LOCUS       NM_001079802            7455 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens fukutin (FKTN), transcript variant 1, mRNA.
ACCESSION   NM_001079802
VERSION     NM_001079802.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7455)
  AUTHORS   Li,M., Fu,H., Li,J., Meng,D., Zhang,Q. and Fei,D.
  TITLE     Compound variants of FKTN, POMGNT1, and LAMB1 gene identified by
            prenatal whole-exome sequencing in three fetuses with congenital
            hydrocephalus
  JOURNAL   J Obstet Gynaecol Res 48 (10), 2624-2629 (2022)
   PUBMED   35843586
  REMARK    GeneRIF: Compound variants of FKTN, POMGNT1, and LAMB1 gene
            identified by prenatal whole-exome sequencing in three fetuses with
            congenital hydrocephalus.
REFERENCE   2  (bases 1 to 7455)
  AUTHORS   Okamura,Y., Yamamoto,T., Tsukui,R., Kato,Y. and Shibata,N.
  TITLE     Fukutin Protein Participates in Cell Proliferation by Enhancing
            Cyclin D1 Expression through Binding to the Transcription Factor
            Activator Protein-1: An In Vitro Study
  JOURNAL   Int J Mol Sci 22 (22), 12153 (2021)
   PUBMED   34830034
  REMARK    GeneRIF: Fukutin Protein Participates in Cell Proliferation by
            Enhancing Cyclin D1 Expression through Binding to the Transcription
            Factor Activator Protein-1: An In Vitro Study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7455)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7455)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
REFERENCE   5  (bases 1 to 7455)
  AUTHORS   Miyake,M., Nakahori,Y., Matsushita,I., Kobayashi,K., Mizuno,K.,
            Hirai,M., Kanazawa,I., Nakagome,Y., Tokunaga,K. and Toda,T.
  TITLE     YAC and cosmid contigs encompassing the Fukuyama-type congenital
            muscular dystrophy (FCMD) candidate region on 9q31
  JOURNAL   Genomics 40 (2), 284-293 (1997)
   PUBMED   9119396
REFERENCE   6  (bases 1 to 7455)
  AUTHORS   Toda,T., Segawa,M., Nomura,Y., Nonaka,I., Masuda,K., Ishihara,T.,
            Sakai,M., Tomita,I., Origuchi,Y., Suzuki M [corrected to Sakai,M.].
            et al.
  TITLE     Localization of a gene for Fukuyama type congenital muscular
            dystrophy to chromosome 9q31-33
  JOURNAL   Nat Genet 5 (3), 283-286 (1993)
   PUBMED   8275093
  REMARK    Erratum:[Nat Genet 1994 May;7(1):113]
REFERENCE   7  (bases 1 to 7455)
  AUTHORS   Pegoraro,E. and Hoffman,E.P.
  TITLE     Limb-Girdle Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301582
REFERENCE   8  (bases 1 to 7455)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
REFERENCE   9  (bases 1 to 7455)
  AUTHORS   Sparks,S.E., Quijano-Roy,S., Harper,A., Rutkowski,A., Gordon,E.,
            Hoffman,E.P. and Pegoraro,E.
  TITLE     Congenital Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301468
REFERENCE   10 (bases 1 to 7455)
  AUTHORS   Saito,K.
  TITLE     Fukuyama Congenital Muscular Dystrophy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301385
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL601876.1, DA917113.1,
            BC117699.1 and AL158070.11.
            
            On Dec 27, 2019 this sequence version replaced NM_001079802.1.
