LOCUS       NM_015258               8766 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens FKBP prolyl isomerase family member 15 (FKBP15), mRNA.
ACCESSION   NM_015258 XM_376903 XM_936355
VERSION     NM_015258.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8766)
  AUTHORS   Shin,J.J.H., Gillingham,A.K., Begum,F., Chadwick,J. and Munro,S.
  TITLE     TBC1D23 is a bridging factor for endosomal vesicle capture by
            golgins at the trans-Golgi
  JOURNAL   Nat Cell Biol 19 (12), 1424-1432 (2017)
   PUBMED   29084197
  REMARK    Erratum:[Nat Cell Biol. 2018 Feb;20(2):222. doi:
            10.1038/s41556-017-0026-7.. PMID: 29311657]
REFERENCE   2  (bases 1 to 8766)
  AUTHORS   Harbour,M.E., Breusegem,S.Y. and Seaman,M.N.
  TITLE     Recruitment of the endosomal WASH complex is mediated by the
            extended 'tail' of Fam21 binding to the retromer protein Vps35
  JOURNAL   Biochem J 442 (1), 209-220 (2012)
   PUBMED   22070227
REFERENCE   3  (bases 1 to 8766)
  AUTHORS   Harbour,M.E., Breusegem,S.Y., Antrobus,R., Freeman,C., Reid,E. and
            Seaman,M.N.
  TITLE     The cargo-selective retromer complex is a recruiting hub for
            protein complexes that regulate endosomal tubule dynamics
  JOURNAL   J Cell Sci 123 (Pt 21), 3703-3717 (2010)
   PUBMED   20923837
REFERENCE   4  (bases 1 to 8766)
  AUTHORS   Pan,Y.F., Viklund,I.M., Tsai,H.H., Pettersson,S. and Maruyama,I.N.
  TITLE     The ulcerative colitis marker protein WAFL interacts with accessory
            proteins in endocytosis
  JOURNAL   Int J Biol Sci 6 (2), 163-171 (2010)
   PUBMED   20376207
  REMARK    GeneRIF: WAFL may play an important role in endocytosis and
            subsequent membrane trafficking by interacting with AP2 through
            KIAA0196 and KIAA1033
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8766)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 8766)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   7  (bases 1 to 8766)
  AUTHORS   Viklund,I.M., Aspenstrom,P., Meas-Yedid,V., Zhang,B., Kopec,J.,
            Agren,D., Schneider,G., D'Amato,M., Olivo-Marin,J.C.,
            Sansonetti,P., Van Nhieu,G.T. and Pettersson,S.
  TITLE     WAFL, a new protein involved in regulation of early endocytic
            transport at the intersection of actin and microtubule dynamics
  JOURNAL   Exp Cell Res 315 (6), 1040-1052 (2009)
   PUBMED   19121306
  REMARK    GeneRIF: findings are compatible with a model whereby WAFL is
            involved in the transport of early endosomes at the level of
            transition between microfilament-based and microtubule-based
            movement.
REFERENCE   8  (bases 1 to 8766)
  AUTHORS   Viklund,I.M., Kuznetsov,N.V., Lofberg,R., Daperno,M., Sostegni,R.,
            Astegiano,M., Rizzetto,M., von Stein,O., D'Amato,M., von Stein,P.
            and Pettersson,S.
  TITLE     Identification of a new WASP and FKBP-like (WAFL) protein in
            inflammatory bowel disease: a potential marker gene for ulcerative
            colitis
  JOURNAL   Int J Colorectal Dis 23 (10), 921-930 (2008)
   PUBMED   18654788
REFERENCE   9  (bases 1 to 8766)
  AUTHORS   Nakajima,O., Nakamura,F., Yamashita,N., Tomita,Y., Suto,F.,
            Okada,T., Iwamatsu,A., Kondo,E., Fujisawa,H., Takei,K. and
            Goshima,Y.
  TITLE     FKBP133: a novel mouse FK506-binding protein homolog alters growth
            cone morphology
  JOURNAL   Biochem Biophys Res Commun 346 (1), 140-149 (2006)
   PUBMED   16756961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB014574.1, DA238568.1, BC077732.1, BQ646813.1 and AL449105.22.
