LOCUS       NM_001387852            2859 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens filamin A interacting protein 1 like (FILIP1L),
            transcript variant 9, mRNA.
ACCESSION   NM_001387852
VERSION     NM_001387852.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2859)
  AUTHORS   Jiang,X., Lin,J. and Zhu,Z.
  TITLE     Long-chain noncoding RNA LINC01569 upregulates filamin
            A-interacting protein 1-like to prevent metastasis of
            triple-negative breast cancer via sponging miR-300
  JOURNAL   Cancer Biomark 39 (2), 79-94 (2024)
   PUBMED   37955081
  REMARK    GeneRIF: Long-chain noncoding RNA LINC01569 upregulates filamin
            A-interacting protein 1-like to prevent metastasis of
            triple-negative breast cancer via sponging miR-300.
REFERENCE   2  (bases 1 to 2859)
  AUTHORS   Jing,R., Hu,C., Qi,T., Yue,J., Wang,G., Zhang,M., Wen,C., Pei,C.
            and Ma,B.
  TITLE     FILIP1L-mediated cell apoptosis, epithelial-mesenchymal transition
            and extracellular matrix synthesis aggravate posterior capsular
            opacification
  JOURNAL   Life Sci 286, 120061 (2021)
   PUBMED   34666037
  REMARK    GeneRIF: FILIP1L-mediated cell apoptosis, epithelial-mesenchymal
            transition and extracellular matrix synthesis aggravate posterior
            capsular opacification.
REFERENCE   3  (bases 1 to 2859)
  AUTHORS   Kwon,M., Rubio,G., Nolan,N., Auteri,P., Volmar,J.A., Adem,A.,
            Javidian,P., Zhou,Z., Verzi,M.P., Pine,S.R. and Libutti,S.K.
  TITLE     FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal
            Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1
  JOURNAL   Cancer Res 81 (21), 5523-5539 (2021)
   PUBMED   34417201
  REMARK    GeneRIF: FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal
            Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1.
REFERENCE   4  (bases 1 to 2859)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2859)
  AUTHORS   Kwon,M., Kim,J.H., Rybak,Y., Luna,A., Choi,C.H., Chung,J.Y.,
            Hewitt,S.M., Adem,A., Tubridy,E., Lin,J. and Libutti,S.K.
  TITLE     Reduced expression of FILIP1L, a novel WNT pathway inhibitor, is
            associated with poor survival, progression and chemoresistance in
            ovarian cancer
  JOURNAL   Oncotarget 7 (47), 77052-77070 (2016)
   PUBMED   27776341
  REMARK    GeneRIF: Studies have shown that FILIP1L expression is related with
            inhibition of metastases and chemoresistance of ovarian neoplasm,
            which is associated with downregulation of EMT through beta-catenin
            degradation. FILIP1L expression correlates with significantly
            improved overall survival.
REFERENCE   6  (bases 1 to 2859)
  AUTHORS   Quaye,L., Dafou,D., Ramus,S.J., Song,H., Gentry-Maharaj,A.,
            Notaridou,M., Hogdall,E., Kjaer,S.K., Christensen,L., Hogdall,C.,
            Easton,D.F., Jacobs,I., Menon,U., Pharoah,P.D. and Gayther,S.A.
  TITLE     Functional complementation studies identify candidate genes and
            common genetic variants associated with ovarian cancer survival
  JOURNAL   Hum Mol Genet 18 (10), 1869-1878 (2009)
   PUBMED   19270026
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2009 Aug 1;18(15):2928. Maharaj, Aleksandra
            Gentry [corrected to Gentry-Maharaj, Aleksandra]]
REFERENCE   7  (bases 1 to 2859)
  AUTHORS   Schwarze,S.R., Fu,V.X., Desotelle,J.A., Kenowski,M.L. and
            Jarrard,D.F.
  TITLE     The identification of senescence-specific genes during the
            induction of senescence in prostate cancer cells
  JOURNAL   Neoplasia 7 (9), 816-823 (2005)
   PUBMED   16229804
REFERENCE   8  (bases 1 to 2859)
  AUTHORS   Tandle,A.T., Mazzanti,C., Alexander,H.R., Roberts,D.D. and
            Libutti,S.K.
