LOCUS       NM_002014               3715 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens FKBP prolyl isomerase 4 (FKBP4), mRNA.
ACCESSION   NM_002014
VERSION     NM_002014.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3715)
  AUTHORS   Zeng,Z., Xu,S., Wang,R. and Han,X.
  TITLE     FKBP4 promotes glycolysis and hepatocellular carcinoma progression
            via p53/HK2 axis
  JOURNAL   Sci Rep 14 (1), 26893 (2024)
   PUBMED   39505995
  REMARK    GeneRIF: FKBP4 promotes glycolysis and hepatocellular carcinoma
            progression via p53/HK2 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3715)
  AUTHORS   Kojima,R., Paslawski,W., Lyu,G., Arenas,E., Zhang,X. and
            Svenningsson,P.
  TITLE     Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in
            CSF and iPS Cells from Parkinson's Disease Patients with GBA1
            Mutations
  JOURNAL   Int J Mol Sci 25 (1), 683 (2024)
   PUBMED   38203854
  REMARK    GeneRIF: Secretome Analyses Identify FKBP4 as a GBA1-Associated
            Protein in CSF and iPS Cells from Parkinson's Disease Patients with
            GBA1 Mutations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3715)
  AUTHORS   Hanaki,S. and Shimada,M.
  TITLE     Impact of FKBP52 on cell proliferation and hormone-dependent
            cancers
  JOURNAL   Cancer Sci 114 (7), 2729-2738 (2023)
   PUBMED   37026526
  REMARK    GeneRIF: Impact of FKBP52 on cell proliferation and
            hormone-dependent cancers.
            Review article
REFERENCE   4  (bases 1 to 3715)
  AUTHORS   Meduri,G., Guillemeau,K., Daguinot,C., Dounane,O., Genet,M.,
            Ferrara,L., Chambraud,B., Baulieu,E.E. and Giustiniani,J.
  TITLE     Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early
            Feature of Different Human and Experimental Tauopathies
  JOURNAL   J Alzheimers Dis 94 (1), 313-331 (2023)
   PUBMED   37248902
  REMARK    GeneRIF: Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is
            an Early Feature of Different Human and Experimental Tauopathies.
REFERENCE   5  (bases 1 to 3715)
  AUTHORS   Ortiz,N.R., Guy,N., Garcia,Y.A., Sivils,J.C., Galigniana,M.D. and
            Cox,M.B.
  TITLE     Functions of the Hsp90-Binding FKBP Immunophilins
  JOURNAL   Subcell Biochem 101, 41-80 (2023)
   PUBMED   36520303
  REMARK    GeneRIF: Functions of the Hsp90-Binding FKBP Immunophilins.
REFERENCE   6  (bases 1 to 3715)
  AUTHORS   Peattie,D.A., Harding,M.W., Fleming,M.A., DeCenzo,M.T.,
            Lippke,J.A., Livingston,D.J. and Benasutti,M.
  TITLE     Expression and characterization of human FKBP52, an immunophilin
            that associates with the 90-kDa heat shock protein and is a
            component of steroid receptor complexes
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10974-10978 (1992)
   PUBMED   1279700
REFERENCE   7  (bases 1 to 3715)
  AUTHORS   Wiederrecht,G., Hung,S., Chan,H.K., Marcy,A., Martin,M.,
            Calaycay,J., Boulton,D., Sigal,N., Kincaid,R.L. and Siekierka,J.J.
  TITLE     Characterization of high molecular weight FK-506 binding activities
            reveals a novel FK-506-binding protein as well as a protein complex
  JOURNAL   J Biol Chem 267 (30), 21753-21760 (1992)
   PUBMED   1383226
REFERENCE   8  (bases 1 to 3715)
  AUTHORS   Tai,P.K., Albers,M.W., Chang,H., Faber,L.E. and Schreiber,S.L.
