LOCUS       NM_001384995            4705 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens fidgetin like 2 (FIGNL2), transcript variant 1, mRNA.
ACCESSION   NM_001384995 XM_005268870
VERSION     NM_001384995.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4705)
  AUTHORS   Smart,K., Kramer,A.H., Smart,S., Hodgson,L. and Sharp,D.J.
  TITLE     Fidgetin-like 2 depletion enhances cell migration by regulating
            GEF-H1, RhoA, and FAK
  JOURNAL   Biophys J 122 (18), 3600-3610 (2023)
   PUBMED   36523161
  REMARK    GeneRIF: Fidgetin-like 2 depletion enhances cell migration by
            regulating GEF-H1, RhoA, and FAK.
REFERENCE   2  (bases 1 to 4705)
  AUTHORS   Charafeddine,R.A., Makdisi,J., Schairer,D., O'Rourke,B.P.,
            Diaz-Valencia,J.D., Chouake,J., Kutner,A., Krausz,A., Adler,B.,
            Nacharaju,P., Liang,H., Mukherjee,S., Friedman,J.M., Friedman,A.,
            Nosanchuk,J.D. and Sharp,D.J.
  TITLE     Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing
  JOURNAL   J Invest Dermatol 135 (9), 2309-2318 (2015)
   PUBMED   25756798
REFERENCE   3  (bases 1 to 4705)
  AUTHORS   Cox,G.A., Mahaffey,C.L., Nystuen,A., Letts,V.A. and Frankel,W.N.
  TITLE     The mouse fidgetin gene defines a new role for AAA family proteins
            in mammalian development
  JOURNAL   Nat Genet 26 (2), 198-202 (2000)
   PUBMED   11017077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068987.38.
            
            On Jul 2, 2020 this sequence version replaced XM_005268870.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.3881995.1,
                                           SRR14372079.2416840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618634.3/ ENSP00000491257.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC068987.38        25163-25341
            180-4705            AC068987.38        51457-55982
FEATURES             Location/Qualifiers
     source          1..4705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..4705
                     /gene="FIGNL2"
                     /note="fidgetin like 2"
                     /db_xref="GeneID:401720"
                     /db_xref="HGNC:HGNC:13287"
                     /db_xref="MIM:620503"
     exon            1..179
                     /gene="FIGNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            180..4705
                     /gene="FIGNL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..2152
                     /gene="FIGNL2"
                     /note="putative fidgetin-like protein 2"
                     /codon_start=1
                     /product="fidgetin-like protein 2"
                     /protein_id="NP_001371924.1"
                     /db_xref="CCDS:CCDS86302.1"
                     /db_xref="GeneID:401720"
                     /db_xref="HGNC:HGNC:13287"
                     /db_xref="MIM:620503"
                     /translation="MHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLELPPGGRQRCHY
                     AWAHDDISALTASNLLKRYAEKYSGVLDSPYERPALGGYSDASFLNGAKGDPEPWPGP
                     EPPYPLASLHEGLPGTKSGGGGGSGALGGSPVLAGNLPEPLYAGNACGGPSAAPEYAA
                     GYGGGYLAPGYCAQTGAALPPPPPAALLQPPPPPGYGPSAPLYNYPAGGYAAQPGYGA
                     LPPPPGPPPAPYLTPGLPAPTPLPAPAPPTAYGFPTAAPGAESGLSLKRKAADEGPEG
                     RYRKYAYEPAKAPVADGASYPAADNGECRGNGFRAKPPGAAEEASGKYGGGVPLKVLG
