LOCUS       NM_007076               3255 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens FIC domain protein adenylyltransferase (FICD), mRNA.
ACCESSION   NM_007076
VERSION     NM_007076.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3255)
  AUTHORS   Rebelo,A.P., Ruiz,A., Dohrn,M.F., Wayand,M., Farooq,A., Danzi,M.C.,
            Beijer,D., Aaron,B., Vandrovcova,J., Houlden,H., Matalonga,L.,
            Abreu,L., Rouleau,G., Estiar,M.A., Van de Vondel,L., Gan-Or,Z.,
            Baets,J., Schule,R. and Zuchner,S.
  TITLE     BiP inactivation due to loss of the deAMPylation function of FICD
            causes a motor neuron disease
  JOURNAL   Genet Med 24 (12), 2487-2500 (2022)
   PUBMED   36136088
REFERENCE   2  (bases 1 to 3255)
  AUTHORS   Perera,L.A., Preissler,S., Zaccai,N.R., Prevost,S., Devos,J.M.,
            Haertlein,M. and Ron,D.
  TITLE     Structures of a deAMPylation complex rationalise the switch between
            antagonistic catalytic activities of FICD
  JOURNAL   Nat Commun 12 (1), 5004 (2021)
   PUBMED   34408154
  REMARK    GeneRIF: Structures of a deAMPylation complex rationalise the
            switch between antagonistic catalytic activities of FICD.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3255)
  AUTHORS   Liu,M., Huai,Z., Tan,H. and Chen,G.
  TITLE     Investigation of the Detailed AMPylated Reaction Mechanism for the
            Huntingtin Yeast-Interacting Protein E Enzyme HYPE
  JOURNAL   Int J Mol Sci 22 (13), 6999 (2021)
   PUBMED   34209803
  REMARK    GeneRIF: Investigation of the Detailed AMPylated Reaction Mechanism
            for the Huntingtin Yeast-Interacting Protein E Enzyme HYPE.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3255)
  AUTHORS   Fauser,J., Gulen,B., Pogenberg,V., Pett,C., Pourjafar-Dehkordi,D.,
            Krisp,C., Hopfner,D., Konig,G., Schluter,H., Feige,M.J.,
            Zacharias,M., Hedberg,C. and Itzen,A.
  TITLE     Specificity of AMPylation of the human chaperone BiP is mediated by
            TPR motifs of FICD
  JOURNAL   Nat Commun 12 (1), 2426 (2021)
   PUBMED   33893288
  REMARK    GeneRIF: Specificity of AMPylation of the human chaperone BiP is
            mediated by TPR motifs of FICD.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3255)
  AUTHORS   Camara,A., George,A., Hebner,E., Mahmood,A., Paluru,J. and
            Mattoo,S.
  TITLE     A Fluorescence Polarization-Based High-Throughput Screen to
            Identify the First Small-Molecule Modulators of the Human
            Adenylyltransferase HYPE/FICD
  JOURNAL   Int J Mol Sci 21 (19), 7128 (2020)
   PUBMED   32992526
  REMARK    GeneRIF: A Fluorescence Polarization-Based High-Throughput Screen
            to Identify the First Small-Molecule Modulators of the Human
            Adenylyltransferase HYPE/FICD.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3255)
  AUTHORS   Engel,P., Goepfert,A., Stanger,F.V., Harms,A., Schmidt,A.,
            Schirmer,T. and Dehio,C.
  TITLE     Adenylylation control by intra- or intermolecular active-site
            obstruction in Fic proteins
  JOURNAL   Nature 482 (7383), 107-110 (2012)
   PUBMED   22266942
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3255)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 3255)
  AUTHORS   Worby,C.A., Mattoo,S., Kruger,R.P., Corbeil,L.B., Koller,A.,
            Mendez,J.C., Zekarias,B., Lazar,C. and Dixon,J.E.
  TITLE     The fic domain: regulation of cell signaling by adenylylation
  JOURNAL   Mol Cell 34 (1), 93-103 (2009)
   PUBMED   19362538
REFERENCE   9  (bases 1 to 3255)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 3255)
  AUTHORS   Faber,P.W., Barnes,G.T., Srinidhi,J., Chen,J., Gusella,J.F. and
            MacDonald,M.E.
  TITLE     Huntingtin interacts with a family of WW domain proteins
  JOURNAL   Hum Mol Genet 7 (9), 1463-1474 (1998)
   PUBMED   9700202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK026074.1, BC001342.1, AF049611.1 and AC010206.8.
