LOCUS       NM_012181               1761 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens FKBP prolyl isomerase 8 (FKBP8), transcript variant 1,
            mRNA.
ACCESSION   NM_012181
VERSION     NM_012181.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1761)
  AUTHORS   Jin,Z., Xu,W., Yu,K., Luo,C., Luo,X., Lian,T. and Liu,C.
  TITLE     The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a
            regulatory network in breast cancer
  JOURNAL   Hereditas 161 (1), 27 (2024)
   PUBMED   39192374
  REMARK    GeneRIF: The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a
            regulatory network in breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1761)
  AUTHORS   Yan,Y., Wang,S., Zhang,Z., Tang,M., Zhao,A.Z., Li,Z., Wu,X. and
            Li,F.
  TITLE     FKBP38 suppresses endometrial cancer cell proliferation and
            metastasis by inhibiting the mTOR pathway
  JOURNAL   Arch Biochem Biophys 752, 109891 (2024)
   PUBMED   38218360
  REMARK    GeneRIF: FKBP38 suppresses endometrial cancer cell proliferation
            and metastasis by inhibiting the mTOR pathway.
REFERENCE   3  (bases 1 to 1761)
  AUTHORS   Dang,T., Yu,J., Yu,Y., Jiang,J., Shi,Y., Yu,S., Peng,C., Min,X.,
            Xiong,Y., Long,P., Zhou,W. and Dai,D.
  TITLE     GPX4 inhibits apoptosis of thyroid cancer cells through regulating
            the FKBP8/Bcl-2 axis
  JOURNAL   Cancer Biomark 39 (4), 349-360 (2024)
   PUBMED   38250761
  REMARK    GeneRIF: GPX4 inhibits apoptosis of thyroid cancer cells through
            regulating the FKBP8/Bcl-2 axis.
REFERENCE   4  (bases 1 to 1761)
  AUTHORS   Dowling,A.L., Walbridge,S., Ertekin,C., Namagiri,S., Camacho,K.,
            Chowdhury,A., Bryant,J.P., Kohut,E., Heiss,J.D., Brown,D.A.,
            Kumbar,S.G. and Banasavadi-Siddegowda,Y.K.
  TITLE     FKBP38 Regulates Self-Renewal and Survival of GBM Neurospheres
  JOURNAL   Cells 12 (21), 2562 (2023)
   PUBMED   37947640
  REMARK    GeneRIF: FKBP38 Regulates Self-Renewal and Survival of GBM
            Neurospheres.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1761)
  AUTHORS   Zhou,Y., Zhao,H., Shuai,L., She,J., Diao,R. and Wang,L.
  TITLE     [Fkbp38 deletion induces premature ovarian insufficiency in mice by
            activating mTOR signaling and inducing granulosa cell apoptosis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (11), 1611-1617 (2022)
   PUBMED   36504053
  REMARK    GeneRIF: [Fkbp38 deletion induces premature ovarian insufficiency
            in mice by activating mTOR signaling and inducing granulosa cell
            apoptosis].
REFERENCE   6  (bases 1 to 1761)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   7  (bases 1 to 1761)
  AUTHORS   Rosner,M., Hofer,K., Kubista,M. and Hengstschlager,M.
  TITLE     Cell size regulation by the human TSC tumor suppressor proteins
            depends on PI3K and FKBP38
  JOURNAL   Oncogene 22 (31), 4786-4798 (2003)
   PUBMED   12894220
  REMARK    GeneRIF: FKBP38 plays a role in TSC gene-dependent cell size
            regulation.
REFERENCE   8  (bases 1 to 1761)
  AUTHORS   Shirane,M. and Nakayama,K.I.
  TITLE     Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria
            and inhibits apoptosis
  JOURNAL   Nat Cell Biol 5 (1), 28-37 (2003)
   PUBMED   12510191
REFERENCE   9  (bases 1 to 1761)
  AUTHORS   Pedersen,K.M., Finsen,B., Celis,J.E. and Jensen,N.A.
  TITLE     muFKBP38: a novel murine immunophilin homolog differentially
            expressed in Schwannoma cells and central nervous system neurons in
            vivo
  JOURNAL   Electrophoresis 20 (2), 249-255 (1999)
   PUBMED   10197430
REFERENCE   10 (bases 1 to 1761)
  AUTHORS   Lam,E., Martin,M. and Wiederrecht,G.
  TITLE     Isolation of a cDNA encoding a novel human FK506-binding protein
            homolog containing leucine zipper and tetratricopeptide repeat
            motifs
  JOURNAL   Gene 160 (2), 297-302 (1995)
   PUBMED   7543869
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX538124.1, BC009966.1 and
            BU752982.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012181.4.
