LOCUS       NM_181342               2876 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens FKBP prolyl isomerase 7 (FKBP7), transcript variant 1,
            mRNA.
ACCESSION   NM_181342
VERSION     NM_181342.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2876)
  AUTHORS   Lobo,J.J., Ayoub,L.J., Moayedi,M. and Linnstaedt,S.D.
  TITLE     Hippocampal volume, FKBP5 genetic risk alleles, and childhood
            trauma interact to increase vulnerability to chronic multisite
            musculoskeletal pain
  JOURNAL   Sci Rep 12 (1), 6511 (2022)
   PUBMED   35444168
  REMARK    GeneRIF: Hippocampal volume, FKBP5 genetic risk alleles, and
            childhood trauma interact to increase vulnerability to chronic
            multisite musculoskeletal pain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2876)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2876)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2876)
  AUTHORS   Ishikawa,Y., Mizuno,K. and Bachinger,H.P.
  TITLE     Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident
            peptidyl prolyl isomerases show different activities toward
            hydroxyproline
  JOURNAL   J Biol Chem 292 (22), 9273-9282 (2017)
   PUBMED   28385890
  REMARK    GeneRIF: observed changes in activity of six rER-resident PPIases,
            cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19
            (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due
            to posttranslational modifications of proline residues in the
            substrate.
REFERENCE   5  (bases 1 to 2876)
  AUTHORS   Peter,I., Papandonatos,G.D., Belalcazar,L.M., Yang,Y., Erar,B.,
            Jakicic,J.M., Unick,J.L., Balasubramanyam,A., Lipkin,E.W.,
            Delahanty,L.M., Wagenknecht,L.E., Wing,R.R., McCaffery,J.M. and
            Huggins,G.S.
  CONSRTM   Look AHEAD Research Group
  TITLE     Genetic modifiers of cardiorespiratory fitness response to
            lifestyle intervention
  JOURNAL   Med Sci Sports Exerc 46 (2), 302-311 (2014)
   PUBMED   23899896
  REMARK    GeneRIF: RUNX1 and FKBP7, involved in erythropoesis and muscle
            protein synthesis, respectively, are related to change in
            cardiorespiratory fitness in response to exercise.
REFERENCE   6  (bases 1 to 2876)
  AUTHORS   Kang,S.M., Shin,M.J., Kim,J.H. and Oh,J.W.
  TITLE     Proteomic profiling of cellular proteins interacting with the
            hepatitis C virus core protein
  JOURNAL   Proteomics 5 (8), 2227-2237 (2005)
   PUBMED   15846844
REFERENCE   7  (bases 1 to 2876)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 2876)
  AUTHORS   Patterson,C.E., Gao,J., Rooney,A.P. and Davis,E.C.
  TITLE     Genomic organization of mouse and human 65 kDa FK506-binding
            protein genes and evolution of the FKBP multigene family
  JOURNAL   Genomics 79 (6), 881-889 (2002)
   PUBMED   12036304
REFERENCE   9  (bases 1 to 2876)
  AUTHORS   Nakamura,T., Yabe,D., Kanazawa,N., Tashiro,K., Sasayama,S. and
            Honjo,T.
  TITLE     Molecular cloning, characterization, and chromosomal localization
            of FKBP23, a novel FK506-binding protein with Ca2+-binding ability
  JOURNAL   Genomics 54 (1), 89-98 (1998)
   PUBMED   9806833
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA020387.1, BC009711.1,
            AC009948.3 and AA447628.1.
            
            On Nov 22, 2018 this sequence version replaced NM_181342.2.