            
            On Nov 23, 2018 this sequence version replaced NM_015258.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014574.1, SRR1803616.195960.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238256.8/ ENSP00000238256.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-936               AB014574.1         12-947
            937-1273            DA238568.1         1-337
            1274-1948           AB014574.1         1285-1959
            1949-1984           BC077732.1         246-281
            1985-3046           AB014574.1         1996-3057
            3047-3777           BQ646813.1         1-731
            3778-4252           AB014574.1         3789-4263
            4253-8766           AL449105.22        97496-102009        c
FEATURES             Location/Qualifiers
     source          1..8766
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..8766
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /note="FKBP prolyl isomerase family member 15"
                     /db_xref="GeneID:23307"
                     /db_xref="HGNC:HGNC:23397"
                     /db_xref="MIM:617398"
     exon            1..87
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..3694
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /EC_number="5.2.1.8"
                     /note="FK506-binding protein 133kDa; WAFL; FKBP-15;
                     FKBP-133; 133 kDa FKBP; protein phosphatase 1, regulatory
                     subunit 76; WASP and FKBP-like protein; FKBP prolyl
                     isomerase 15; 133 kDa FK506-binding protein; FK506 binding
                     protein 15, 133kDa"
                     /codon_start=1
                     /product="FK506-binding protein 15"
                     /protein_id="NP_056073.1"
                     /db_xref="CCDS:CCDS48007.1"
                     /db_xref="GeneID:23307"
                     /db_xref="HGNC:HGNC:23397"
                     /db_xref="MIM:617398"
                     /translation="MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAP
                     KQPKKGQGTAATGNQATPKTAPATMSTPTILVATAVHAYRYTNGQYVKQGKFGAAVLG
                     NHTAREYRILLYISQQQPVTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAA
                     VEFNKQVCIAKCNSTSSLDAVLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVF
                     DSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVIGWTQAT
                     DSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFK
                     SGEPALRTKSNSLSEQLAINTSPDAVKAKLISRMAKMGQPMLPILPPQLDSNDSEIED
                     VNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSH
                     SAVSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFL
                     MTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSN
                     IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTAT
                     ENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDL
                     LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLE
                     KNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQ
                     AELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALT
                     KQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTIL
                     GTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPL
                     NRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEALSEIKDGSLPPELS
                     CIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVREVAPDGP
                     LQESSTRLSLTSDPEEGDPLALGPESPGEPQPPQLKKDDVTSSTGPHKELSSTEAGST
                     VAGAALRPSHHSQRSSLSGDEEDELFKGATLKALRPKAQPEEEDEDEVSMKGRPPPTP
                     LFGDDDDDDDIDWLG"
     exon            88..203
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            204..288
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            289..358
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            359..433
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            434..532
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            533..682
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            683..751
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            752..898
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1041
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1099
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1207
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1310
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1417
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1532
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1642
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1750
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1845
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1948
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2120
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2257
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2413
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2566
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2692
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2800
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..3519
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3616
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..8766
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4229..4234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /note="hexamer: AATAAA"
     regulatory      4242..4247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /note="hexamer: AATGAA"
     polyA_site      4253
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /note="major polyA site"
     polyA_site      4258
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
     regulatory      6107..6112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /note="hexamer: AATAAA"
     polyA_site      6129
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
     regulatory      6293..6298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /note="hexamer: AATAAA"
     polyA_site      6321
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
     regulatory      8744..8749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
                     /note="hexamer: AATAAA"
     polyA_site      8766
                     /gene="FKBP15"
                     /gene_synonym="FKBP133; KIAA0674; PPP1R76"
ORIGIN      
        1 gcttcctccc cgcaacccgg tgaaagccaa cgcaatgttc ggtgcggggg acgaggacga
       61 caccgatttc ctctcgccga gcggcggtgc cagattggcc tcactttttg gactggatca
      121 ggcagctgct ggccatggaa atgaattttt ccagtacaca gccccaaaac agcctaagaa
      181 aggccaggga acggcagcaa caggaaatca ggcaacacca aaaacagcac cagccaccat
      241 gagcactccc acaatactgg tcgcaacagc agtccatgca tatcgataca caaatggtca
      301 atatgtaaag cagggcaaat ttggtgctgc agttctgggg aaccacacag ccagagagta
      361 taggattctt ctttatatca gtcaacaaca gccagttacg gttgctagga ttcatgtgaa
