LOCUS       NM_007270               3424 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens FKBP prolyl isomerase 9 (FKBP9), transcript variant 1,
            mRNA.
ACCESSION   NM_007270
VERSION     NM_007270.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3424)
  AUTHORS   Xu,H., Liu,P., Yan,Y., Fang,K., Liang,D., Hou,X., Zhang,X., Wu,S.,
            Ma,J., Wang,R., Li,T., Piao,H. and Meng,S.
  TITLE     FKBP9 promotes the malignant behavior of glioblastoma cells and
            confers resistance to endoplasmic reticulum stress inducers
  JOURNAL   J Exp Clin Cancer Res 39 (1), 44 (2020)
   PUBMED   32111229
  REMARK    GeneRIF: FKBP9 promotes the malignant behavior of glioblastoma
            cells and confers resistance to endoplasmic reticulum stress
            inducers.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3424)
  AUTHORS   Jiang,F.N., Dai,L.J., Yang,S.B., Wu,Y.D., Liang,Y.X., Yin,X.L.,
            Zou,C.Y. and Zhong,W.D.
  TITLE     Increasing of FKBP9 can predict poor prognosis in patients with
            prostate cancer
  JOURNAL   Pathol Res Pract 216 (1), 152732 (2020)
   PUBMED   31780055
  REMARK    GeneRIF: Increasing of FKBP9 can predict poor prognosis in patients
            with prostate cancer.
REFERENCE   3  (bases 1 to 3424)
  AUTHORS   Zhang,H., Li,X.J., Martin,D.B. and Aebersold,R.
  TITLE     Identification and quantification of N-linked glycoproteins using
            hydrazide chemistry, stable isotope labeling and mass spectrometry
  JOURNAL   Nat Biotechnol 21 (6), 660-666 (2003)
   PUBMED   12754519
REFERENCE   4  (bases 1 to 3424)
  AUTHORS   Patterson,C.E., Gao,J., Rooney,A.P. and Davis,E.C.
  TITLE     Genomic organization of mouse and human 65 kDa FK506-binding
            protein genes and evolution of the FKBP multigene family
  JOURNAL   Genomics 79 (6), 881-889 (2002)
   PUBMED   12036304
REFERENCE   5  (bases 1 to 3424)
  AUTHORS   Shadidy,M., Caubit,X., Olsen,R., Seternes,O.M., Moens,U. and
            Krauss,S.
  TITLE     Biochemical analysis of mouse FKBP60, a novel member of the FKPB
            family
  JOURNAL   Biochim Biophys Acta 1446 (3), 295-307 (1999)
   PUBMED   10524204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA234297.1, BC101723.1 and BC099918.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007270.4.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075331.1, SRR1803615.247093.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242209.9/ ENSP00000242209.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DA234297.1         37-72
            37-1904             BC101723.1         1-1868
            1905-3424           BC099918.1         503-2022
FEATURES             Location/Qualifiers
     source          1..3424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..3424
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /note="FKBP prolyl isomerase 9"
                     /db_xref="GeneID:11328"
                     /db_xref="HGNC:HGNC:3725"
                     /db_xref="MIM:616257"
     exon            1..355
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1847
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; peptidyl-prolyl cis-trans isomerase FKBP9;
                     rotamase; FK506-binding protein 9; FKBP-9; FKBP-63; 63 kDa