            
            Summary: The protein encoded by this gene belongs to the FKBP-type
            peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of
            this family exhibit PPIase activity and function as molecular
            chaperones. A similar protein in mouse is located in the
            endoplasmic reticulum and binds calcium. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.158278.1,
                                           SRR1660807.250813.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA2145245 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424785.7/ ENSP00000413152.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                DA020387.1         29-78
            51-941              BC009711.1         1-891
            942-2659            AC009948.3         70471-72188         c
            2660-2876           AA447628.1         6-222               c
FEATURES             Location/Qualifiers
     source          1..2876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.2"
     gene            1..2876
                     /gene="FKBP7"
                     /gene_synonym="FKBP23; PPIase"
                     /note="FKBP prolyl isomerase 7"
                     /db_xref="GeneID:51661"
                     /db_xref="HGNC:HGNC:3723"
                     /db_xref="MIM:607062"
     exon            1..322
                     /gene="FKBP7"
                     /gene_synonym="FKBP23; PPIase"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..770
                     /gene="FKBP7"
                     /gene_synonym="FKBP23; PPIase"
                     /EC_number="5.2.1.8"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; rotamase; FK506-binding protein 23;
                     peptidyl-prolyl cis-trans isomerase FKBP7; FKBP-7;
                     FKBP-23; 23 kDa FKBP; PPIase FKBP7; FK506 binding protein
                     7; 23 kDa FK506-binding protein"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP7
                     isoform a precursor"
                     /protein_id="NP_851939.1"
                     /db_xref="CCDS:CCDS2280.1"
                     /db_xref="GeneID:51661"
                     /db_xref="HGNC:HGNC:3723"
                     /db_xref="MIM:607062"
                     /translation="MPKTMHFLFRFIVFFYLWGLFTAQRQKKEESTEEVKIEVLHRPE
                     NCSKTSKKGDLLNAHYDGYLAKDGSKFYCSRTQNEGHPKWFVLGVGQVIKGLDIAMTD
                     MCPGEKRKVVIPPSFAYGKEGYAEGKIPPDATLIFEIELYAVTKGPRSIETFKQIDMD
                     NDRQLSKAEINLYLQREFEKDEKPRDKSYQDAVLEDIFKKNDHDGDGFISPKEYNVYQ
                     HDEL"
     exon            323..474
                     /gene="FKBP7"
                     /gene_synonym="FKBP23; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            475..608
                     /gene="FKBP7"
                     /gene_synonym="FKBP23; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            609..2876
                     /gene="FKBP7"
                     /gene_synonym="FKBP23; PPIase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      912..917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP7"
                     /gene_synonym="FKBP23; PPIase"
                     /note="hexamer: AATAAA"
     polyA_site      941
                     /gene="FKBP7"
                     /gene_synonym="FKBP23; PPIase"
                     /note="major polyA site"
     regulatory      2849..2854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP7"
                     /gene_synonym="FKBP23; PPIase"
                     /note="hexamer: AATAAA"
     polyA_site      2876
                     /gene="FKBP7"
