LOCUS       NM_002013               1299 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens FKBP prolyl isomerase 3 (FKBP3), mRNA.
ACCESSION   NM_002013
VERSION     NM_002013.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Li,S., Yang,L. and Li,J.
  TITLE     FKBP3, a poor prognostic indicator, promotes the progression of
            LUAD via regulating ferroptosis and immune infiltration
  JOURNAL   Medicine (Baltimore) 103 (26), e38606 (2024)
   PUBMED   38941396
  REMARK    GeneRIF: FKBP3, a poor prognostic indicator, promotes the
            progression of LUAD via regulating ferroptosis and immune
            infiltration.
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Dong,J., Chen,J., Li,Q. and Qiu,S.
  TITLE     Knockdown of FKBP3 suppresses nasopharyngeal carcinoma cell growth,
            invasion and migration, deactivated NF-kappaB/IL-6 signaling
            pathway through inhibiting histone deacetylase 2 expression
  JOURNAL   Chin J Physiol 66 (2), 85-92 (2023)
   PUBMED   37082996
  REMARK    GeneRIF: Knockdown of FKBP3 suppresses nasopharyngeal carcinoma
            cell growth, invasion and migration, deactivated NF-kappaB/IL-6
            signaling pathway through inhibiting histone deacetylase 2
            expression.
REFERENCE   3  (bases 1 to 1299)
  AUTHORS   Yang,Y., Chen,X., Yao,W., Cui,X., Li,N., Lin,Z., Zhao,B. and
            Miao,J.
  TITLE     Esterase D stabilizes FKBP25 to suppress mTORC1
  JOURNAL   Cell Mol Biol Lett 26 (1), 50 (2021)
   PUBMED   34875997
  REMARK    GeneRIF: Esterase D stabilizes FKBP25 to suppress mTORC1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1299)
  AUTHORS   Yang,X., Zhao,X., Zhu,Y., Shen,Y., Wang,Y., Lu,P., Jiang,Z.,
            Pan,H., Yang,J., Xun,J., Zhao,L., Wang,J., Liang,Z., Shen,X.,
            Liang,Y., Lin,Q., Liang,H., Jin,L., Zhang,D., Liu,J., Wang,B.,
            Jiang,S., Xu,J., Wu,H., Lu,H. and Zhu,H.
  TITLE     FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by
            Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal
            Repeat
  JOURNAL   mBio 12 (4), e0079521 (2021)
   PUBMED   34281390
  REMARK    GeneRIF: FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency
            by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal
            Repeat.
REFERENCE   5  (bases 1 to 1299)
  AUTHORS   Dilworth,D., Gong,F., Miller,K. and Nelson,C.J.
  TITLE     FKBP25 participates in DNA double-strand break repair
  JOURNAL   Biochem Cell Biol 98 (1), 42-49 (2020)
   PUBMED   30620620
  REMARK    GeneRIF: The results identify FKBP25 as a component of the DNA
            double-strand breaks (DSB) repair pathway.
REFERENCE   6  (bases 1 to 1299)
  AUTHORS   Jin,Y.J. and Burakoff,S.J.
  TITLE     The 25-kDa FK506-binding protein is localized in the nucleus and
            associates with casein kinase II and nucleolin
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7769-7773 (1993)
   PUBMED   7689229
REFERENCE   7  (bases 1 to 1299)
  AUTHORS   Jin,Y.J., Burakoff,S.J. and Bierer,B.E.
  TITLE     Molecular cloning of a 25-kDa high affinity rapamycin binding
            protein, FKBP25
  JOURNAL   J Biol Chem 267 (16), 10942-10945 (1992)
   PUBMED   1375932
REFERENCE   8  (bases 1 to 1299)
  AUTHORS   Wiederrecht,G., Martin,M.M., Sigal,N.H. and Siekierka,J.J.
  TITLE     Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin
            binding protein
  JOURNAL   Biochem Biophys Res Commun 185 (1), 298-303 (1992)
   PUBMED   1376117
REFERENCE   9  (bases 1 to 1299)
  AUTHORS   Hung,D.T. and Schreiber,S.L.
  TITLE     cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein
  JOURNAL   Biochem Biophys Res Commun 184 (2), 733-738 (1992)
   PUBMED   1374240
REFERENCE   10 (bases 1 to 1299)
  AUTHORS   Porat,R., Poutsiaka,D.D., Miller,L.C., Granowitz,E.V. and
            Dinarello,C.A.
  TITLE     Interleukin-1 (IL-1) receptor blockade reduces endotoxin and
            Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear
            cells
  JOURNAL   FASEB J 6 (7), 2482-2486 (1992)
   PUBMED   1532945
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI598048.1, BC020809.1 and
            CN315192.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002013.3.
