LOCUS       NM_203371               2976 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens fin bud initiation factor homolog (FIBIN), mRNA.
ACCESSION   NM_203371 XM_370617
VERSION     NM_203371.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2976)
  AUTHORS   Peng,M., Yang,L., Liao,J., Le,X., Dai,F., Sun,R., Wu,F., Jiang,Y.,
            Tian,R., Shao,B., Zhou,L., Wu,M., Guo,S. and Xiang,T.
  TITLE     The novel DNA methylation marker FIBIN suppresses non-small cell
            lung cancer metastasis by negatively regulating ANXA2
  JOURNAL   Cell Signal 120, 111197 (2024)
   PUBMED   38697447
  REMARK    GeneRIF: The novel DNA methylation marker FIBIN suppresses
            non-small cell lung cancer metastasis by negatively regulating
            ANXA2.
REFERENCE   2  (bases 1 to 2976)
  AUTHORS   Wheeler,H.E., Metter,E.J., Tanaka,T., Absher,D., Higgins,J.,
            Zahn,J.M., Wilhelmy,J., Davis,R.W., Singleton,A., Myers,R.M.,
            Ferrucci,L. and Kim,S.K.
  TITLE     Sequential use of transcriptional profiling, expression
            quantitative trait mapping, and gene association implicates MMP20
            in human kidney aging
  JOURNAL   PLoS Genet 5 (10), e1000685 (2009)
   PUBMED   19834535
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2976)
  AUTHORS   Wakahara,T., Kusu,N., Yamauchi,H., Kimura,I., Konishi,M., Miyake,A.
            and Itoh,N.
  TITLE     Fibin, a novel secreted lateral plate mesoderm signal, is essential
            for pectoral fin bud initiation in zebrafish
  JOURNAL   Dev Biol 303 (2), 527-535 (2007)
   PUBMED   17196583
REFERENCE   4  (bases 1 to 2976)
  AUTHORS   Jia,L., Young,M.F., Powell,J., Yang,L., Ho,N.C., Hotchkiss,R.,
            Robey,P.G. and Francomano,C.A.
  TITLE     Gene expression profile of human bone marrow stromal cells:
            high-throughput expressed sequence tag sequencing analysis
  JOURNAL   Genomics 79 (1), 7-17 (2002)
   PUBMED   11827452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ882486.1, BC026873.1, CB962364.1, D79377.1, AA452778.1 and
            AI755024.1.
            
            On May 17, 2019 this sequence version replaced NM_203371.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660807.230966.1,
                                        SRR1803613.182862.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318627.4/ ENSP00000321962.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               BQ882486.1         32-405
            375-1948            BC026873.1         177-1750
            1949-2321           CB962364.1         151-523
            2322-2376           D79377.1           358-412
            2377-2399           CB962364.1         579-601
            2400-2601           AA452778.1         26-227
            2602-2976           AI755024.1         18-392              c
FEATURES             Location/Qualifiers
     source          1..2976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.2"
     gene            1..2976
                     /gene="FIBIN"
                     /note="fin bud initiation factor homolog"
                     /db_xref="GeneID:387758"
                     /db_xref="HGNC:HGNC:33747"
                     /db_xref="MIM:617085"
     exon            1..2976
                     /gene="FIBIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..1051
                     /gene="FIBIN"
                     /codon_start=1
                     /product="fin bud initiation factor homolog precursor"
                     /protein_id="NP_976249.1"
                     /db_xref="CCDS:CCDS7861.1"
                     /db_xref="GeneID:387758"
                     /db_xref="HGNC:HGNC:33747"
                     /db_xref="MIM:617085"
                     /translation="MVFLKFFCMSFFCHLCQGYFDGPLYPEMSNGTLHHYFVPDGDYE
                     ENDDPEKCQLLFRVSDHRRCSQGEGSQVGSLLSLTLREEFTVLGRQVEDAGRVLEGIS
                     KSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNE
                     DFLGMLVHTRSLLKETLDISVGLRDKYELLALTIRSHGTRLGRLKNDYLKV"
     regulatory      1990..1995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FIBIN"