            
            Summary: The protein encoded by this gene is a putative
            transmembrane protein that is localized to the cis-Golgi
            compartment, where it may be involved in the glycosylation of
            alpha-dystroglycan in skeletal muscle. The encoded protein is
            thought to be a glycosyltransferase and could play a role in brain
            development. Defects in this gene are a cause of Fukuyama-type
            congenital muscular dystrophy (FCMD), Walker-Warburg syndrome
            (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated
            cardiomyopathy type 1X (CMD1X). Alternatively spliced transcript
            variants have been found for this gene. [provided by RefSeq, Nov
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein (a). Variants 1, 2 and 4
            encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058842.1, DRR138518.369574.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357998.10/ ENSP00000350687.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL601876.1         5-39
            36-578              DA917113.1         35-577
            579-5032            BC117699.1         396-4849
            5033-7455           AL158070.11        118150-120572
FEATURES             Location/Qualifiers
     source          1..7455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.2"
     gene            1..7455
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /note="fukutin"
                     /db_xref="GeneID:2218"
                     /db_xref="HGNC:HGNC:3622"
                     /db_xref="MIM:607440"
     exon            1..35
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            36..127
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            128..320
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1601
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /note="isoform a is encoded by transcript variant 1;
                     Fukuyama type congenital muscular dystrophy protein;
                     patient fukutin; ribitol-5-phosphate transferase;
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform a"
                     /protein_id="NP_001073270.1"
                     /db_xref="CCDS:CCDS6766.1"
                     /db_xref="GeneID:2218"
                     /db_xref="HGNC:HGNC:3622"
                     /db_xref="MIM:607440"
                     /translation="MSRINKNVVLALLTLTSSAFLLFQLYYYKHYLSTKNGAGLSKSK
                     GSRIGFDSTQWRAVKKFIMLTSNQNVPVFLIDPLILELINKNFEQVKNTSHGSTSQCK
                     FFCVPRDFTAFALQYHLWKNEEGWFRIAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYICKLATHAIHLVVFHERSGNYLWHGHLRLKEHIDRKFVPFRKLQFGRYPGAFDRPE
                     LQQVTVDGLEVLIPKDPMHFVEEVPHSRFIECRYKEARAFFQQYLDDNTVEAVAFRKS
                     AKELLQLAAKTLNKLGVPFWLSSGTCLGWYRQCNIIPYSKDVDLGIFIQDYKSDIILA
                     FQDAGLPLKHKFGKVEDSLELSFQGKDDVKLDVFFFYEETDHMWNGGTQAKTGKKFKY
                     LFPKFTLCWTEFVDMKVHVPCETLEYIEANYGKTWKIPVKTWDWKRSPPNVQPNGIWP
                     ISEWDEVIQLY"
     exon            321..380
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            381..584
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            585..862
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            863..995
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1125
