LOCUS       NM_014344               2406 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens four-jointed box kinase 1 (FJX1), mRNA.
ACCESSION   NM_014344
VERSION     NM_014344.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2406)
  AUTHORS   Zhang,H., Zhang,Z., Wang,Q., Wang,L., Yang,Z., Geng,Z., Wang,Y.,
            Li,J. and Zuo,L.
  TITLE     [FJX1 overexpression is associated with poor prognosis and promotes
            gastric cancer proliferation via the PI3K/AKT signaling pathway]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (6), 975-984 (2023)
   PUBMED   37439170
  REMARK    GeneRIF: [FJX1 overexpression is associated with poor prognosis and
            promotes gastric cancer proliferation via the PI3K/AKT signaling
            pathway].
REFERENCE   2  (bases 1 to 2406)
  AUTHORS   Cheng,T., Zhu,X., Lu,J. and Teng,X.
  TITLE     MiR-532-3p suppresses cell proliferation, migration and invasion of
            colon adenocarcinoma via targeting FJX1
  JOURNAL   Pathol Res Pract 232, 153835 (2022)
   PUBMED   35278814
  REMARK    GeneRIF: MiR-532-3p suppresses cell proliferation, migration and
            invasion of colon adenocarcinoma via targeting FJX1.
REFERENCE   3  (bases 1 to 2406)
  AUTHORS   Wan,N., Yang,W., Cheng,H. and Wang,J.
  TITLE     FOXD3-AS1 Contributes to the Progression of Melanoma Via
            miR-127-3p/FJX1 Axis
  JOURNAL   Cancer Biother Radiopharm 35 (8), 596-604 (2020)
   PUBMED   32354225
  REMARK    GeneRIF: FOXD3-AS1 Contributes to the Progression of Melanoma Via
            miR-127-3p/FJX1 Axis.
REFERENCE   4  (bases 1 to 2406)
  AUTHORS   Dang,W. and Zhu,Z.
  TITLE     MicroRNA-1249 targets four-jointed box kinase 1 and reduces cell
            proliferation, migration and invasion of colon adenocarcinoma
  JOURNAL   J Gene Med 22 (7), e3183 (2020)
   PUBMED   32159255
  REMARK    GeneRIF: MicroRNA-1249 targets four-jointed box kinase 1 and
            reduces cell proliferation, migration and invasion of colon
            adenocarcinoma.
REFERENCE   5  (bases 1 to 2406)
  AUTHORS   Chai,S.J., Ahmad Zabidi,M.M., Gan,S.P., Rajadurai,P., Lim,P.V.H.,
            Ng,C.C., Yap,L.F., Teo,S.H., Lim,K.P., Patel,V. and Cheong,S.C.
  TITLE     An Oncogenic Role for Four-Jointed Box 1 (FJX1) in Nasopharyngeal
            Carcinoma
  JOURNAL   Dis Markers 2019, 3857853 (2019)
   PUBMED   31236144
  REMARK    GeneRIF: FJX1 transcript and protein level is upregulated in
            nasopharyngeal carcinoma tissue samples.  FJX1 promotes cell
            proliferation, anchorage-dependent growth, and cellular invasion in
            vitro.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2406)
  AUTHORS   Chang,H.J., Yoo,J.Y., Kim,T.H., Fazleabas,A.T., Young,S.L.,
            Lessey,B.A. and Jeong,J.W.
  TITLE     Overexpression of Four Joint Box-1 Protein (FJX1) in Eutopic
            Endometrium From Women With Endometriosis
  JOURNAL   Reprod Sci 25 (2), 207-213 (2018)
   PUBMED   28673206
  REMARK    GeneRIF: The results of our Western blot analysis reveal a
            significant positive correlation between FJX1 and HIF1alpha
            proteins in endometrium of women with and without endometriosis.
REFERENCE   7  (bases 1 to 2406)
  AUTHORS   Sadeqzadeh,E., de Bock,C.E., O'Donnell,M.R., Timofeeva,A.,
            Burns,G.F. and Thorne,R.F.
  TITLE     FAT1 cadherin is multiply phosphorylated on its ectodomain but
            phosphorylation is not catalysed by the four-jointed homologue
  JOURNAL   FEBS Lett 588 (18), 3511-3517 (2014)
   PUBMED   25150169
  REMARK    GeneRIF: FJX1 does not influence the levels of FAT1 ectodomain
            phosphorylation.