            
            On Nov 22, 2018 this sequence version replaced NM_007076.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000014.1, AY358992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000552695.6/ ENSP00000446479.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AK026074.1         4-42
            40-1571             BC001342.1         1-1532
            1572-1648           AF049611.1         608-684
            1649-3255           AC010206.8         9282-10888          c
FEATURES             Location/Qualifiers
     source          1..3255
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..3255
                     /gene="FICD"
                     /gene_synonym="HIP13; HYPE; SPG92; UNQ3041"
                     /note="FIC domain protein adenylyltransferase"
                     /db_xref="GeneID:11153"
                     /db_xref="HGNC:HGNC:18416"
                     /db_xref="MIM:620875"
     exon            1..85
                     /gene="FICD"
                     /gene_synonym="HIP13; HYPE; SPG92; UNQ3041"
                     /inference="alignment:Splign:2.1.0"
     exon            86..444
                     /gene="FICD"
                     /gene_synonym="HIP13; HYPE; SPG92; UNQ3041"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1520
                     /gene="FICD"
                     /gene_synonym="HIP13; HYPE; SPG92; UNQ3041"
                     /EC_number="2.7.7.108"
                     /note="huntingtin interactor protein E; fic S-phase
                     protein cell division homolog; Huntingtin interacting
                     protein E; adenosine monophosphate-protein transferase
                     FICD; HIP-13; AMPylator FICD; huntingtin yeast partner E;
                     FIC domain-containing protein; huntingtin-interacting
                     protein E; huntingtin-interacting protein 13; de-AMPylase
                     FICD; FIC domain containing"
                     /codon_start=1
                     /product="protein adenylyltransferase FICD"
                     /protein_id="NP_009007.2"
                     /db_xref="CCDS:CCDS9116.1"
                     /db_xref="GeneID:11153"
                     /db_xref="HGNC:HGNC:18416"
                     /db_xref="MIM:620875"
                     /translation="MMLIPMASVMAVTEPKWVSVWSRFLWVTLLSMVLGSLLALLLPL
                     GAVEEQCLAVLKGLYLLRSKPDRAQHAATKCTSPSTELSITSRGATLLVAKTKASPAG
                     KLEARAALNQALEMKRQGKREKAQKLFMHALKMDPDFVDALTEFGIFSEEDKDIIQAD
                     YLYTRALTISPYHEKALVNRDRTLPLVEEIDQRYFSIIDSKVKKVMSIPKGNSALRRV
                     MEETYYHHIYHTVAIEGNTLTLSEIRHILETRYAVPGKSLEEQNEVIGMHAAMKYINT
                     TLVSRIGSVTISDVLEIHRRVLGYVDPVEAGRFRTTQVLVGHHIPPHPQDVEKQMQEF
                     VQWLNSEEAMNLHPVEFAALAHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPITIR
                     KEQRSDYYHVLEAANEGDVRPFIRFIAKCTETTLDTLLFATTEYSVALPEAQPNHSGF
                     KETLPVKP"
     exon            445..3255
                     /gene="FICD"
                     /gene_synonym="HIP13; HYPE; SPG92; UNQ3041"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3232..3237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FICD"
                     /gene_synonym="HIP13; HYPE; SPG92; UNQ3041"
                     /note="hexamer: AATAAA"
     polyA_site      3255
                     /gene="FICD"
                     /gene_synonym="HIP13; HYPE; SPG92; UNQ3041"
                     /note="major polyA site"
ORIGIN      
        1 gccggcggag aaggaggacc cgggagccgg cggcccggag ctgggagcgc ggggaaggcg
       61 gttggggttc tgacagctgc gcgcgatcct gctctctctc agccgcctgt ggacatgcgc
      121 aaagggccct ctcctgagtc cagatgatgc tcataccaat ggcttcagtg atggcggtga
      181 ctgaaccgaa atgggtctcg gtctggagcc gcttcctctg ggtgacgctg ctgagcatgg
