LOCUS       NM_001351501            7481 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens fukutin (FKTN), transcript variant 9, mRNA.
ACCESSION   NM_001351501 XM_017014479
VERSION     NM_001351501.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7481)
  AUTHORS   Li,M., Fu,H., Li,J., Meng,D., Zhang,Q. and Fei,D.
  TITLE     Compound variants of FKTN, POMGNT1, and LAMB1 gene identified by
            prenatal whole-exome sequencing in three fetuses with congenital
            hydrocephalus
  JOURNAL   J Obstet Gynaecol Res 48 (10), 2624-2629 (2022)
   PUBMED   35843586
  REMARK    GeneRIF: Compound variants of FKTN, POMGNT1, and LAMB1 gene
            identified by prenatal whole-exome sequencing in three fetuses with
            congenital hydrocephalus.
REFERENCE   2  (bases 1 to 7481)
  AUTHORS   Okamura,Y., Yamamoto,T., Tsukui,R., Kato,Y. and Shibata,N.
  TITLE     Fukutin Protein Participates in Cell Proliferation by Enhancing
            Cyclin D1 Expression through Binding to the Transcription Factor
            Activator Protein-1: An In Vitro Study
  JOURNAL   Int J Mol Sci 22 (22), 12153 (2021)
   PUBMED   34830034
  REMARK    GeneRIF: Fukutin Protein Participates in Cell Proliferation by
            Enhancing Cyclin D1 Expression through Binding to the Transcription
            Factor Activator Protein-1: An In Vitro Study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7481)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7481)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
REFERENCE   5  (bases 1 to 7481)
  AUTHORS   Miyake,M., Nakahori,Y., Matsushita,I., Kobayashi,K., Mizuno,K.,
            Hirai,M., Kanazawa,I., Nakagome,Y., Tokunaga,K. and Toda,T.
  TITLE     YAC and cosmid contigs encompassing the Fukuyama-type congenital
            muscular dystrophy (FCMD) candidate region on 9q31
  JOURNAL   Genomics 40 (2), 284-293 (1997)
   PUBMED   9119396
REFERENCE   6  (bases 1 to 7481)
  AUTHORS   Toda,T., Segawa,M., Nomura,Y., Nonaka,I., Masuda,K., Ishihara,T.,
            Sakai,M., Tomita,I., Origuchi,Y., Suzuki M [corrected to Sakai,M.].
            et al.
  TITLE     Localization of a gene for Fukuyama type congenital muscular
            dystrophy to chromosome 9q31-33
  JOURNAL   Nat Genet 5 (3), 283-286 (1993)
   PUBMED   8275093
  REMARK    Erratum:[Nat Genet 1994 May;7(1):113]
REFERENCE   7  (bases 1 to 7481)
  AUTHORS   Pegoraro,E. and Hoffman,E.P.
  TITLE     Limb-Girdle Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301582
REFERENCE   8  (bases 1 to 7481)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
REFERENCE   9  (bases 1 to 7481)
  AUTHORS   Sparks,S.E., Quijano-Roy,S., Harper,A., Rutkowski,A., Gordon,E.,
            Hoffman,E.P. and Pegoraro,E.
  TITLE     Congenital Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301468
REFERENCE   10 (bases 1 to 7481)
  AUTHORS   Saito,K.
  TITLE     Fukuyama Congenital Muscular Dystrophy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301385
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL601876.1, DW425749.1,
            DA917113.1, BP354825.1, BC117699.1, AL158070.11 and AW014603.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001351501.1.