      421 ctttgagcta atggttcggc ccaataacta tagcaccttt tatgatgacc agagacagaa
      481 ctggtccatc atgtttgagt cggaaaaggc tgctgtggag ttcaataagc aggtgtgcat
      541 tgctaagtgc aacagtacct cttccctgga tgcagtgctc tcccaggacc tcattgtggc
      601 agacggccct gctgtagaag ttggagattc tttggaagtg gcctataccg gctggctctt
      661 tcagaatcat gtgctgggcc aggttttcga ctccactgct aacaaagata agttgcttcg
      721 cttgaagtta ggatcaggaa aagtcatcaa gggctgggag gatggaatgc tgggcatgaa
      781 aaaaggagga aagcgattgc ttattgtccc tccagcctgt gctgttggct cagaaggggt
      841 aataggctgg actcaagcaa cggactcgat cctggtgttc gaggtggagg ttaggcgggt
      901 gaagtttgcc agagattctg gctctgatgg tcacagtgtt agttcccgcg attctgcagc
      961 tccgtctccc atccctggtg ctgacaacct ctctgctgat cctgttgtgt caccacccac
     1021 atcaatacct ttcaaatcag gggagccagc tcttcgtacc aaatctaact ccctcagtga
     1081 acaacttgca ataaatacaa gtcccgatgc agtcaaagcc aagttgatct ctcggatggc
     1141 taaaatgggc cagcccatgc tgcccatcct tccaccacag ctggattcca atgattcaga
     1201 aatcgaagat gtgaacactc tgcaaggagg tgggcagcct gtggtgactc cgtccgtcca
     1261 gccctctctt catccggccc atccagcgtt accacagatg acctcacagg cacctcagcc
     1321 atctgttact gggctccagg caccttctgc tgccttaatg caagtgtcat ctctcgattc
     1381 ccactcagct gtatctggaa atgcccaatc ctttcagccc tatgcaggta tgcaagccta
     1441 cgcttatccc caggcatctg ccgtcacctc ccagctgcag cccgttcggc ctttgtaccc
     1501 agcaccgctc tctcagcctc cccatttcca aggatcaggt gatatggctt catttctcat
     1561 gactgaagcc cggcaacata acactgaaat tcgaatggca gtcagcaaag tggctgataa
     1621 aatggatcat ctcatgacta aggttgaaga gttacagaaa catagtgctg gcaattccat
     1681 gcttattcct agcatgtcag ttacaatgga aacaagcatg attatgagca acatccagcg
     1741 aatcattcag gaaaatgaaa gattgaagca agagatcctt gaaaagagca atcggataga
     1801 agaacagaat gacaagatta gtgaactaat tgaacgaaat cagaggtatg ttgagcagag
     1861 taacctgatg atggagaaga ggaacaactc acttcagaca gccacagaaa acacacaggc
     1921 aagagtattg catgctgaac aagagaaggc caaggtgaca gaggagttag cagcggccac
     1981 tgcacaggtc tctcatctgc agctgaaaat gactgctcac caaaaaaagg aaacagagct
     2041 gcagatgcag ctgacagaaa gcctgaagga gacagatctt ctcaggggcc agctcaccaa
     2101 agtgcaggca aagctctcag agctccaaga aacctctgag caagcacagt ccaaattcaa
     2161 aagtgaaaag cagaaccgga aacaactgga actcaaggtg acatccctgg aggaggaact
     2221 gactgacctt cgagttgaga aggagtcctt ggaaaagaac ctctcagaaa ggaaaaagaa
     2281 gtcagctcaa gagcgttctc aggccgagga ggagatagat gaaattcgca agtcatacca
     2341 ggaggaattg gacaaacttc gacagctctt gaaaaagact cgagtgtcca cagaccaagc
     2401 agctgcagag cagctgtctt tagtacaggc tgagctacag acccagtggg aagcaaaatg
     2461 tgaacatttg ttggcctccg ccaaggatga gcacctgcag cagtaccagg aggtgtgcgc
     2521 acagagagat gcctaccagc agaagctggt acaacttcag gaaaagtgtt tagccctcca
     2581 ggcccaaatc acagctctca ccaagcaaaa tgaacagcac atcaaggaac tagagaagaa
     2641 caagtcccag atgtctgggg ttgaagctgc tgcatctgac ccctcagaga aggtcaagaa
     2701 gatcatgaac caggtgttcc agtccttacg gagagagttt gagctggagg aatcttacaa
     2761 tggcaggacc attctgggaa ccatcatgaa tacgatcaag atggtgactc ttcagctgtt
     2821 aaaccaacag gagcaagaga aggaagagag cagcagtgaa gaagaagaag aaaaagcaga
     2881 agagcggcca cgaagacctt cccaggagca gtcagcctca gccagttctg ggcagcctca
     2941 agcacccctg aatagggaga ggccagagtc ccccatggtg ccctcagagc aggtggtcga
     3001 ggaagctgtc ccgttgcctc ctcaggccct caccacttcc caggatggac acagaaggaa
     3061 aggggactca gaagctgagg cactctcaga gataaaagat ggttcccttc cacccgaact
     3121 gtcttgcatc ccatcccaca gagttctagg gcccccgact tcaattccac ctgagcccct
     3181 aggccctgta tccatggact ctgagtgtga ggagtcactt gctgccagcc caatggcagc