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1259
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1387
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..7455
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6370..6375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /note="hexamer: AATAAA"
     polyA_site      6390
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
     regulatory      7432..7437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /note="hexamer: AATAAA"
     polyA_site      7455
                     /gene="FKTN"
                     /gene_synonym="CMD1X; FCMD; LGMD2M; LGMDR13; MDDGA4;
                     MDDGB4; MDDGC4"
                     /note="major polyA site"
ORIGIN      
        1 taaagcggag cggctgcagc ctgctgttga gtgagattga aaggaaacac actgaatgag
       61 gaaaaactaa catacggtca tcaacatcct tgtataacct agtttttaaa aaaattggat
      121 ttcaaagaaa acaaaattat cttcctttcc aaatccaaaa agatgaaaac gactgagata
      181 ctttcaaaag acaaccaagt gagcagcaca gactaatgag tagaatcaat aagaacgtgg
      241 ttttggccct tttaacgctg acaagttctg catttctgct gtttcagttg tactactaca
      301 agcactattt atcaacaaag aatggagctg gtttgtcaaa atccaaagga agccgaattg
      361 gatttgatag cacacagtgg cgtgcagtta aaaaatttat tatgttaaca tccaaccaaa
      421 atgtaccagt gtttcttatt gatcctttga tactggaatt gattaataag aactttgaac
      481 aagtcaaaaa tacttctcat ggctctactt cacaatgcaa gtttttctgt gttccaagag
      541 actttactgc atttgcactg cagtatcacc tatggaagaa tgaggaaggc tggtttcgga
      601 tagctgagaa tatgggattt cagtgcctaa agattgagag taaagatccc cggctagacg
      661 ggatagactc actctctgga actgaaatcc ccctgcacta tatctgcaaa ctggccactc
      721 atgcgatcca cttggtagtc tttcatgaga ggagtggcaa ctacctctgg cacggccact
      781 tgagacttaa agaacacatt gacaggaaat ttgttccctt ccgaaagtta cagtttggtc
      841 gttatccagg agcttttgac aggccagagt tacagcaagt tactgttgat ggactggaag
      901 ttctcattcc aaaggatcca atgcactttg tagaagaagt accacactct aggtttattg
      961 agtgtaggta taaagaagct cgagcattct ttcagcagta ccttgatgat aacactgtgg
     1021 aagctgtggc ctttcggaag agtgcaaagg aattactgca actagcagcg aaaacattaa
     1081 acaaattggg agtaccattc tggctgagca gtggaacttg tctaggatgg tatcgacaat
     1141 gcaacattat tccttatagc aaagatgttg acctaggaat ttttatacaa gattacaaat
     1201 ctgatattat tttagcattt caggatgcag gacttccgct caaacacaaa tttgggaagg
     1261 tagaagacag cttggaacta tccttccagg gaaaagatga tgtaaaactt gatgtttttt
     1321 tcttctatga agaaactgat cacatgtgga atggaggcac tcaggccaaa acaggaaaaa
     1381 aattcaaata cctgtttccg aagtttacac tgtgctggac tgagtttgta gacatgaagg
     1441 tccatgtacc ctgtgaaacc ctcgaataca ttgaagccaa ctatggtaag acctggaaga
     1501 ttcctgtaaa gacgtgggac tggaagcgct ctcctcccaa tgtgcaaccc aatggaatct
     1561 ggcctatttc tgagtgggat gaggttatcc agttatattg agatagtagg ttgaaatggg
     1621 agaatttctc ttttggaaaa aaaggtagat aactgtttaa aaaatacatg tctatttgtc
     1681 aaacataagt gggaaccaaa gaaaaaatgt gacaagtttg aagacacaga aagagtcatc
     1741 tgatgtaatt ctctcactta gtactgagga attttcatgt gccacataca atgctaggtt
     1801 acagtggaga agcctagatg aatgagacaa atacctactt cttttattcc tccttttggt
     1861 aaacaactca attttccttt gagggaaccc tcccccaccc tttgaagagt tcaagttctg
     1921 tacaggtttt taaaacgtga agtaatgttt gaactggaag atgagctcac caggcaaagc
     1981 taaggaagga tatactagtt gaaaagaata acccactcct cttctgggca tttaagctgg
     2041 tatgttagtg ctacttttaa gattgtggag tctgagttaa tattcaagtg atcagacttt