            
            Summary: The protein encoded by this gene is a putative
            transmembrane protein that is localized to the cis-Golgi
            compartment, where it may be involved in the glycosylation of
            alpha-dystroglycan in skeletal muscle. The encoded protein is
            thought to be a glycosyltransferase and could play a role in brain
            development. Defects in this gene are a cause of Fukuyama-type
            congenital muscular dystrophy (FCMD), Walker-Warburg syndrome
            (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated
            cardiomyopathy type 1X (CMD1X). Alternatively spliced transcript
            variants have been found for this gene. [provided by RefSeq, Nov
            2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.154109.1,
                                           SRR1660803.32774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL601876.1         5-13
            10-276              DW425749.1         18-284
            277-408             DA917113.1         368-499
            409-619             BP354825.1         339-549
            620-5058            BC117699.1         411-4849
            5059-6923           AL158070.11        118150-120014
            6924-7481           AW014603.1         17-574              c
FEATURES             Location/Qualifiers
     source          1..7481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.2"
     gene            1..7481
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /note="fukutin"
                     /db_xref="GeneID:2218"
                     /db_xref="HGNC:HGNC:3622"
                     /db_xref="MIM:607440"
     exon            1..35
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            36..228
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            229..288
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            289..492
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            493..610
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            611..888
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             638..1627
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /note="isoform e is encoded by transcript variant 9;
                     Fukuyama type congenital muscular dystrophy protein;
                     patient fukutin; ribitol-5-phosphate transferase;
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform e"
                     /protein_id="NP_001338430.1"
                     /db_xref="GeneID:2218"
                     /db_xref="HGNC:HGNC:3622"
                     /db_xref="MIM:607440"
                     /translation="MGFQCLKIESKDPRLDGIDSLSGTEIPLHYICKLATHAIHLVVF
                     HERSGNYLWHGHLRLKEHIDRKFVPFRKLQFGRYPGAFDRPELQQVTVDGLEVLIPKD
                     PMHFVEEVPHSRFIECRYKEARAFFQQYLDDNTVEAVAFRKSAKELLQLAAKTLNKLG
                     VPFWLSSGTCLGWYRQCNIIPYSKDVDLGIFIQDYKSDIILAFQDAGLPLKHKFGKVE
                     DSLELSFQGKDDVKLDVFFFYEETDHMWNGGTQAKTGKKFKYLFPKFTLCWTEFVDMK
                     VHVPCETLEYIEANYGKTWKIPVKTWDWKRSPPNVQPNGIWPISEWDEVIQLY"
     exon            889..1021
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1151
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1285
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1413
