LOCUS       NM_000801               1514 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens FKBP prolyl isomerase 1A (FKBP1A), transcript variant
            1, mRNA.
ACCESSION   NM_000801
VERSION     NM_000801.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Guo,J.R., He,K.Y., Yuan,J.L., An,W., Yin,W.T., Li,Q.T., Lu,L.Y.,
            Yang,J.Y., Liu,M.J., Li,Y.J., Zhao,Y., Yang,Q., Lei,X.Y., Gao,F.,
            Zhang,L., Wu,D.H., Li,J.Q., Zhao,Z.L., Liu,H., Zhu,L.J.,
            Xiang,X.Y., Sun,Q.H., Jian,Y.P. and Xu,Z.X.
  TITLE     HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR
            inhibitors through the ETS1-FKBP12 axis
  JOURNAL   Int J Biol Sci 20 (7), 2640-2657 (2024)
   PUBMED   38725843
  REMARK    GeneRIF: HMGA1 sensitizes esophageal squamous cell carcinoma to
            mTOR inhibitors through the ETS1-FKBP12 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Watcharanurak,P., Mutirangura,A., Aksornkitti,V., Bhummaphan,N. and
            Puttipanyalears,C.
  TITLE     The high FKBP1A expression in WBCs as a potential screening
            biomarker for pancreatic cancer
  JOURNAL   Sci Rep 14 (1), 7888 (2024)
   PUBMED   38570626
  REMARK    GeneRIF: The high FKBP1A expression in WBCs as a potential
            screening biomarker for pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Yang,X. and Sun,P.
  TITLE     Circ_0088212 Targeting miR-576-5p/FKBP1A Axis Inhibits Osteosarcoma
            Progression
  JOURNAL   Ann Clin Lab Sci 53 (4), 548-561 (2023)
   PUBMED   37625838
  REMARK    GeneRIF: Circ_0088212 Targeting miR-576-5p/FKBP1A Axis Inhibits
            Osteosarcoma Progression.
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Cai,S., Chen,Z., Tang,H., Meng,S., Tao,L. and Wang,Q.
  TITLE     Upregulated FKBP1A Suppresses Glioblastoma Cell Growth via
            Apoptosis Pathway
  JOURNAL   Int J Mol Sci 23 (23), 14935 (2022)
   PUBMED   36499275
  REMARK    GeneRIF: Upregulated FKBP1A Suppresses Glioblastoma Cell Growth via
            Apoptosis Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Li,Z., Cui,Y., Duan,Q., Zhang,J., Shao,D., Cao,X., Gao,Y., Wang,S.,
            Li,J., Jones,O.D., Lei,X., Wang,L., Zhou,X., Xu,M., Ma,J., Liu,Y.
            and Xu,X.
  TITLE     The Prognostic Significance of FKBP1A and Its Related Immune
            Infiltration in Liver Hepatocellular Carcinoma
  JOURNAL   Int J Mol Sci 23 (21), 12797 (2022)
   PUBMED   36361587
  REMARK    GeneRIF: The Prognostic Significance of FKBP1A and Its Related
            Immune Infiltration in Liver Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   DiLella,A.G., Hawkins,A., Craig,R.J., Schreiber,S.L. and
            Griffin,C.A.
  TITLE     Chromosomal band assignments of the genes encoding human FKBP12 and
            FKBP13
  JOURNAL   Biochem Biophys Res Commun 189 (2), 819-823 (1992)
   PUBMED   1281998
REFERENCE   7  (bases 1 to 1514)
  AUTHORS   Jayaraman,T., Brillantes,A.M., Timerman,A.P., Fleischer,S.,
            Erdjument-Bromage,H., Tempst,P. and Marks,A.R.
  TITLE     FK506 binding protein associated with the calcium release channel
            (ryanodine receptor)
  JOURNAL   J Biol Chem 267 (14), 9474-9477 (1992)
   PUBMED   1374404
REFERENCE   8  (bases 1 to 1514)
  AUTHORS   Lepre,C.A., Thomson,J.A. and Moore,J.M.
