LOCUS       NM_014845               3025 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens FIG4 phosphoinositide 5-phosphatase (FIG4), mRNA.
ACCESSION   NM_014845
VERSION     NM_014845.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3025)
  AUTHORS   Beloribi-Djefaflia,S., Morales,R.J., Fatehi,F., Isapof,A.,
            Servais,L., Leonard-Louis,S., Michaud,M., Verdure,P., Gidaro,T.,
            Pouget,J., Poinsignon,V., Bonello-Palot,N. and Attarian,S.
  TITLE     Clinical and genetic features of patients suffering from CMT4J
  JOURNAL   J Neurol 271 (3), 1355-1365 (2024)
   PUBMED   37950760
  REMARK    GeneRIF: Clinical and genetic features of patients suffering from
            CMT4J.
REFERENCE   2  (bases 1 to 3025)
  AUTHORS   Xiang,Q., Wang,Z., Mu,G., Xie,Q., Liu,Z., Zhou,S., Zhang,H.,
            Wang,Z., Hu,K., Song,H., Yuan,D., Xia,Q., Huang,Y. and Cui,Y.
  TITLE     PROK2, HRNR, and FIG4 as potential genetic biomarkers of high
            bleeding propensity in East Asian patients with acute coronary
            syndrome using ticagrelor
  JOURNAL   Pharmacotherapy 42 (12), 872-879 (2022)
   PUBMED   36263704
  REMARK    GeneRIF: PROK2, HRNR, and FIG4 as potential genetic biomarkers of
            high bleeding propensity in East Asian patients with acute coronary
            syndrome using ticagrelor.
REFERENCE   3  (bases 1 to 3025)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3025)
  AUTHORS   Sbrissa,D., Ikonomov,O.C., Fu,Z., Ijuin,T., Gruenberg,J.,
            Takenawa,T. and Shisheva,A.
  TITLE     Core protein machinery for mammalian phosphatidylinositol
            3,5-bisphosphate synthesis and turnover that regulates the
            progression of endosomal transport. Novel Sac phosphatase joins the
            ArPIKfyve-PIKfyve complex
  JOURNAL   J Biol Chem 282 (33), 23878-23891 (2007)
   PUBMED   17556371
REFERENCE   5  (bases 1 to 3025)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   6  (bases 1 to 3025)
  AUTHORS   Minagawa,T., Ijuin,T., Mochizuki,Y. and Takenawa,T.
  TITLE     Identification and characterization of a sac domain-containing
            phosphoinositide 5-phosphatase
  JOURNAL   J Biol Chem 276 (25), 22011-22015 (2001)
   PUBMED   11274189
REFERENCE   7  (bases 1 to 3025)
  AUTHORS   Li,J.
  TITLE     Charcot-Marie-Tooth Neuropathy Type 4J - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24228289
REFERENCE   8  (bases 1 to 3025)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Neuropathy Type 4 - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301641
REFERENCE   9  (bases 1 to 3025)
  AUTHORS   Siddique,N. and Siddique,T.
  TITLE     Amyotrophic Lateral Sclerosis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301623
REFERENCE   10 (bases 1 to 3025)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Hereditary Neuropathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301532
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA811740.1, BC041338.2,
            AK222732.1 and BU683891.1.
            
            On Dec 4, 2019 this sequence version replaced NM_014845.5.