                     SPVYGPQLEPFEKFPERAPAPRGGFAVPSGETPKGVDPGALELVTSKMVDCGPPVQWA
                     DVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLG
                     ATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAAAGG
                     ALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYVALPDSPARGQI
                     LQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAGAGLPGLQRPLSYKDLE
                     AALAKVGPRASAKELDSFVEWDKMYGSGH"
     regulatory      4687..4692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FIGNL2"
                     /note="hexamer: ATTAAA"
     polyA_site      4705
                     /gene="FIGNL2"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgctc ccgcccgcgg cggccgcagc agccgcagca gcagcggctc caggatggtg
       61 agcgccactg ccccccagcc caggcctgtc gcccccggcc cgcgccgccg ccccggtccc
      121 cgggccggac gcgcccccag gccgcgcaca ctcacctagg acccggccgt gatgccgagc
      181 tctgttgaag atgcactgga caccagaaca cgcccagccc ctcaaccagt ggccagagca
      241 gcacctggac gtctcctcca ccaccccgtc gccggcccac aagttggagt tgccccctgg
      301 gggtcgccaa cgctgccact acgcttgggc acacgacgac atctcagccc tcactgcctc
      361 caacctccta aagcgctatg cagagaagta ctctggggtc ttggattctc cctacgagcg
      421 tccggccctg ggcgggtaca gcgacgcctc cttcctcaac ggcgccaaag gggatcccga
      481 gccctggcca gggccggagc caccctaccc cttggcctca ctccacgaag gcctcccagg
      541 aaccaaatcg ggcggtggcg gcggttccgg ggccctgggg ggctccccag ttttagccgg
      601 gaacctccct gaacccctct acgccggcaa tgcgtgcggg ggcccatcgg cggcgcccga
      661 gtacgcggcc ggctacggcg gggggtacct ggcgccgggt tactgcgcgc agacgggcgc
      721 cgcgctgccc ccgccgcccc cggccgcgct cctgcagccc ccaccgcctc cggggtacgg
      781 gccctcagcg ccgctgtaca actatcccgc agggggctac gcagcgcagc ccggctatgg
      841 cgcgctcccg ccgcccccag gcccaccccc ggccccctac ctgaccccgg gcctgcccgc
      901 gcccacgccc ctgcccgcgc cggcaccgcc caccgcctat ggcttcccca cggccgcgcc
      961 gggtgccgaa tccgggctgt cgctgaagcg caaggccgcc gacgaggggc ccgagggccg
     1021 ctaccgcaag tacgcgtacg agcccgccaa ggcccccgtg gctgacggag cctcctaccc
     1081 cgccgcggac aacggcgaat gtcggggcaa cgggttccgg gccaagccgc caggagccgc
     1141 ggaggaggcg tcgggcaagt acggtggcgg cgtccccctc aaggtcctgg gctcccccgt
     1201 ctacggcccg caactggagc cctttgaaaa gttcccggag cgggccccgg ctcctcgtgg
     1261 ggggttcgcc gtgccgtcgg gggagactcc caaaggcgtg gaccctgggg ccctggagct
     1321 ggtgacgagc aagatggtgg actgcgggcc cccggtgcag tgggcggatg tggcgggcca
     1381 gggcgcgctc aaggcggcgc tggaggagga gctggtgtgg cccctgctca ggccgcccgc
     1441 ctacccgggc agcctgcgcc cgccgcggac cgtcctgctc tttgggccgc ggggcgcggg
     1501 caaagcgctg ctgggccgct gcctcgccac gcagctgggc gccacgctgt tgcgcctgcg
     1561 cggcgcgacc ctggctgcgc ccggcgccgc cgagggcgcg cgcctcctcc aggccgcctt
     1621 cgcggccgcg cgctgccgcc caccctccgt actcctcatc agcgagctag aggcgctgct
     1681 ccccgcccgg gacgacggcg cggcggcagg gggcgcgctg caggtgccgc tcctggcctg
     1741 cctggacggg ggctgcggcg cgggggctga cggcgtgctg gttgtgggca ccacctcgcg
     1801 gcccgcggct ctggacgagg cgacccgccg gcgcttctct ctccgcttct acgtggcgct
     1861 gcccgacagc ccggcccgcg ggcagatcct gcagcgggcg ctggcccagc agggctgcgc
     1921 gctcagtgag cgggaactgg cggcgctggt gcagggcacg cagggcttct ctgggggcga
     1981 gctggggcag ctgtgccagc aggcggcggc cggggcgggc ctcccggggc tgcagcgccc