     2101 gagtgacatc aagaaaagat gatatcaggt tcatttttca actaatctta tgtggaattg
     2161 aattagagaa caaggcatta ttcttttagg gaaggtgaga gcttatttgt atcagagctt
     2221 attacttgtc aggataagta aatttctgta catgtactgt tttcatatgt gaagtgagaa
     2281 gaaactttat gcttgtttaa tgcttaaatt tccatccatt gtgagaatat tttcactgac
     2341 ctctgatggc acttgttgac aaatcattca agtgagacca tgttactaga catgatcttg
     2401 aaagaggcca tgatttcaca aaactcattt ttattttatt ctcagacagt ctgttaggta
     2461 aaaatatgag aaattcatgt acattttata ttttctgaat ttataatctg tgcactccca
     2521 attttaatga cactaaaata ttaatagaat tttttaaata tactctaatt tttaaaacat
     2581 actctttatt atcttcattt atcaattaca gcttcgtatc tctaatttat ggtctatata
     2641 ccaatttaaa tggcatgtaa acctgcctgt ttcttctcct cttctaatat atcagatctc
     2701 caaaatggaa gctaaatggt ggacttgaca actattcacc ctacctcaga tcatagagtt
     2761 tgtaaagttt gtgtccctcc ccagtttttc agtctgttga atgtcgatgg ggcaagaact
     2821 cagacttcta ctttaccaag taccacacac tctggaatgc tttagtttcc ttttcccctc
     2881 aagatgtctg agtcagctag gatgctgttt accccatctc tctcttatat cacttgaatg
     2941 atatattgta agtgagaggt aaaggaaaat gtaggcacaa taagcactgc tatttttctc
     3001 tttgtctagg aaaggaagct gaatcttata tcttatctat gctatttagg actactttct
     3061 ggagcttggc agattttcct ctgacaccag agaacaatag tagtctcaag aatggaaacc
     3121 tgaatgtctg agggaatggg ctggtagact ttttcgaaaa caaattagag aaagtaactt
     3181 acaaccaccc attccggatt tgtaaagcaa catgaaaacc tttgataaat gataaccaac
     3241 agtcttctgt cctaatttgc attctcaatg cagaattatt gggtctttca taaataacat
     3301 gagtggtttc tggagacatt taagattgtc agcaaacttg tcccaaaatg gcacatcatc
     3361 ataatccatt ttctctttgc tagaaaatca gcccatagag tgcattccca aattctaaat
     3421 agctgaccct aaattcattt ttcatgctta aaaataatag aacaaataat aatactattt
     3481 ttgggcaaaa tccaccctac ttgatgagga ccatttgctt gtgctcagta tttagaaatg
     3541 catacactcc acatttctcc ccatttccaa ttgggactcc cattctttgc caggagatct
     3601 tacccatccc ttttcagatt aatcttttat cctttcctga agtacaaagt cttaagagtg
     3661 tctgaaatcc aagacatctt ggcccaattg acacaggttc tatattcttc cctacataga
     3721 ccactggctg ctgaaatact tttcttgtct tctggtttca caggcttcag ctcatgggtt
     3781 ccaccctaac ttggggaaac aaaagccttc tctagaatct gaaggccagg cttacctctg
     3841 attctgattc atccatactt catcttatgt attttaacag ttgggttctg tggagtgtcc
     3901 agagaccttg ggttaggtat atccatcttc agtacctcat tggatcactt ttctttcatc
     3961 acttgagtat tctagcagtc attctcctaa tctgaccact ttcaggttta gtttacctgg
     4021 cttacctggg gaagttgaca acttgttggt agttaggcac ccatgaatgt ctccagagac
     4081 atcctgagag gcaagattcc tcttaattga taaccaggac aaccaggtag tcacccagtc
     4141 ctctctaagc agggagcact tgtccttctc tcctctgctg cagctactga tatctggccc
     4201 ctggaataaa accatagttc ctaaaattga gcatccctaa gagtagctgc ttggtgggac
     4261 agctgatttc tttgattccc tagctgcaaa acctgaaatt gaccactagg tgacagaatg
     4321 tttgccagta tccccacaaa acaagttaaa acttaagtga aaatcattct gcttttgaat
     4381 cttaaaagct agaaaaacca taatgtaata ttctttttaa accctcttat tttataacta
     4441 aataaataat cacagaaaag aatgatctga acaagaacag ctgaggctaa aacccaagac
     4501 tgccgtgact cctagtccaa tgtctgtttc gcatcacaac acagtatctt taacagtgct
     4561 tgagatgctt aacagagaag gcatccagtg cttcattgag gctaagtctc agggtgtttc
     4621 tgccgcttag tatctttttg ttcagattga gaacctaagg cgacagagag gtcaagggga
     4681 agtattttct agttcagaat tcagaattct taggcaacct tcataccttt atctggaaaa
     4741 tgccttctct ccagacaata agacagttca catctggaga catcagcctt tggtacctaa
