LOCUS       NM_016594                691 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens FKBP prolyl isomerase 11 (FKBP11), transcript variant
            1, mRNA.
ACCESSION   NM_016594
VERSION     NM_016594.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 691)
  AUTHORS   Zeng,D., Li,J., Yuan,X., Cai,F., Yu,B., Liu,L., Chen,Q., Zhang,F.,
            Liang,Y., Tang,X., Peng,Y., Qu,G., Wu,P., Jiao,Q., Sun,L., Lv,X.B.
            and Liao,Q.
  TITLE     FKBP11 improves the malignant property of osteosarcoma cells and
            acts as a prognostic factor of osteosarcoma
  JOURNAL   Aging (Albany NY) 15 (7), 2450-2459 (2023)
   PUBMED   37014329
  REMARK    GeneRIF: FKBP11 improves the malignant property of osteosarcoma
            cells and acts as a prognostic factor of osteosarcoma.
REFERENCE   2  (bases 1 to 691)
  AUTHORS   Thokerunga,E., Huang,F., Bongolo,C.C., Rugera,S.P., Akankwatsa,G.
            and Tu,J.C.
  TITLE     FKBP11 upregulation promotes proliferation and migration in
            hepatocellular carcinoma
  JOURNAL   Cancer Biomark 37 (2), 109-120 (2023)
   PUBMED   37248890
  REMARK    GeneRIF: FKBP11 upregulation promotes proliferation and migration
            in hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 691)
  AUTHORS   Preisendorfer,S., Ishikawa,Y., Hennen,E., Winklmeier,S.,
            Schupp,J.C., Knuppel,L., Fernandez,I.E., Binzenhofer,L.,
            Flatley,A., Juan-Guardela,B.M., Ruppert,C., Guenther,A.,
            Frankenberger,M., Hatz,R.A., Kneidinger,N., Behr,J., Feederle,R.,
            Schepers,A., Hilgendorff,A., Kaminski,N., Meinl,E., Bachinger,H.P.,
            Eickelberg,O. and Staab-Weijnitz,C.A.
  TITLE     FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody
            Folding Catalyst with Increased Expression in Idiopathic Pulmonary
            Fibrosis
  JOURNAL   Cells 11 (8), 1341 (2022)
   PUBMED   35456020
  REMARK    GeneRIF: FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific
            Antibody Folding Catalyst with Increased Expression in Idiopathic
            Pulmonary Fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 691)
  AUTHORS   Qiu,L., Liu,H., Wang,S., Dai,X.H., Shang,J.W., Lian,X.L., Wang,G.H.
            and Zhang,J.
  TITLE     FKBP11 promotes cell proliferation and tumorigenesis via
            p53-related pathways in oral squamous cell carcinoma
  JOURNAL   Biochem Biophys Res Commun 559, 183-190 (2021)
   PUBMED   33945996
  REMARK    GeneRIF: FKBP11 promotes cell proliferation and tumorigenesis via
            p53-related pathways in oral squamous cell carcinoma.
REFERENCE   5  (bases 1 to 691)
  AUTHORS   Ishikawa,Y., Mizuno,K. and Bachinger,H.P.
  TITLE     Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident
            peptidyl prolyl isomerases show different activities toward
            hydroxyproline
  JOURNAL   J Biol Chem 292 (22), 9273-9282 (2017)
   PUBMED   28385890
  REMARK    GeneRIF: observed changes in activity of six rER-resident PPIases,
            cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19
            (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due
            to posttranslational modifications of proline residues in the
            substrate.
REFERENCE   6  (bases 1 to 691)
  AUTHORS   Lin,I.Y., Yen,C.H., Liao,Y.J., Lin,S.E., Ma,H.P., Chan,Y.J. and
            Chen,Y.M.
  TITLE     Identification of FKBP11 as a biomarker for hepatocellular
            carcinoma
  JOURNAL   Anticancer Res 33 (6), 2763-2769 (2013)
   PUBMED   23749938
  REMARK    GeneRIF: results suggest a progressively elevated expression of
            FKBP11 during the development of hepatocellular carcinoma
REFERENCE   7  (bases 1 to 691)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 691)
  AUTHORS   Rulten,S.L., Kinloch,R.A., Tateossian,H., Robinson,C., Gettins,L.
            and Kay,J.E.
  TITLE     The human FK506-binding proteins: characterization of human FKBP19
  JOURNAL   Mamm Genome 17 (4), 322-331 (2006)
   PUBMED   16596453
REFERENCE   9  (bases 1 to 691)
  AUTHORS   Patterson,C.E., Gao,J., Rooney,A.P. and Davis,E.C.