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..7481
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6396..6401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /note="hexamer: AATAAA"
     polyA_site      6416
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
     regulatory      7458..7463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /note="hexamer: AATAAA"
     polyA_site      7481
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /note="major polyA site"
ORIGIN      
        1 taaagcggag cggctgcagc ctgctgttga gtgagaaaac aaaattatct tcctttccaa
       61 atccaaaaag atgaaaacga ctgagatact ttcaaaagac aaccaagtga gcagcacaga
      121 ctaatgagta gaatcaataa gaacgtggtt ttggcccttt taacgctgac aagttctgca
      181 tttctgctgt ttcagttgta ctactacaag cactatttat caacaaagaa tggagctggt
      241 ttgtcaaaat ccaaaggaag ccgaattgga tttgatagca cacagtggcg tgcagttaaa
      301 aaatttatta tgttaacatc caaccaaaat gtaccagtgt ttcttattga tcctttgata
      361 ctggaattga ttaataagaa ctttgaacaa gtcaaaaata cttctcatgg ctctacttca
      421 caatgcaagt ttttctgtgt tccaagagac tttactgcat ttgcactgca gtatcaccta
      481 tggaagaatg agggtctcac tttgtcaccc aggcttgagt gcagtggcac aatcttggct
      541 cactgcagcc ttgatctctc aggttcaagt gatcctcctg gctcagaccc ccaagtagct
      601 gggactacag gaaggctggt ttcggatagc tgagaatatg ggatttcagt gcctaaagat
      661 tgagagtaaa gatccccggc tagacgggat agactcactc tctggaactg aaatccccct
      721 gcactatatc tgcaaactgg ccactcatgc gatccacttg gtagtctttc atgagaggag
      781 tggcaactac ctctggcacg gccacttgag acttaaagaa cacattgaca ggaaatttgt
      841 tcccttccga aagttacagt ttggtcgtta tccaggagct tttgacaggc cagagttaca
      901 gcaagttact gttgatggac tggaagttct cattccaaag gatccaatgc actttgtaga
      961 agaagtacca cactctaggt ttattgagtg taggtataaa gaagctcgag cattctttca
     1021 gcagtacctt gatgataaca ctgtggaagc tgtggccttt cggaagagtg caaaggaatt
     1081 actgcaacta gcagcgaaaa cattaaacaa attgggagta ccattctggc tgagcagtgg
     1141 aacttgtcta ggatggtatc gacaatgcaa cattattcct tatagcaaag atgttgacct
     1201 aggaattttt atacaagatt acaaatctga tattatttta gcatttcagg atgcaggact
     1261 tccgctcaaa cacaaatttg ggaaggtaga agacagcttg gaactatcct tccagggaaa
     1321 agatgatgta aaacttgatg tttttttctt ctatgaagaa actgatcaca tgtggaatgg
     1381 aggcactcag gccaaaacag gaaaaaaatt caaatacctg tttccgaagt ttacactgtg
     1441 ctggactgag tttgtagaca tgaaggtcca tgtaccctgt gaaaccctcg aatacattga
     1501 agccaactat ggtaagacct ggaagattcc tgtaaagacg tgggactgga agcgctctcc
     1561 tcccaatgtg caacccaatg gaatctggcc tatttctgag tgggatgagg ttatccagtt
     1621 atattgagat agtaggttga aatgggagaa tttctctttt ggaaaaaaag gtagataact
     1681 gtttaaaaaa tacatgtcta tttgtcaaac ataagtggga accaaagaaa aaatgtgaca
     1741 agtttgaaga cacagaaaga gtcatctgat gtaattctct cacttagtac tgaggaattt
     1801 tcatgtgcca catacaatgc taggttacag tggagaagcc tagatgaatg agacaaatac
     1861 ctacttcttt tattcctcct tttggtaaac aactcaattt tcctttgagg gaaccctccc
     1921 ccaccctttg aagagttcaa gttctgtaca ggtttttaaa acgtgaagta atgtttgaac
     1981 tggaagatga gctcaccagg caaagctaag gaaggatata ctagttgaaa agaataaccc
     2041 actcctcttc tgggcattta agctggtatg ttagtgctac ttttaagatt gtggagtctg
     2101 agttaatatt caagtgatca gactttgagt gacatcaaga aaagatgata tcaggttcat
     2161 ttttcaacta atcttatgtg gaattgaatt agagaacaag gcattattct tttagggaag
