LOCUS       NM_004214               1361 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens FGF1 intracellular binding protein (FIBP), transcript
            variant 2, mRNA.
ACCESSION   NM_004214
VERSION     NM_004214.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1361)
  AUTHORS   Kilic,E. and Kosukcu,C.
  TITLE     New cases of recently described Thauvin-Robinet-Faivre syndrome
            with a novel homozygous FIBP gene variant
  JOURNAL   Am J Med Genet A 194 (3), e63449 (2024)
   PUBMED   37876348
  REMARK    GeneRIF: New cases of recently described Thauvin-Robinet-Faivre
            syndrome with a novel homozygous FIBP gene variant.
REFERENCE   2  (bases 1 to 1361)
  AUTHORS   Xu,Y., Li,J., Zhu,K., Zeng,Y., Chen,J., Dong,X., Zhang,S., Xu,S.
            and Wu,G.
  TITLE     FIBP interacts with transcription factor STAT3 to induce EME1
            expression and drive radioresistance in lung adenocarcinoma
  JOURNAL   Int J Biol Sci 19 (12), 3816-3829 (2023)
   PUBMED   37564211
  REMARK    GeneRIF: FIBP interacts with transcription factor STAT3 to induce
            EME1 expression and drive radioresistance in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1361)
  AUTHORS   Akawi,N., Ben-Salem,S., Lahti,L., Partanen,J., Ali,B.R. and
            Al-Gazali,L.
  TITLE     A recessive syndrome of intellectual disability, moderate
            overgrowth, and renal dysplasia predisposing to Wilms tumor is
            caused by a mutation in FIBP gene
  JOURNAL   Am J Med Genet A 170 (8), 2111-2118 (2016)
   PUBMED   27183861
  REMARK    GeneRIF: these findings provide convincing evidence implicating
            FIBP aberrations in the newly recognized overgrowth syndrome and
            expand the associated phenotypes to include possible Wilms tumor
            predisposition.
            Review article
REFERENCE   4  (bases 1 to 1361)
  AUTHORS   Xu,S., Li,X., Gong,Z., Wang,W., Li,Y., Nair,B.C., Piao,H., Yang,K.,
            Wu,G. and Chen,J.
  TITLE     Proteomic analysis of the human cyclin-dependent kinase family
            reveals a novel CDK5 complex involved in cell growth and migration
  JOURNAL   Mol Cell Proteomics 13 (11), 2986-3000 (2014)
   PUBMED   25096995
REFERENCE   5  (bases 1 to 1361)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1361)
  AUTHORS   Giatromanolaki,A., Kotsiou,S., Koukourakis,M.I. and Sivridis,E.
  TITLE     Angiogenic factor expression in hepatic cirrhosis
  JOURNAL   Mediators Inflamm 2007, 67187 (2007)
   PUBMED   17497037
  REMARK    GeneRIF: Data Show aFGF was expressed in regenerative hepatocytes,
            but not in fibroblasts, suggesting its role in promoting oxidative
            stress produced by hepatocytes may contribute to the development of
            fibrous bands in hepatic cirrhosis.
REFERENCE   7  (bases 1 to 1361)
  AUTHORS   Skjerpen,C.S., Nilsen,T., Wesche,J. and Olsnes,S.
  TITLE     Binding of FGF-1 variants to protein kinase CK2 correlates with
            mitogenicity
  JOURNAL   EMBO J 21 (15), 4058-4069 (2002)
   PUBMED   12145206
REFERENCE   8  (bases 1 to 1361)
  AUTHORS   Tassi,E., Al-Attar,A., Aigner,A., Swift,M.R., McDonnell,K.,
            Karavanov,A. and Wellstein,A.
  TITLE     Enhancement of fibroblast growth factor (FGF) activity by an
            FGF-binding protein
  JOURNAL   J Biol Chem 276 (43), 40247-40253 (2001)
   PUBMED   11509569
REFERENCE   9  (bases 1 to 1361)
  AUTHORS   Kolpakova,E., Frengen,E., Stokke,T. and Olsnes,S.
  TITLE     Organization, chromosomal localization and promoter analysis of the
            gene encoding human acidic fibroblast growth factor intracellular
            binding protein
  JOURNAL   Biochem J 352 Pt 3 (Pt 3), 629-635 (2000)
   PUBMED   11104667
REFERENCE   10 (bases 1 to 1361)
  AUTHORS   Kolpakova,E., Wiedlocha,A., Stenmark,H., Klingenberg,O.,
            Falnes,P.O. and Olsnes,S.
  TITLE     Cloning of an intracellular protein that binds selectively to
            mitogenic acidic fibroblast growth factor
  JOURNAL   Biochem J 336 (Pt 1) (Pt 1), 213-222 (1998)
   PUBMED   9806903
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD109589.1, BC017448.1 and
            AI925637.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_004214.4.