      241 tgctggggtc cctgctggcc ctgctgctgc cgctgggggc tgtggaggag cagtgcttgg
      301 ctgtgctcaa aggcctctac ctgctcagga gcaaaccgga cagggcgcag catgccgcca
      361 ccaagtgcac cagcccgtcc acggagctca gcatcacctc caggggcgcg acgctgctgg
      421 tggccaagac caaggcctct ccagcgggta agttggaagc cagagctgcc ctgaaccagg
      481 ccctggagat gaagcgccag ggcaagcggg aaaaagccca aaagctcttc atgcacgccc
      541 tcaagatgga cccggacttc gtggacgcgc tcaccgagtt tggcatcttc tcggaagaag
      601 acaaggacat catccaggcg gactacttgt acaccagagc attgaccatc tcaccctacc
      661 atgagaaagc actggtcaac cgcgatcgga cactgcctct tgtggaagag atcgaccaga
      721 ggtatttcag catcatcgac agcaaagtga agaaggtcat gtccatcccc aaggggaact
      781 cagctctgcg cagggtcatg gaggagacct actaccatca catctaccac acagtggcca
      841 tcgagggcaa caccctcacc ctctcggaaa tcaggcacat cctggagacc cgctacgccg
      901 tgcccgggaa gagcctggag gagcagaacg aggtcatagg catgcatgca gccatgaagt
      961 acatcaacac gactctggtt tcgcgcatcg gctccgtcac catcagcgac gtgctggaga
     1021 tccacaggcg ggtgctgggc tacgtggacc ccgtggaagc cggcaggttt cggacaacac
     1081 aggtcctggt cggacaccac atccctcccc atccgcagga tgtggaaaag cagatgcagg
     1141 agtttgtaca gtggctcaac tccgaggaag ccatgaacct gcacccagtg gagtttgcag
     1201 ccttagccca ttataaactc gtttacatcc accctttcat tgatggcaac gggaggacct
     1261 cccgtctgct catgaacctc atcctcatgc aggcgggcta cccgcccatc accatccgca
     1321 aggagcagcg gtccgactac taccacgtgt tggaagctgc caacgagggc gacgtgaggc
     1381 ctttcattcg cttcatcgcc aagtgtactg agaccaccct ggacaccctg ctttttgcca
     1441 caactgagta ctcggtggca ctgccagaag cccaacccaa ccactctggg ttcaaggaga
     1501 cgcttcctgt gaagccctaa ccctagaaat cctcagtgac aaaggctgtc ctgaggtagg
     1561 aaaaaaaaaa agaaacagca tttctagaaa cctagtcact tcctaaagca aaaggagaaa
     1621 cattctttac ctccaaatgt tttagtttta aaaaaaaaaa aaaactaagt tatgaagcct
     1681 tgtctctaaa ataacttata attcaaccaa gctatttatt ttcttctttg gagcaagcta
     1741 gtcagtattg tatggtgtct gctgtgtctt gctggtggcc gtgctttagg ggcaacagtg
     1801 ccaccatgtg accagaacaa aggttctgga gcagaatttg cactaaggtg gaggagcggc
     1861 caagaggtgt gggacggggc ccagagccac tgacataact cctccaagtg cttctctgaa
     1921 acaggctgag aggttctgtg actgcaactg ggaagtcaga cccaagtcgc agctgagaga
     1981 aatggttgaa agctcacttt ctcaaggttt agattagtgg tgactaactt ccaagcaaac
     2041 ttcatagaag agaaaatgaa tgccgacatt ccttacttac ctgcaggaag actttttgag
     2101 ccatagtttg caaactttag tgccagcagc tgtttttttt tttttttttt tcatattgag
     2161 actatttttc taattaagaa tagggggtag ccataaagag ctgtatgttg gagggggaaa
     2221 catggtgggc gggcagtttg gttttctttg tgtatccgcg tttctctcac acttcatttg
     2281 tagcaactca ggccagatgt tttcgtctga aattctctgg gcttgtcatt ccacctgtat
     2341 cgtgctgcaa accaggtgtt atgctagtag gcatctgccc tcacccctct gcctgagttt
     2401 tctgtaggca gatgttaacc tgagaaaaca agtgccatgt ggacaccaag taagcatttt
     2461 tgataatgaa ttagagcacc agtttctact gaatggagca aaaaccttca gccatggcca
     2521 ggctgcatcc ctttggtcct ggagtttcat ctacttactg ccatcttcca cggtctttgc
     2581 actgtcccgt gtcccatccc cctgggaggc agaagagatt gcctcggagt ggccttattt
     2641 ttctcgcaac ttgtgaaatg atgtagtgct ctatgtaata tggccgggtt tccaagctgt
     2701 catccaatgg aagtagaatc ttctctttga atcatatggt acaggtgcca atatgactgc
     2761 tgctatttag agtcagagag gtggaagtca ctgggtccct ttcccagtga cagagcccat
     2821 gatgtctaac actactgcac tttgtcagtg tgtgagtgat ggcgaatacg cagtgttgtc
     2881 tctttgattt ggtaattccg ttcctgacag taatgaggcc actgctctaa agtagtttat
     2941 acagttcttc agttgtataa atagcacaga gtagtttttg aaaggttaag aaaaataagt
     3001 gaaaagacat acacgatata tgaaatggct ccaaatgata attgttcaaa cctttataaa
     3061 atgtgttttc gtactcttat gctgccagag gtacttctta aaactcttct cgtcttggtt
     3121 ttataagcac accacggagg tctgacagat gtgcttgctt ctactacaga gcaagagaat
     3181 ttgcacttta gctatatgtg aaggatatta ttttaacaaa ttcctgattc taataaagtt
     3241 attttattac atgaa
//
