LOCUS       NM_001387850            5635 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens filamin A interacting protein 1 like (FILIP1L),
            transcript variant 7, mRNA.
ACCESSION   NM_001387850
VERSION     NM_001387850.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5635)
  AUTHORS   Jiang,X., Lin,J. and Zhu,Z.
  TITLE     Long-chain noncoding RNA LINC01569 upregulates filamin
            A-interacting protein 1-like to prevent metastasis of
            triple-negative breast cancer via sponging miR-300
  JOURNAL   Cancer Biomark 39 (2), 79-94 (2024)
   PUBMED   37955081
  REMARK    GeneRIF: Long-chain noncoding RNA LINC01569 upregulates filamin
            A-interacting protein 1-like to prevent metastasis of
            triple-negative breast cancer via sponging miR-300.
REFERENCE   2  (bases 1 to 5635)
  AUTHORS   Jing,R., Hu,C., Qi,T., Yue,J., Wang,G., Zhang,M., Wen,C., Pei,C.
            and Ma,B.
  TITLE     FILIP1L-mediated cell apoptosis, epithelial-mesenchymal transition
            and extracellular matrix synthesis aggravate posterior capsular
            opacification
  JOURNAL   Life Sci 286, 120061 (2021)
   PUBMED   34666037
  REMARK    GeneRIF: FILIP1L-mediated cell apoptosis, epithelial-mesenchymal
            transition and extracellular matrix synthesis aggravate posterior
            capsular opacification.
REFERENCE   3  (bases 1 to 5635)
  AUTHORS   Kwon,M., Rubio,G., Nolan,N., Auteri,P., Volmar,J.A., Adem,A.,
            Javidian,P., Zhou,Z., Verzi,M.P., Pine,S.R. and Libutti,S.K.
  TITLE     FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal
            Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1
  JOURNAL   Cancer Res 81 (21), 5523-5539 (2021)
   PUBMED   34417201
  REMARK    GeneRIF: FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal
            Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1.
REFERENCE   4  (bases 1 to 5635)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5635)
  AUTHORS   Kwon,M., Kim,J.H., Rybak,Y., Luna,A., Choi,C.H., Chung,J.Y.,
            Hewitt,S.M., Adem,A., Tubridy,E., Lin,J. and Libutti,S.K.
  TITLE     Reduced expression of FILIP1L, a novel WNT pathway inhibitor, is
            associated with poor survival, progression and chemoresistance in
            ovarian cancer
  JOURNAL   Oncotarget 7 (47), 77052-77070 (2016)
   PUBMED   27776341
  REMARK    GeneRIF: Studies have shown that FILIP1L expression is related with
            inhibition of metastases and chemoresistance of ovarian neoplasm,
            which is associated with downregulation of EMT through beta-catenin
            degradation. FILIP1L expression correlates with significantly
            improved overall survival.
REFERENCE   6  (bases 1 to 5635)
  AUTHORS   Quaye,L., Dafou,D., Ramus,S.J., Song,H., Gentry-Maharaj,A.,
            Notaridou,M., Hogdall,E., Kjaer,S.K., Christensen,L., Hogdall,C.,
            Easton,D.F., Jacobs,I., Menon,U., Pharoah,P.D. and Gayther,S.A.
  TITLE     Functional complementation studies identify candidate genes and
            common genetic variants associated with ovarian cancer survival
  JOURNAL   Hum Mol Genet 18 (10), 1869-1878 (2009)
   PUBMED   19270026
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2009 Aug 1;18(15):2928. Maharaj, Aleksandra
            Gentry [corrected to Gentry-Maharaj, Aleksandra]]
REFERENCE   7  (bases 1 to 5635)
  AUTHORS   Schwarze,S.R., Fu,V.X., Desotelle,J.A., Kenowski,M.L. and
            Jarrard,D.F.
  TITLE     The identification of senescence-specific genes during the
            induction of senescence in prostate cancer cells
  JOURNAL   Neoplasia 7 (9), 816-823 (2005)
   PUBMED   16229804
REFERENCE   8  (bases 1 to 5635)
  AUTHORS   Tandle,A.T., Mazzanti,C., Alexander,H.R., Roberts,D.D. and
            Libutti,S.K.
  TITLE     Endothelial monocyte activating polypeptide-II induced gene
            expression changes in endothelial cells
  JOURNAL   Cytokine 30 (6), 347-358 (2005)
   PUBMED   15935955
  REMARK    GeneRIF: DOC1 might play a role in mediating some of the effects of
            EMAP-II on endothelial cells
REFERENCE   9  (bases 1 to 5635)
  AUTHORS   Schwarze,S.R., DePrimo,S.E., Grabert,L.M., Fu,V.X., Brooks,J.D. and
            Jarrard,D.F.