  TITLE     Association of a 59-kilodalton immunophilin with the glucocorticoid
            receptor complex
  JOURNAL   Science 256 (5061), 1315-1318 (1992)
   PUBMED   1376003
REFERENCE   9  (bases 1 to 3715)
  AUTHORS   Yem,A.W., Tomasselli,A.G., Heinrikson,R.L., Zurcher-Neely,H.,
            Ruff,V.A., Johnson,R.A. and Deibel,M.R. Jr.
  TITLE     The Hsp56 component of steroid receptor complexes binds to
            immobilized FK506 and shows homology to FKBP-12 and FKBP-13
  JOURNAL   J Biol Chem 267 (5), 2868-2871 (1992)
   PUBMED   1371107
REFERENCE   10 (bases 1 to 3715)
  AUTHORS   Sanchez,E.R., Faber,L.E., Henzel,W.J. and Pratt,W.B.
  TITLE     The 56-59-kilodalton protein identified in untransformed steroid
            receptor complexes is a unique protein that exists in cytosol in a
            complex with both the 70- and 90-kilodalton heat shock proteins
  JOURNAL   Biochemistry 29 (21), 5145-5152 (1990)
   PUBMED   2378870
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA392592.1, BC001786.1,
            BU685040.1, AK024694.1, BQ083177.1 and BQ446607.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002014.3.
            
            Summary: The protein encoded by this gene is a member of the
            immunophilin protein family, which play a role in immunoregulation
            and basic cellular processes involving protein folding and
            trafficking. This encoded protein is a cis-trans prolyl isomerase
            that binds to the immunosuppressants FK506 and rapamycin. It has
            high structural and functional similarity to FK506-binding protein
            1A (FKBP1A), but unlike FKBP1A, this protein does not have
            immunosuppressant activity when complexed with FK506. It interacts
            with interferon regulatory factor-4 and plays an important role in
            immunoregulatory gene expression in B and T lymphocytes. This
            encoded protein is known to associate with phytanoyl-CoA
            alpha-hydroxylase. It can also associate with two heat shock
            proteins (hsp90 and hsp70) and thus may play a role in the
            intracellular trafficking of hetero-oligomeric forms of the steroid
            hormone receptors. This protein correlates strongly with
            adeno-associated virus type 2 vectors (AAV) resulting in a
            significant increase in AAV-mediated transgene expression in human
            cell lines. Thus this encoded protein is thought to have important
            implications for the optimal use of AAV vectors in human gene
            therapy. The human genome contains several non-transcribed
            pseudogenes similar to this gene. [provided by RefSeq, Sep 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.159743.1,
                                           SRR1803615.213037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000001008.6/ ENSP00000001008.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DA392592.1         29-45
            18-2234             BC001786.1         1-2217
            2235-2369           BU685040.1         454-588
            2370-3028           AK024694.1         42-700
            3029-3294           BQ083177.1         1-266
            3295-3715           BQ446607.1         15-435              c
FEATURES             Location/Qualifiers
     source          1..3715
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..3715
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /note="FKBP prolyl isomerase 4"
                     /db_xref="GeneID:2288"
                     /db_xref="HGNC:HGNC:3720"
                     /db_xref="MIM:600611"
     exon            1..275
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1550
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /EC_number="5.2.1.8"
