LOCUS       NM_001320047            4011 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens FIGNL1 interacting regulator of recombination and
            mitosis (FIRRM), transcript variant 2, mRNA.
ACCESSION   NM_001320047 XM_011509731
VERSION     NM_001320047.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4011)
  AUTHORS   Tischler,J.D., Tsuchida,H., Bosire,R., Oda,T.T., Park,A. and
            Adeyemi,R.O.
  TITLE     FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association
            to promote viability after replication stress
  JOURNAL   Nat Commun 15 (1), 866 (2024)
   PUBMED   38286805
  REMARK    GeneRIF: FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin
            association to promote viability after replication stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4011)
  AUTHORS   Zhou,Z., Yang,H., Liang,X., Zhou,T., Zhang,T., Yang,Y., Wang,J. and
            Wang,W.
  TITLE     C1orf112 teams up with FIGNL1 to facilitate RAD51 filament
            disassembly and DNA interstrand cross-link repair
  JOURNAL   Cell Rep 42 (8), 112907 (2023)
   PUBMED   37515771
REFERENCE   3  (bases 1 to 4011)
  AUTHORS   Stok,C., Tsaridou,S., van den Tempel,N., Everts,M., Wierenga,E.,
            Bakker,F.J., Kok,Y., Alves,I.T., Jae,L.T., Raas,M.W.D., Huis In 't
            Veld,P.J., de Boer,H.R., Bhattacharya,A., Karanika,E., Warner,H.,
            Chen,M., van de Kooij,B., Dessapt,J., Ter Morsche,L.,
            Perepelkina,P., Fradet-Turcotte,A., Guryev,V., Tromer,E.C.,
            Chan,K.L., Fehrmann,R.S.N. and van Vugt,M.A.T.M.
  TITLE     FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51
            dynamics
  JOURNAL   Cell Rep 42 (7), 112668 (2023)
   PUBMED   37347663
REFERENCE   4  (bases 1 to 4011)
  AUTHORS   Mazouzi,A., Moser,S.C., Abascal,F., van den Broek,B., Del Castillo
            Velasco-Herrera,M., van der Heijden,I., Hekkelman,M., Drenth,A.P.,
            van der Burg,E., Kroese,L.J., Jalink,K., Adams,D.J., Jonkers,J. and
            Brummelkamp,T.R.
  TITLE     FIRRM/C1orf112 mediates resolution of homologous recombination
            intermediates in response to DNA interstrand crosslinks
  JOURNAL   Sci Adv 9 (22), eadf4409 (2023)
   PUBMED   37256941
REFERENCE   5  (bases 1 to 4011)
  AUTHORS   Zhang,Z., Tan,Z., Lv,Q., Wang,L., Yu,K., Yang,H., Liang,H., Lu,T.,
            Ji,Y., Chen,J., He,W., Chen,Z., Chen,S. and Shen,X.
  TITLE     High Expression of C1ORF112 Predicts a Poor Outcome: A Potential
            Target for the Treatment of Low-Grade Gliomas
  JOURNAL   Front Genet 12, 710944 (2021)
   PUBMED   34880897
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4011)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   7  (bases 1 to 4011)
  AUTHORS   van Dam,S., Cordeiro,R., Craig,T., van Dam,J., Wood,S.H. and de
            Magalhaes,J.P.
  TITLE     GeneFriends: an online co-expression analysis tool to identify
            novel gene targets for aging and complex diseases
  JOURNAL   BMC Genomics 13, 535 (2012)
   PUBMED   23039964
  REMARK    GeneRIF: Knockdown of C1orf112 by siRNA in HeLa cells significantly
            suppressed their growth.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4011)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4011)
  AUTHORS   Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
            Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
  TITLE     Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
            genetic association with bone mineral density variation
  JOURNAL   Hum Mol Genet 18 (4), 679-687 (2009)
   PUBMED   19064610
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 4011)
  AUTHORS   Fedorova,N.I.
