LOCUS       NM_001287492            3930 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens fidgetin like 1 (FIGNL1), transcript variant 3, mRNA.
ACCESSION   NM_001287492 XM_005271779
VERSION     NM_001287492.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3930)
  AUTHORS   Matsuzaki,K., Shinohara,A. and Shinohara,M.
  TITLE     Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated ultra-fine
            bridge formation
  JOURNAL   Nucleic Acids Res 52 (10), 5774-5791 (2024)
   PUBMED   38597669
  REMARK    GeneRIF: Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated
            ultra-fine bridge formation.
REFERENCE   2  (bases 1 to 3930)
  AUTHORS   Tischler,J.D., Tsuchida,H., Bosire,R., Oda,T.T., Park,A. and
            Adeyemi,R.O.
  TITLE     FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association
            to promote viability after replication stress
  JOURNAL   Nat Commun 15 (1), 866 (2024)
   PUBMED   38286805
  REMARK    GeneRIF: FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin
            association to promote viability after replication stress.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3930)
  AUTHORS   Wang,J., Sun,L., Liu,Y. and Zhang,Y.
  TITLE     FIGNL1 Promotes Hepatocellular Carcinoma Formation via Remodeling
            ECM-receptor Interaction Pathway Mediated by HMMR
  JOURNAL   Curr Gene Ther 24 (3), 249-263 (2024)
   PUBMED   37929733
  REMARK    GeneRIF: FIGNL1 Promotes Hepatocellular Carcinoma Formation via
            Remodeling ECM-receptor Interaction Pathway Mediated by HMMR.
REFERENCE   4  (bases 1 to 3930)
  AUTHORS   Ito,M., Furukohri,A., Matsuzaki,K., Fujita,Y., Toyoda,A. and
            Shinohara,A.
  TITLE     FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic
            DNA replication and meiotic recombination
  JOURNAL   Nat Commun 14 (1), 6857 (2023)
   PUBMED   37891173
  REMARK    GeneRIF: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in
            pre-meiotic DNA replication and meiotic recombination.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3930)
  AUTHORS   Stok,C., Tsaridou,S., van den Tempel,N., Everts,M., Wierenga,E.,
            Bakker,F.J., Kok,Y., Alves,I.T., Jae,L.T., Raas,M.W.D., Huis In 't
            Veld,P.J., de Boer,H.R., Bhattacharya,A., Karanika,E., Warner,H.,
            Chen,M., van de Kooij,B., Dessapt,J., Ter Morsche,L.,
            Perepelkina,P., Fradet-Turcotte,A., Guryev,V., Tromer,E.C.,
            Chan,K.L., Fehrmann,R.S.N. and van Vugt,M.A.T.M.
  TITLE     FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51
            dynamics
  JOURNAL   Cell Rep 42 (7), 112668 (2023)
   PUBMED   37347663
REFERENCE   6  (bases 1 to 3930)
  AUTHORS   Yuan,J. and Chen,J.
  TITLE     FIGNL1-containing protein complex is required for efficient
            homologous recombination repair
  JOURNAL   Proc Natl Acad Sci U S A 110 (26), 10640-10645 (2013)
   PUBMED   23754376
  REMARK    GeneRIF: RAD51-binding protein fidgetin-like 1 (FIGNL1) is
            identified; FIGNL1 specifically interacts with RAD51 through its
            conserved RAD51 binding domain. Cells depleted of FIGNL1 show
            defective homologous recombination repair.