  TITLE     Endothelial monocyte activating polypeptide-II induced gene
            expression changes in endothelial cells
  JOURNAL   Cytokine 30 (6), 347-358 (2005)
   PUBMED   15935955
  REMARK    GeneRIF: DOC1 might play a role in mediating some of the effects of
            EMAP-II on endothelial cells
REFERENCE   9  (bases 1 to 2859)
  AUTHORS   Schwarze,S.R., DePrimo,S.E., Grabert,L.M., Fu,V.X., Brooks,J.D. and
            Jarrard,D.F.
  TITLE     Novel pathways associated with bypassing cellular senescence in
            human prostate epithelial cells
  JOURNAL   J Biol Chem 277 (17), 14877-14883 (2002)
   PUBMED   11836256
REFERENCE   10 (bases 1 to 2859)
  AUTHORS   Mok,S.C., Wong,K.K., Chan,R.K., Lau,C.C., Tsao,S.W., Knapp,R.C. and
            Berkowitz,R.S.
  TITLE     Molecular cloning of differentially expressed genes in human
            epithelial ovarian cancer
  JOURNAL   Gynecol Oncol 52 (2), 247-252 (1994)
   PUBMED   8314147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129803.3, AC117419.5, AC024938.29 and AC069222.23.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2151741,
                              SAMEA2155550 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AC129803.3         132902-133350
            450-711             AC117419.5         59171-59432
            712-885             AC117419.5         60172-60345
            886-1064            AC024938.29        58389-58567         c
            1065-2859           AC069222.23        37225-39019
FEATURES             Location/Qualifiers
     source          1..2859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.1"
     gene            1..2859
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="filamin A interacting protein 1 like"
                     /db_xref="GeneID:11259"
                     /db_xref="HGNC:HGNC:24589"
                     /db_xref="MIM:612993"
     exon            1..449
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /inference="alignment:Splign:2.1.0"
     exon            450..711
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..1209
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="isoform 8 is encoded by transcript variant 9; 90
                     kDa GPBP-interacting protein; 130 kDa GPBP-interacting
                     protein; protein down-regulated in ovarian cancer 1"
                     /codon_start=1
                     /product="filamin A-interacting protein 1-like isoform 8"
                     /protein_id="NP_001374781.1"
                     /db_xref="GeneID:11259"
                     /db_xref="HGNC:HGNC:24589"
                     /db_xref="MIM:612993"
                     /translation="MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSES
                     DVILPCPKAEKPHSGNGHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLAL
                     LEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQ
                     LLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERSRRYASRESQHGSLNR
                     NLQASPRFPLKPPQCLWISLFTKMAVGSYTS"
     exon            712..885
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1064
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..2859
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1714..1719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="hexamer: ATTAAA"
     polyA_site      1740
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="major polyA site"
     regulatory      1954..1959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="hexamer: AATACA"
     polyA_site      1981
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
     regulatory      2830..2835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="hexamer: ATTAAA"