            
            Summary: Acidic fibroblast growth factor is mitogenic for a variety
            of different cell types and acts by stimulating mitogenesis or
            inducing morphological changes and differentiation. The FIBP
            protein is an intracellular protein that binds selectively to
            acidic fibroblast growth factor (aFGF). It is postulated that FIBP
            may be involved in the mitogenic action of aFGF. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site compared to variant 1. The resulting isoform (b) has
            the same N- and C-termini but is shorter compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1173479.1, BC014388.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357519.9/ ENSP00000350124.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-487               CD109589.1         96-582
            488-1180            BC017448.1         452-1144
            1181-1361           AI925637.1         2-182               c
FEATURES             Location/Qualifiers
     source          1..1361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1361
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /note="FGF1 intracellular binding protein"
                     /db_xref="GeneID:9158"
                     /db_xref="HGNC:HGNC:3705"
                     /db_xref="MIM:608296"
     exon            1..138
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1127
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /note="isoform b is encoded by transcript variant 2;
                     acidic fibroblast growth factor intracellular-binding
                     protein; aFGF intracellular-binding protein"
                     /codon_start=1
                     /product="acidic fibroblast growth factor
                     intracellular-binding protein isoform b"
                     /protein_id="NP_004205.2"
                     /db_xref="CCDS:CCDS8118.1"
                     /db_xref="GeneID:9158"
                     /db_xref="HGNC:HGNC:3705"
                     /db_xref="MIM:608296"
                     /translation="MTSELDIFVGNTTLIDEDVYRLWLDGYSVTDAVALRVRSGILEQ
                     TGATAAVLQSDTMDHYRTFHMLERLLHAPPKLLHQLIFQIPPSRQALLIERYYAFDEA
                     FVREVLGKKLSKGTKKDLDDISTKTGITLKSCRRQFDNFKRVFKVVEEMRGSLVDNIQ
                     QHFLLSDRLARDYAAIVFFANNRFETGKKKLQYLSFGDFAFCAELMIQNWTLGAVDSQ
                     MDDMDMDLDKEFLQDLKELKVLVADKDLLDLHKSLVCTALRGKLGVFSEMEANFKNLS
                     RGLVNVAAKLTHNKDVRDLFVDLVEKFVEPCRSDHWPLSDVRFFLNQYSASVHSLDGF
                     RHQALWDRYMGTLRGCLLRLYHD"
     exon            139..337
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            338..464
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            465..565
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            566..699
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            700..808
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            809..872
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            873..959
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1057
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1361
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1158..1163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /note="hexamer: AATAAA"
     polyA_site      1180
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
                     /note="major polyA site"
     polyA_site      1361
                     /gene="FIBP"
                     /gene_synonym="FGFIBP; FIBP-1; TROFAS"
ORIGIN      
        1 agtcccgagc agtgctcgct cctgctcggg gcgctgcggc cccgggcgtc gccatgacca
       61 gtgagctgga catcttcgtg gggaacacga cccttatcga cgaggacgtg tatcgcctct
      121 ggctcgatgg ttactcggtg accgacgcgg tggccctgcg ggtgcgctcg ggaatcctgg
      181 agcagactgg cgccacggca gcggtgctgc agagcgacac catggaccat taccgcacct
      241 tccacatgct cgagcggctg ctgcatgcgc cgcccaagct actgcaccag ctcatcttcc
      301 agattccgcc ctcccggcag gcactactca tcgagaggta ctatgccttt gatgaggcct
      361 ttgttcggga ggtgctgggc aagaagctgt ccaaaggcac caagaaagac ctggatgaca
      421 tcagcaccaa aacaggcatc accctcaaga gctgccggag acagtttgac aactttaaac
      481 gggtcttcaa ggtggtagag gaaatgcggg gctccctggt ggacaatatt cagcaacact
      541 tcctcctctc tgaccggttg gccagggact atgcagccat cgtcttcttt gctaacaacc
      601 gctttgagac agggaagaaa aaactgcagt atctgagctt cggtgacttt gccttctgcg
      661 ctgagctcat gatccaaaac tggacccttg gagccgtcga ctcacagatg gatgacatgg
      721 acatggactt agacaaggaa tttctccagg acttgaagga gctcaaggtg ctagtggctg
      781 acaaggacct tctggacctg cacaagagcc tggtgtgcac tgctctccgg ggaaagctgg
      841 gcgtcttctc tgagatggaa gccaacttca agaacctgtc ccgggggctg gtgaacgtgg
      901 ccgccaagct gacccacaat aaagatgtca gagacctgtt tgtggacctc gtggagaagt
      961 ttgtggaacc ctgccgctcc gaccactggc cactcagcga cgtgcggttc ttcctgaatc
     1021 agtattcagc gtctgtccac tccctcgatg gcttccgaca ccaggccctc tgggaccgct
     1081 acatgggcac cctccgcggc tgcctcctgc gcctgtatca tgactgaggt gcctcccaac
     1141 gctccgccca cgctgacaat aaagttgctc tgagtttgga gactggtcct cgctccgggg
     1201 agcaagtggg gggcgtgcag atgtgcctgt gtctgtctct gagcacctgg tgtccgtgta
     1261 caaggatgga tgtgtacagt ggctccttgg gaactgagac atatctcagg gaatggtgtc
     1321 tgtgctcagc ccatccacca gaagagtctg ctcacaagcc a
//