            
            Summary: The protein encoded by this gene belongs to the SAC
            domain-containing protein gene family. The SAC domain,
            approximately 400 amino acids in length and consisting of seven
            conserved motifs, has been shown to possess phosphoinositide
            phosphatase activity. The yeast homolog, Sac1p, is involved in the
            regulation of various phosphoinositides, and affects diverse
            cellular functions such as actin cytoskeleton organization, Golgi
            function, and maintenance of vacuole morphology. Membrane-bound
            phosphoinositides function as signaling molecules and play a key
            role in vesicle trafficking in eukaryotic cells. Mutations in this
            gene have been associated with Charcot-Marie-Tooth disease, type
            4J. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291671.1, D87464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230124.8/ ENSP00000230124.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-492               DA811740.1         81-572
            493-2383            BC041338.2         524-2414
            2384-2698           AK222732.1         2356-2670
            2699-3025           BU683891.1         24-350              c
FEATURES             Location/Qualifiers
     source          1..3025
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3025
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /note="FIG4 phosphoinositide 5-phosphatase"
                     /db_xref="GeneID:9896"
                     /db_xref="HGNC:HGNC:16873"
                     /db_xref="MIM:609390"
     exon            1..206
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2864
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.36"
                     /EC_number="3.1.3.86"
                     /note="Sac domain-containing inositol phosphatase 3; FIG4
                     homolog, SAC domain containing lipid phosphatase; SAC
                     domain-containing protein 3; FIG4 homolog, SAC1 lipid
                     phosphatase domain containing; phosphatidylinositol
                     3,5-bisphosphate 5-phosphatase; FIG4 homolog, SAC1 domain
                     containing lipid phosphatase; serine-protein phosphatase
                     FIG4"
                     /codon_start=1
                     /product="polyphosphoinositide phosphatase"
                     /protein_id="NP_055660.1"
                     /db_xref="CCDS:CCDS5078.1"
                     /db_xref="GeneID:9896"
                     /db_xref="HGNC:HGNC:16873"
                     /db_xref="MIM:609390"
                     /translation="MPTAAAPIISSVQKLVLYETRARYFLVGSNNAETKYRVLKIDRT
                     EPKDLVIIDDRHVYTQQEVRELLGRLDLGNRTKMGQKGSSGLFRAVSAFGVVGFVRFL
                     EGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVRVTHPDEARYLRIFQNVDLS
                     SNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNRQESFDIFEDEGLITQGGSGVF
                     GICSEPYMKYVWNGELLDIIKSTVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRS
                     SKFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLYWSQ
                     DISTMMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIIILNLVKEREKRKHERILSE
                     ELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNR
                     PDSYCSILRPDEKWNELGGCVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQ
                     LYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQH
                     SKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMRL
                     LPTRRSYTYWWTPEVIKHLPLPYDEVICAVNLKKLIVKKFHKYEEEIDIHNEFFRPYE
                     LSSFDDTFCLAMTSSARDFMPKTVGIDPSPFTVRKPDETGKSVLGNKSNREEAVLQRK
                     TAASAPPPPSEEAVSSSSEDDSGTDREEEGSVSQRSTPVKMTDAGDSAKVTENVVQPM
                     KELYGINLSDGLSEEDFSIYSRFVQLGQSQHKQDKNSQQPCSRCSDGVIKLTPISAFS
                     QDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDSSMYREYIRNRYL"
     exon            207..305
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            306..429
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            430..586
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            587..637
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            638..786
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            787..915
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1016
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1179
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1277
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1411
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1528
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1574
