LOCUS       NM_001080472            4628 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens fat storage inducing transmembrane protein 2 (FITM2),
            mRNA.
ACCESSION   NM_001080472 XM_371399
VERSION     NM_001080472.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4628)
  AUTHORS   Chen,Y., Ji,L.J., Wang,Y. and Guo,X.F.
  TITLE     High FITM2 expression promotes cell migration ability of
            hepatocellular carcinoma by regulating the formation of caveolae
            and indicates poor patient survival
  JOURNAL   Histol Histopathol 36 (10), 1085-1092 (2021)
   PUBMED   34672358
  REMARK    GeneRIF: High FITM2 expression promotes cell migration ability of
            hepatocellular carcinoma by regulating the formation of caveolae
            and indicates poor patient survival.
REFERENCE   2  (bases 1 to 4628)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4628)
  AUTHORS   Chen,F., Yan,B., Ren,J., Lyu,R., Wu,Y., Guo,Y., Li,D., Zhang,H. and
            Hu,J.
  TITLE     FIT2 organizes lipid droplet biogenesis with ER tubule-forming
            proteins and septins
  JOURNAL   J Cell Biol 220 (5) (2021)
   PUBMED   33861319
  REMARK    GeneRIF: FIT2 organizes lipid droplet biogenesis with ER
            tubule-forming proteins and septins.
REFERENCE   4  (bases 1 to 4628)
  AUTHORS   Becuwe,M., Bond,L.M., Pinto,A.F.M., Boland,S., Mejhert,N.,
            Elliott,S.D., Cicconet,M., Graham,M.M., Liu,X.N., Ilkayeva,O.,
            Saghatelian,A., Walther,T.C. and Farese,R.V. Jr.
  TITLE     FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic
            reticulum homeostasis
  JOURNAL   J Cell Biol 219 (10) (2020)
   PUBMED   32915949
  REMARK    GeneRIF: FIT2 is an acyl-coenzyme A diphosphatase crucial for
            endoplasmic reticulum homeostasis.
REFERENCE   5  (bases 1 to 4628)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4628)
  AUTHORS   Agrawal,M., Yeo,C.R., Shabbir,A., Chhay,V., Silver,D.L., Magkos,F.,
            Vidal-Puig,A. and Toh,S.A.
  TITLE     Fat storage-inducing transmembrane protein 2 (FIT2) is less
            abundant in type 2 diabetes, and regulates triglyceride
            accumulation and insulin sensitivity in adipocytes
  JOURNAL   FASEB J 33 (1), 430-440 (2019)
   PUBMED   30020828
  REMARK    GeneRIF: Low FIT2 expression is associated with type 2 diabetes.
REFERENCE   7  (bases 1 to 4628)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 4628)
  AUTHORS   Zazo Seco,C., Castells-Nobau,A., Joo,S.H., Schraders,M., Foo,J.N.,
            van der Voet,M., Velan,S.S., Nijhof,B., Oostrik,J., de Vrieze,E.,
            Katana,R., Mansoor,A., Huynen,M., Szklarczyk,R., Oti,M.,
            Tranebjaerg,L., van Wijk,E., Scheffer-de Gooyert,J.M., Siddique,S.,
            Baets,J., de Jonghe,P., Kazmi,S.A., Sadananthan,S.A., van de
            Warrenburg,B.P., Khor,C.C., Gopfert,M.C., Qamar,R., Schenck,A.,
            Kremer,H. and Siddiqi,S.
  TITLE     A homozygous FITM2 mutation causes a deafness-dystonia syndrome
            with motor regression and signs of ichthyosis and sensory
            neuropathy
  JOURNAL   Dis Model Mech 10 (2), 105-118 (2017)
   PUBMED   28067622
  REMARK    GeneRIF: In order to obtain independent evidence for the
            involvement of FITM2 in the human pathology, downregulation of the
            single Fitm ortholog, CG10671, in Drosophila melanogaster was
            pursued using RNA interference.