REFERENCE   8  (bases 1 to 2406)
  AUTHORS   Gawin,B., Niederfuhr,A., Schumacher,N., Hummerich,H., Little,P.F.
            and Gessler,M.
  TITLE     A 7.5 Mb sequence-ready PAC contig and gene expression map of human
            chromosome 11p13-p14.1
  JOURNAL   Genome Res 9 (11), 1074-1086 (1999)
   PUBMED   10568747
REFERENCE   9  (bases 1 to 2406)
  AUTHORS   Ashery-Padan,R., Alvarez-Bolado,G., Klamt,B., Gessler,M. and
            Gruss,P.
  TITLE     Fjx1, the murine homologue of the Drosophila four-jointed gene,
            codes for a putative secreted protein expressed in restricted
            domains of the developing and adult brain
  JOURNAL   Mech Dev 80 (2), 213-217 (1999)
   PUBMED   10072791
REFERENCE   10 (bases 1 to 2406)
  AUTHORS   Thate,C., Pongratz,J., Konig,A., Klamt,B., Tsaoussidou,S.,
            Higgins,M., Shows,T., Jones,C. and Gessler,M.
  TITLE     CpG island clones for chromosome 11p--a resource for mapping and
            gene identification
  JOURNAL   Mamm Genome 6 (6), 421-425 (1995)
   PUBMED   7647465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC049171.1 and AK026069.1.
            
            On May 17, 2019 this sequence version replaced NM_014344.3.
            
            Summary: The protein encoded by this gene is the human ortholog of
            mouse and Drosophila four-jointed gene product. The Drosophila
            protein is important for growth and differentiation of legs and
            wings, and for proper development of the eyes. The exact function
            of this gene in humans is not known. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ245599.1, BC071898.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317811.6/ ENSP00000400223.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2251              BC049171.1         20-2270
            2252-2406           AK026069.1         1488-1642
FEATURES             Location/Qualifiers
     source          1..2406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..2406
                     /gene="FJX1"
                     /note="four-jointed box kinase 1"
                     /db_xref="GeneID:24147"
                     /db_xref="HGNC:HGNC:17166"
                     /db_xref="MIM:612206"
     exon            1..2406
                     /gene="FJX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1491
                     /gene="FJX1"
                     /note="putative secreted ligand homologous to fjx1;
                     four-jointed protein homolog; four jointed box 1"
                     /codon_start=1
                     /product="four-jointed box protein 1"
                     /protein_id="NP_055159.2"
                     /db_xref="CCDS:CCDS44570.1"
                     /db_xref="GeneID:24147"
                     /db_xref="HGNC:HGNC:17166"
                     /db_xref="MIM:612206"
                     /translation="MGRRMRGAAATAGLWLLALGSLLALWGGLLPPRTELPASRPPED
                     RLPRRPARSGGPAPAPRFPLPPPLAWDARGGSLKTFRALLTLAAGADGPPRQSRSEPR
                     WHVSARQPRPEESAAVHGGVFWSRGLEEQVPPGFSEAQAAAWLEAARGARMVALERGG
                     CGRSSNRLARFADGTRACVRYGINPEQIQGEALSYYLARLLGLQRHVPPLALARVEAR
                     GAQWAQVQEELRAAHWTEGSVVSLTRWLPNLTDVVVPAPWRSEDGRLRPLRDAGGELA
                     NLSQAELVDLVQWTDLILFDYLTANFDRLVSNLFSLQWDPRVMQRATSNLHRGPGGAL
                     VFLDNEAGLVHGYRVAGMWDKYNEPLLQSVCVFRERTARRVLELHRGQDAAARLLRLY