            
            Summary: The protein encoded by this gene is a member of the
            immunophilin protein family, which play a role in immunoregulation
            and basic cellular processes involving protein folding and
            trafficking. This encoded protein is a cis-trans prolyl isomerase
            that binds the immunosuppressants FK506 and rapamycin, as well as
            histone deacetylases, the transcription factor YY1, casein kinase
            II, and nucleolin. It has a higher affinity for rapamycin than for
            FK506 and thus may be an important target molecule for
            immunosuppression by rapamycin. [provided by RefSeq, Sep 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.146351.1,
                                           SRR3476690.574190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267760 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396062.4/ ENSP00000379374.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BI598048.1         54-67
            15-996              BC020809.1         1-982
            997-1299            CN315192.1         7-309               c
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.2"
     gene            1..1299
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /note="FKBP prolyl isomerase 3"
                     /db_xref="GeneID:2287"
                     /db_xref="HGNC:HGNC:3719"
                     /db_xref="MIM:186947"
     exon            1..133
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..700
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /EC_number="5.2.1.8"
                     /note="FK506-binding protein 3; rapamycin-selective 25 kDa
                     immunophilin; rotamase; rapamycin binding protein;
                     FK506-binding protein 25, T-cell; 25 kDa FKBP; PPIase
                     FKBP3; immunophilin FKBP25; 25 kDa FK506-binding protein;
                     FK506 binding protein 3, 25kDa"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP3"
                     /protein_id="NP_002004.1"
                     /db_xref="CCDS:CCDS9683.1"
                     /db_xref="GeneID:2287"
                     /db_xref="HGNC:HGNC:3719"
                     /db_xref="MIM:186947"
                     /translation="MAAAVPQRAWTVEQLRSEQLPKKDIIKFLQEHGSDSFLAEHKLL
                     GNIKNVAKTANKDHLVTAYNHLFETKRFKGTESISKVSEQVKNVKLNEDKPKETKSEE
                     TLDEGPPKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSAKKKKNAK
                     PLSFKVGVGKVIRGWDEALLTMSKGEKARLEIEPEWAYGKKGQPDAKIPPNAKLTFEV
                     ELVDID"
     exon            134..235
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            236..343
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            344..479
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            480..547
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            548..645
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            646..1299
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      828..833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /note="hexamer: AATAAA"
     polyA_site      852
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
     regulatory      972..977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /note="hexamer: AATAAA"
     polyA_site      996
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /note="major polyA site"
     regulatory      1280..1285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /note="hexamer: AATAAA"
     polyA_site      1299
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
ORIGIN      
        1 agtaaagcgg aggcagcggg ggaagatggc ggcggccgtt ccacagcggg cgtggaccgt
       61 ggagcagctg cgcagtgagc agctgcccaa gaaggacatt atcaagtttc tgcaggaaca
      121 cggttcagat tcgtttcttg cagaacataa attattagga aacattaaaa atgtggccaa
      181 gacagctaac aaggaccact tggttacagc ctataaccat ctttttgaaa ctaagcgttt
      241 taagggtact gaaagtataa gtaaagtgtc tgagcaagta aaaaatgtga agcttaatga
      301 agataaaccc aaagaaacca agtctgaaga gaccctggat gagggtccac caaaatatac
      361 taaatctgtt ctgaaaaagg gagataaaac caactttccc aaaaagggag atgttgttca
      421 ctgctggtat acaggaacac tacaagatgg gactgttttt gatactaata ttcaaacaag
      481 tgcaaagaag aagaaaaatg ccaagccttt aagttttaag gtcggagtag gcaaagttat
      541 cagaggatgg gatgaagctc tcttgactat gagtaaagga gaaaaggctc gactggagat
      601 tgaaccagaa tgggcttacg gaaagaaagg acagcctgat gccaaaattc caccaaatgc
      661 aaaactcact tttgaagtgg aattagtgga tattgattga aatagcagtg cttcagctct
      721 aaggatatta gcaacaatga taaaacttgg ccttgaagaa atttacacaa ctagttagaa
      781 cttgttacta ttgtaaagga agagtcaact ggaaaattca aggagttaat aaaatttgtt
      841 tacttggtcc cagcttttga gagataaatc ccttatgaat ccctggtcta aaatactttc
      901 ctacagctgt gtaaaatact ggtcaaggag aactttttcc ttttacctca tgttgtaaac
      961 ttaagtggct caataaaaat tgatccactg tcttgatctg actgtgattt gtttggtgtt
     1021 aatatattat tgttctgatt agggaattgg aactaaggac ctcatcaaac cagggagtaa
     1081 ctcccagtaa aattatctgg acagattgcc tgtataatga gaaggcaaaa gcataaggct
     1141 tgaggggaaa caaaatgcta aaagcagaaa aatcttggca ggaagatcaa gacctgaatt
     1201 tagaaaaggt gtacttcaaa accaatgagc cactaataaa ggtgaacata aggttaatat
     1261 tactaattga tccccccaaa ataaattcat aaacaatta
//