     4801 ttctctaagc tcaagatgca tcccattgcc actttaccat tctatttccc aagggaacca
     4861 tcagcaccaa cctgctaaat gcctgtattt gaagtctctc cccttcctga agtgaccttt
     4921 tatgaggctc tttccttcct aagggacctt tccctggtag tagtggtctc attcacaaaa
     4981 aagaataata gatgtaactg gagtcacttt gcagttttca agattttttt tttatctgct
     5041 tggctggaaa ggagactaga gtatctagtt tttagtattt aaactacttt taattattta
     5101 tattgatact ctctgataaa tgcaggtagt taagaataga ttgtactcat tcctttttga
     5161 gtttgtgacc tcaaaccatt gtttttattc ttacacgact acagtacttc aaatggcaca
     5221 tagataggca ggatattaca taggtaagca ggaatttata cattgggtac cagagctaaa
     5281 tctggaaaac acatttggaa tgagcttcca cacttcagtc taaaatctca cccaaactta
     5341 tggctacata tttttctaag tttcccccct agtttcactt tctggaaagt gaacagtttt
     5401 ttaaatccta aatgttataa atccttagga gaaatattcc ctcaaaacct agtcaagaaa
     5461 gtgccacatt cccaccttct aacaggtaat tattagttgt aatagcttta atgcatggaa
     5521 aaacttcagt tactgaccag tcaagagaat ttctcaagaa aaatcccagc aacgttccct
     5581 ctttcctcct tgtcttccac tatcattaag acctgggcta gatcacctct aacatctcac
     5641 tcagggaagg caatgtgttg ccataaaaag accacaagct tttgagttag gcctgaattt
     5701 gaatttcagc ttaatcatgt gggatttatg gtgggggccc tttcagtctc aatttccaca
     5761 ttagtgaact ggggaaatga tacatacttc taagggtttt tagggggatt aaatgaagta
     5821 tacagttctt agcctcaggc ctaggattaa gtaagtactc aagaaatgtg caattttcta
     5881 gttccatgtt tcttttctaa tcttcaaatg gaattataga aaccatgggt cagaacatat
     5941 tcctttactc aaaagattgc atgactgaat ttgcttaaga aaaaaaaaat tgtatcaagt
     6001 cattaataca attatacatt aattatatta cattaataca atatatggtt tgtgaattca
     6061 gagacattac cagtttgcct ccttctctca atagaacttg tattttcatt ttcttggtta
     6121 agcagttgtc tcctaatatt atcccatatg ctacctagtt tgctggtccc aagcagttta
     6181 ctgtacttca ctagatttgg tacctgctct cccctggact tctttttcaa tattctagcc
     6241 tttcctagat gtaaatcttt acctccttgt tagtgaaatt agatataagc catgatttgg
     6301 agagggaaga aatctggaat acttaatttc atttaattat ctatgctgat gaatgcctgt
     6361 atcattgtta ataaaggaga attgaaaata ctcatttcta ctttctgccc tcaaatttct
     6421 gtttctatct caactaggca agaatcagca gggtgcatga tgccatttta agctgcttca
     6481 catcagactg aaatcctaat tacagttcat aagtgaaaca gactaattca atggcaatac
     6541 cttttgtata ggtcctgtgc ttaaaggagg caagtataaa ttttctaata agaaatccct
     6601 gcttcttttg ggtgcagtgg ctcacacctg taataccagc agtttgagaa gctaaggcag
     6661 gtggatcact tgaggccagg agttcgagac cagcctggcc aacatagtga aaccccgtct
     6721 cttctaaaaa tacaaaaaaa ttagctgggc atggtggtgc acgcctatag tcccagctac
     6781 acaggaggct gaggcaggag aatcacttga acccgggaag cagagtctgc agtgagccaa
     6841 gatcgcggca ttgcacttca gcctgggcga tagagcaaga ctctgtctca gaaaaaaaaa
     6901 aaaaggaaag aaagaaatct ctgcttccgt actatcaaaa cttctaccct agaatacccc
     6961 ctggcacctt ctaacccaac ctaatacaga gattttgtag ggacccatta acaagctcct
     7021 atataattat aagcagctct cacagtaggg ttgaaagaga atataaggaa aattagaagt
     7081 actgtatttt tgctattgga aatgaaatat tgtttcatgc acctttgaaa aaaataacag
     7141 gattttacag ccttctgatg attcattcaa agcatgggga atagttcata tgtttgttaa
     7201 atgaaaatct tatgtagcta tttgtgtgtc cctcccactt cataactaca aaaacatata
     7261 tatgaatttc taaacaaagt gatattttaa agatgaattg attcaatgtg tacttaccag
     7321 tttactgtgt ggttttatct tcaggtacag atagtttgtg gtactacttg aaaatacctt
     7381 taatattatt ttcatcagaa tttgtaatat ataatccagt ttgggatgat gaataaaatt
     7441 tttctaatct cttga
//