  TITLE     Novel pathways associated with bypassing cellular senescence in
            human prostate epithelial cells
  JOURNAL   J Biol Chem 277 (17), 14877-14883 (2002)
   PUBMED   11836256
REFERENCE   10 (bases 1 to 5635)
  AUTHORS   Mok,S.C., Wong,K.K., Chan,R.K., Lau,C.C., Tsao,S.W., Knapp,R.C. and
            Berkowitz,R.S.
  TITLE     Molecular cloning of differentially expressed genes in human
            epithelial ovarian cancer
  JOURNAL   Gynecol Oncol 52 (2), 247-252 (1994)
   PUBMED   8314147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129803.3, AC117419.5, AC024938.29 and AC069222.23.
            
            Transcript Variant: This variant (7) encodes the longest isoform
            (6).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2151741,
                              SAMEA2154361 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000477258.2/ ENSP00000417617.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AC129803.3         132902-133350
            450-711             AC117419.5         59171-59432
            712-885             AC117419.5         60172-60345
            886-1064            AC024938.29        58389-58567         c
            1065-3840           AC069222.23        16760-19535
            3841-5635           AC069222.23        37225-39019
FEATURES             Location/Qualifiers
     source          1..5635
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.1"
     gene            1..5635
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="filamin A interacting protein 1 like"
                     /db_xref="GeneID:11259"
                     /db_xref="HGNC:HGNC:24589"
                     /db_xref="MIM:612993"
     exon            1..449
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /inference="alignment:Splign:2.1.0"
     exon            450..711
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..4032
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="isoform 6 is encoded by transcript variant 7; 90
                     kDa GPBP-interacting protein; 130 kDa GPBP-interacting
                     protein; protein down-regulated in ovarian cancer 1"
                     /codon_start=1
                     /product="filamin A-interacting protein 1-like isoform 6"
                     /protein_id="NP_001374779.1"
                     /db_xref="CCDS:CCDS93331.1"
                     /db_xref="GeneID:11259"
                     /db_xref="HGNC:HGNC:24589"
                     /db_xref="MIM:612993"
                     /translation="MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSES
                     DVILPCPKAEKPHSGNGHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLAL
                     LEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQ
                     LLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKE
                     QEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL
                     AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQI
                     DELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKM
                     EEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEK
                     ERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMS
                     EKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDD
                     LKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNK
                     IKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKM
                     ELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQ
                     GDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSK
                     EVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDEGSVLSFKCSQSTPCP
                     VNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQPLHIKVTPDHVQNT
                     ATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSKTSTEDLMNLEQG
                     MSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSPEPTEISAKHA
                     IFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRPASPSAPLQ
                     DNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITIKEVCKQRIPARIPKPKST
                     GITKISTKAPTVPMDKPIYQNGCGKLHIVRTVTSNTFLHVGGRR"
     exon            712..885
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1064
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..3840
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /inference="alignment:Splign:2.1.0"
     exon            3841..5635
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4490..4495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="hexamer: ATTAAA"
     polyA_site      4516
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="major polyA site"
     regulatory      4730..4735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="hexamer: AATACA"
     polyA_site      4757
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
     regulatory      5606..5611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="hexamer: ATTAAA"
     polyA_site      5635
                     /gene="FILIP1L"
                     /gene_synonym="DOC-1; DOC1; GIP130; GIP90"
                     /note="major polyA site"
ORIGIN      
        1 acacacagac gtgctcacgg agcctgtgcc tgcctctact tgtctgctct gcgcagatgg
       61 ttcctggctt ttgggtcacc tcatcctgca gcccagtcca gttagaacct ttcttccaca
      121 gagactggca agctgtgggg taagagtttt ggtaaggctg cctgtcttca gagcatgaag
      181 gacactgccc ggagagggaa gagggcaata tttagtgttt gggcctactt gttgttgggc
      241 tccccactgc ctctcctttg cagagctatc actggcccct ggttgcaaac tctcggtggc
      301 tttcaagcct acaaaacaaa aactgagagg gtgtccaaaa agagaagaag aaaacgttgt
      361 tgttggtcct ggattccact gttggatttt ggtggggatg agaagaagga attaccaggt
      421 gtgatcaaca cctgcacggt acctgcacgg ctttaaagaa tgcgttccag aggcagtgat
      481 accgagggct cagcccaaaa gaaatttcca agacatacta aaggccacag tttccaaggg
      541 cctaaaaaca tgaagcatag acagcaagac aaagactccc ccagtgagtc ggatgtaata
      601 cttccgtgtc ccaaggcaga gaagccacac agtggtaatg gccaccaagc agaagacctc
      661 tcaagagatg acctgttatt tctcctcagc attctggagg gagaactgca ggctcgagat
      721 gaggtcatag gcattttaaa ggctgaaaaa atggacctgg ctttgctgga agctcagtat
      781 gggtttgtca ctccaaaaaa ggtgttagag gctctccaga gagatgcttt tcaagcgaaa
      841 tctacccctt ggcaggagga catctatgag aaaccaatga atgagttgga caaagttgtg
      901 gaaaaacata aagaatctta cagacgaatc ctgggacagc ttttagtggc agaaaaatcc
      961 cgtaggcaaa ccatattgga gttggaggaa gaaaagagaa aacataaaga atacatggag
     1021 aagagtgatg aattcatatg cctactagaa caggaatgtg aaagattaaa gaagctaatt
     1081 gatcaagaaa tcaagtctca ggaggagaag gagcaagaaa aggagaaaag ggtcaccacc
     1141 ctgaaagagg agctgaccaa gctgaagtct tttgctttga tggtggtgga tgaacagcaa
     1201 aggctgacgg cacagctcac ccttcaaaga cagaaaatcc aagagctgac cacaaatgca
     1261 aaggaaacac ataccaaact agcccttgct gaagccagag ttcaggagga agagcagaag
     1321 gcaaccagac tagagaagga actgcaaacg cagaccacaa agtttcacca agaccaagac
     1381 acaattatgg cgaagctcac caatgaggac agtcaaaatc gccagcttca acaaaagctg
     1441 gcagcactca gccggcagat tgatgagtta gaagagacaa acaggtcttt acgaaaagca
     1501 gaagaggagc tgcaagatat aaaagaaaaa atcagtaagg gagaatatgg aaacgctggt
     1561 atcatggctg aagtggaaga gctcaggaaa cgtgtgctag atatggaagg gaaagatgaa
     1621 gagctcataa aaatggagga gcagtgcaga gatctcaata agaggcttga aagggagacg
     1681 ttacagagta aagactttaa actagaggtt gaaaaactca gtaaaagaat tatggctctg
     1741 gaaaagttag aagacgcttt caacaaaagc aaacaagaat gctactctct gaaatgcaat
     1801 ttagaaaaag aaaggatgac cacaaagcag ttgtctcaag aactggagag tttaaaagta
     1861 aggatcaaag agctagaagc cattgaaagt cggctagaaa agacagaatt cactctaaaa
     1921 gaggatttaa ctaaactgaa aacattaact gtgatgtttg tagatgaacg gaaaacaatg
     1981 agtgaaaaat taaagaaaac tgaagataaa ttacaagctg cttcttctca gcttcaagtg
     2041 gagcaaaata aagtaacaac agttactgag aagttaattg aggaaactaa aagggcgctc
     2101 aagtccaaaa ccgatgtaga agaaaagatg tacagcgtaa ccaaggagag agatgattta
     2161 aaaaacaaat tgaaagcgga agaagagaaa ggaaatgatc tcctgtcaag agttaatatg
     2221 ttgaaaaata ggcttcaatc attggaagca attgagaaag atttcctaaa aaacaaatta
     2281 aatcaagact ctgggaaatc cacaacagca ttacaccaag aaaacaataa gattaaggag
     2341 ctctctcaag aagtggaaag actgaaactg aagctaaagg acatgaaagc cattgaggat