  TITLE     Solution structure of FK506 bound to FKBP-12
  JOURNAL   FEBS Lett 302 (1), 89-96 (1992)
   PUBMED   1375171
REFERENCE   9  (bases 1 to 1514)
  AUTHORS   Standaert,R.F., Galat,A., Verdine,G.L. and Schreiber,S.L.
  TITLE     Molecular cloning and overexpression of the human FK506-binding
            protein FKBP
  JOURNAL   Nature 346 (6285), 671-674 (1990)
   PUBMED   1696686
REFERENCE   10 (bases 1 to 1514)
  AUTHORS   Maki,N., Sekiguchi,F., Nishimaki,J., Miwa,K., Hayano,T.,
            Takahashi,N. and Suzuki,M.
  TITLE     Complementary DNA encoding the human T-cell FK506-binding protein,
            a peptidylprolyl cis-trans isomerase distinct from cyclophilin
  JOURNAL   Proc Natl Acad Sci U S A 87 (14), 5440-5443 (1990)
   PUBMED   1695378
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC119732.1, AL136531.16 and
            CA450516.1.
            
            On Dec 7, 2018 this sequence version replaced NM_000801.4.
            
            Summary: The protein encoded by this gene is a member of the
            immunophilin protein family, which play a role in immunoregulation
            and basic cellular processes involving protein folding and
            trafficking. The protein is a cis-trans prolyl isomerase that binds
            the immunosuppressants FK506 and rapamycin. It interacts with
            several intracellular signal transduction proteins including type I
            TGF-beta receptor. It also interacts with multiple intracellular
            calcium release channels, and coordinates multi-protein complex
            formation of the tetrameric skeletal muscle ryanodine receptor. In
            mouse, deletion of this homologous gene causes congenital heart
            disorder known as noncompaction of left ventricular myocardium.
            Multiple alternatively spliced variants, encoding the same protein,
            have been identified. The human genome contains five pseudogenes
            related to this gene, at least one of which is transcribed.
            [provided by RefSeq, Sep 2008].
            
            Transcript Variant: This variant (1, also known as 12B) represents
            the longest transcript and encodes the longer isoform (a). Both
            variants 1 and 2 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.163989.1,
                                           SRR3476690.532936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400137.9/ ENSP00000383003.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               BC119732.1         56-518
            464-1483            AL136531.16        110982-112001       c
            1484-1514           CA450516.1         18-48               c
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..1514
                     /gene="FKBP1A"
                     /gene_synonym="FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12;
                     PKCI2; PPIASE"
                     /note="FKBP prolyl isomerase 1A"
                     /db_xref="GeneID:2280"
                     /db_xref="HGNC:HGNC:3711"
                     /db_xref="MIM:186945"
     exon            1..93
                     /gene="FKBP1A"
                     /gene_synonym="FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12;
                     PKCI2; PPIASE"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..383
                     /gene="FKBP1A"
                     /gene_synonym="FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12;
                     PKCI2; PPIASE"
                     /EC_number="5.2.1.8"
                     /note="isoform a is encoded by transcript variant 1;
                     calstabin-1; FK506-binding protein, T-cell, 12-kD; protein
                     kinase C inhibitor 2; rotamase; immunophilin FKBP12;
                     FK506-binding protein 1; peptidyl-prolyl cis-trans
                     isomerase FKBP1A; FKBP12-Exip3; FK506 binding protein12;
                     FK506-binding protein 12; 12 kDa FKBP; PPIase FKBP1A; 12