                     /gene_synonym="FKBP23; PPIase"
ORIGIN      
        1 gtgacgcagg acaacgcctg ccacgcgtcg gaactcggcc gcgggacatc cacggggcgc
       61 gagtgacacg cgggagggag agcagtgttc tgctggagcc gatgccaaaa accatgcatt
      121 tcttattcag attcattgtt ttcttttatc tgtggggcct ttttactgct cagagacaaa
      181 agaaagagga gagcaccgaa gaagtgaaaa tagaagtttt gcatcgtcca gaaaactgct
      241 ctaagacaag caagaaggga gacctactaa atgcccatta tgacggctac ctggctaaag
      301 acggctcgaa attctactgc agccggacac aaaatgaagg ccaccccaaa tggtttgttc
      361 ttggtgttgg gcaagtcata aaaggcctag acattgctat gacagatatg tgccctggag
      421 aaaagcgaaa agtagttata cccccttcat ttgcatacgg aaaggaaggc tatgcagaag
      481 gcaagattcc accggatgct acattgattt ttgagattga actttatgct gtgaccaaag
      541 gaccacggag cattgagaca tttaaacaaa tagacatgga caatgacagg cagctctcta
      601 aagccgagat aaacctctac ttgcaaaggg aatttgaaaa agatgagaag ccacgtgaca
      661 agtcatatca ggatgcagtt ttagaagata tttttaagaa gaatgaccat gatggtgatg
      721 gcttcatttc tcccaaggaa tacaatgtat accaacacga tgaactatag catatttgta
      781 tttctacttt ttttttttag ctatttactg tactttatgt ataaaacaaa gtcacttttc
      841 tccaagttgt atttgctatt tttcccctat gagaagatat tttgatctcc ccaatacatt
      901 gattttggta taataaatgt gaggctgttt tgcaaactta acttgcagga atggtatgac
      961 tgtgtttcct actgctttat tctgtaaaca agaattgtag caccatgaaa cagacctctg
     1021 ggtcccagtg ggcatttttt cccctttcag gatgtaggag gacatgtata gtatgtcaaa
     1081 aactgcaagc ttttcccaac tttaacctta ccagcatgtt aatatccagt ttttttatag
     1141 tttaaaagtt aaagtgcctc atattttgaa aatatccatt aaggacccag gaattagcat
     1201 ttcacttgtt tatacatttt tataacatta tgaagacgat ataaaaatcc tagaactgaa
     1261 gagtcttcct ttggtatatg tgcaggaaga tagttgtata tctctgttcc acaaagaacg
     1321 caacacagtc tctaaacttt ttggtgtaag cttctagcct tgggtatttt ccagtgggga
     1381 atgtttaaaa atatttgacc aaaccaaaga ctttttgcct cttatagcaa gcataaagac
     1441 tgtactgcct ggcttttgta ttccttcaga cattattgta aatgtgcaac tcctcttccc
     1501 tcttgtaaac ctttataaga tgtctgccac cccaagcttt tgtcttgata gttttaaatt
     1561 gatgccatga aatttcttag ttttcgttcc ctttctctag ttatctcttt ccttatgtca
     1621 cctcatttcc catcattctt gtcactaatg atgaatgatc attacaaatt ggtatgctgt
     1681 caaattttga taaatgtgcc aaacaaagga ggatatacag tgccatggca attttgtgtc
     1741 atggtcaagt tatgatatca tatgacttga gaatagtatg taagagatgc tgtagaagat
     1801 cacgttggta ccaaagaaag ggcacatgtc tatcggaaca tagattttgc atactgcatg
     1861 gtatggtcag gctttgtgtc cacacccaaa tctcatcttg aaattataat ccccataatt
     1921 tccataatcc ccacatgtca atggagagac caggtggagg taactgaatc atgggggtgg
     1981 ttttccccgt gctgttctca tgcaatctga tggttttata agtgtttggt agttcctctt
     2041 gcattcattc tcccacccgc caccttgtga agaaagtcct tgcttccccg ccttccacca
     2101 tgattgtaag cttcctgagg cctccccagc catggggaac catgagtcaa tttaacctct
     2161 ttcctttaca aattacccag tctggggcag ttctttatag cagtgtgaaa atggactact
     2221 acactgcata tataggaaag tatggtcaga cagtaaatag ctctgttcaa aataattgag
     2281 ttccaaacaa gtaaagtttt ttctaccttc tgaaacttgc tctttccaaa ccattgttca
     2341 tcctttaact tctttacact atcaaaaatt ctatttaaaa atagagggct ttcagatgag
     2401 tacatacaaa aacaaacaaa agtatacata ggggtaacac aaccatgaga ttagtaaata
     2461 atacatatgg ctagcacata atttgacacc ttataaaaca agaatctgta ctatcttttc
     2521 cttcctccca atatttcttc atttctatgc tcaattttct aatacttttt cacatgctta
     2581 atcatttact ctttcatcgc cttccctcaa aaaaacctgc tccgttgaag taaactaagt
     2641 aactcaatat tctttatttt ggtttggaac ctgtctcaat tttttgtatc catattaaga
     2701 agtcacccta taatctaaac tttgtaattc taattttttt gtcccattat catacaaagt
     2761 gcttttaaac ttgtttttaa aaaatgacag ataatgccac atgaatagga agatgattca
     2821 ttctaaaact tgtatttaca taattaaaaa taaatttata atcattctac atacaa
//