  TITLE     [Remote results of health resort treatment of chronic prostatitis]
  JOURNAL   Vestn Dermatol Venerol 46 (2), 71-73 (1972)
   PUBMED   4260926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC401980.1, DA770714.1, BC091516.1 and AL031297.4.
            
            On Nov 22, 2018 this sequence version replaced NM_001320047.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091516.1, AK096493.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359326.9/ ENSP00000352276.4
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                DC401980.1         42-91
            51-99               DA770714.1         1-49
            100-314             DA770714.1         51-265
            315-3019            BC091516.1         270-2974
            3020-4011           AL031297.4         61966-62957         c
FEATURES             Location/Qualifiers
     source          1..4011
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..4011
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /note="FIGNL1 interacting regulator of recombination and
                     mitosis"
                     /db_xref="GeneID:55732"
                     /db_xref="HGNC:HGNC:25565"
     exon            1..76
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..231
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            232..333
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..422
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..2918
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     uncharacterized protein C1orf112; associating protein with
                     POLO1; Fidgetin-like-1 interacting protein;
                     POLO1-associating protein"
                     /codon_start=1
                     /product="FIGNL1-interacting regulator of recombination
                     and mitosis isoform 1"
                     /protein_id="NP_001306976.1"
                     /db_xref="CCDS:CCDS1285.1"
                     /db_xref="GeneID:55732"
                     /db_xref="HGNC:HGNC:25565"
                     /translation="MFLPHMNHLTLEQTFFSQVLPKTVKLFDDMMYELTSQARGLSSQ
                     NLEIQTTLRNILQTMVQLLGALTGCVQHICATQESIILENIQSLPSSVLHIIKSTFVH
                     CKNSESVYSGCLHLVSDLLQALFKEAYSLQKQLMELLDMVCMDPLVDDNDDILNMVIV
                     IHSLLDICSVISSMDHAFHANTWKFIIKQSLKHQSIIKSQLKHKDIITSLCEDILFSF
                     HSCLQLAEQMTQSDAQDNADYRLFQKTLKLCRFFANSLLHYAKEFLPFLSDSCCTLHQ
                     LYLQIHSKFPPSLYATRISKAHQEEIAGAFLVTLDPLISQLLTFQPFMQVVLDSKLDL
                     PCELQFPQCLLLVVVMDKLPSQPKEVQTLWCTDSQVSETTTRISLLKAVFYSFEQCSG
                     ELSLPVHLQGLKSKGKAEVAVTLYQHVCVHLCTFITSFHPSLFAELDAALLNAVLSAN
                     MITSLLAMDAWCFLARYGTAELCAHHVTIVAHLIKSCPGECYQLINLSILLKRLFFFM
                     APPHQLEFIQKFSPKEAENLPLWQHISFQALPPELREQTVHEVTTVGTAECRKWLSRS
                     RTLGELESLNTVLSALLAVCNSAGEALDTGKQTAIIEVVSQLWAFLNIKQVADQPYVQ
                     QTFSLLLPLLGFFIQTLDPKLILQAVTLQTSLLKLELPDYVRLAMLDFVSSLGKLFIP
                     EAIQDRILPNLSCMFALLLADRSWLLEQHTLEAFTQFAEGTNHEEIVPQCLSSEETKN
                     KVVSFLEKTGFVDETEAAKVERVKQEKGIFWEPFANVTVEEAKRSSLQPYAKRARQEF
                     PWEEEYRSALHTIAGALEATESLLQKGPAPAWLSMEMEALQERMDKLKRYIHTLG"
     exon            423..527
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..668
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..834
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..919