     2221 gtgagagctt atttgtatca gagcttatta cttgtcagga taagtaaatt tctgtacatg
     2281 tactgttttc atatgtgaag tgagaagaaa ctttatgctt gtttaatgct taaatttcca
     2341 tccattgtga gaatattttc actgacctct gatggcactt gttgacaaat cattcaagtg
     2401 agaccatgtt actagacatg atcttgaaag aggccatgat ttcacaaaac tcatttttat
     2461 tttattctca gacagtctgt taggtaaaaa tatgagaaat tcatgtacat tttatatttt
     2521 ctgaatttat aatctgtgca ctcccaattt taatgacact aaaatattaa tagaattttt
     2581 taaatatact ctaattttta aaacatactc tttattatct tcatttatca attacagctt
     2641 cgtatctcta atttatggtc tatataccaa tttaaatggc atgtaaacct gcctgtttct
     2701 tctcctcttc taatatatca gatctccaaa atggaagcta aatggtggac ttgacaacta
     2761 ttcaccctac ctcagatcat agagtttgta aagtttgtgt ccctccccag tttttcagtc
     2821 tgttgaatgt cgatggggca agaactcaga cttctacttt accaagtacc acacactctg
     2881 gaatgcttta gtttcctttt cccctcaaga tgtctgagtc agctaggatg ctgtttaccc
     2941 catctctctc ttatatcact tgaatgatat attgtaagtg agaggtaaag gaaaatgtag
     3001 gcacaataag cactgctatt tttctctttg tctaggaaag gaagctgaat cttatatctt
     3061 atctatgcta tttaggacta ctttctggag cttggcagat tttcctctga caccagagaa
     3121 caatagtagt ctcaagaatg gaaacctgaa tgtctgaggg aatgggctgg tagacttttt
     3181 cgaaaacaaa ttagagaaag taacttacaa ccacccattc cggatttgta aagcaacatg
     3241 aaaacctttg ataaatgata accaacagtc ttctgtccta atttgcattc tcaatgcaga
     3301 attattgggt ctttcataaa taacatgagt ggtttctgga gacatttaag attgtcagca
     3361 aacttgtccc aaaatggcac atcatcataa tccattttct ctttgctaga aaatcagccc
     3421 atagagtgca ttcccaaatt ctaaatagct gaccctaaat tcatttttca tgcttaaaaa
     3481 taatagaaca aataataata ctatttttgg gcaaaatcca ccctacttga tgaggaccat
     3541 ttgcttgtgc tcagtattta gaaatgcata cactccacat ttctccccat ttccaattgg
     3601 gactcccatt ctttgccagg agatcttacc catccctttt cagattaatc ttttatcctt
     3661 tcctgaagta caaagtctta agagtgtctg aaatccaaga catcttggcc caattgacac
     3721 aggttctata ttcttcccta catagaccac tggctgctga aatacttttc ttgtcttctg
     3781 gtttcacagg cttcagctca tgggttccac cctaacttgg ggaaacaaaa gccttctcta
     3841 gaatctgaag gccaggctta cctctgattc tgattcatcc atacttcatc ttatgtattt
     3901 taacagttgg gttctgtgga gtgtccagag accttgggtt aggtatatcc atcttcagta
     3961 cctcattgga tcacttttct ttcatcactt gagtattcta gcagtcattc tcctaatctg
     4021 accactttca ggtttagttt acctggctta cctggggaag ttgacaactt gttggtagtt
     4081 aggcacccat gaatgtctcc agagacatcc tgagaggcaa gattcctctt aattgataac
     4141 caggacaacc aggtagtcac ccagtcctct ctaagcaggg agcacttgtc cttctctcct
     4201 ctgctgcagc tactgatatc tggcccctgg aataaaacca tagttcctaa aattgagcat
     4261 ccctaagagt agctgcttgg tgggacagct gatttctttg attccctagc tgcaaaacct
     4321 gaaattgacc actaggtgac agaatgtttg ccagtatccc cacaaaacaa gttaaaactt
     4381 aagtgaaaat cattctgctt ttgaatctta aaagctagaa aaaccataat gtaatattct
     4441 ttttaaaccc tcttatttta taactaaata aataatcaca gaaaagaatg atctgaacaa
     4501 gaacagctga ggctaaaacc caagactgcc gtgactccta gtccaatgtc tgtttcgcat
     4561 cacaacacag tatctttaac agtgcttgag atgcttaaca gagaaggcat ccagtgcttc
     4621 attgaggcta agtctcaggg tgtttctgcc gcttagtatc tttttgttca gattgagaac
     4681 ctaaggcgac agagaggtca aggggaagta ttttctagtt cagaattcag aattcttagg
     4741 caaccttcat acctttatct ggaaaatgcc ttctctccag acaataagac agttcacatc
     4801 tggagacatc agcctttggt acctaattct ctaagctcaa gatgcatccc attgccactt
