LOCUS       NM_001127391            2064 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens flagellum associated containing coiled-coil domains 1
            (FLACC1), transcript variant 2, mRNA.
ACCESSION   NM_001127391
VERSION     NM_001127391.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2064)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2064)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   3  (bases 1 to 2064)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   4  (bases 1 to 2064)
  AUTHORS   Stacey,S.N., Helgason,H., Gudjonsson,S.A., Thorleifsson,G.,
            Zink,F., Sigurdsson,A., Kehr,B., Gudmundsson,J., Sulem,P.,
            Sigurgeirsson,B., Benediktsdottir,K.R., Thorisdottir,K.,
            Ragnarsson,R., Fuentelsaz,V., Corredera,C., Gilaberte,Y., Grasa,M.,
            Planelles,D., Sanmartin,O., Rudnai,P., Gurzau,E., Koppova,K.,
            Nexo,B.A., Tjonneland,A., Overvad,K., Jonasson,J.G.,
            Tryggvadottir,L., Johannsdottir,H., Kristinsdottir,A.M.,
            Stefansson,H., Masson,G., Magnusson,O.T., Halldorsson,B.V.,
            Kong,A., Rafnar,T., Thorsteinsdottir,U., Vogel,U., Kumar,R.,
            Nagore,E., Mayordomo,J.I., Gudbjartsson,D.F., Olafsson,J.H. and
            Stefansson,K.
  TITLE     New basal cell carcinoma susceptibility loci
  JOURNAL   Nat Commun 6, 6825 (2015)
   PUBMED   25855136
  REMARK    GeneRIF: rs13014235 is associated with susceptibility to cutaneous
            basal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2064)
  AUTHORS   Lin,W.Y., Camp,N.J., Ghoussaini,M., Beesley,J., Michailidou,K.,
            Hopper,J.L., Apicella,C., Southey,M.C., Stone,J., Schmidt,M.K.,
            Broeks,A., Van't Veer,L.J., Th Rutgers,E.J., Muir,K.,
            Lophatananon,A., Stewart-Brown,S., Siriwanarangsan,P.,
            Fasching,P.A., Haeberle,L., Ekici,A.B., Beckmann,M.W., Peto,J.,
            Dos-Santos-Silva,I., Fletcher,O., Johnson,N., Bolla,M.K., Wang,Q.,
            Dennis,J., Sawyer,E.J., Cheng,T., Tomlinson,I., Kerin,M.J.,
            Miller,N., Marme,F., Surowy,H.M., Burwinkel,B., Guenel,P.,
            Truong,T., Menegaux,F., Mulot,C., Bojesen,S.E., Nordestgaard,B.G.,
            Nielsen,S.F., Flyger,H., Benitez,J., Zamora,M.P., Arias Perez,J.I.,
            Menendez,P., Gonzalez-Neira,A., Pita,G., Alonso,M.R., Alvarez,N.,
            Herrero,D., Anton-Culver,H., Brenner,H., Dieffenbach,A.K.,
            Arndt,V., Stegmaier,C., Meindl,A., Lichtner,P., Schmutzler,R.K.,
            Muller-Myhsok,B., Brauch,H., Bruning,T., Ko,Y.D., Tessier,D.C.,
            Vincent,D., Bacot,F., Nevanlinna,H., Aittomaki,K., Blomqvist,C.,
            Khan,S., Matsuo,K., Ito,H., Iwata,H., Horio,A., Bogdanova,N.V.,
            Antonenkova,N.N., Dork,T., Lindblom,A., Margolin,S., Mannermaa,A.,
            Kataja,V., Kosma,V.M., Hartikainen,J.M., Wu,A.H., Tseng,C.C., Van
            Den Berg,D., Stram,D.O., Neven,P., Wauters,E., Wildiers,H.,
