LOCUS       NM_004117               3750 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens FKBP prolyl isomerase 5 (FKBP5), transcript variant 1,
            mRNA.
ACCESSION   NM_004117
VERSION     NM_004117.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3750)
  AUTHORS   Zhang,Y., Yue,W. and Li,J.
  TITLE     The association of FKBP5 gene polymorphism with genetic
            susceptibility to depression and response to antidepressant
            treatment- a systematic review
  JOURNAL   BMC Psychiatry 24 (1), 274 (2024)
   PUBMED   38609904
  REMARK    GeneRIF: The association of FKBP5 gene polymorphism with genetic
            susceptibility to depression and response to antidepressant
            treatment- a systematic review.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3750)
  AUTHORS   Zimmer,C., Jimeno,B. and Martin,L.B.
  TITLE     HPA flexibility and FKBP5: promising physiological targets for
            conservation
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 379 (1898), 20220512 (2024)
   PUBMED   38310934
  REMARK    GeneRIF: HPA flexibility and FKBP5: promising physiological targets
            for conservation.
            Review article
REFERENCE   3  (bases 1 to 3750)
  AUTHORS   Hori,H., Yoshida,F., Ishida,I., Matsuo,J., Ogawa,S., Hattori,K.,
            Kim,Y. and Kunugi,H.
  TITLE     Blood mRNA expression levels of glucocorticoid receptors and FKBP5
            are associated with depressive disorder and altered HPA axis
  JOURNAL   J Affect Disord 349, 244-253 (2024)
   PUBMED   38199409
  REMARK    GeneRIF: Blood mRNA expression levels of glucocorticoid receptors
            and FKBP5 are associated with depressive disorder and altered HPA
            axis.
REFERENCE   4  (bases 1 to 3750)
  AUTHORS   Grossmann,N.L., Weihs,A., Kuhn,L., Sauer,S., Roh,S., Wiechmann,T.,
            Rex-Haffner,M., Volzke,H., Volker,U., Binder,E.B., Teumer,A.,
            Homuth,G., Klinger-Konig,J. and Grabe,H.J.
  TITLE     Methylation Patterns of the FKBP5 Gene in Association with
            Childhood Maltreatment and Depressive Disorders
  JOURNAL   Int J Mol Sci 25 (3), 1485 (2024)
   PUBMED   38338761
  REMARK    GeneRIF: Methylation Patterns of the FKBP5 Gene in Association with
            Childhood Maltreatment and Depressive Disorders.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3750)
  AUTHORS   Stroud,L.R., Jao,N.C., Ward,L.G., Lee,S.Y. and Marsit,C.J.
  TITLE     Differential impact of prenatal PTSD symptoms and preconception
            trauma exposure on placental NR3C1 and FKBP5 methylation
  JOURNAL   Stress 27 (1), 2321595 (2024)
   PUBMED   38676353
  REMARK    GeneRIF: Differential impact of prenatal PTSD symptoms and
            preconception trauma exposure on placental NR3C1 and FKBP5
            methylation.
REFERENCE   6  (bases 1 to 3750)
  AUTHORS   Nair,S.C., Rimerman,R.A., Toran,E.J., Chen,S., Prapapanich,V.,
            Butts,R.N. and Smith,D.F.
  TITLE     Molecular cloning of human FKBP51 and comparisons of immunophilin
            interactions with Hsp90 and progesterone receptor
  JOURNAL   Mol Cell Biol 17 (2), 594-603 (1997)
   PUBMED   9001212
REFERENCE   7  (bases 1 to 3750)
  AUTHORS   Johnson,J., Corbisier,R., Stensgard,B. and Toft,D.
  TITLE     The involvement of p23, hsp90, and immunophilins in the assembly of
            progesterone receptor complexes
  JOURNAL   J Steroid Biochem Mol Biol 56 (1-6 Spec No), 31-37 (1996)
   PUBMED   8603045
REFERENCE   8  (bases 1 to 3750)
  AUTHORS   Baughman,G., Wiederrecht,G.J., Campbell,N.F., Martin,M.M. and
            Bourgeois,S.
  TITLE     FKBP51, a novel T-cell-specific immunophilin capable of calcineurin
            inhibition
  JOURNAL   Mol Cell Biol 15 (8), 4395-4402 (1995)
   PUBMED   7542743
REFERENCE   9  (bases 1 to 3750)
  AUTHORS   Smith,D.F., Albers,M.W., Schreiber,S.L., Leach,K.L. and Deibel,M.R.
            Jr.
  TITLE     FKBP54, a novel FK506-binding protein in avian progesterone
            receptor complexes and HeLa extracts
  JOURNAL   J Biol Chem 268 (32), 24270-24273 (1993)
   PUBMED   7693698
REFERENCE   10 (bases 1 to 3750)
  AUTHORS   Smith,D.F., Baggenstoss,B.A., Marion,T.N. and Rimerman,R.A.
  TITLE     Two FKBP-related proteins are associated with progesterone receptor
            complexes
  JOURNAL   J Biol Chem 268 (24), 18365-18371 (1993)
   PUBMED   7688746
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB066174.1, BC111050.1,
            U42031.1, AL033519.42 and AW182642.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_004117.3.
