LOCUS       NM_016068                870 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens fission, mitochondrial 1 (FIS1), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_016068
VERSION     NM_016068.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Choi,H.Y., Zhu,Y., Zhao,X., Mehta,S., Hernandez,J.C., Lee,J.J.,
            Kou,Y., Machida,R., Giacca,M., Del Sal,G., Ray,R., Eoh,H.,
            Tahara,S.M., Chen,L., Tsukamoto,H. and Machida,K.
  TITLE     NOTCH localizes to mitochondria through the TBC1D15-FIS1
            interaction and is stabilized via blockade of E3 ligase and CDK8
            recruitment to reprogram tumor-initiating cells
  JOURNAL   Exp Mol Med 56 (2), 461-477 (2024)
   PUBMED   38409448
  REMARK    GeneRIF: NOTCH localizes to mitochondria through the TBC1D15-FIS1
            interaction and is stabilized via blockade of E3 ligase and CDK8
            recruitment to reprogram tumor-initiating cells.
            Erratum:[Exp Mol Med. 2024 Oct;56(10):2323. doi:
            10.1038/s12276-024-01325-9.. PMID: 39465353]
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Ihenacho,U.K., Toro,R., Mansour,R.H. and Hill,R.B.
  TITLE     A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1
            recruitment for mitochondrial fission
  JOURNAL   J Biol Chem 299 (11), 105303 (2023)
   PUBMED   37777154
  REMARK    GeneRIF: A conserved, noncanonical insert in FIS1 mediates TBC1D15
            and DRP1 recruitment for mitochondrial fission.
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Zhou,X., Jiang,Y., Wang,Y., Fan,L., Zhu,Y., Chen,Y., Wang,Y.,
            Zhu,Y., Wang,H., Pan,Z., Li,Z., Zhu,X., Ren,R., Ge,Z., Lai,D.,
            Lai,E.Y., Chen,T., Wang,K., Liang,P., Qin,L., Liu,C., Qiu,C.,
            Simons,M. and Yu,L.
  TITLE     Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary
            Hypertension
  JOURNAL   Circ Res 133 (6), 508-531 (2023)
   PUBMED   37589160
  REMARK    GeneRIF: Endothelial FIS1 DeSUMOylation Protects Against Hypoxic
            Pulmonary Hypertension.
REFERENCE   4  (bases 1 to 870)
  AUTHORS   An,S., Yao,Y., Hu,H., Wu,J., Li,J., Li,L., Wu,J., Sun,M., Deng,Z.,
            Zhang,Y., Gong,S., Huang,Q., Chen,Z. and Zeng,Z.
  TITLE     PDHA1 hyperacetylation-mediated lactate overproduction promotes
            sepsis-induced acute kidney injury via Fis1 lactylation
  JOURNAL   Cell Death Dis 14 (7), 457 (2023)
   PUBMED   37479690
  REMARK    GeneRIF: PDHA1 hyperacetylation-mediated lactate overproduction
            promotes sepsis-induced acute kidney injury via Fis1 lactylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Egner,J.M., Nolden,K.A., Harwig,M.C., Bonate,R.P., De Anda,J.,
            Tessmer,M.H., Noey,E.L., Ihenacho,U.K., Liu,Z., Peterson,F.C.,
            Wong,G.C.L., Widlansky,M.E. and Hill,R.B.
  TITLE     Structural studies of human fission protein FIS1 reveal a dynamic
            region important for GTPase DRP1 recruitment and mitochondrial
            fission
  JOURNAL   J Biol Chem 298 (12), 102620 (2022)
   PUBMED   36272645
  REMARK    GeneRIF: Structural studies of human fission protein FIS1 reveal a
            dynamic region important for GTPase DRP1 recruitment and
            mitochondrial fission.
REFERENCE   6  (bases 1 to 870)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   7  (bases 1 to 870)
  AUTHORS   Dohm,J.A., Lee,S.J., Hardwick,J.M., Hill,R.B. and Gittis,A.G.
  TITLE     Cytosolic domain of the human mitochondrial fission protein fis1
            adopts a TPR fold
  JOURNAL   Proteins 54 (1), 153-156 (2004)
   PUBMED   14705031
  REMARK    GeneRIF: Cytosolic domain of fis1 adopts a tetratricopeptide repeat
            domain fold.
REFERENCE   8  (bases 1 to 870)
  AUTHORS   Suzuki,M., Jeong,S.Y., Karbowski,M., Youle,R.J. and Tjandra,N.
  TITLE     The solution structure of human mitochondria fission protein Fis1
            reveals a novel TPR-like helix bundle
  JOURNAL   J Mol Biol 334 (3), 445-458 (2003)
   PUBMED   14623186
REFERENCE   9  (bases 1 to 870)
  AUTHORS   James,D.I., Parone,P.A., Mattenberger,Y. and Martinou,J.C.