            Lambrechts,D., Chang-Claude,J., Rudolph,A., Seibold,P.,
            Flesch-Janys,D., Radice,P., Peterlongo,P., Manoukian,S.,
            Bonanni,B., Couch,F.J., Wang,X., Vachon,C., Purrington,K.,
            Giles,G.G., Milne,R.L., Mclean,C., Haiman,C.A., Henderson,B.E.,
            Schumacher,F., Le Marchand,L., Simard,J., Goldberg,M.S.,
            Labreche,F., Dumont,M., Teo,S.H., Yip,C.H., Hassan,N.,
            Vithana,E.N., Kristensen,V., Zheng,W., Deming-Halverson,S.,
            Shrubsole,M.J., Long,J., Winqvist,R., Pylkas,K.,
            Jukkola-Vuorinen,A., Kauppila,S., Andrulis,I.L., Knight,J.A.,
            Glendon,G., Tchatchou,S., Devilee,P., Tollenaar,R.A., Seynaeve,C.,
            Van Asperen,C.J., Garcia-Closas,M., Figueroa,J., Lissowska,J.,
            Brinton,L., Czene,K., Darabi,H., Eriksson,M., Brand,J.S.,
            Hooning,M.J., Hollestelle,A., Van Den Ouweland,A.M., Jager,A.,
            Li,J., Liu,J., Humphreys,K., Shu,X.O., Lu,W., Gao,Y.T., Cai,H.,
            Cross,S.S., Reed,M.W., Blot,W., Signorello,L.B., Cai,Q.,
            Pharoah,P.D., Perkins,B., Shah,M., Blows,F.M., Kang,D., Yoo,K.Y.,
            Noh,D.Y., Hartman,M., Miao,H., Chia,K.S., Putti,T.C., Hamann,U.,
            Luccarini,C., Baynes,C., Ahmed,S., Maranian,M., Healey,C.S.,
            Jakubowska,A., Lubinski,J., Jaworska-Bieniek,K., Durda,K.,
            Sangrajrang,S., Gaborieau,V., Brennan,P., Mckay,J., Slager,S.,
            Toland,A.E., Yannoukakos,D., Shen,C.Y., Hsiung,C.N., Wu,P.E.,
            Ding,S.L., Ashworth,A., Jones,M., Orr,N., Swerdlow,A.J.,
            Tsimiklis,H., Makalic,E., Schmidt,D.F., Bui,Q.M., Chanock,S.J.,
            Hunter,D.J., Hein,R., Dahmen,N., Beckmann,L., Aaltonen,K.,
            Muranen,T.A., Heikkinen,T., Irwanto,A., Rahman,N., Turnbull,C.A.,
            Waisfisz,Q., Meijers-Heijboer,H.E., Adank,M.A., Van Der Luijt,R.B.,
            Hall,P., Chenevix-Trench,G., Dunning,A., Easton,D.F. and Cox,A.
  CONSRTM   GENICA Network; kConFab Investigators; Australian Ovarian Cancer
            Study Group; Breast and Ovarian Cancer Susceptibility (BOCS) Study
  TITLE     Identification and characterization of novel associations in the
            CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk
  JOURNAL   Hum Mol Genet 24 (1), 285-298 (2015)
   PUBMED   25168388
  REMARK    GeneRIF: Genome-wide association studies show a significant
            association between the intronic SNP rs1830298 in ALS2CR12 gene and
            breast cancer; further expression studies suggest that CASP8 might
            be the target gene.
REFERENCE   6  (bases 1 to 2064)
  AUTHORS   Guey,L.T., Garcia-Closas,M., Murta-Nascimento,C., Lloreta,J.,
            Palencia,L., Kogevinas,M., Rothman,N., Vellalta,G., Calle,M.L.,
            Marenne,G., Tardon,A., Carrato,A., Garcia-Closas,R., Serra,C.,
            Silverman,D.T., Chanock,S., Real,F.X. and Malats,N.