            
            Summary: The protein encoded by this gene is a member of the
            immunophilin protein family, which play a role in immunoregulation
            and basic cellular processes involving protein folding and
            trafficking. This encoded protein is a cis-trans prolyl isomerase
            that binds to the immunosuppressants FK506 and rapamycin. It is
            thought to mediate calcineurin inhibition. It also interacts
            functionally with mature hetero-oligomeric progesterone receptor
            complexes along with the 90 kDa heat shock protein and P23 protein.
            This gene has been found to have multiple polyadenylation sites.
            Alternative splicing results in multiple transcript
            variants.[provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (1). Variants 1, 2 and 3
            encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647390.1, BC111050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357266.9/ ENSP00000349811.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DB066174.1         28-39
            13-539              BC111050.1         1-527
            540-1887            U42031.1           386-1733
            1888-3685           AL033519.42        77692-79489         c
            3686-3750           AW182642.1         17-81               c
FEATURES             Location/Qualifiers
     source          1..3750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..3750
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /note="FKBP prolyl isomerase 5"
                     /db_xref="GeneID:2289"
                     /db_xref="HGNC:HGNC:3721"
                     /db_xref="MIM:602623"
     exon            1..112
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /inference="alignment:Splign:2.1.0"
     exon            113..236
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1505
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1; 54
                     kDa progesterone receptor-associated immunophilin; T-cell
                     FK506-binding protein; peptidylprolyl cis-trans isomerase;
                     rotamase; FF1 antigen; HSP90-binding immunophilin;
                     peptidyl-prolyl cis-trans isomerase FKBP5;
                     androgen-regulated protein 6; FKBP-51; 51 kDa FKBP; PPIase
                     FKBP5; FK506 binding protein 5; 51 kDa FK506-binding
                     protein"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP5
                     isoform 1"
                     /protein_id="NP_004108.1"
                     /db_xref="CCDS:CCDS4808.1"
                     /db_xref="GeneID:2289"
                     /db_xref="HGNC:HGNC:3721"
                     /db_xref="MIM:602623"
                     /translation="MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGE
                     ETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEI
                     CHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLFEDGGIIRRTKRKGEGYS
                     NPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILY
                     LGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGT
                     VYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYT
                     KAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQIS
                     MCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEGVTNEKGTDSQAMEE
                     EKPEGHV"
     exon            237..381
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /inference="alignment:Splign:2.1.0"
     exon            382..524
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /inference="alignment:Splign:2.1.0"
     exon            525..639
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /inference="alignment:Splign:2.1.0"
     exon            640..796
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /inference="alignment:Splign:2.1.0"
     exon            797..887
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /inference="alignment:Splign:2.1.0"
     exon            888..971
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1157
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1397
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..3750
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3729..3734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /note="hexamer: AATAAA"
     polyA_site      3750
                     /gene="FKBP5"
                     /gene_synonym="AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10"
                     /note="major polyA site"
ORIGIN      
        1 agtctcgggc ggcggtgtcc ggcgcgcggg cggcctgctg ggcgggctga agggttagcg