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1058
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1139
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1204
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1353
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1483
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1670
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1753
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1805
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1895
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2081
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2204
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2300
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2414
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2519
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2600
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2720
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..4011
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2994..2999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /note="hexamer: TATAAA"
     regulatory      2999..3004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /note="hexamer: AACAAA"
     polyA_site      3016
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
     polyA_site      3019
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /note="major polyA site"
     regulatory      3177..3182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /note="hexamer: AATAAG"
     polyA_site      3195
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
     regulatory      3980..3985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
                     /note="hexamer: AATAAA"
     polyA_site      4011
                     /gene="FIRRM"
                     /gene_synonym="Apolo1; C1orf112; FLIP; MEICA1"
ORIGIN      
        1 actgcgagtt tccggtctgg gctttggcgg gtctggtttg aagctctcct gtttgacgaa
       61 agtatgtctc aggaaggctg gagtctttct gaaagagttc ttccgcttgt tgttggcttt
      121 caactgttgg atttgaggcg cttagcgcct tcttcgtccg ggtgcagcac attcttgatt
      181 ggtctcatgc ctttgtggtt gtaaatgtgc ctggaatcct agcctttcat ggtttgttct
      241 gagtaatgaa taccctatta ctatgatact agtatcttcc ttaattatcc tactcattgt
      301 ctcaacattc tgacagttgg attgagcata ttcaaatttt gaaaattatt gtagaaatgt
      361 ttttacctca tatgaaccac ctgacattgg aacagacttt cttttcacaa gtgttaccaa
      421 agactgtgaa attattcgat gacatgatgt atgaattaac cagtcaagcc agaggactgt
      481 caagccaaaa tttggaaatc cagaccactc taaggaatat tttacaaaca atggtgcagc
      541 tcttaggagc tctcacagga tgtgttcagc atatctgtgc cacacaggaa tccatcattt
      601 tggaaaatat tcagagtctc ccctcctcag tccttcatat aattaaaagc acatttgtgc
      661 attgtaagaa tagtgaatct gtgtattctg ggtgtttaca cctagtttca gaccttctcc
      721 aggctctttt caaggaggcc tattctcttc aaaagcagtt aatggaactg ctggacatgg
      781 tttgcatgga ccctttagta gatgacaatg atgatatttt gaatatggta atagttattc
      841 attctttatt ggatatctgc tctgttattt ccagtatgga ccatgcattt catgccaata
      901 cttggaagtt tataattaag cagagcctta agcaccagtc cataataaaa agccagttga
      961 aacacaaaga tataattact agcttgtgtg aagacattct tttctccttc cattcttgtt
     1021 tacagttagc tgagcagatg acacagtcag atgcacagga taatgctgac tacagattat
     1081 ttcagaaaac actcaaattg tgtcgttttt ttgccaactc ccttttgcac tacgctaagg
     1141 aatttcttcc tttcctctct gattcttgct gtactttgca ccaactgtat cttcagatac
     1201 acagcaagtt tcctccaagc ctttatgcta ccaggatttc taaagcacac caagaggaaa