     polyA_site      2859
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="major polyA site"
ORIGIN      
        1 acacacagac gtgctcacgg agcctgtgcc tgcctctact tgtctgctct gcgcagatgg
       61 ttcctggctt ttgggtcacc tcatcctgca gcccagtcca gttagaacct ttcttccaca
      121 gagactggca agctgtgggg taagagtttt ggtaaggctg cctgtcttca gagcatgaag
      181 gacactgccc ggagagggaa gagggcaata tttagtgttt gggcctactt gttgttgggc
      241 tccccactgc ctctcctttg cagagctatc actggcccct ggttgcaaac tctcggtggc
      301 tttcaagcct acaaaacaaa aactgagagg gtgtccaaaa agagaagaag aaaacgttgt
      361 tgttggtcct ggattccact gttggatttt ggtggggatg agaagaagga attaccaggt
      421 gtgatcaaca cctgcacggt acctgcacgg ctttaaagaa tgcgttccag aggcagtgat
      481 accgagggct cagcccaaaa gaaatttcca agacatacta aaggccacag tttccaaggg
      541 cctaaaaaca tgaagcatag acagcaagac aaagactccc ccagtgagtc ggatgtaata
      601 cttccgtgtc ccaaggcaga gaagccacac agtggtaatg gccaccaagc agaagacctc
      661 tcaagagatg acctgttatt tctcctcagc attctggagg gagaactgca ggctcgagat
      721 gaggtcatag gcattttaaa ggctgaaaaa atggacctgg ctttgctgga agctcagtat
      781 gggtttgtca ctccaaaaaa ggtgttagag gctctccaga gagatgcttt tcaagcgaaa
      841 tctacccctt ggcaggagga catctatgag aaaccaatga atgagttgga caaagttgtg
      901 gaaaaacata aagaatctta cagacgaatc ctgggacagc ttttagtggc agaaaaatcc
      961 cgtaggcaaa ccatattgga gttggaggaa gaaaagagaa aacataaaga atacatggag
     1021 aagagtgatg aattcatatg cctactagaa caggaatgtg aaagatcaag gaggtatgca
     1081 agcagagaat cccagcacgg atccctaaac cgaaatctac aggcatcacc aagatttcca
     1141 ctaaagcccc cacagtgcct atggataagc ctatttacca aaatggctgt gggaagctac
     1201 acatcgtgag aactgtcacc tccaacacct tcctccacgt gggagggaga aggtaactca
     1261 taccaatgca ctgcctggat acattcatct acagaaatat gtggaaagct aaaattacca
     1321 ctatgaaagg ccaaaggacc atctctccag gaaatggtga agcagctttg tggacctgat
     1381 gaagatcatc ccccaaaaag cagcacgtct acaattattt tacttctata tgtgtatatg
     1441 cacacacaaa cactcgcagg cctagaccca cacccaaatc tacccatttc ctcatccgac
     1501 atataatcta acccaaagat gaactatcta gaatcagcct gggataggac tgaattcact
     1561 agaacagttc aagagttttc tggtgaaaac agaagtaatt cttcattcta cagaactttg
     1621 ctgattaatc atattttgct aagaaaaggt gatagcaaaa attcctaatc tgagtcaaga
     1681 aaatcagatt atttccatca agatgacagg acaattaaaa tcacacttta aggtctaaaa
     1741 ctatgatttc tttatgacca ggagggaaaa agcaaagtga taattcttaa aggaggaaaa
     1801 gcataacaaa agtgaataac agccgaatat atcctttgtg cagaatacct gacaatcact
     1861 ggtgtagtaa gcatacctga ccactggcac ttagtctcag taacattgag atattttagg
     1921 gagacatgaa tcaatattcc aggtgcttga aaaaatacag aatttatcat ctcacaggac
     1981 attgtttatt catatctctt ctctgaataa acactatcga aaatcagttg attcaacaaa
     2041 agcttggggt taggagactc aaattccaat cctagatttt cattcatgtg acaacgagct
     2101 ttgcattcat caatctaagc cttgagtttc cacatgtaaa acaggaaagt gaaataattc
     2161 ctcaggtccc ttccagttct gataacctat gaatatgccc aactattaat acaaaatgtt
     2221 gaattcaaac agtcatctat aagggtagac acagtcccct ggcagaaagc taaagcaatt
     2281 ctttacatca cactgaaaac tctctcattg aattgagaga aaggtgtgcc tgtaattcag
     2341 tgtggacaga gtaatacagg acattttaag acaaggcatg tttgacacaa aaggcagttc
     2401 aaaaaacatt tcaaaaagct tcaatcgagg ggggaaaaaa atcaatggaa cgacactaaa
     2461 cattttttgt gatccttcac taaaaactgg aagcatgacc ctggaagaaa tcctcatggt
     2521 taaggactgc tttagccagc tgccctgggt tggagccagc agagcaagag taaaggaact
     2581 cccattcccc atacttatct aactaagtcc acctcattgc actaatgcca ctgtacaaac
     2641 acccccaggc ccctgcaatt tcaaggagga gaaggagcta gaggcctggg cagcattgaa
     2701 agggatgatg ggcagcattg agagggatga tgggcagcat tgagagggat gataggcagc
     2761 attgagaggg atgatgggca gcagtcccag caggcaagtg gcagagggca gtagggggag
     2821 gtcaagtgaa ttaaaagcct gaaatggaaa agtcgaagt
//