            
            Summary: The protein encoded by this gene is a member of the
            immunophilin protein family, which play a role in immunoregulation
            and basic cellular processes involving protein folding and
            trafficking. Unlike the other members of the family, this encoded
            protein does not seem to have PPIase/rotamase activity. It may have
            a role in neurons associated with memory function. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647405.1, BX538124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000608443.6/ ENSP00000476767.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-543               BX538124.1         2-544
            544-664             BC009966.1         274-394
            665-687             BX538124.1         666-688
            688-1760            BC009966.1         415-1487
            1761-1761           BU752982.1         28-28               c
FEATURES             Location/Qualifiers
     source          1..1761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1761
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /note="FKBP prolyl isomerase 8"
                     /db_xref="GeneID:23770"
                     /db_xref="HGNC:HGNC:3724"
                     /db_xref="MIM:604840"
     exon            1..88
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /inference="alignment:Splign:2.1.0"
     exon            89..405
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1355
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peptidyl-prolyl cis-trans isomerase FKBP8; FKBP-8;
                     FKBP-38; hFKBP38; rotamase; FK506-binding protein 8; 38
                     kDa FKBP; PPIase FKBP8; 38 kDa FK506-binding protein;
                     FK506 binding protein 8, 38kDa"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP8
                     isoform 1"
                     /protein_id="NP_036313.3"
                     /db_xref="CCDS:CCDS32961.1"
                     /db_xref="GeneID:23770"
                     /db_xref="HGNC:HGNC:3724"
                     /db_xref="MIM:604840"
                     /translation="MASCAEPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEE
                     EEDDLSELPPLEDMGQPPAEEAEQPGALAREFLAAMEPEPAPAPAPEEWLDILGNGLL
                     RKKTLVPGPPGSSRPVKGQVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSV
                     PLMDVGETAMVTADSKYCYGPQGSRSPYIPPHAALCLEVTLKTAVDGPDLEMLTGQER
                     VALANRKRECGNAHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCL
                     NNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAAL
                     KLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSIPWKWL
                     FGATAVALGGVALSVVIAARN"
     exon            406..575
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /inference="alignment:Splign:2.1.0"
     exon            576..664
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /inference="alignment:Splign:2.1.0"
     exon            665..885
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1058
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1136
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1268
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1761
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1741..1746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /note="hexamer: AATAAA"
     polyA_site      1761
                     /gene="FKBP8"
                     /gene_synonym="FKBP38; FKBPr38"
                     /note="major polyA site"
ORIGIN      
        1 ggccgaacct ggttcccgag gcgcggcggc cgcggctggg ggcggggagg ggggcgcagg
       61 accccaagtg ggggtcccgg agccagaggg ccaattcctg tccccccagc agcatggcat
      121 cgtgtgctga accctctgag ccctctgccc cactgcccgc cggggtccca ccgctcgagg
      181 acttcgaggt actggatggg gttgaggatg cagagggtga ggaggaagag gaggaggaag
      241 aggaggaaga ggatgacctg agtgagctgc caccgctgga ggacatggga caacccccgg
      301 cggaggaggc tgagcagcct ggggccctgg cccgagagtt ccttgctgcc atggagcccg
      361 agcccgcccc agccccggcc ccagaagagt ggctggacat tctggggaac gggctgttga
      421 ggaagaagac gctggtccca gggccgccag gttcgagccg cccggtcaag ggccaggtgg
      481 tcaccgtaca tctgcagacg tcgctggaga atggcacacg ggtgcaggag gagccggagc
      541 tggtgttcac tctgggtgac tgtgacgtca tccaggccct ggatctcagt gtcccactca
      601 tggacgtggg ggagacggcc atggtcactg ctgactccaa gtactgctac ggcccccaag
      661 gcagcaggag cccatacatc cccccgcacg cggccctgtg cctggaggtg accctgaaga
      721 cggctgtgga cgggcctgac ctggagatgc tcacggggca ggagcgcgtg gccctggcca
      781 accggaagcg ggagtgcggc aacgcccact accagcgggc ggacttcgtc ctggccgcca
      841 actcctacga cctcgccatc aaggctatca cctccagcgc caaagtggac atgacgttcg
      901 aggaggaggc acagctcctg cagttgaagg tgaagtgtct gaacaacctg gcggcctcgc
      961 agctgaagct cgaccactac cgcgcagccc tgcgctcctg cagccttgtg ctggagcacc
     1021 agccagacaa catcaaggct ctcttccgca agggcaaggt gctggcccag cagggggagt
     1081 acagtgaggc catccccatc ctgagggcag ccctgaagct ggaaccttcc aacaagacga
     1141 tccacgcaga gctctcaaag ctggtgaaga agcatgcggc gcagcggagc acggagaccg
     1201 ccttgtaccg gaaaatgctg ggcaacccca gccggctgcc tgctaagtgc cctggcaagg
     1261 gtgcctggtc catcccatgg aagtggctgt ttggggcgac tgctgttgcc ttggggggtg
     1321 tggcactctc tgtggtcatc gctgccagga actgaccacc taggtggctg ccaccccctc
     1381 tgcacaccat ggaccctgcc ctgcgctccc caactccccc aggctccctg tccactgccc
     1441 tccctggtct ggccccctcc tccgggttag gggagcaagg attgggggtc gtgcagccca
     1501 gccagcagga gggactgagg ccctctagga ggaaagccca gagggagggg gccctcattc
     1561 cttcagaccc agttttcccc caccctcctt accccgctgg gctaggtctc cgccagggct
     1621 ggcctcagtt tctcctcaac aggcctgggg gcagcccttc ccctgcctag tccccgcctg
     1681 agtgccagcc ccccaccccg cctgccgccc cctgtccagg ttccctcccc gccacagtga
     1741 aataaagcat cccaccctgc a
//