       61 gagcacgggc aaggcggaga gtgacggagt cggcgagccc ccgcggcgac aggttctcta
      121 cttaaaagac aatgactact gatgaaggtg ccaagaacaa tgaagaaagc cccacagcca
      181 ctgttgctga gcagggagag gatattacct ccaaaaaaga caggggagta ttaaagattg
      241 tcaaaagagt ggggaatggt gaggaaacgc cgatgattgg agacaaagtt tatgtccatt
      301 acaaaggaaa attgtcaaat ggaaagaagt ttgattccag tcatgataga aatgaaccat
      361 ttgtctttag tcttggcaaa ggccaagtca tcaaggcatg ggacattggg gtggctacca
      421 tgaagaaagg agagatatgc catttactgt gcaaaccaga atatgcatat ggctcggctg
      481 gcagtctccc taaaattccc tcgaatgcaa ctctcttttt tgagattgag ctccttgatt
      541 tcaaaggaga ggatttattt gaagatggag gcattatccg gagaaccaaa cggaaaggag
      601 agggatattc aaatccaaac gaaggagcaa cagtagaaat ccacctggaa ggccgctgtg
      661 gtggaaggat gtttgactgc agagatgtgg cattcactgt gggcgaagga gaagaccacg
      721 acattccaat tggaattgac aaagctctgg agaaaatgca gcgggaagaa caatgtattt
      781 tatatcttgg accaagatat ggttttggag aggcagggaa gcctaaattt ggcattgaac
      841 ctaatgctga gcttatatat gaagttacac ttaagagctt cgaaaaggcc aaagaatcct
      901 gggagatgga taccaaagaa aaattggagc aggctgccat tgtcaaagag aagggaaccg
      961 tatacttcaa gggaggcaaa tacatgcagg cggtgattca gtatgggaag atagtgtcct
     1021 ggttagagat ggaatatggt ttatcagaaa aggaatcgaa agcttctgaa tcatttctcc
     1081 ttgctgcctt tctgaacctg gccatgtgct acctgaagct tagagaatac accaaagctg
     1141 ttgaatgctg tgacaaggcc cttggactgg acagtgccaa tgagaaaggc ttgtatagga
     1201 ggggtgaagc ccagctgctc atgaacgagt ttgagtcagc caagggtgac tttgagaaag
     1261 tgctggaagt aaacccccag aataaggctg caagactgca gatctccatg tgccagaaaa
     1321 aggccaagga gcacaacgag cgggaccgca ggatatacgc caacatgttc aagaagtttg
     1381 cagagcagga tgccaaggaa gaggccaata aagcaatggg caagaagact tcagaagggg
     1441 tcactaatga aaaaggaaca gacagtcaag caatggaaga agagaaacct gagggccacg
     1501 tatgacgcca cgccaaggag ggaagagtcc cagtgaactc ggcccctcct caatgggctt
     1561 tcccccaact caggacagaa cagtgtttaa tgtaaagttt gttatagtct atgtgattct
     1621 ggaagcaaat ggcaaaacca gtagcttccc aaaaacagcc cccctgctgc tgcccggagg
     1681 gttcactgag gggtggcacg ggaccactcc aggtggaaca aacagaaatg actgtggtgt
     1741 ggagggagtg agccagcagc ttaagtccag ctcatttcag tttctatcaa ccttcaagta
     1801 tccaattcag ggtccctgga gatcatccta acaatgtggg gctgttaggt tttacctttg
     1861 aactttcata gcactgcaga aacctttaaa aaaaaaatgc ttcatgaatt tctcctttcc
     1921 tacagttggg tagggtaggg gaaggaggat aagcttttgt tttttaaatg actgaagtgc
     1981 tataaatgta gtctgttgca tttttaacca acagaaccca cagtagaggg gtctcatgtc
     2041 tccccagttc cacagcagtg tcacagacgt gaaagccaga acctcagagg ccacttgctt
     2101 gctgacttag cctcctccca aagtccccct cctcagccag cctccttgtg agagtggctt
     2161 tctaccacac acagcctgtc cctgggggag taattctgtc attcctaaaa cacccttcag
     2221 caatgataat gagcagatga gagtttctgg attagctttt cctattttcg atgaagttct
     2281 gagatactga aatgtgaaaa gagcaatcag aattgtgctt tttctcccct cctctattcc
     2341 ttttagggaa taatattcaa tacacagtac ttcctcccag cattgctact gctcagcttc
     2401 ttctttcatt ctaatccttg ctattaagaa tttaagactt gtgcttacaa tatttttgac
     2461 ctggagtgga tctatttaca tagtcattta ggatccatgc agcttttttt gtctttttaa
     2521 gattattggc tcataagcat atgtatactg gtttatggaa ctttatttac actcctctat
     2581 catgcaaaaa aattttgact ttttagtact aagcttaatt tttaaaaaca aaatctgtag
     2641 ggttgacaaa taaatagttg ctcttctaca ctaggggttt cacctgcagg tttgacacgc
     2701 agttgctcgc ttttcctgcc ctgtcaagct tctctgttct ggcgtgagtt gtgaaagagt
     2761 tgaagacagc ttcccatgcc ggtacacagc cagtagccta aatctccagt acttgagctg
     2821 accattgaac tagggcaagt cttaaatgtg tacatgtagt tgaatttcag tccttacggg
     2881 taaacagatt gagcatggct ctctattccc tcagcctaag aaacactcat gggaatgcat
     2941 ttggcaaccc aaggaaccat ttgcttaaac ctggaacatc tcaccttttt aaatcctaaa
     3001 aaacactggc agttatattt taaattagtt tttattttta tgatggtttt atcaaaagac
     3061 ttttattatt agattgggac ccccttcaaa cctaaaaatc aagttatttc cttttataat
     3121 acttttcttc cccatggaac aaatgggatc aatttgtgag ttttttcctt taatgataac
     3181 taaaatccct ctaatttctc atttatgctt ttgtcttttt tatgaaatat ttcttttaaa
     3241 agccccagtc tcacctacga aatatgaaga gcaaaagctg attttgctta cttgctaaac
     3301 tgttgggaaa gctctgtaga gcatggttcc agtgaggcca agattgaaat ttgatactaa
     3361 aaaggccacc tagctttttg cagataacaa acaagaaagc tattccaaga ctcagatgat
     3421 gccagctgtc tcccacgtgt gtattatggt tcaccagggg gaactggcaa aagtgtgtgt
     3481 ggggagggga agggtgtgtg agtggttctg agcaaataac tacagggtgc ccattaccac
     3541 tcaagaagac acttcacgta ttcttgtatc aaattcaata atcttaaaca atttgtgtag
     3601 aagtccacag acatctttca accacctttt aggctgcata tggattgcca agtcagcata
     3661 tgaggaatta aagacattgt ttttaaaaaa aaaaaatcat ttagatgcac ttttttgtgt
     3721 gttctttaaa taaatccaaa aaaaatgtga
//