                     /note="hexamer: AATAAA"
     polyA_site      2010
                     /gene="FIBIN"
                     /note="major polyA site"
     regulatory      2952..2957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FIBIN"
                     /note="hexamer: AATAAA"
     polyA_site      2976
                     /gene="FIBIN"
ORIGIN      
        1 attcccaccc agtccagaaa ttgaaatact atcagggggc aagagccttt ctctccagct
       61 acacactcca tctcccggga gcaaggggaa actccgagag gagggcaaca gagccagcat
      121 cttgccaggg ccccggagga ggggttcccc gctacgcctg tgccggagga gttccagtca
      181 ccgagcgagg ggcgcaaggg tgggtgcatc ctgcgctgcg gcgggcgcgc tacccagacg
      241 ctggtgtgca gagccacatg aagcctgctg gggactgggg gccagggagc agcaagccag
      301 ctgggactga ggcggacgct gtctcaggga gacgctgact cgcaaagaca ctcccttcct
      361 tgtgcctggg taaaaagtct cctcctgggg tccctggcca tcctgaatat ccagaatggt
      421 gtttctgaag ttcttctgca tgagtttctt ctgccacctg tgtcaaggct acttcgatgg
      481 ccccctctac ccagagatgt ccaatgggac tctgcaccac tacttcgtgc ccgatgggga
      541 ctatgaggag aacgatgacc ccgagaagtg ccagctgctc ttcagggtga gtgaccacag
      601 gcgctgctcc cagggggagg ggagccaggt tggcagcctg ctgagcctca ccctgcggga
      661 ggagttcacc gtgctgggcc gccaggtgga ggatgctggg cgcgtgctgg agggcatcag
      721 caaaagcatc tcctacgacc tagacgggga agagagctat ggcaagtacc tgcggcggga
      781 gtcccaccag atcggggatg cctactccaa ctcggacaaa tccctcactg agctggagag
      841 caagttcaag cagggccagg aacaggacag ccggcaggag agcaggctca acgaggactt
      901 tctgggaatg ctggtccaca ccaggtccct gctgaaggag acactggaca tctctgtggg
      961 gctcagggac aaatacgagc tgctggccct caccattagg agccatggga cccgactagg
     1021 tcggctgaaa aatgattatc ttaaagtata ggtggaagga tacaaatgct agaaagaggg
     1081 aatcaaatca gccccgtttt ggagggtggg ggacagaaga tggggctaca tttcccccat
     1141 acctactatt tttttatatc ccgatttgca ctttgagaat acatctaagg tcatctttca
     1201 aaagagaaaa attggacact tgagtgactt tgtttttagt tttgtttttg tacattattt
     1261 atgtgattgt tatggaattg tcacctggaa agaacaattt taagcaatgt catttctaga
     1321 tgggtttcta attctgcaga gacacccgtt tcagccacat ctaaaagagc acagtttatg
     1381 tggtgcggaa ttaaacttcc ccatcctgca gattatgtgg aaatacccaa agataatagt
     1441 gcatagctcc tttcagcctc tagccttcac tcctgggctc caaaagctat cccagttgcc
     1501 tgtttttcaa atgaggttca aggtgctgct ttgcatgcct gccaacccat ggaagttgtt
     1561 tcttacttct tttctctctt atttattaac catggtctga gagttgtttt tgttctatgt
     1621 aacagtattg ccacaaaact ataggcaaat cgtgtttgca gggagatttc tgatgcctct
     1681 gtgggtgtgt gtaagttaaa gtggccacat ttaagaaggc caagctttgt agtggttgca
     1741 cagtcacact gatatgctga tttgctcttt ctcattgtat gtctatgctt tgtcatcagt
     1801 gctatagtaa attacaaaga aataggtaga ttgtatgaac atacccacaa atgcctatga
     1861 tttaggttac caatgtattc tttctcattt ggggttttgc ttctgtctgt ctgtttattg
     1921 gaaacttgta cttcaagtag ggggaatcct aattctaata actccttagc taagttttat
     1981 tattcaggca ataaacatgt tttcatgtaa tactggctta ctttgtaatt tacatctgta
     2041 actttcatat ttctaaaagg ggccaatgca aaaggagaga gaaggactgg atttaagcca
     2101 gtttacttag agtatatgat aaagaaggca gaggaatagc tacatatttg gcaattctcc
     2161 tctctgtagt caccctgaca tcctcacaag aaaacaaatc tagccattgc ccaaacttta
     2221 aatttgatct ctataggtct gcttaaagac tcaaattttc tccagtttct ctcataaatt
     2281 caattgcaaa agtttctgac aaggctcata ccctgtaccc ttatgcagag caagcattcc
     2341 atcctaagtt ataaactaca gtgatgttta attttgaagc caggtctaca ttatttaatt
     2401 aatggcttca aaaggtggag atgcacttta tttaatgtct ttccctagct aattcttact
     2461 ctcaccttaa atatgctttc ttgttgcata tatgcacaga tacacacaca cacacacacg
     2521 aaaataaata aatgttcata ttcttctgtt caacagacat ttattttctc ctctcccttg
     2581 aataagaaaa taagttttcc attcctatga actgtctaat atctttctat tacagaaggg
     2641 gaaactgagg ctgggaaagg ctaaatgact tatcctccat cagttataac agcccctggt
     2701 cttcttaaat ttaaacacgg gacttcccga actaattttt ttaaggatac tgaaaaatga
     2761 gagagagtgg tcgaatgcct gaaattttgc ttaacttact gtacttaaaa tcaattataa
     2821 cttctttttg ttactcaggg ccccactttt tgttgctttc tagacttgtg tgtagaaaga
     2881 agattaatga tcacttaaag tagtttcctt ctttattctg aaaaaatgag gaaaaaataa
     2941 caacagtggc aaataaaatc atatttggta ctaaaa
//