  TITLE     Genomic organization of mouse and human 65 kDa FK506-binding
            protein genes and evolution of the FKBP multigene family
  JOURNAL   Genomics 79 (6), 881-889 (2002)
   PUBMED   12036304
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358998.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016594.2.
            
            Summary: FKBP11 belongs to the FKBP family of peptidyl-prolyl
            cis/trans isomerases, which catalyze the folding of
            proline-containing polypeptides. The peptidyl-prolyl isomerase
            activity of FKBP proteins is inhibited by the immunosuppressant
            compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed
            16596453]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027973.1, AF238079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000550765.6/ ENSP00000449751.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-691               AY358998.1         14-704
FEATURES             Location/Qualifiers
     source          1..691
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..691
                     /gene="FKBP11"
                     /gene_synonym="FKBP19"
                     /note="FKBP prolyl isomerase 11"
                     /db_xref="GeneID:51303"
                     /db_xref="HGNC:HGNC:18624"
                     /db_xref="MIM:610571"
     exon            1..193
                     /gene="FKBP11"
                     /gene_synonym="FKBP19"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..670
                     /gene="FKBP11"
                     /gene_synonym="FKBP19"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; peptidyl-prolyl cis-trans isomerase FKBP11;
                     FKBP-11; FKBP-19; rotamase; 19 kDa FKBP; PPIase FKBP11; 19
                     kDa FK506-binding protein; FK506 binding protein 11, 19
                     kDa; FK506-binding protein 11"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP11
                     isoform 1 precursor"
                     /protein_id="NP_057678.1"
                     /db_xref="CCDS:CCDS8773.1"
                     /db_xref="GeneID:51303"
                     /db_xref="HGNC:HGNC:18624"
                     /db_xref="MIM:610571"
                     /translation="MTLRPSLLPLHLLLLLLLSAAVCRAEAGLETESPVRTLQVETLV
                     EPPEPCAEPAAFGDTLHIHYTGSLVDGRIIDTSLTRDPLVIELGQKQVIPGLEQSLLD
                     MCVGEKRRAIIPSHLAYGKRGFPPSVPADAVVQYDVELIALIRANYWLKLVKGILPLV
                     GMAMVPALLGLIGYHLYRKANRPKVSKKKLKEEKRNKSKKK"
     exon            194..259
                     /gene="FKBP11"
                     /gene_synonym="FKBP19"
                     /inference="alignment:Splign:2.1.0"
     exon            260..347
                     /gene="FKBP11"
                     /gene_synonym="FKBP19"
                     /inference="alignment:Splign:2.1.0"
     exon            348..381
                     /gene="FKBP11"
                     /gene_synonym="FKBP19"
                     /inference="alignment:Splign:2.1.0"
     exon            382..452
                     /gene="FKBP11"
                     /gene_synonym="FKBP19"
                     /inference="alignment:Splign:2.1.0"
     exon            453..691
                     /gene="FKBP11"
                     /gene_synonym="FKBP19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      676..681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FKBP11"
                     /gene_synonym="FKBP19"
                     /note="hexamer: AATAAA"
     polyA_site      691
                     /gene="FKBP11"
                     /gene_synonym="FKBP19"
                     /note="major polyA site"
ORIGIN      
        1 gtcctggctg ccgccacccg aacagcctgt cctggtgccc cggctccctg ccccgcgccc
       61 agtcatgacc ctgcgcccct cactcctccc gctccatctg ctgctgctgc tgctgctcag
      121 tgcggcggtg tgccgggctg aggctgggct cgaaaccgaa agtcccgtcc ggaccctcca
      181 agtggagacc ctggtggagc ccccagaacc atgtgccgag cccgctgctt ttggagacac
      241 gcttcacata cactacacgg gaagcttggt agatggacgt attattgaca cctccctgac
      301 cagagaccct ctggttatag aacttggcca aaagcaggtg attccaggtc tggagcagag
      361 tcttctcgac atgtgtgtgg gagagaagcg aagggcaatc attccttctc acttggccta
      421 tggaaaacgg ggatttccac catctgtccc agcggatgca gtggtgcagt atgacgtgga
      481 gctgattgca ctaatccgag ccaactactg gctaaagctg gtgaagggca ttttgcctct
      541 ggtagggatg gccatggtgc cagccctcct gggcctcatt gggtatcacc tatacagaaa
      601 ggccaataga cccaaagtct ccaaaaagaa gctcaaggaa gagaaacgaa acaagagcaa
      661 aaagaaataa taaataataa attttaaaaa a
//