REFERENCE   7  (bases 1 to 3930)
  AUTHORS   Franke,A., McGovern,D.P., Barrett,J.C., Wang,K.,
            Radford-Smith,G.L., Ahmad,T., Lees,C.W., Balschun,T., Lee,J.,
            Roberts,R., Anderson,C.A., Bis,J.C., Bumpstead,S., Ellinghaus,D.,
            Festen,E.M., Georges,M., Green,T., Haritunians,T., Jostins,L.,
            Latiano,A., Mathew,C.G., Montgomery,G.W., Prescott,N.J.,
            Raychaudhuri,S., Rotter,J.I., Schumm,P., Sharma,Y., Simms,L.A.,
            Taylor,K.D., Whiteman,D., Wijmenga,C., Baldassano,R.N., Barclay,M.,
            Bayless,T.M., Brand,S., Buning,C., Cohen,A., Colombel,J.F.,
            Cottone,M., Stronati,L., Denson,T., De Vos,M., D'Inca,R.,
            Dubinsky,M., Edwards,C., Florin,T., Franchimont,D., Gearry,R.,
            Glas,J., Van Gossum,A., Guthery,S.L., Halfvarson,J.,
            Verspaget,H.W., Hugot,J.P., Karban,A., Laukens,D., Lawrance,I.,
            Lemann,M., Levine,A., Libioulle,C., Louis,E., Mowat,C., Newman,W.,
            Panes,J., Phillips,A., Proctor,D.D., Regueiro,M., Russell,R.,
            Rutgeerts,P., Sanderson,J., Sans,M., Seibold,F., Steinhart,A.H.,
            Stokkers,P.C., Torkvist,L., Kullak-Ublick,G., Wilson,D.,
            Walters,T., Targan,S.R., Brant,S.R., Rioux,J.D., D'Amato,M.,
            Weersma,R.K., Kugathasan,S., Griffiths,A.M., Mansfield,J.C.,
            Vermeire,S., Duerr,R.H., Silverberg,M.S., Satsangi,J.,
            Schreiber,S., Cho,J.H., Annese,V., Hakonarson,H., Daly,M.J. and
            Parkes,M.
  TITLE     Genome-wide meta-analysis increases to 71 the number of confirmed
            Crohn's disease susceptibility loci
  JOURNAL   Nat Genet 42 (12), 1118-1125 (2010)
   PUBMED   21102463
REFERENCE   8  (bases 1 to 3930)
  AUTHORS   de Krom,M., Staal,W.G., Ophoff,R.A., Hendriks,J., Buitelaar,J.,
            Franke,B., de Jonge,M.V., Bolton,P., Collier,D., Curran,S., van
            Engeland,H. and van Ree,J.M.
  TITLE     A common variant in DRD3 receptor is associated with autism
            spectrum disorder
  JOURNAL   Biol Psychiatry 65 (7), 625-630 (2009)
   PUBMED   19058789
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3930)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   10 (bases 1 to 3930)
  AUTHORS   Park,S.J., Kim,S.J., Rhee,Y., Byun,J.H., Kim,S.H., Kim,M.H.,
            Lee,E.J. and Lim,S.K.
  TITLE     Fidgetin-like 1 gene inhibited by basic fibroblast growth factor
            regulates the proliferation and differentiation of osteoblasts
  JOURNAL   J Bone Miner Res 22 (6), 889-896 (2007)
   PUBMED   17352653
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018705.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_001287492.3.
            
            Summary: This gene encodes a member of the AAA ATPase family of
            proteins. The encoded protein is recruited to sites of DNA damage
            where it plays a role in DNA double-strand break repair via
            homologous recombination. This protein has also been shown to
            localize to the centrosome and inhibit ciliogenesis, and may
            regulate the proliferation and differentiation of osteoblasts.
            [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (3) encodes the longer isoform
            (1). Variants 1-6 and 10-15 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.2131964.1, AK027537.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000433017.6/ ENSP00000399997.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC018705.10        42816-42865         c
            51-656              AC018705.10        41633-42238         c
            657-765             AC018705.10        40696-40804         c
            766-3930            AC018705.10        36648-39812         c