REFERENCE   9  (bases 1 to 4628)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4628)
  AUTHORS   Kadereit,B., Kumar,P., Wang,W.J., Miranda,D., Snapp,E.L.,
            Severina,N., Torregroza,I., Evans,T. and Silver,D.L.
  TITLE     Evolutionarily conserved gene family important for fat storage
  JOURNAL   Proc Natl Acad Sci U S A 105 (1), 94-99 (2008)
   PUBMED   18160536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            KF456918.1 and AL117382.28.
            
            On Nov 22, 2018 this sequence version replaced NM_001080472.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.265784.1,
                                           SRR1660809.177131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396825.4/ ENSP00000380037.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               KF456918.1         1-166               c
            167-227             AL117382.28        43320-43380         c
            228-4628            AL117382.28        35184-39584         c
FEATURES             Location/Qualifiers
     source          1..4628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..4628
                     /gene="FITM2"
                     /gene_synonym="C20orf142; dJ881L22.2; Fit2; SIDDIS"
                     /note="fat storage inducing transmembrane protein 2"
                     /db_xref="GeneID:128486"
                     /db_xref="HGNC:HGNC:16135"
                     /db_xref="MIM:612029"
     exon            1..227
                     /gene="FITM2"
                     /gene_synonym="C20orf142; dJ881L22.2; Fit2; SIDDIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..843
                     /gene="FITM2"
                     /gene_synonym="C20orf142; dJ881L22.2; Fit2; SIDDIS"
                     /note="fat-inducing transcript 2; fat-inducing protein 2"
                     /codon_start=1
                     /product="acyl-coenzyme A diphosphatase FITM2"
                     /protein_id="NP_001073941.1"
                     /db_xref="CCDS:CCDS33473.1"
                     /db_xref="GeneID:128486"
                     /db_xref="HGNC:HGNC:16135"
                     /db_xref="MIM:612029"
                     /translation="MEHLERCEWLLRGTLVRAAVRRYLPWALVASMLAGSLLKELSPL
                     PESYLSNKRNVLNVYFVKVAWAWTFCLLLPFIALTNYHLTGKAGLVLRRLSTLLVGTA
                     IWYICTSIFSNIEHYTGSCYQSPALEGVRKEHQSKQQCHQEGGFWHGFDISGHSFLLT
                     FCALMIVEEMSVLHEVKTDRSHCLHTAITTLVVALGILTFIWVLMFLCTAVYFHNLSQ
                     KVFGTLFGLLSWYGTYGFWYPKAFSPGLPPQSCSLNLKQDSYKK"
     exon            228..4628
                     /gene="FITM2"
                     /gene_synonym="C20orf142; dJ881L22.2; Fit2; SIDDIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4604..4609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FITM2"
                     /gene_synonym="C20orf142; dJ881L22.2; Fit2; SIDDIS"
                     /note="hexamer: AGTAAA"
     polyA_site      4628
                     /gene="FITM2"