                     kDa FK506-binding protein; FK506 binding protein 1A,
                     12kDa; FK506-binding protein 1A"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP1A
                     isoform a"
                     /protein_id="NP_000792.1"
                     /db_xref="CCDS:CCDS13014.1"
                     /db_xref="GeneID:2280"
                     /db_xref="HGNC:HGNC:3711"
                     /db_xref="MIM:186945"
                     /translation="MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRN
                     KPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDV
                     ELLKLE"
     exon            94..141
                     /gene="FKBP1A"
                     /gene_synonym="FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12;
                     PKCI2; PPIASE"
                     /inference="alignment:Splign:2.1.0"
     exon            142..254
                     /gene="FKBP1A"
                     /gene_synonym="FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12;
                     PKCI2; PPIASE"
                     /inference="alignment:Splign:2.1.0"
     exon            255..419
                     /gene="FKBP1A"
                     /gene_synonym="FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12;
                     PKCI2; PPIASE"
                     /inference="alignment:Splign:2.1.0"
     exon            420..1514
                     /gene="FKBP1A"
                     /gene_synonym="FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12;
                     PKCI2; PPIASE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1485..1490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP1A"
                     /gene_synonym="FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12;
                     PKCI2; PPIASE"
                     /note="hexamer: AATAAA"
     polyA_site      1514
                     /gene="FKBP1A"
                     /gene_synonym="FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12;
                     PKCI2; PPIASE"
                     /note="major polyA site"
ORIGIN      
        1 gctgttggtc cacgccgccc gtcgcgccgc ccgcccgctc agcgtccgcc gccgccatgg
       61 gagtgcaggt ggaaaccatc tccccaggag acgggcgcac cttccccaag cgcggccaga
      121 cctgcgtggt gcactacacc gggatgcttg aagatggaaa gaaatttgat tcctcccggg
      181 acagaaacaa gccctttaag tttatgctag gcaagcagga ggtgatccga ggctgggaag
      241 aaggggttgc ccagatgagt gtgggtcaga gagccaaact gactatatct ccagattatg
      301 cctatggtgc cactgggcac ccaggcatca tcccaccaca tgccactctc gtcttcgatg
      361 tggagcttct aaaactggaa tgacaggaat ggcctcctcc cttagctccc tgttcttgga
      421 tctgccatgg agggatctgg tgcctccaga catgtgcaca tgaatccata tggagctttt
      481 cctgatgttc cactccactt tgtatagaca tctgccctga ctgaatgtgt tctgtcactc
      541 agctttgctt ccgacacctc tgtttcctct tcccctttct cctcgtatgt gtgtttacct
      601 aaactatatg ccataaacct caagttattc attttatttt gttttcattt tggggtgaag
      661 attcagtttc agtcttttgg atataggttt ccaattaagt acatggtcaa gtattaacag
      721 cacaagtggt aggttaacat tagaatagga attggtgttg gggggggggt ttgcaagaat
      781 attttatttt aattttttgg atgaaatttt tatctattat atattaaaca ttcttgctgc
      841 tgcgctgcaa agccatagca gatttgaggc gctgttgagg actgaattac tctccaagtt
      901 gagagatgtc tttgggttaa attaaaagcc ctacctaaaa ctgaggtggg gatggggaga
      961 gcctttgcct ccaccattcc cacccaccct ccccttaaac cctctgcctt tgaaagtaga
     1021 tcatgttcac tgcaatgctg gacactacag gtatctgtcc ctgggccagc agggacctct
     1081 gaagccttct ttgtggcctt tttttttttt catcctgtgg tttttctaat ggactttcag
     1141 gaattttgta atctcataac tttccaagct ccaccacttc ctaaatctta agaactttaa
     1201 ttgacagttt caattgaagg tgctgtttgt agacttaaca cccagtgaaa gcccagccat
     1261 catgacaaat ccttgaatgt tctcttaaga aaatgatgct ggtcatcgca gcttcagcat
     1321 ctcctgtttt ttgatgcttg gctccctctg ctgatctcag tttcctggct tttcctccct
     1381 cagccccttc tcaccccttt gctgtcctgt gtagtgattt ggtgagaaat cgttgctgca
     1441 cccttccccc agcaccattt atgagtctca agttttatta ttgcaataaa agtgctttat
     1501 gccggctttt ctca
//