FEATURES             Location/Qualifiers
     source          1..3930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p12.2"
     gene            1..3930
                     /gene="FIGNL1"
                     /note="fidgetin like 1"
                     /db_xref="GeneID:63979"
                     /db_xref="HGNC:HGNC:13286"
                     /db_xref="MIM:615383"
     exon            1..50
                     /gene="FIGNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            51..656
                     /gene="FIGNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..765
                     /gene="FIGNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            766..3930
                     /gene="FIGNL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             776..2800
                     /gene="FIGNL1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     fidgetin-like protein 1"
                     /codon_start=1
                     /product="fidgetin-like protein 1 isoform 1"
                     /protein_id="NP_001274421.1"
                     /db_xref="CCDS:CCDS5510.1"
                     /db_xref="GeneID:63979"
                     /db_xref="HGNC:HGNC:13286"
                     /db_xref="MIM:615383"
                     /translation="MQTSSSRSVHLSEWQKNYFAITSGICTGPKADAYRAQILRIQYA
                     WANSEISQVCATKLFKKYAEKYSAIIDSDNVESGLNNYAENILTLAGSQQTDSDKWQS
                     GLSINNVFKMSSVQKMMQAGKKFKDSLLEPALASVVIHKEATVFDLPKFSVCGSSQES
                     DSLPNSAHDRDRTQDFPESNRLKLLQNAQPPMVTNTARTCPTFSAPVGESATAKFHVT
                     PLFGNVKKENHSSAKENIGLNVFLSNQSCFPAACENPQRKSFYGSGTIDALSNPILNK
                     ACSKTEDNGPKEDSSLPTFKTAKEQLWVDQQKKYHQPQRASGSSYGGVKKSLGASRSR
                     GILGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIELIMNEIM
                     DHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLI
                     GKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQ
                     RGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIP
                     LPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQ
                     TADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFGCGK"
     regulatory      3907..3912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FIGNL1"
                     /note="hexamer: ATTAAA"
     polyA_site      3930
                     /gene="FIGNL1"
                     /note="major polyA site"
ORIGIN      
        1 gtcagtcccc gcgcttttcg gaggctgcca gcgtcccaca ccagccgcag gtgaaaaccg
       61 gcagaaagac attaagagat tttcctgcag tcactgctgg cagatgatag agccaggatt
      121 tgaaagcagg cagcctggct ccagaccctg tgctcttaac tcccgttttg catcaagaac
      181 agaatcctat gaaaggcttg cacagtgctt ggtactgagt aggcactccg tcagtatttt
      241 agtagctatt attccaaagg acactgtatt ctaggtacta agacaatgtg aatggaatgg
      301 aaaacaattc ctccctgcag aagccaactg tctaggaaga cagataatga cattattaaa
      361 ataatcagaa cattggcaaa ataaagaaga ttgaaatgca gttcatatga cagtgctaat
      421 taatcatact ttttagatct aggaaaggcc ataaaggtta aattgacttg gaaatggtaa
      481 acaagacaat ggttgtgtca ctgatcggtg atggccagtt tttggttatc cttatttgcc
      541 atttaaatga ttgaattgaa aggaagaagt aagacttgga agatgaatat tgaaggaaag
      601 gtgaagatgg aaaagagaag ggggtttatt ctgagaacag tgactagaac tctgaggata
      661 gcagcatcaa ggagcattgt gtacatgcag aagtgcacag tacctggagt gaaactgctt
      721 gtgttcgatt tctgatacca ttcataactg gctgtgtgat ctcaaaacct ctaaaatgca
      781 gacctccagc tctagatctg tgcacctgag tgaatggcag aagaattact tcgcaattac
      841 atctggcata tgtaccggac cgaaggcaga tgcataccgt gcacagatat tacgcattca
      901 gtatgcatgg gcaaactctg agatttccca ggtctgtgct accaaactgt tcaaaaaata