     3241 taagcccgac aacccatcag gaaaggtctg tgtcagggaa gtagcaccag atggcccact
     3301 acaagaaagc tccacaagac tgtccctgac ttcagacccc gaggaggggg acccactggc
     3361 cttagggcct gaaagcccag gagagcctca gcctccacag ctcaagaaag atgatgtcac
     3421 tagctccacc ggtccccaca aggagctgtc aagcacagag gcaggttcca cagttgcagg
     3481 agcagccctc agacccagcc atcattccca gcgttccagt ctctctgggg atgaagagga
     3541 tgaactgttt aaaggggcaa ctctgaaagc tctgaggccc aaagcacagc ctgaggagga
     3601 ggatgaagac gaggtgagca tgaagggacg cccgccccca acgccccttt ttggagatga
     3661 tgatgatgac gatgacattg actggctggg atgaagaccc aggaaactgg tgcaaaggtt
     3721 tctctgcaac ccttccctaa gcatgatttt gcacagccaa ccctgggtct aggcgaacca
     3781 cagggtgagg tcaaggtgag cattctggga acaatatttg ggctcagagg gtgggttggc
     3841 caccttctga gccccacccc cgccagacct ggtgaagagg atcataaccc tgtcttcaag
     3901 aacactggga tttcagcagc aagttggaag aaggactggt aggttcccct ccaagccagt
     3961 cacctgtaag agtcctgtcc tctgccagac tttttaatct cttcattaac tctcagactg
     4021 acctgggagc cctcctctac ctgaatccag tgctcaactg tgccccggca acaagacctg
     4081 ggctgaggtc tccctggtag aactaaggga gattacacca tctaaatccc agtgcagtca
     4141 acagcctggc ctatagtcct gggacatgta tcttcttctt tgccttaaat ctgatacaag
     4201 aggtcaatga ctttgaaaat aaaactaaaa taaatgtcta taatgaaact tgacccaagc
     4261 ccttggagaa aaattgagtt tggttccaag ggctgtctgt gctcttttgg gaatctaagg
     4321 gtaggagtct tacagatctg ggtcagttaa tgtgcacaaa acgttgtggc atatttactc
     4381 cctttgatac ctaaccctgg aacttttagg ctttcaaaga aagtcaccac tgtagtccta
     4441 gctcatccct ggggcatgat ggttctgtga ggaccagtcc agtcatcctc ttgctcctgc
     4501 aggcttagtc ctgcagtcta ggaagccatg caaagaaggt gagagggtcc cttctttcca
     4561 ttgttcatgg cacctgaggg attcttcact ttgagagcag cttccattcc cttagaactc
     4621 atgggaccag gacttatgca gagaacagta gtgagaaaat acttgtggtc attttcttga
     4681 ttccaggatc ttccaaagat tatgcaatca gtctttaaaa aaacagaata attaatttta
     4741 ataaaaaatg tttcttgatt ttaaatgttt taaaagatag gacccaaaat tccacttcat
     4801 ctggcctggc atcatccttg caggctttgg atatgtctcc cgtgtgcgga cctgggaggc
     4861 agtgagaact aattatttct ttgttgctta acaaaaggcg gtgctgtttg gcactttcac
     4921 agactggctt atctccagca accactgcag aagacagtgt tatcaccatt ttatagagga
     4981 gaaaactgag acttagagag gtaaagtaat ttgcccaaag ttacatatct aggaagcctc
     5041 agcacaagaa ttcaaatcct ggccatctga ttccagagcc tgggctcttg gccagcacag
     5101 cctgactgtc actggttggg ggaaggggcg gtgatgcttt tagaaacagg cttcttgaga
     5161 caccaggcag ctttccagtt ccctgcaaac atgggggaat gccctgatca gtcctaaagg
     5221 tgtgacatag tctactttct agggcagtta tttcttattg taaattaact agtggctatt
     5281 atatttgctt ctgcccgcag ggagagaaga tgctgagtaa ttgtgccaac acaggtgctt
     5341 aaagtccgtg tgacagttac ttttcttata gcatgtactc aattaatact tgttacatga
     5401 atgaagaatg acttgacttg cctcagttgg cattctgggg tgtctacctg ggtgcagcat
     5461 ttcagggctg ggtttccctg agcagagttg tctttgtagc agatggatgg actctgtcct
     5521 cagacaggct tataaagagt actaccagtt ctattagccc cactcagccc ctgcagttgt
     5581 tacaagggtt catgtgcttt ctgttggaat taggagaaca gaacagtcat agactattta
     5641 aaaatatata tttactaaaa tgtatttgtt tgtttttaat tcccaaagct tacaaccatc
     5701 ttttcatcta atctgtgagg tatttagtat acagcagtga ttttctctct ttcctttttt
     5761 ataaagtgaa gaggttcaac tatccagaga gtcccatcta actcaaaaaa tgtaatggct
     5821 ttggttggat tgcatcttca gtcagtacct gcccatggct taatcagtat tttaagtgaa
     5881 tgaatcatgt ttccccacta gatcattacg agtaagcagt aagtaataaa tagagaatat
     5941 taagtattga acattattag atgcagcttt ttgttctgca tagaagaaag atgaggataa
