LOCUS       NM_022110               1342 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens FKBP prolyl isomerase like (FKBPL), mRNA.
ACCESSION   NM_022110
VERSION     NM_022110.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1342)
  AUTHORS   Chhor,M., Chen,H., Jerotic,D., Tesic,M., Nikolic,V.N., Pavlovic,M.,
            Vucic,R.M., Rayner,B., Watson,C.J., Ledwidge,M., McDonald,K.,
            Robson,T., McGrath,K.C. and McClements,L.
  TITLE     FK506-Binding Protein like (FKBPL) Has an Important Role in Heart
            Failure with Preserved Ejection Fraction Pathogenesis with
            Potential Diagnostic Utility
  JOURNAL   Biomolecules 13 (2), 395 (2023)
   PUBMED   36830764
  REMARK    GeneRIF: FK506-Binding Protein like (FKBPL) Has an Important Role
            in Heart Failure with Preserved Ejection Fraction Pathogenesis with
            Potential Diagnostic Utility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1342)
  AUTHORS   Obradovic,D.D., Milic,N.M., Miladinovic,N., McClements,L. and
            Opric,D.M.
  TITLE     Loss of Expression of Antiangiogenic Protein FKBPL in Endometrioid
            Endometrial Carcinoma: Implications for Clinical Practice
  JOURNAL   Medicina (Kaunas) 58 (10), 1330 (2022)
   PUBMED   36295491
  REMARK    GeneRIF: Loss of Expression of Antiangiogenic Protein FKBPL in
            Endometrioid Endometrial Carcinoma: Implications for Clinical
            Practice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1342)
  AUTHORS   Sengun,D.A., Tanoglu,E.G. and Ulucan,H.
  TITLE     A novel mutation in FK506 binding protein-like (FKBPL) causes male
            infertility
  JOURNAL   Croat Med J 62 (3), 227-232 (2021)
   PUBMED   34212559
  REMARK    GeneRIF: A novel mutation in FK506 binding protein-like (FKBPL)
            causes male infertility.
REFERENCE   4  (bases 1 to 1342)
  AUTHORS   Alqudah,A., Eastwood,K.A., Jerotic,D., Todd,N., Hoch,D.,
            McNally,R., Obradovic,D., Dugalic,S., Hunter,A.J., Holmes,V.A.,
            McCance,D.R., Young,I.S., Watson,C.J., Robson,T., Desoye,G.,
            Grieve,D.J. and McClements,L.
  TITLE     FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy
            Impacting on Angiogenesis and Endothelial Function
  JOURNAL   Front Endocrinol (Lausanne) 12, 650328 (2021)
   PUBMED   34149611
  REMARK    GeneRIF: FKBPL and SIRT-1 Are Downregulated by Diabetes in
            Pregnancy Impacting on Angiogenesis and Endothelial Function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1342)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1342)
  AUTHORS   McKeen,H.D., McAlpine,K., Valentine,A., Quinn,D.J., McClelland,K.,
            Byrne,C., O'Rourke,M., Young,S., Scott,C.J., McCarthy,H.O.,
            Hirst,D.G. and Robson,T.
  TITLE     A novel FK506-like binding protein interacts with the
            glucocorticoid receptor and regulates steroid receptor signaling
  JOURNAL   Endocrinology 149 (11), 5724-5734 (2008)
   PUBMED   18669603
  REMARK    GeneRIF: FKBPL can be classed as a new member of the FKBP protein
            family with a role in steroid receptor complexes and signaling.
REFERENCE   7  (bases 1 to 1342)
  AUTHORS   Jascur,T., Brickner,H., Salles-Passador,I., Barbier,V., El
            Khissiin,A., Smith,B., Fotedar,R. and Fotedar,A.
  TITLE     Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding
            TPR protein
  JOURNAL   Mol Cell 17 (2), 237-249 (2005)
   PUBMED   15664193
  REMARK    GeneRIF: Results demonstrate the importance of posttranslational
            stabilization of p21 protein by WISp39 in regulating cellular p21
            activity.
REFERENCE   8  (bases 1 to 1342)
  AUTHORS   Robson,T., Price,M.E., Moore,M.L., Joiner,M.C.,
            McKelvey-Martin,V.J., McKeown,S.R. and Hirst,D.G.
  TITLE     Increased repair and cell survival in cells treated with DIR1
            antisense oligonucleotides: implications for induced
            radioresistance
  JOURNAL   Int J Radiat Biol 76 (5), 617-623 (2000)
   PUBMED   10866283
REFERENCE   9  (bases 1 to 1342)
  AUTHORS   Robson,T., Joiner,M.C., Wilson,G.D., McCullough,W., Price,M.E.,
            Logan,I., Jones,H., McKeown,S.R. and Hirst,D.G.
  TITLE     A novel human stress response-related gene with a potential role in
            induced radioresistance
  JOURNAL   Radiat Res 152 (5), 451-461 (1999)
   PUBMED   10521921
REFERENCE   10 (bases 1 to 1342)
  AUTHORS   Robson,T.A., Lohrer,H., Bailie,J.R., Hirst,D.G., Joiner,M.C. and
            Arrand,J.E.
  TITLE     Gene regulation by low-dose ionizing radiation in a normal human
            lung epithelial cell line
  JOURNAL   Biochem Soc Trans 25 (1), 335-342 (1997)
   PUBMED   9056895
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662884.11.