  CONSRTM   EPICURO/Spanish Bladder Cancer Study investigators
  TITLE     Genetic susceptibility to distinct bladder cancer subphenotypes
  JOURNAL   Eur Urol 57 (2), 283-292 (2010)
   PUBMED   19692168
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2064)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   8  (bases 1 to 2064)
  AUTHORS   Ng,D., Hu,N., Hu,Y., Wang,C., Giffen,C., Tang,Z.Z., Han,X.Y.,
            Yang,H.H., Lee,M.P., Goldstein,A.M. and Taylor,P.R.
  TITLE     Replication of a genome-wide case-control study of esophageal
            squamous cell carcinoma
  JOURNAL   Int J Cancer 123 (7), 1610-1615 (2008)
   PUBMED   18649358
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2064)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   10 (bases 1 to 2064)
  AUTHORS   Hadano,S., Hand,C.K., Osuga,H., Yanagisawa,Y., Otomo,A.,
            Devon,R.S., Miyamoto,N., Showguchi-Miyata,J., Okada,Y.,
            Singaraja,R., Figlewicz,D.A., Kwiatkowski,T., Hosler,B.A.,
            Sagie,T., Skaug,J., Nasir,J., Brown,R.H. Jr., Scherer,S.W.,
            Rouleau,G.A., Hayden,M.R. and Ikeda,J.E.
  TITLE     A gene encoding a putative GTPase regulator is mutated in familial
            amyotrophic lateral sclerosis 2
  JOURNAL   Nat Genet 29 (2), 166-173 (2001)
   PUBMED   11586298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031603.1, DB034999.1, AB053314.1 and BX095441.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001127391.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            resulting isoform (b) has the same N- and C-termini but is shorter
            compared to isoform a. Variants 2 and 3 encode the same protein
            (isoform b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031603.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392257.8/ ENSP00000376086.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-537               BC031603.1         34-570
            538-593             DB034999.1         526-581
            594-1784            BC031603.1         627-1817
            1785-1832           AB053314.1         1492-1539
            1833-1837           BX095441.1         701-705
            1838-2064           AB053314.1         1545-1771
FEATURES             Location/Qualifiers
     source          1..2064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..2064
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /note="flagellum associated containing coiled-coil domains
                     1"
                     /db_xref="GeneID:130540"
                     /db_xref="HGNC:HGNC:14439"
                     /db_xref="MIM:619796"
     exon            1..364
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            365..524
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..1680
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /note="isoform b is encoded by transcript variant 2;
                     amyotrophic lateral sclerosis 2 chromosomal region
                     candidate gene 12 protein; amyotrophic lateral sclerosis 2
                     (juvenile) chromosome region, candidate 12; amyotrophic
                     lateral sclerosis 2 chromosome region candidate 12;
                     amyotrophic lateral sclerosis 2 chromosome region 12; ALS2
                     chromosome region 12; flagellum-associated coiled-coil
                     domain-containing protein 1"
                     /codon_start=1
                     /product="flagellum-associated coiled-coil
                     domain-containing protein 1 isoform b"
                     /protein_id="NP_001120863.1"
                     /db_xref="CCDS:CCDS46488.1"
                     /db_xref="GeneID:130540"
                     /db_xref="HGNC:HGNC:14439"
                     /db_xref="MIM:619796"
                     /translation="MYPNPLIYCTCWDPWNLGPRKLIKTPQLPRKNSTGSSKLTPLVP
                     APKNHNYLQPTKPVVSPKMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGD
                     EMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMD
                     LRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLK
                     NMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKK
                     INESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVMQEELHAQALILESLNTNL
                     YYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEIC
                     EGCSGRLASITVSKDDSDTVQDGSKKGQES"
     exon            525..596
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            597..645
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            646..779
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            780..873
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            874..935
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1033
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1086
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1186
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1290
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1353
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1443
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1553
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..2064
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1911
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /note="major polyA site"
     regulatory      1954..1959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
                     /note="hexamer: AAGAAA"
     polyA_site      1980
                     /gene="FLACC1"
                     /gene_synonym="ALS2CR12"
ORIGIN      
        1 caactcaggc ccaagtcaca ggaatctgaa tggtggggtg accttctcct ctagtttaat
       61 ttcattgcaa tactgagaaa cttcaactgt tttgtcttta gaagggaaat tcatgtttgt
      121 gccaggccag cctttgtaaa agcctttgat tggattcact agaagtctgt cttcccgcag
      181 tacatatact gtgaattttc tccttcggca tttcaaccac ttggaatggc cactaaagtg
      241 gcttttgatc taaagtaaac tctgattctg tgttgatggg gaaccatttc tctctaacat
      301 ggtggtttct ttaagatgtt tgacttgggc cacatgagaa taacagatct ttgggcagtc
      361 caagcaagag cctcctgatc tagcagccaa gactccccct gacctttggc catgtacccc
      421 aaccctctca tctactgcac ctgctgggac ccctggaact tgggaccacg gaagctaatc
      481 aagacccctc aactaccacg caagaactcc acagggagtt ccaagctaac tcctcttgta
      541 ccagctccaa aaaatcacaa ttacctccaa ccaacaaaac ctgttgtttc cccaaaaatg
      601 aaaatccatt cagcaaggca agaagagact aataaatcat tttatgaagt gatcaacgtg
      661 tcacctggct atcaacttgt tcggaatcgg gaacagattt ctgtcacctt aggggatgag
      721 atgtttgata ggaaaaagcg gtgggaatcg gagatcccgg acaaaggcag attttccagg
      781 accaacatca tttctgacct agaagagcaa atctcagagc tgacagcaat aattgaacaa
      841 atgaacagag accaccagtc tgcccagaaa ttgctctcca gtgaaatgga tctccgctgt
      901 gctgagatga aacagaactt tgaaaacaag aacagggagc tcaaagaggc ccatgaagca
      961 gaactcagtg agttggagaa caactacaaa gcagccttga aggcagagaa gttggctgcc
     1021 caagagaagc tagaggagat gggaaaagaa tacaagtatt tgaagaatat gtttcgtacg
     1081 tatcaggaca gtatttatga tgaaatggaa gagaagtggt caaaacagaa ggcgaaatgg
     1141 aagaaggatg agaagttcga gcgagaaaat atcctgctac agcaaaaaaa aaagatgacc
     1201 aaaaaattcg aaatggagtc aggagaagaa gataagaaaa taaatgaatc ctgcagtgct
     1261 gtctttgaga acttcattca agagaaggag gagctcttga aacaacatca aagtgacacc
     1321 ttgcaattag aagagctgag aaaaaccaaa gaggtcatgc aggaagaatt gcatgcacaa
     1381 gcccttatcc tagagtcact gaacacaaac ctctactata cccagttgga actccagaaa
     1441 gagaaagcta tagtgggaaa tctggagaaa atgcttcaaa ccaagtttgc tgaaactgaa
     1501 gaaaagtata agcacaccat acagatcctg acggaagaga acattcatct gaagcaaaag
     1561 ataatttcta agaatgaaga aatttgtgaa ggatgttctg ggagattggc ctctattact
     1621 gtttctaagg atgattctga cactgtgcaa gatggtagca agaaaggaca agaatcataa
     1681 acaaaaagtt gctctgcatt gttgaagatg gttggcacac catttctgta ggcccaggaa
     1741 actcctggga gggttttctt gagaaaatgc atataatgag tttagttctt gggttgctct
     1801 gactctctga atgtctgaaa atgtttgaat tcgcatctga atttcacagc ttatcacgga
     1861 ctcttcactg aaaaatgatg ctctccatac tgggagctga gctttctctg agttttgtac
     1921 tatttttctt ctaccttgac gtatttcgtt agaaagaaac tgatttgaag gccttcttca
     1981 tattgaactt ttactatatt tgggaggtgt acctttgtcc cctggggcat ttaggtagca
     2041 aaaaaagatg atgtgttgat ttta
//