                     FKBP; PPIase FKBP9; 63 kDa FK506-binding protein; FK506
                     binding protein 9, 63 kDa"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP9
                     isoform 1 precursor"
                     /protein_id="NP_009201.2"
                     /db_xref="CCDS:CCDS5439.1"
                     /db_xref="GeneID:11328"
                     /db_xref="HGNC:HGNC:3725"
                     /db_xref="MIM:616257"
                     /translation="MAFRGWRPPPPPLLLLLLWVTGQAAPVAGLGSDAELQIERRFVP
                     DECPRTVRSGDFVRYHYVGTFPDGQKFDSSYDRDSTFNVFVGKGQLITGMDQALVGMC
                     VNERRFVKIPPKLAYGNEGVSGVIPPNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCP
                     RTIQVSDFVRYHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEK
                     RIITIPPFLAYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQ
                     SGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIV
                     VPPHLGYGEEGRGNIPGSAVLVFDIHVIDFHNPSDSISITSHYKPPDCSVLSKKGDYL
                     KYHYNASLLDGTLLDSTWNLGKTYNIVLGSGQVVLGMDMGLREMCVGEKRTVIIPPHL
                     GYGEAGVDGEVPGSAVLVFDIELLELVAGLPEGYMFIWNGEVSPNLFEEIDKDGNGEV
                     LLEEFSEYIHAQVASGKGKLAPGFDAELIVKNMFTNQDRNGDGKVTAEEFKLKDQEAK
                     HDEL"
     exon            356..501
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            502..691
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            692..837
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1027
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1173
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1360
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1506
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1670
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..3424
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3406..3411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /note="hexamer: TATAAA"
     polyA_site      3424
                     /gene="FKBP9"
                     /gene_synonym="FKBP60; FKBP63; PPIase"
                     /note="major polyA site"
ORIGIN      
        1 gagacggggt ggcggctgca gcccgggtag ggccaggaga cccggtccac gtttgcaaac
       61 gcagccgaac gcccaggccg acccgtgccg cccgagcgcc gcgctgcgtc cgcgccactc
      121 ttctcgccgc cccgatggcg ttccggggct ggaggccccc gccgccaccg ctgctcctgc
      181 tgctgctctg ggtgaccggg caggcagcgc ccgtggcggg cctgggctcc gacgcggagc
      241 tgcagatcga gcggcgcttc gtgcccgacg agtgcccgcg caccgtgcgc agcggcgact
      301 tcgtgcgcta ccactacgtg gggacgttcc ccgacggcca gaagttcgac tccagctatg
      361 acagagactc cactttcaat gtgtttgtgg gaaaaggaca gctgatcaca gggatggacc
      421 aggctcttgt tgggatgtgc gtaaacgaga gacgtttcgt gaagattccc ccaaagcttg
      481 cctacggaaa tgaaggagtt tctggtgtga tcccccccaa ttcagtgctt cattttgatg
      541 tacttctgat ggatatttgg aattctgaag accaggttca gattcacacc tatttcaagc
      601 ccccgagttg ccctcggacc atccaggtgt ctgattttgt gaggtaccac tacaacggga
      661 cgttcctgga cggaactctg tttgattcga gtcacaatcg catgaaaaca tatgacacgt
      721 atgtgggaat tggctggctg attcctggaa tggataaagg gctgctgggg atgtgtgtgg
      781 gtgagaagcg catcatcacc attcctcctt ttctggccta tggagaggat ggagatggga