                     /gene_synonym="C20orf142; dJ881L22.2; Fit2; SIDDIS"
                     /note="major polyA site"
ORIGIN      
        1 gatacggtgg ccgagagggc acggagagga ggacggtggc tgacgagatc cggcatggag
       61 catctggagc gctgcgagtg gttgttgcgg gggacgctgg tgcgggcggc cgtgcggcgc
      121 tacctgccct gggccctggt ggcctccatg ctggcgggct ccctcctcaa ggagttgtcc
      181 ccgttgcccg agagctacct cagcaacaag cgcaacgtcc tcaacgtgta ttttgtcaaa
      241 gtggcctggg cctggacgtt ctgtctcctt ctgcctttca ttgccctcac caactaccat
      301 ctgaccggca aggctggctt ggtcctgcgg cggctgagca ccctgcttgt gggcacggcc
      361 atctggtaca tctgcacctc catcttctcc aacatcgaac actacacggg cagctgctac
      421 cagtccccag ccctggaggg ggtcagaaag gaacaccaga gcaagcagca gtgccaccag
      481 gaagggggct tttggcatgg ctttgacatc tcaggtcact ccttcctgct gaccttctgc
      541 gccctcatga ttgtagaaga gatgtctgtg ctgcatgagg tgaagacgga ccgaagccac
      601 tgcctccaca ccgccatcac caccctggtt gtggccctgg gcattctgac tttcatctgg
      661 gtgttgatgt ttctgtgcac agctgtttat ttccacaact tgtcccagaa ggtgtttggc
      721 accttgtttg gtttgctgag ctggtacggg acatacgggt tttggtatcc gaaagccttt
      781 tccccaggac ttcctcccca gagctgtagt ttgaatttga agcaagatag ttacaagaaa
      841 taaaagagta acagaggggg gacagaagga caatggctaa tctatttttc aaatatatat
      901 tttgcttagt tatttggcta aattattgat cctacttcag agggaaagtg taccaggcag
      961 ttttggtggg tggtgctgaa gtctggggag tgagtttagt cttcagacta ttcttggcga
     1021 catcaccagt gttgcaagca ccaccattcc cagttaggca ctttttgtcc ctggtaagac
     1081 ttgaccttta tctggaacac tccttttgtc cctagagtgg ggacctaagg ctcagcaaaa
     1141 gggcagaatc aggaaagcct ttatggtgtg gctaaaggag tggccagagc cttgggactc
     1201 ctttgctgcc ttctccctgg ttccagttgt ctttagattt tcacggctct tactgctgtt
     1261 acttaacagt attttccagc caggcatggt ggttcacacc tctaatccct gcactttggg
     1321 aggccgaggc aggcggatca cctgagattg ggagttcgag accagcctgt ccaacatggc
     1381 gaacctcgtc tcttctaaaa atacaaaaat tagctgggtg tggtggcaca tgcctgtaat
     1441 cccagctact caggaggctg aggcaggaga attgcttgga cctaggaggt ggaggttgca
     1501 gtgagctgag atcgcaccac tgcactccag cctgggtgac agagcagact ccacctcaaa
     1561 aaagaaaaaa caaaacaaaa cagtatttcc cactggtcag ttttgcatag gcatctattt
     1621 caggcagggt ttttttcttt tttttgagat ggagttttgc tcttgttgcc caggctgggg
     1681 tgcaatggcc cgatctcggc tcaccgcaac ctccacctcc caggttcaag cgattctcct
     1741 gcctcagcct cccgagtagc tgggattaca ggcatgcgtc accacaccag gctaattttg
     1801 tatttttagt agagatgggg tttctccatg ttggtcaggc tggtctcaaa ctcctgaccg
     1861 caggtgatcc acctgcctcg gcctcccaaa gtgctgggat tacaggcatg agccaccgcg
     1921 cccggctcag gcagggttct ttataaaaac agcctgatgc ctgaaggaca ctctctggtt
     1981 gtaatatttg tttcatccat gaagtgttta aatattgcaa ctgacttgcg attagccacc
     2041 aaaacaggcc cttttagatg cagtgcctct ccgaccaagt attggatgat tcatacgtaa
     2101 tggactatga tcattttctg tccatgtttt ctattactat atgctggttt ttttggagca
     2161 ataagattac tttttttctg ttctattttg agcgaatcct ttacagtttt tgataagaac
     2221 tgtgacattt gttctttgtt gataaaactc ctgaaaataa ctcacaaggc cagtgctgca