                     /note="FK506 binding protein 4, 59kDa; T-cell
                     FK506-binding protein, 59kD; HSP binding immunophilin;
                     peptidylprolyl cis-trans isomerase; rotamase"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP4"
                     /protein_id="NP_002005.1"
                     /db_xref="CCDS:CCDS8512.1"
                     /db_xref="GeneID:2288"
                     /db_xref="HGNC:HGNC:3720"
                     /db_xref="MIM:600611"
                     /translation="MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGT
                     EMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEV
                     CHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEG
                     YAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSI
                     VYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKER
                     GTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQA
                     FSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQ
                     LAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAG
                     SQSQVETEA"
     exon            276..420
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            421..563
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            564..684
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            685..841
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            842..932
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1016
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1202
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1442
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..3715
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2214..2219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /note="hexamer: AATAAA"
     regulatory      2228..2233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /note="hexamer: AATAAA"
     polyA_site      2234
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /note="major polyA site"
     polyA_site      2250
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
     regulatory      2716..2721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /note="hexamer: AGTAAA"
     polyA_site      2739
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
     regulatory      3083..3088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /note="hexamer: ATTAAA"
     polyA_site      3105
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
     regulatory      3682..3687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
                     /note="hexamer: ATTAAA"
     polyA_site      3715
                     /gene="FKBP4"
                     /gene_synonym="FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52;
                     PPIase"
ORIGIN      
        1 cctaccccag ctctcgcgcc gcgtgcagag gtgctcaagc ctcctcgcgg tccgcagtca
       61 gtgccgccgc gcccggcctc ccgcacgccc cgcaggtagc gcccccgccc gcggcccaga
      121 gtgcgctcgc gccggcacca gctcccggat aaacggcgcg ccgcgcggag atgacagccg
      181 aggagatgaa ggcgaccgag agcggggcgc agtcggcgcc gctgcccatg gagggagtgg
      241 acatcagccc caaacaggac gaaggcgtgc tgaaggtcat caagagagag ggcacaggta
      301 cagagatgcc catgattggg gaccgagtct ttgtccacta cactggctgg ctattagatg
      361 gcacaaagtt tgactccagt ctggatcgca aggacaaatt ctcctttgac ctgggaaaag
      421 gggaggtcat caaggcttgg gacattgcca tagccaccat gaaggtgggg gaggtgtgcc
      481 acatcacctg caaaccagaa tatgcctacg gttcagcagg cagtcctcca aagattcccc
      541 ccaatgccac gcttgtattt gaggtggagt tgtttgagtt taagggagaa gatctgacgg
      601 aagaggaaga tggcggaatc attcgcagaa tacagactcg cggtgaaggc tatgctaagc
      661 ccaatgaggg tgctatcgtg gaggttgcac tggaagggta ctacaaggac aagctctttg