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1723
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1890
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2029
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2088
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2236
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2320
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2516
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2599
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2686
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..3025
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3007..3012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /note="hexamer: AATAAA"
     polyA_site      3025
                     /gene="FIG4"
                     /gene_synonym="ALS11; BOP; BTOP; CMT4J; dJ249I4.1;
                     KIAA0274; SAC3; YVS"
                     /note="major polyA site"
ORIGIN      
        1 gatcatctat aggtttagtg cctaatgggt gttgttcctg gctggacttg atgtccaggg
       61 cctgaggggt tttctcgccg agtctcctgg ggcggtccgg aggctcgtgc cctgttgtgg
      121 ggcccccatt tgccgccgcc atgcccacgg ccgccgcccc catcatcagc tcggtccaga
      181 agctggttct gtatgagact agagctagat actttctagt tgggagcaat aatgcagaaa
      241 cgaaatatcg tgtcttgaag attgatagaa cagaaccaaa agatttggtc ataattgatg
      301 acaggcatgt ctatactcaa caagaagtaa gggaacttct tggccgcttg gatcttggaa
      361 atagaacaaa gatgggacag aaaggatcct cgggcttatt tcgagcggtt tcagcttttg
      421 gtgttgtggg ttttgtcagg ttcttagaag gctattatat tgtgttaata actaaaagga
      481 ggaagatggc ggatattgga ggtcatgcaa tctataaggt cgaagataca aatatgatct
      541 atatacccaa tgattctgta cgggttactc atcctgatga agctaggtat ctacgaatat
      601 ttcaaaatgt ggacctatct agcaattttt actttagtta cagctatgat ttgtcccact
      661 cacttcaata taatctcact gtcttgcgaa tgcccctgga gatgttaaag tcagaaatga
      721 cccagaatcg ccaagagagc tttgacatct ttgaagatga aggattaatt acacaaggtg
      781 gaagcggggt atttgggatc tgtagtgagc cttatatgaa atatgtatgg aatggtgaac
      841 ttctggatat aattaaaagt actgtgcatc gtgactggct tttgtatatt attcatgggt
      901 tctgtgggca gtcaaagctg ttgatctatg gacgaccagt gtatgtcact ctaatagcta
      961 gaagatccag taaatttgct ggcacccgtt ttcttaaaag aggtgcaaac tgtgagggtg
     1021 atgttgcaaa tgaagtggag actgaacaaa tactctgcga tgcttctgtg atgtctttca
     1081 ctgcaggaag ttattcttca tatgtacaag ttagaggatc tgtgccctta tactggtctc
     1141 aggacatttc aactatgatg cctaaaccac ctattacatt ggatcaggca gatccatttg
     1201 cacatgtggc tgcccttcac tttgaccaga tgttccagag gtttggctct cccatcatca
     1261 tcttgaattt agtgaaggaa cgagagaaaa gaaagcatga aagaattctg agtgaagaac
     1321 ttgttgctgc tgtgacctat ctcaaccaat ttttgcctcc tgagcacact attgtttata
     1381 ttccctggga catggccaag tataccaaaa gcaagctgtg taatgttctt gatcgactaa
     1441 atgtgattgc agaaagtgtg gtgaagaaaa caggtttctt tgtaaaccgc cctgattctt
     1501 actgtagcat tttgcggcca gatgaaaagt ggaatgaact aggaggatgt gtgattccca
     1561 ctggtcgcct gcagactggc atccttcgaa ccaactgtgt ggactgttta gatcgcacca
     1621 acacagcaca gtttatggtg ggaaaatgtg ctctggccta tcagctgtat tcactgggac
     1681 tgattgacaa acctaatcta cagtttgata cagatgcagt taggttattt gaggaactct
     1741 atgaagatca tggtgatacc ctatcccttc agtatggtgg ttctcaactt gttcatcgtg
     1801 tgaaaaccta cagaaagata gcaccatgga cccagcactc caaagacatc atgcaaaccc
     1861 tgtctagata ttacagcaat gctttttcag atgccgatag acaagattcc attaatctct
     1921 tcctgggagt tttccatccc actgaaggga aacctcatct ctgggagctc ccaacagatt
     1981 tttatttgca tcacaaaaat accatgagac ttttgccaac aagaagaagt tatacttact
     2041 ggtggacacc agaggtgata aagcatttac cattgcccta tgatgaagtt atctgtgctg
     2101 tgaacttaaa gaagttgata gtgaagaaat tccacaaata tgaagaagag attgatatcc
     2161 acaatgagtt ctttcggcca tatgagttga gcagctttga tgataccttt tgcttggcta
     2221 tgacaagctc agcacgtgac tttatgccta agaccgttgg aattgatcca agtccattta
     2281 ctgtgcgtaa accagatgaa actggaaaat cagtattggg aaacaaaagc aatagagaag
     2341 aagctgtatt acagcggaaa acggcagcca gcgccccgcc gccccccagc gaggaggctg
     2401 tgtccagcag ctctgaggat gactctggga ctgatcggga agaagagggc tctgtgtctc
     2461 agcgctccac tcccgtgaag atgactgatg caggagacag tgccaaagtg accgagaatg
     2521 tggtccaacc catgaaggag ctatatggaa ttaacctctc agatggcctc tcagaagaag
     2581 atttctccat ttattcaaga tttgttcagc tggggcagag tcaacataaa caagacaaga
     2641 atagccagca gccctgttct aggtgctcag atggagttat aaaactaaca cccatctcgg
     2701 ctttctcgca agataacatc tatgaagttc agcccccaag agtagacaga aaatctacag
     2761 agatcttcca agcccacatc caggccagcc aaggtatcat gcagccccta ggaaaagagg
     2821 actcctccat gtaccgagag tacatcagga accgctacct gtgaaaagag cgcaggtcca
     2881 cctggtggac acgtctgatt agcttagaac ctgtcttgtc tcatcttcaa aaggtaactt
     2941 attaaaagtc ctttgcgtct gaagcctttc tccttttctg tcacttgcaa attccaaatt
     3001 atagctaata aagatgacta gataa
//