     2281 ctctggcaca tgtaggttgt tttgagggtt tgttggttgg ttggttggct ggttgattgg
     2341 ttggttggtt tagaacacta atgtacttgt tatgaaccaa actctggtct tacagtctta
     2401 aattccacct catggggctg ttttctctgt tagcaatgaa acctgggcca ggtgtagtgg
     2461 ctcacaccta taatcctggc actttgggag gctgaggtgg gaggattact ggatcccagg
     2521 agtttgagac cagcctgggc aacatagtga gaccctggtt tctataaata aataagataa
     2581 tcaaaccaga aagcaggcat tttagtaaca gcctgttgaa ttttaaggtg aatcaaggta
     2641 attttgcaga atgcgttctt gcaccgaaat gtccctgacc acatatcagt ggtatagact
     2701 gaacagtgtg cttcagggtc atgtgctgag tgcactgatc actctgctgt ggcccagggc
     2761 atctgtacct gttggacaag attatgataa ttcagaagtg aagtaaaatg cctccctctg
     2821 atggcaaaaa gccaacctgt ttgcaaaatc acccttattg aagggtggca tggctgtggt
     2881 ccctccctcc tgttacttgc atcaccaacc aaactaaacc aaaccatacc tgggcctgtt
     2941 cagctggact tgaaatcagt ttcctttttc tctccccttt gcagcacttt tcagtttcca
     3001 gctttgtcat tctgtggcct ttgctgtgac aatgctggga agggttagaa atcctgtcac
     3061 ctccatccac aaaggcacag ttccacgccc tgtgataaga tatcccctct tctctcccag
     3121 actgtctcct taagcctttc aaactgagcc ccttgctgtt ggggtaatca cccttaaggc
     3181 cgccttgatg cccctctctc caatcaagtc caatagtagc attaactgag aagcactaca
     3241 cctgactggc ttcactgaag cttaagtggt tgaggatgaa tcttcggtgt aaaatctttt
     3301 actataagga tatattttaa atatttcata tcccatcaag ttggaggtta attttatcca
     3361 tcacaatgag tcatgatttg ttgcacccaa aaggagcaga aacacaggtg atgagatatg
     3421 ggaggtggca ccatggtgct ttggaggcgt tggtaagatg tgaccctctg ttgcctatgc
     3481 ccataaacca gtggtgggag tggccatgga gtagatggca ggggcttgtt gaagggattg
     3541 aaagctctcc taggctaggc atggtggctc acacctgtaa tcctagcact ttgggaggct
     3601 gagatgggag gatcacttga ggttgggcca gcctagccaa catgataaaa ccccgtctcg
     3661 actaaaaata caaaaattag ccaggtgtgg tggtacacgc ctgtaatccc agctactcgg
     3721 gaggctgggg caggagaatc gcttgaaccc aggaggcaga ggttgcagtg agctaggatc
     3781 acgccactgc actccagcct gagcgacaga gtgagactct gtctcaaaaa aaaaaaaggc
     3841 tctccaaagt gtcatgttca gcaccaaaag ggaataggca cagggtgacc ccagaagttc
     3901 atttgtgaca cttaaatctc cagatattta tcccacgtgg gtctgatgcg ggctcagcac
     3961 taaattaact gtatgtggaa agtgtcaatt gcagagcctt ctgtatcgat gaggcttccg
     4021 ccacttgtcc atgcttagcc cccttgcctc ttccttggga gcatgctttc tattcctatg
     4081 tgaaacagcc tgacataagt gaaaggattt gggctcaagc aaacatgaga tgtgggttca
     4141 tatcttggca ccactcctga tagctgtgtg atcatggcaa acctcgtttt catcgtctgt
     4201 caggtggaga tgaagagaaa tggtgcatgt aaagtgctca gcatctgtgc ttagcaggcc
     4261 atagtctccc tgcctccttt ttcttgagta agcctttaga actttctgac tcctctagag
     4321 aaggcagaga aacgaatata ttttgggtgc catttggagt ctgggtcttt tgttaaaatt
     4381 gtcctgtatt atgttgaaaa gtgtcggtta cccccaggct ctgggggcat ctgtgatcat
     4441 agaatactgc catgcttatt ttgcctttct atgttgagat taattcactg acgcctcatt
     4501 ttccacgtgc atctgtcata gtctgggtac cagattgtat ttagagaatg gctcttgcca
     4561 ctgttatgta cacacagatc gtgtgtgtaa acaagcaaat taaagtaaac tgagataatg
     4621 aaatccca
//