      961 tgcagagaaa tattctgcaa ttattgattc tgacaatgtt gaatctgggt tgaataatta
     1021 tgcagaaaac attttaactt tggcaggatc tcaacaaaca gatagtgaca agtggcagtc
     1081 tggattgtca ataaataatg ttttcaaaat gagtagtgta cagaagatga tgcaagctgg
     1141 caaaaaattc aaagactctc tgttggaacc tgctcttgca tcagtggtaa tccataagga
     1201 ggccactgtc tttgatcttc ctaaatttag tgtttgtggt agttctcaag agagtgactc
     1261 attacctaac tcagctcatg atcgagaccg gacccaagac ttcccggaga gcaatcgttt
     1321 gaaactcctt cagaatgccc agccacctat ggtgactaac actgctagga cttgtcctac
     1381 attctcagca cctgtaggtg agtcagctac tgcaaaattc catgtcacac cattgtttgg
     1441 aaatgtcaaa aaggaaaatc acagctctgc aaaagaaaac ataggactta atgtgttctt
     1501 atctaaccag tcttgttttc ctgctgcctg tgaaaatcca cagaggaagt ctttttatgg
     1561 ttctggcacc attgatgcac tttccaatcc aatactgaat aaggcttgta gtaaaacaga
     1621 agataatggc ccaaaggagg atagcagcct gcctacattt aaaactgcaa aagaacaatt
     1681 atgggtagat cagcaaaaaa agtaccacca acctcagcgt gcatcagggt cttcatatgg
     1741 tggtgtaaaa aagtctctag gagctagtag atcccgaggg atacttggaa agtttgttcc
     1801 tcctataccc aagcaagatg ggggagagca gaatggagga atgcaatgta agccttatgg
     1861 ggcaggacct acagaaccag cacatccagt tgatgagcgt ctgaagaact tggagccaaa
     1921 gatgattgaa cttattatga atgagattat ggatcatgga cctccagtaa attgggaaga
     1981 tattgcagga gtagaatttg ctaaagccac cataaaggaa atagttgtgt ggcccatgtt
     2041 gaggccagac atctttactg gtttaagggg accccctaaa ggaattttgc tctttggtcc
     2101 tcctgggact ggtaaaactc taattggcaa gtgcattgct agtcagtctg gggcaacatt
     2161 ctttagcatc tctgcttcat ccttaacttc taaatgggta ggtgaggggg agaaaatggt
     2221 ccgtgcattg tttgctgttg caaggtgtca gcaaccagct gtgatattta ttgacgaaat
     2281 tgattccttg ttatctcaac ggggagatgg tgagcatgaa tcttctagaa ggataaaaac
     2341 agaattttta gttcaattag atggagcaac aacatcttct gaagatcgta tcctagtggt
     2401 gggagcaaca aatcggccac aagaaattga tgaggctgcc cggagaagat tggtgaaaag
     2461 gctttatatt cccctcccag aagcttcagc caggaaacag atagtaatta atctaatgtc
     2521 caaagagcag tgttgcctca gtgaagaaga aattgaacag attgtacagc agtctgatgc
     2581 gttttcagga gcagacatga cacagctttg cagggaggct tctcttggtc ctattcgcag
     2641 tttacaaact gctgacattg ctaccataac accggatcaa gttcgaccca tagcttacat
     2701 tgattttgaa aatgctttta gaactgtgcg acctagtgtt tctccaaaag atttagagct
     2761 ttatgaaaac tggaacaaaa cttttggttg tggaaagtaa gtgggatact tggaatcaag
     2821 gcatctctgt agtacagtct tctttatttt ttagcataga aagttgggga tgtgttaatt
     2881 gtatttttaa gaatatattc taagttctgt acttcaaata atagcacaga ttttacatct
     2941 gattgacata gtgtatgtta atgtaagttt tgctttccag tgattacctg atacgtaagc
     3001 ctatttgaac aaagtgagaa tgaacttttg tttctaagaa gtctttatct tgaagctata
     3061 taacatgaaa agtgagctca aatttttttt agttgaagat tacatataaa gttgtgtctg
     3121 attaatattc atcttttatt gaagaaagtg ccttctgatg gccacataat tcttaatgtc
     3181 agctagtata atggtttaca tttggacaaa gtattgctta gtgttattta agtagattta
     3241 agatctcaaa gctaaagtgc caatttttac tttcttcagc caatttgtta cctcttttat
     3301 ggtttttaat ttttatcagg actaacattt tcagaaatag caaggtgtga tctagtatta
     3361 gattcacaga actgaaaggt taattaagaa tgttggttat tttcacggga gcgtgtgata
     3421 tttaacatta atattttatt tgacactaca gcctgtaata ctgctctctt tcaaaaacaa
     3481 gttttcagat ttttataaca gacccatttt gttttatgaa acatgttcat tacagaaaca
     3541 tgagaaaata gagataagta aaaagaataa aagtcactat tatcctacca ctttgcggga
     3601 cacactatta atatttaagc atagattctt ccagatgttt tgttttatac agcagtagga
     3661 ttgtgtaatg tattctctct tgtagcctat tcttcaaagc gtatcttcac tttccatgtt
     3721 aacataaatg tccttttatg attgtctagg attccatgga tggatggaat ataattgagt
     3781 catctggtag agcgcatata ggacaggacg ctaggttgtt tatcttttgt ttattgtaaa
     3841 ggaactatgt gggatgcatt tggtgatctt tttaaaaaat gtataaattt cttgagtaat
     3901 tcctggatta aagaatatgc actttttaaa
//