            
            On Nov 25, 2018 this sequence version replaced NM_022110.3.
            
            Summary: The protein encoded by this gene has similarity to the
            immunophilin protein family, which play a role in immunoregulation
            and basic cellular processes involving protein folding and
            trafficking. The encoded protein is thought to have a potential
            role in the induced radioresistance. Also it appears to have some
            involvement in the control of the cell cycle. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027119.1, BC011966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375156.4/ ENSP00000364298.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AL662884.11        42922-43115         c
            195-1342            AL662884.11        41534-42681         c
FEATURES             Location/Qualifiers
     source          1..1342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..1342
                     /gene="FKBPL"
                     /gene_synonym="DIR1; NG7; WISP39"
                     /note="FKBP prolyl isomerase like"
                     /db_xref="GeneID:63943"
                     /db_xref="HGNC:HGNC:13949"
                     /db_xref="MIM:617076"
     exon            1..194
                     /gene="FKBPL"
                     /gene_synonym="DIR1; NG7; WISP39"
                     /inference="alignment:Splign:2.1.0"
     exon            195..1342
                     /gene="FKBPL"
                     /gene_synonym="DIR1; NG7; WISP39"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1318
                     /gene="FKBPL"
                     /gene_synonym="DIR1; NG7; WISP39"
                     /EC_number="5.2.1.8"
                     /note="WAF-1/CIP1 stabilizing protein 39; peptidyl-prolyl
                     cis-trans isomerase; FK506 binding protein like"
                     /codon_start=1
                     /product="FK506-binding protein-like"
                     /protein_id="NP_071393.2"
                     /db_xref="CCDS:CCDS4738.1"
                     /db_xref="GeneID:63943"
                     /db_xref="HGNC:HGNC:13949"
                     /db_xref="MIM:617076"
                     /translation="METPPVNTIGEKDTSQPQQEWEKNLRENLDSVIQIRQQPRDPPT
                     ETLELEVSPDPASQILEHTQGAEKLVAELEGDSHKSHGSTSQMPEALQASDLWYCPDG
                     SFVKKIVIRGHGLDKPKLGSCCRVLALGFPFGSGPPEGWTELTMGVGPWREETWGELI
                     EKCLESMCQGEEAELQLPGHSGPPVRLTLASFTQGRDSWELETSEKEALAREERARGT
                     ELFRAGNPEGAARCYGRALRLLLTLPPPGPPERTVLHANLAACQLLLGQPQLAAQSCD
                     RVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGK
                     NQDAGLAQGLRKMFG"
     regulatory      1318..1323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBPL"
                     /gene_synonym="DIR1; NG7; WISP39"
                     /note="hexamer: ATTAAA"
     polyA_site      1342
                     /gene="FKBPL"
                     /gene_synonym="DIR1; NG7; WISP39"
                     /note="major polyA site"
ORIGIN      
        1 gttagttgtc agtatctttc ccagttgttc cgccccctac ccccgcctcc cgcaccgcgc
       61 ccctctccgg ctgccctctc cgcgtggggc aaggctccga gggcagcatt cagtagccat
      121 ttagctttgg aaggagaggt gattcgaatg gcccggctcc tcctgtcacc atgctaggca
      181 ctttggccgc gcaggtgctg acctgaacct ggttcatccc tttctgacca aaactgttca
      241 ctcaccgtgg aagggactaa gcatccatat ggagacgcca ccagtcaata caattggaga
      301 aaaggacacc tctcagccgc aacaagagtg ggaaaagaac cttcgggaga accttgattc
      361 agttattcag attaggcagc agccccgaga ccctcctacc gaaacgcttg agctggaagt
      421 aagcccagat ccagccagcc aaattctaga gcatactcaa ggagctgaaa aactggttgc
      481 tgaacttgaa ggagactctc ataagtctca tggatcaacc agtcagatgc cagaggccct
      541 tcaagcttct gatctctggt actgccccga tgggagcttt gtcaagaaga tcgtaatccg
      601 tggccatggc ttggacaaac ccaaactagg ctcctgctgc cgggtactgg ctttggggtt
      661 tcctttcgga tcagggccgc cagagggctg gacagagcta actatgggcg tagggccatg
      721 gagggaggaa acttgggggg agctcataga gaaatgcttg gagtccatgt gtcaaggtga
      781 ggaagcagag cttcagctgc ctgggcactc tggacctcct gtcaggctca cactggcatc
      841 cttcactcaa ggccgagact cctgggagct ggagactagc gagaaggaag ccctggccag
      901 ggaagaacgt gcaaggggca cagaactatt tcgagctggg aaccctgaag gagctgcccg
      961 atgctatgga cgggctcttc ggctgctcct gactttaccc ccacctggcc ctccagaacg
     1021 aactgtcctt catgccaatc tggctgcctg tcagttgttg ctagggcagc ctcagttggc
     1081 agcccagagc tgtgaccggg tgttggagcg ggagcctggc catttaaagg ccttataccg
     1141 aaggggggtt gcccaggctg cccttgggaa cctggaaaaa gcaactgctg acctcaagaa
     1201 ggtgctggcg atagatccca aaaaccgggc agcccaggag gaactgggga aggtggtcat
     1261 tcaggggaag aaccaggatg cagggctggc tcagggtctg cgcaagatgt ttggctgatt
     1321 aaaagttaaa ccttaaaaga ga
//