  TITLE     hFis1, a novel component of the mammalian mitochondrial fission
            machinery
  JOURNAL   J Biol Chem 278 (38), 36373-36379 (2003)
   PUBMED   12783892
  REMARK    GeneRIF: hFis1 is part of the mammalian fission machinery and
            regulation of the fission processes might be involved in apoptotic
            mechanisms
            Erratum:[J Biol Chem. 2004 Aug 20;279(34):36166]
REFERENCE   10 (bases 1 to 870)
  AUTHORS   Yoon,Y., Krueger,E.W., Oswald,B.J. and McNiven,M.A.
  TITLE     The mitochondrial protein hFis1 regulates mitochondrial fission in
            mammalian cells through an interaction with the dynamin-like
            protein DLP1
  JOURNAL   Mol Cell Biol 23 (15), 5409-5420 (2003)
   PUBMED   12861026
  REMARK    GeneRIF: regulates mitochondrial fission in mammalian cells through
            an interaction with the dynamin-like protein DLP1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI836529.1, BC009428.1 and AC006329.5.
            
            On May 17, 2019 this sequence version replaced NM_016068.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.347142.1,
                                           SRR1163655.172599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465403 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000223136.5/
                                                  ENSP00000223136.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BI836529.1         10-22
            14-730              BC009428.1         1-717
            731-870             AC006329.5         8746-8885           c
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..870
                     /gene="FIS1"
                     /gene_synonym="CGI-135; TTC11"
                     /note="fission, mitochondrial 1"
                     /db_xref="GeneID:51024"
                     /db_xref="HGNC:HGNC:21689"
                     /db_xref="MIM:609003"
     exon            1..122
                     /gene="FIS1"
                     /gene_synonym="CGI-135; TTC11"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..536
                     /gene="FIS1"
                     /gene_synonym="CGI-135; TTC11"
                     /note="tetratricopeptide repeat domain 11; H_NH0132A01.6;
                     hFis1; FIS1 homolog; TPR repeat protein 11;
                     tetratricopeptide repeat protein 11; mitochondrial fission
                     molecule; fission 1 (mitochondrial outer membrane)
                     homolog"
                     /codon_start=1
                     /product="mitochondrial fission 1 protein"
                     /protein_id="NP_057152.2"
                     /db_xref="CCDS:CCDS43626.1"
                     /db_xref="GeneID:51024"
                     /db_xref="HGNC:HGNC:21689"
                     /db_xref="MIM:609003"
                     /translation="MEAVLNELVSVEDLLKFEKKFQSEKAAGSVSKSTQFEYAWCLVR
                     SKYNDDIRKGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEP
                     QNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS"
     exon            123..255
                     /gene="FIS1"
                     /gene_synonym="CGI-135; TTC11"
                     /inference="alignment:Splign:2.1.0"
     exon            256..332
                     /gene="FIS1"
                     /gene_synonym="CGI-135; TTC11"
                     /inference="alignment:Splign:2.1.0"
     exon            333..438
                     /gene="FIS1"
                     /gene_synonym="CGI-135; TTC11"
                     /inference="alignment:Splign:2.1.0"
     exon            439..870
                     /gene="FIS1"
                     /gene_synonym="CGI-135; TTC11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      705..710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FIS1"
                     /gene_synonym="CGI-135; TTC11"
                     /note="hexamer: AATAAA"
     polyA_site      730
                     /gene="FIS1"
                     /gene_synonym="CGI-135; TTC11"
                     /note="major polyA site"
ORIGIN      
        1 gttctccgcc cctgccactg ggccatggag actgtggcac agtagactgt agtgtgaggc
       61 tcgcgggggc agtggccatg gaggccgtgc tgaacgagct ggtgtctgtg gaggacctgc
      121 tgaagtttga aaagaaattt cagtctgaga aggcagcagg ctcggtgtcc aagagcacgc
      181 agtttgagta cgcctggtgc ctggtgcgga gcaagtacaa tgatgacatc cgtaaaggca
      241 tcgtgctgct cgaggagctg ctgcccaaag ggagcaagga ggaacagcgg gattacgtct
      301 tctacctggc cgtggggaac taccggctca aggaatacga gaaggcctta aagtacgtcc
      361 gcgggttgct gcagacagag ccccagaaca accaggccaa ggaactggag cggctcattg
      421 acaaggccat gaagaaagat ggactcgtgg gcatggccat cgtgggaggc atggccctgg
      481 gtgtggcggg actggccgga ctcatcggac ttgctgtgtc caagtccaaa tcctgaagga
      541 gacgcgggag cccacggaga acgctccagg agggcctgtc catcctcgct gtcctttccc
      601 tgttctcccc ctgccccccg tctctatcct ctgtggcctt cagctaattt ctgctcccct
      661 gagattcgtc cttcagcccc atcatgtgct ttgggatgag tgtaaataaa acggggctgt
      721 ggcttgggaa cccccgtgtc tgcgttgagg ggaggggtgg gttctgaacg ctgggcacag
      781 ggggcggaga cgtcactcct ggtcctctcc tgcccctgcc ctccaggttg gcacggggtt
      841 ctttgtccac cccgcagccc agagcccaca
//