     2041 cctctcctac aaggacctgg aggcggcgct ggccaaggtg ggccctaggg cctctgccaa
     2101 ggaactggac tcgttcgtgg agtgggacaa aatgtacggc tccggacact gacggcgcgc
     2161 gggggaggcc gcgggagccg cagtccctcc gtccccgccg cctccgcgtg ggagggatgt
     2221 cactgactaa acccggctgg caggggctgg agtggtgaat gtgggatcgg ggacaggagg
     2281 ggtctgccgg tggatatttt ttttttcgtg ggaaggaaaa tgcttctgcc aggcagatgc
     2341 catatgcgcc gtgtactcag gtttttccta tttattgtgg actggaagct cgccatctcc
     2401 gcccggcaga ccgggcagat ccggcatggg ctggcacccg gggccttaag aactcctgct
     2461 ctcttgccac aacgcttttg tctcctcgct atctgaatgg caccctcctt ctccctcact
     2521 ctctccatcc cattctctgc attctcttgg ttttctctcc cttttgcttt gtcgctgaca
     2581 cccctgccca ccccatgctg gccctgtttc tctcctgccc ctccctcccc agctctccat
     2641 ccctcaccct ctgtgcttct gtctccatcc ctggctctcc agcgtccctg gccttttggt
     2701 ccctgagctt taatgccttt ccctgccttc tgttcttatt tggactgcag tggccctttg
     2761 caggagctct ggaggcccag gggctgagga ggagggttac ccctctaccc atctgaaacc
     2821 tagggtctag ggggatcaag gaaaaaaagt ccccaaagaa ggggaatttt ttgtttgttt
     2881 ttgaggggag atcccagaaa tgtagcttgt ttcatatttt agtcttctta tttttgtaaa
     2941 atgtgtagaa tttgctgttt ttctttttct tttgacaact caggaagaaa ctgacctcag
     3001 aaagaatgtt agactttggc tgctctcctg tgtgcccctc acacctgccc cctccccccc
     3061 actccatcca ggggaccaaa ttctcccaga cactcaaaaa atgagactta cggggaaggg
     3121 gagaggaaga cccagaggcc tcagtgaaac cccagctatt cctggtcaga agcagaatgt
     3181 attcctaagg gcttcctccc cagggccgag gcctaggcat gaatgtgggg agtgggctgt
     3241 ggggtttgag agaagggagg ccttattcct ctcctgctgc tccccacccc ctgccccacc
     3301 caacccctcc gctgagtgtt ttctgtgaag ggctatccag agttaggatg cccttgccca
     3361 attccttcct gagacccaga aggtagggtg ggagggccca aatgggaagg tgacctaagc
     3421 agaaagtctc cagaaaggtc atgtcccctg gccctgcctt ggcagaggtc cccagtgact
     3481 tatgctagga ggattccatc tgggtagaca gtctggccac aaaatcagct actggacctc
     3541 agccatctct gctggaggct ctgaggagga gtgagcatcc ctcacttgtg ggggctctgt
     3601 gaggaaatgt gccttcccca ttcccccgga gtcctaggtc tggagctcca gggctgggag
     3661 agggtgaggg agatgggcag gggtgttttc tctgaccttg ggggcttagt ctcagtcctg
     3721 cctgaacttt ccactaggct tggaaccctt ccaagaacca tatttctctc cttcccacca
     3781 attttccctt gatgaggctt tagcagtttg ctcccaccac ccccagccca tttcacaact
     3841 ctgatcttag tccaaagcag gggacacgcc cccccaccac cactttttct ctctcccatc
     3901 tcagcctcct gtgcagttcc ttgcctgccc gtgcatttcc tagagtctac tgcctccccc
     3961 ctggctggga gggtgtctgg gggggatctt tcaggggccc tggcacccag ggcctgtgct
     4021 ggcctaggag tgctgaccag aaggctgctc tgttcccccc cacccccgtt gctttctggc
     4081 cccctctttg gagccagcca cccacagggc tttggtgcct cagaagcagt gggctgccgg
     4141 gtcacagccg caggctgcaa aagaccctcg gagggagcat ggagtgaggg gttctctctc
     4201 aggtgtgtat gtattggggg gtgggggtgg gtggagggtg tcagggaagt tggggtggga
     4261 tcccagcctt cccttcaaga ggcagggagc tctgggaggt ggagtcccca ccgctttctc
     4321 tactaggctc ctcctgttcc ccaggcttgg ggagctttgc acaaggagac tgcccccagc
     4381 ctagtggcac ctacctcatg ggctctgggg caggtagggg aagggccagt ccagctctgg
     4441 taatgctggg gggaggcata ccaaagaatc caggggcagg gagtggggag ggtgacttcc
     4501 gagctggcct ctccccttcc tctacccaga ctggggctgg gatcctctcc tcccgctgta
     4561 accatttcta cctcattttg ctgcgtgttg tacatggacg tatttatctc ctgtctgacg
     4621 atgctctgca gttgtggtct gtctacctca gaagagactg tattttaaaa gaaagtatta
     4681 cacagtatta aagcgatgac atgtg
//