     6001 aggagggcat tgaggccacg aagagcttcc cagacaccca cggccatcag atcatcttct
     6061 tcctgcaggc agtgccttct ggtggaagga gctcagtcta tcagagaata aaccaggagc
     6121 ctgaaagcag tcctgtgtct ctgcctttaa tcagctgtca cttattctct ccccaagaaa
     6181 gggaaatagg tctcagcagt ttctgccatc catcatgaat caatgaaatc atttcattaa
     6241 aaattttttt gtatgaatgt gcaaaattgc caactaggag ttcaatggga aaaataaaaa
     6301 aaacttagtt tgtcaacatg atccatagac gagatgatct tcatgtgttc caaaggcaga
     6361 aaggtgagaa aaaggatcta gcttggtctc tgtccctcaa agacagaaga ggtcaggaag
     6421 tccaatgggc gatgctcctg tagataaggc acaaagcagg agagctgagg gtgtccaggt
     6481 tccatgccct gcatcaccaa gaacccttct ccctggcttg aaatctttgg aaattcctgg
     6541 tttgagtcac agagaagcat tgtcatgggc tcagtaaccc tgccacccct gttatctcca
     6601 ttctcccttt ggtcacagca gctgtcttaa gacacaagac catgcctggg ccctacgtag
     6661 gctggctgag aaggaaggtt gctgcaatgg cttccgaact ccagggagca agtgctggct
     6721 tcagctcaaa gtttccaggg gctgggaata aggtggagga atagccatca gaagaaaggg
     6781 cagttggaag tatagtgtct ggaagagggg gctccatgtc cctccagcct cagtgcctgc
     6841 acgttcctca ccagctaagc tgtgctgaga agtgggtaag ctaggtagta gcccacagca
     6901 gagcccaaga ccacaccaag gaaaatccag gtgttgtagg acattacggc cagcatgatg
     6961 aagtagccga tgaccacctg gatgacatgg attagagact ggccaaagtg acacaaatac
     7021 cacctagata aaaaggagaa gcaagttaat cctggtaatg agctggtaat gaggaagctg
     7081 ggagtagata tcagggagta gaaagctgtt gagttacgtg acccgattga tttataactt
     7141 gtatgcttaa cccaggagtg atttctttct gcccctccca cccccgcccc cagaaaaaac
     7201 tcgagattta tttttaaaga gacatatctt cactacattt ggtttcaagc ttcctggcat
     7261 cctaggcaaa ggggaaaatg agggtatcta taatctgtct ttctgataag gaataagaga
     7321 aaatcatcag taaggcatat ttcccccctg aatctacttc gggaggcagt atgacaatgg
     7381 aaagaaaaag catggtctta ggtgacatta tcagttccta gacctgccac taactaaaag
     7441 tggcctagac aaatgtctta acctctctga acgtaagatt ccttatcagt aaaacaggaa
     7501 tgagaatact tcccttgcag tgcagttgtg aagatctgag acacccatgt agggtggcta
     7561 gtgatggagc gggcaggctt attaagcaca ggtgaggctg gggctggaca gagggcagaa
     7621 cagggaccct aaatggttgc ctgattcgag tgggaaggga ggagaggaga gcttgtcatc
     7681 ctcctcccac caagtgggat acattgcttc aggacagctg cagatcccct cctggatatg
     7741 ggagcctagt gacccatgga actggtgaga tttgggggag ggtgggtggc cacctcattt
     7801 gctagatagg ggcctgcacc tgaagatcac tgttccctaa agaaagcctt ctgagcctct
     7861 caagtggctg gctgttcaca gagtgctttg gcctgggcat caggagacat gagctctagt
     7921 tcacttggct atgtgtagcc actttggcaa gtcctggtcc ttccctgggc ctcgctgtcc
     7981 tctctgtgaa gtggggctaa tgctgtctgg gccagcctgt ctctcagggt gaatgtgagg
     8041 cttctgcccc tttcccatac ccactgcctg tacctgtggt gggttctgcc aacagggaat
     8101 gaatctgagc ctgcagagtc cccgtctgtc tctgcgatgg tctgctggct gatggaggtt
     8161 ggcaggttca ccagtacctg gttgagcagc ttggctttgc caaccttgat gccttcatac
     8221 agtacagcca gaagcaggag caccaacacc gaaagggcca tgcctgtcaa aggaggcaga
     8281 gttgtggaga cctggccagg ccagcactgt ttcccttcca gcacctccac ctgttcatgg
     8341 aatccactcc atccacctct atcctgcacc ttcttcccca cccttgctga gttccgaact
     8401 tcttcactgt cttcaccaga cttttcttag ctggagtgtg gctttgagat caggaagaga
     8461 agccacctga aaaatccagg ggctgagggt gaagaagcca cgtaccatta ccccacccac
     8521 tcccccagca ggctgcacaa atctgtcgtg acttcttgtt aagtgatgag tactgcaagg
     8581 tcctatttat atgtaagtat gcaaaaaatg tctggaagga aagataaata gcacaagagt
     8641 aatagttatc tcagcaaagt aggatacagg tggtttttat gttcttgcct aactttctaa
     8701 ggtttctttt atatatatta cttttataat aggggaaaaa cccaataaat tattttacca
     8761 aaacta
//