      721 accagcggga gctccgcttt gagattggcg agggggagaa cctggatctg ccttatggtc
      781 tggagagggc cattcagcgc atggagaaag gagaacattc catcgtgtac ctcaagccca
      841 gctatgcttt tggcagtgtt gggaaggaaa agttccaaat cccaccaaat gctgagctga
      901 aatatgaatt acacctcaag agttttgaaa aggccaagga gtcttgggag atgaattcag
      961 aagagaagct ggaacagagc accatagtga aagagcgggg cactgtgtac ttcaaggaag
     1021 gtaaatacaa gcaagcttta ctacagtata agaagatcgt gtcttggctg gaatatgagt
     1081 ctagtttttc caatgaggaa gcacagaaag cacaggccct tcgactggcc tctcacctca
     1141 acctggccat gtgtcatctg aaactacagg ccttctctgc tgccattgaa agctgtaaca
     1201 aggccctaga actggacagc aacaacgaga agggcctctt ccgccgggga gaggcccacc
     1261 tggccgtgaa tgactttgaa ctggcacggg ctgatttcca gaaggtcctg cagctctacc
     1321 ccaacaacaa agccgccaag acccagctgg ctgtgtgcca gcagcggatc cgaaggcagc
     1381 ttgcccggga gaagaagctc tatgccaata tgtttgagag gctggctgag gaggagaaca
     1441 aggccaaggc agaggcttcc tcaggagacc atcccactga cacagagatg aaggaggagc
     1501 agaagagcaa cacggcaggg agccagtctc aggtggagac agaagcatag cccctctcca
     1561 ccagccctac tcctgcggct gcctgccccc cagtctcccc actccaccct gttagttttg
     1621 taaaaactga agaattttga gtgaattaga cctttatttt tctatctggt tggatggtgg
     1681 ctttagggga agggggaaag gtgtaggctg ggggattgag gtggggaatc attttagctg
     1741 gtgtcagccc ctcttccctt cctccattgc acatgaacat atgtccatcc atatatattc
     1801 atcagaatgt taatttattt tgctccctct gttaggtcca ttttctaagg gtagaagagg
     1861 caagtggtag ggatgaggtc tgataagaac ccagggtgga gagggagact cctgggcagc
     1921 cgttttcctc atcctttccc tctcccagtc catttccaaa tgtggcctcc atgtgggtgc
     1981 tagggacatg ggaaaaacca ctgctatgcc atttcttctc tctgttccct tcctcacccc
     2041 cgacggtgtg gctgatgatg tcttctggtg tcatggtgac caccccctgt tccctgttct
     2101 ggtatttccc ctgtcagttt cccctctcgg ccaggttgtg tcccaaaatc ccctcagcct
     2161 cttctctgca cgttgctgaa ggtccaggct tgcctcaagt tccatgcttg agcaataaag
     2221 tggaaacaat aaaacctggg tgtcagacaa ccctttctgt tcagccttgg agtggtgggt
     2281 atgggtgggt acataatggg tagtagcaca atcaaggggt cacccactta gttccagttg
     2341 agcttaaata agtgagcatc tcatgtagat gccatagttg ggcaggaagc agccccacca
     2401 tgcatggctt cctgagcact gcacaggctg ccgctgggat ttgtgtctat ggcttcgccc
     2461 aaggttccca gcactccctc cctccagcaa cctggcagtt ttagtgcctc tggttttctt
     2521 ccctgacact taggaagacg aaagtataaa gatctagaag actgggacac catgcatgtt
     2581 cattttgaag ttggaattgg tcttctgcct acctctgatc tggcagaggt atctgcattt
     2641 tggtttgtta acaaggtaaa actcctggtg tcactgacct cctcctgtca gataacttac
     2701 atgattaagg ttaagagtaa agcagagtgt tcacgtccag cttccttctc agccttaaca
     2761 ggaaaaggct tgtgcttttt ttctaactat gctttgaccc ttaactccta tggcatgatg
     2821 gggccctggg agaagccagg cagcacaagc cagtcatgct gagctgcctc cagataatcc
     2881 tggctccagg ccagagcccg tgtctgccct catccctctc tcctactgtg agctctccag
     2941 tcctttccca acagcgatgt ggttgtctgc ttagccacat gcctgtatag ttccttccag
     3001 aagaaatgta taatggtgga agatgtattt ctgtgtgaaa attttcacca agtcatacaa
     3061 cacagctgat gctggagcca ggattaaaat tggggtgtac aagtctccca gtgtgagtat
     3121 cccttgagcc caagacacca aggatgcaga gaactgtgac tgtgccactg cacgccagcc
     3181 tgggcaagag agtgagacca tctctttttt aaaaaagtcc ctgtgtaact gctttcttac
     3241 tgggcttacc tcacatcaca gccctgtgtt tgtggtttgt gtctgggtcc tcttggtatt
     3301 tcaaaagtag tagattctta cgcctgcagc caacaataat cactaactca agcatttatg
     3361 gagtaagcct agcactgtac tgacagcatc acatgagtga aactgaatcc ttgcaaccat
     3421 cctacaaaga aggtataact ttaataaccc tatttacaga taagaaaacc aagactcaga
     3481 agttaaatgg aaaggtgagg tctctgaact aatccagact ctcccatgag gttcctttgg
     3541 caagtcctgg gcttctgtcc tcatctgcaa aatcgaaagc attcctgagg tttcttccag
     3601 ctctgcatcc tgtaggattc caagaatgta aaactgcatg taaccgtgga acatctagag
     3661 ataagtctta gtttatgtaa cattaaaact gtctagtgag gatgttttgt taaaa
//