      841 aagacattcc cggtcaggca tctctggtgt ttgatgttgc attattggac ctccataacc
      901 ccaaggacag catttccatt gagaacaagg tagtacctga aaactgtgag cggataagtc
      961 aaagtgggga ctttctcagg tatcattaca atggcacgct tctggatggc accctctttg
     1021 attccagcta ctctcggaac cgcacgtttg acacgtacat tgggcagggc tacgtgattc
     1081 ctgggatgga tgaaggtcta cttggtgttt gcattggaga aaagcgaagg attgtggtcc
     1141 cgcctcacct ggggtatgga gaggaaggaa gagggaatat ccccggctcg gctgtgctgg
     1201 tgtttgacat ccatgtgatc gacttccaca acccttcgga ctccatcagc atcacctccc
     1261 actacaaacc ccctgactgc tcagtgctga gtaagaaggg agattacctc aaatatcact
     1321 acaatgcctc acttctggat gggaccctgc tggactccac gtggaattta ggcaaaactt
     1381 acaatattgt tctgggatct gggcaagttg tgttggggat ggacatgggt ctcagagaga
     1441 tgtgcgttgg cgagaaacgg acagtgatca ttccgcctca cctgggctat ggggaagctg
     1501 gcgtggatgg agaagtgccc ggcagtgccg tattagtgtt tgacattgag ctgctggagc
     1561 tggtggctgg ccttcctgag gggtacatgt tcatatggaa tggtgaggtg tcacccaacc
     1621 tctttgaaga aattgacaag gatggcaacg gagaagtcct cctggaagag ttctcagagt
     1681 acattcacgc ccaggtggca tctggcaaag ggaaactcgc tcctggcttt gatgctgagc
     1741 tgattgtgaa gaatatgttc accaaccagg accggaatgg agatgggaag gtcacagccg
     1801 aggaatttaa actcaaagac caggaagcca aacacgatga actctaaacc tggcatgaac
     1861 cagatggtgc cagggagtac gtgacaccaa gccacctgtg tggcaagacg tgcagtgagg
     1921 gtgcaagggt ctctcagaag ttgcatcatt agccagtagt aggtgggtca catagtacct
     1981 ggtgtacaca tcggggtggg ttgatatatg gggtgagaag tttgggctga tcgccagtga
     2041 tagtaaacaa aatctgtgca gagggcctta gcatgggatg tgtccagtat tgaaaaggct
     2101 gcactgccaa ccatgatttg tgagccttct gggaaatttt gttattaaag gaatatatag
     2161 tgtcagacgg aagttataat catcttggag gaaccataag aaaaggtgtc cagggtatct
     2221 atataaagag ggttaaattt ttttttaact tgctggttaa aacattttag aaatattcta
     2281 gagatgggca ggagagtcaa agggcttgct tgccccagca gagttcccag cagacagcca
     2341 tggctcttcc cagcagcctg tgcaaattct gatgatggcc ccacccccgc acacgcacac
     2401 gcacatcatg cttttccagc tcatcacacc ccgccccact atgggcctac cattaatagt
     2461 gtataacttg gaggttaaaa gagccttttg gacagaaaac tgggccagga aaaggcatct
     2521 cagaccacaa atagagaatt tgattcctca tttgccacat aagtcatctg cttagctttt
     2581 cctttccttt tttttttttt ttttttttct ggaggcagag tctccctttg tcgccaggct
     2641 ggagtgcagt ggtgccatct cggctcactg cagcactgtc tcggctcact gcagcctccg
     2701 cctcccgtat tcaagcgatt ctcctgtctc agcctcctga gtagctggga ctacaggtgt
     2761 gcaccaccac gcccggctaa tttttgtatt tttagtagag acggggtttc actgtgttgg
     2821 ccaggatggt ctcaatctcg acctcgtgat ccgcccacct tggcctccca aagtgttggg
     2881 attacaggcg tgactcacca tgcccagcca cttagttttt tcttattccc acctttctat
     2941 cccatagaac actctttttt atcttccctg aaccatattg atgagataaa tagggctggg
     3001 ggctgggccc cgctggtcac tcaacagagt atttcccttg gccgagatgg aagttttgtc
     3061 ccaatagatg agctgctgag catcaacaag gtgacatttt tctgctgccc atttgtgtcc
     3121 tggagacggt ggtaccctga aggcagaggc cagctgccgc aagacagcaa tgacagtcca
     3181 cctgccgacc tgattcctgc atcatggaat aaccacatgg ctaccttcta tcctctgttc
     3241 ccaaatggtg gtggcactta tcctgaagtc gtcaatgatt tccctttgaa actactttat
     3301 tttactaatt taaactattt tgtactgatg tagccctgag gtagttcatg aaaatgctgt
     3361 gcactcattc catggaataa atgttggaaa gctgatcttt tctgatataa aatgttgaat
     3421 gata
//