     1261 tagcaggtgc tttcctagtg acactggatc cacttatcag tcagctgctc acatttcagc
     1321 ctttcatgca ggtggttttg gacagtaaat tagacctgcc atgtgaactg cagtttccac
     1381 aatgtcttct tctggttgtt gtcatggata agctgccatc tcagcctaag gaagtgcaaa
     1441 ccctgtggtg cacagacagc caggtctcag aaacgacaac caggatatct ctactcaaag
     1501 ccgttttcta cagttttgag cagtgttctg gtgaactctc tctacctgtt catttacagg
     1561 gattaaagag taaggggaaa gctgaggtgg ctgtcacctt gtatcagcat gtttgtgttc
     1621 atctgtgtac atttattact tcctttcatc cctcactgtt tgctgaactg gatgctgctc
     1681 tgctgaatgc tgtacttagt gctaatatga tcacctcttt gttagctatg gatgcatggt
     1741 gcttccttgc tcgatatggg actgctgaac tgtgtgcaca ccatgtcacc atagtggctc
     1801 atctgataaa gtcatgccct ggagaatgtt atcaactcat caacctatca atactgttga
     1861 agcgtctctt tttcttcatg gcaccacccc atcagctgga gtttatccag aaattttccc
     1921 caaaagaagc agaaaatctg cctctgtggc aacatatttc cttccaggcg ttacctcctg
     1981 agcttaggga acaaactgtc catgaggtca ccacagtagg cactgcagaa tgcaggaaat
     2041 ggctgagcag gagtcgtact ttgggagaac tagaatctct gaacacagta ctgtctgctt
     2101 tgcttgcagt atgtaattct gctggtgaag ctttggatac aggaaaacaa actgcaatta
     2161 tcgaagttgt gagtcagctt tgggcttttt taaacattaa acaggtagca gatcaacctt
     2221 atgttcaaca gacattcagc cttttacttc cactgttggg atttttcatt caaactctag
     2281 atcctaaact gatacttcag gcagtaactt tgcagacctc gctacttaaa ttagagcttc
     2341 ctgactatgt tcgtttggca atgttggatt ttgtatcttc tttaggaaaa ctttttatac
     2401 ctgaagctat ccaggacaga attctgccca acctgtcctg tatgtttgcc ttactgctag
     2461 ctgacaggag ttggctgcta gaacaacata ccttggaggc gtttactcag ttcgctgagg
     2521 gaacaaatca tgaagagata gttccacagt gtctcagttc tgaagaaact aagaacaaag
     2581 ttgtatcctt tctggagaag actgggtttg tagatgaaac tgaagctgcc aaagtggaac
     2641 gtgtgaaaca ggaaaaaggt attttctggg aaccctttgc taatgtgact gtagaagaag
     2701 caaagaggtc atctttacag ccttatgcaa aaagagctcg tcaggagttc ccctgggaag
     2761 aagagtacag gtcagcgctg catacaatag caggggcttt ggaagcaact gagtcactac
     2821 tccaaaaggg tcctgctcca gcctggcttt caatggaaat ggaggcgctc caagaaagga
     2881 tggataagct aaaacgttac atacatactc tagggtgaaa cttatcacta ggcagaactg
     2941 ggtttgatgc tttgtcaact gaaaatactt atgtctgtac attttctaac agatataaaa
     3001 caaattttgt aaagttgaat ctagtgaaaa taatctttat ttgacattta gagaacagga
     3061 ttgtggggaa tattcttatt aagaactttg gtacaatgta ctacatgtgg aacagtcagg
     3121 aactgcctag gtccacaaag aaccatttac tcagatagtc taactgtaaa caaataaata
     3181 agctgcctaa ggaaacctca gcaatttaaa atcatttata taatttatag ctaaaatttt
     3241 ttaaagttgt atttcataat agagcttact cttatgttaa agaatggcac aaaattaagc
     3301 taaccagctt gaattacatt ttctttactt ccagaattgt cctggaaaaa gcagtaaatt
     3361 cgacctctcc tcagctactt gctcttcata gaaactggcc tcagtcaaat gcacaaaggc
     3421 tcttcctcct ggaaaccagt actgtgagcc tcaccaccca gggcttttag ccagcactca
     3481 cagtcagtct cctacttcag ttggcacaga ctggataatg agctcctggg atgggaaaag
     3541 caggccactt tggggttttc ttgtcccaaa gcctgctttt gaggtattga ttttttttaa
     3601 aaaaagggaa tcctttttcc taaagtttaa ctcacatcta ttgtcaccag ttattatctt
     3661 cccagttcag ctccccttct tcttcccagc cttcagcctc tccctgcaac aaaataaagc
     3721 acaccaagaa cccactgaaa caaatcatat gcaaaaatca tacgcaaatt tgaaaaagca
     3781 ggaatttaaa atttatcttt tgatgccaga aacactacct cgtactaagt aaaataactt
     3841 agagctctaa cagaaagttg aaaagtagga ttacaaaacc atggcactgg aaaatagctt
     3901 ttcaaaaacc ataaaatcca gtaaaaatca gtgtggatga caccaaatcc ttattttaat
     3961 cccttttttt tctttttcaa ataaaaaggt tacaatagct cattaaacaa a
//