                     RRHEPRFPELAALADPHAQLLQRRLDFLAKHILHCKAKYGRRSGT"
     regulatory      2384..2389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FJX1"
                     /note="hexamer: AATAAA"
     polyA_site      2406
                     /gene="FJX1"
                     /note="major polyA site"
ORIGIN      
        1 agttcccagc gccgggcgga gcgccggaca gagccccgca gcgccccgcg gccgcgatgg
       61 ggccgaagcg cccgaagccc cggagcccac aaactgccgg gcccgcctcg ccgccgggac
      121 ccgggtgcct gggctcggct tgaagcggcg gcggcgcacc ggcacagccg cgggagcatg
      181 ggcaggagga tgcggggcgc cgccgccacc gcggggctct ggctgctggc gctgggctcg
      241 ctgctggcgc tgtggggagg gctcctgccg ccgcggaccg agctgcccgc ctcccggccg
      301 cccgaagacc gactcccacg gcgcccggcc cggagcggcg gccccgcgcc cgcgcctcgc
      361 ttccctctgc ccccgcccct ggcgtgggac gcccgcggcg gctccctgaa aactttccgg
      421 gcgctgctca ccctggcggc cggcgcggac ggcccgcccc ggcagtcccg gagcgagccc
      481 aggtggcacg tgtcagccag gcagccccgg ccggaggaga gcgccgcggt gcacgggggc
      541 gtcttctgga gccgcggcct ggaggagcag gtgcccccgg gcttttcgga ggcccaggcg
      601 gcggcgtggc tggaggcggc tcgcggcgcc cggatggtgg ccctggagcg cgggggttgc
      661 gggcgcagct ccaaccgact ggcccgtttt gccgacggca cccgcgcctg cgtgcgctac
      721 ggcatcaacc cggagcagat tcagggcgag gccctgtctt actatctggc gcgcctgctg
      781 ggcctccagc gccacgtgcc gccgctggca ctggctcggg tggaggctcg gggcgcgcag
      841 tgggcgcagg tgcaggagga gctgcgcgct gcgcactgga ccgagggcag cgtggtgagc
      901 ctgacacgct ggctgcccaa cctcacggac gtggtggtgc ccgcgccctg gcgctcggag
      961 gacggccgtc tgcgccccct ccgggatgcc gggggtgagc tggccaacct cagccaggcg
     1021 gagctggtgg acctagtaca atggaccgac ttaatccttt tcgactacct gacggccaac
     1081 ttcgaccggc tcgtaagcaa cctcttcagc ctgcagtggg acccgcgcgt catgcagcgt
     1141 gccaccagca acctgcaccg cggtccgggc ggggcgctgg tctttctgga caatgaggcg
     1201 ggcttggtgc acggctaccg ggtagcaggc atgtgggaca agtataacga gccgctgttg
     1261 cagtcagtgt gcgtgttccg cgagcggacc gcgcggcgcg tcctggagct gcaccgcgga
     1321 caggacgccg cggcccggct gctgcgcctc taccggcgcc acgagcctcg cttccccgag
     1381 ctggccgccc ttgcagaccc ccacgctcag ctgctacagc gccgcctcga cttcctcgcc
     1441 aagcacattt tgcactgtaa ggccaagtac ggccgccggt ctgggactta gtgtcaccgg
     1501 gaggaaaaga gagagatctg gggctggggt atggatgatg gggggaaggg cggtcgcctc
     1561 tgccactgtc agggaccagc cggccaacgc ccacccgcaa aggtgtctaa aaacttcagc
     1621 ttttcaccca cctgcccctt tctttcaatc ccacgctgtt tcctttcaaa gttctgggag
     1681 gacgaactca ccgaggcgag aagtgtaaca ttctctccac ccagcttata aaaggattct
     1741 ttactgtgcc agcacgggga ttggatccga agaaactggc tactggggtt tggcccccga
     1801 gtggccgtcc ctgtgggaga tgcaccccat tcttgggccc cccctcattc cctttccgaa
     1861 aaaggaaaac ttgcgtttga gccgttgagc taattctgca attttctacc aaacagagcg
     1921 ctggtggccc cggagcaggg ctgtgacatt ggctggtgga gcccccttcc tgtgttctcc
     1981 ctttgttcca gcgccgcgat ggtgagatca ctgttccaag cagggggacg gctcgcgata
     2041 ggacaaagag agcaggacct ccagactctg gggagccctg cagaccttga caatttgcct
     2101 gactcattcc tgacctcttg tcattttggc ctgaaggcta caaattcagg gtcagctgta
     2161 tgcactaagt caaataatga atttcttcct ccctctcgca accgaccaaa attttgacaa
     2221 cgatgatgtt caccagaagg aaaaaaaaaa atcagtttta tgcactttat tttgttttga
     2281 ttttcatttt ttattaagaa aaaattttat tttacagaat ttaccttctc tgtatatatg
     2341 tgcataaagt gtggtgtaaa tatactaaac aaacttatat ttcaataaaa gggagtttaa
     2401 aattta
//