     2401 gacctcatga aaacagaaga tgaatatgag actctagaac gaaggtatgc taatgaacga
     2461 gacaaagctc aatttttatc taaagagcta gaacatgtta aaatggaact tgctaagtac
     2521 aagttagcag aaaagacaga gaccagccat gaacaatggc ttttcaaaag gcttcaagaa
     2581 gaagaagcta agtcagggca cctctcaaga gaagtggatg cattaaaaga gaaaattcat
     2641 gaatacatgg caactgaaga cctaatatgt cacctccagg gagatcactc agtcctgcaa
     2701 aaaaaactaa atcaacaaga aaacaggaac agagatttag gaagagagat tgaaaacctc
     2761 actaaggagt tagagaggta ccggcatttc agtaagagcc tcaggcctag tctcaatgga
     2821 agaagaattt ccgatcctca agtattttct aaagaagttc agacagaagc agtagacaat
     2881 gaaccacctg attacaagag cctcattcct ctggaacgtg cagtcatcaa tggtcagtta
     2941 tatgaggaga gtgagaatca agacgaggac cctaatgatg agggatctgt gctgtccttc
     3001 aaatgcagcc agtctactcc atgtcctgtt aacagaaagc tatggattcc ctggatgaaa
     3061 tccaaggagg gccatcttca gaatggaaaa atgcaaacta aacccaatgc caactttgtg
     3121 caacctggag atctagtcct aagccacaca cctgggcagc cacttcatat aaaggttact
     3181 ccagaccatg tacaaaacac agccactctt gaaatcacaa gtccaaccac agagagtcct
     3241 cactcttaca cgagtactgc agtgataccg aactgtggca cgccaaagca aaggataacc
     3301 atcctccaaa acgcctccat aacaccagta aagtccaaaa cctctaccga agacctcatg
     3361 aatttagaac aaggcatgtc cccaattacc atggcaacct ttgccagagc acagacccca
     3421 gagtcttgtg gttctctaac tccagaaagg acaatgtccc ctattcaggt tttggctgtg
     3481 actggttcag ctagctctcc tgagcaggga cgctccccag aaccaacaga aatcagtgcc
     3541 aagcatgcga tattcagagt ctccccagac cggcagtcat catggcagtt tcagcgttca
     3601 aacagcaata gctcaagtgt gataactact gaggataata aaatccacat tcacttagga
     3661 agtccttaca tgcaagctgt agccagccct gtgagacctg ccagcccttc agcaccactg
     3721 caggataacc gaactcaagg cttaattaac ggggcactaa acaaaacaac caataaagtc
     3781 accagcagta ttactatcac accaacagcc acacctcttc ctcgacaatc acaaattaca
     3841 atcaaggagg tatgcaagca gagaatccca gcacggatcc ctaaaccgaa atctacaggc
     3901 atcaccaaga tttccactaa agcccccaca gtgcctatgg ataagcctat ttaccaaaat
     3961 ggctgtggga agctacacat cgtgagaact gtcacctcca acaccttcct ccacgtggga
     4021 gggagaaggt aactcatacc aatgcactgc ctggatacat tcatctacag aaatatgtgg
     4081 aaagctaaaa ttaccactat gaaaggccaa aggaccatct ctccaggaaa tggtgaagca
     4141 gctttgtgga cctgatgaag atcatccccc aaaaagcagc acgtctacaa ttattttact
     4201 tctatatgtg tatatgcaca cacaaacact cgcaggccta gacccacacc caaatctacc
     4261 catttcctca tccgacatat aatctaaccc aaagatgaac tatctagaat cagcctggga
     4321 taggactgaa ttcactagaa cagttcaaga gttttctggt gaaaacagaa gtaattcttc
     4381 attctacaga actttgctga ttaatcatat tttgctaaga aaaggtgata gcaaaaattc
     4441 ctaatctgag tcaagaaaat cagattattt ccatcaagat gacaggacaa ttaaaatcac
     4501 actttaaggt ctaaaactat gatttcttta tgaccaggag ggaaaaagca aagtgataat
     4561 tcttaaagga ggaaaagcat aacaaaagtg aataacagcc gaatatatcc tttgtgcaga
     4621 atacctgaca atcactggtg tagtaagcat acctgaccac tggcacttag tctcagtaac
     4681 attgagatat tttagggaga catgaatcaa tattccaggt gcttgaaaaa atacagaatt
     4741 tatcatctca caggacattg tttattcata tctcttctct gaataaacac tatcgaaaat
     4801 cagttgattc aacaaaagct tggggttagg agactcaaat tccaatccta gattttcatt
     4861 catgtgacaa cgagctttgc attcatcaat ctaagccttg agtttccaca tgtaaaacag
     4921 gaaagtgaaa taattcctca ggtcccttcc agttctgata acctatgaat atgcccaact
     4981 attaatacaa aatgttgaat tcaaacagtc atctataagg gtagacacag tcccctggca
     5041 gaaagctaaa gcaattcttt acatcacact gaaaactctc tcattgaatt gagagaaagg
     5101 tgtgcctgta attcagtgtg gacagagtaa tacaggacat tttaagacaa ggcatgtttg
     5161 acacaaaagg cagttcaaaa aacatttcaa aaagcttcaa tcgagggggg aaaaaaatca
     5221 atggaacgac actaaacatt ttttgtgatc cttcactaaa aactggaagc atgaccctgg
     5281 aagaaatcct catggttaag gactgcttta gccagctgcc ctgggttgga gccagcagag
     5341 caagagtaaa ggaactccca ttccccatac ttatctaact aagtccacct cattgcacta
     5401 atgccactgt acaaacaccc ccaggcccct gcaatttcaa ggaggagaag gagctagagg
     5461 cctgggcagc attgaaaggg atgatgggca gcattgagag ggatgatggg cagcattgag
     5521 agggatgata ggcagcattg agagggatga tgggcagcag tcccagcagg caagtggcag
     5581 agggcagtag ggggaggtca agtgaattaa aagcctgaaa tggaaaagtc gaagt
//
