acaaaataga
     3781 acattttaaa tggtgatata aaaataaatt gaaactgaaa ttcta
//