     4861 taccattcta tttcccaagg gaaccatcag caccaacctg ctaaatgcct gtatttgaag
     4921 tctctcccct tcctgaagtg accttttatg aggctctttc cttcctaagg gacctttccc
     4981 tggtagtagt ggtctcattc acaaaaaaga ataatagatg taactggagt cactttgcag
     5041 ttttcaagat ttttttttta tctgcttggc tggaaaggag actagagtat ctagttttta
     5101 gtatttaaac tacttttaat tatttatatt gatactctct gataaatgca ggtagttaag
     5161 aatagattgt actcattcct ttttgagttt gtgacctcaa accattgttt ttattcttac
     5221 acgactacag tacttcaaat ggcacataga taggcaggat attacatagg taagcaggaa
     5281 tttatacatt gggtaccaga gctaaatctg gaaaacacat ttggaatgag cttccacact
     5341 tcagtctaaa atctcaccca aacttatggc tacatatttt tctaagtttc ccccctagtt
     5401 tcactttctg gaaagtgaac agttttttaa atcctaaatg ttataaatcc ttaggagaaa
     5461 tattccctca aaacctagtc aagaaagtgc cacattccca ccttctaaca ggtaattatt
     5521 agttgtaata gctttaatgc atggaaaaac ttcagttact gaccagtcaa gagaatttct
     5581 caagaaaaat cccagcaacg ttccctcttt cctccttgtc ttccactatc attaagacct
     5641 gggctagatc acctctaaca tctcactcag ggaaggcaat gtgttgccat aaaaagacca
     5701 caagcttttg agttaggcct gaatttgaat ttcagcttaa tcatgtggga tttatggtgg
     5761 gggccctttc agtctcaatt tccacattag tgaactgggg aaatgataca tacttctaag
     5821 ggtttttagg gggattaaat gaagtataca gttcttagcc tcaggcctag gattaagtaa
     5881 gtactcaaga aatgtgcaat tttctagttc catgtttctt ttctaatctt caaatggaat
     5941 tatagaaacc atgggtcaga acatattcct ttactcaaaa gattgcatga ctgaatttgc
     6001 ttaagaaaaa aaaaattgta tcaagtcatt aatacaatta tacattaatt atattacatt
     6061 aatacaatat atggtttgtg aattcagaga cattaccagt ttgcctcctt ctctcaatag
     6121 aacttgtatt ttcattttct tggttaagca gttgtctcct aatattatcc catatgctac
     6181 ctagtttgct ggtcccaagc agtttactgt acttcactag atttggtacc tgctctcccc
     6241 tggacttctt tttcaatatt ctagcctttc ctagatgtaa atctttacct ccttgttagt
     6301 gaaattagat ataagccatg atttggagag ggaagaaatc tggaatactt aatttcattt
     6361 aattatctat gctgatgaat gcctgtatca ttgttaataa aggagaattg aaaatactca
     6421 tttctacttt ctgccctcaa atttctgttt ctatctcaac taggcaagaa tcagcagggt
     6481 gcatgatgcc attttaagct gcttcacatc agactgaaat cctaattaca gttcataagt
     6541 gaaacagact aattcaatgg caataccttt tgtataggtc ctgtgcttaa aggaggcaag
     6601 tataaatttt ctaataagaa atccctgctt cttttgggtg cagtggctca cacctgtaat
     6661 accagcagtt tgagaagcta aggcaggtgg atcacttgag gccaggagtt cgagaccagc
     6721 ctggccaaca tagtgaaacc ccgtctcttc taaaaataca aaaaaattag ctgggcatgg
     6781 tggtgcacgc ctatagtccc agctacacag gaggctgagg caggagaatc acttgaaccc
     6841 gggaagcaga gtctgcagtg agccaagatc gcggcattgc acttcagcct gggcgataga
     6901 gcaagactct gtctcagaaa aaaaaaaaaa ggaaagaaag aaatctctgc ttccgtacta
     6961 tcaaaacttc taccctagaa taccccctgg caccttctaa cccaacctaa tacagagatt
     7021 ttgtagggac ccattaacaa gctcctatat aattataagc agctctcaca gtagggttga
     7081 aagagaatat aaggaaaatt agaagtactg tatttttgct attggaaatg aaatattgtt
     7141 tcatgcacct ttgaaaaaaa taacaggatt ttacagcctt ctgatgattc attcaaagca
     7201 tggggaatag ttcatatgtt tgttaaatga aaatcttatg tagctatttg tgtgtccctc
     7261 ccacttcata actacaaaaa catatatatg aatttctaaa caaagtgata ttttaaagat
     7321 gaattgattc aatgtgtact taccagttta ctgtgtggtt ttatcttcag gtacagatag
     7381 tttgtggtac tacttgaaaa tacctttaat attattttca tcagaatttg taatatataa
     7441 tccagtttgg gatgatgaat aaaatttttc taatctcttg a
//
