LOCUS       NM_032843               3650 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens fibrinogen C domain containing 1 (FIBCD1), transcript
            variant 1, mRNA.
ACCESSION   NM_032843
VERSION     NM_032843.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3650)
  AUTHORS   Williams,H.M., Moeller,J.B., Burns,I., Schlosser,A., Sorensen,G.L.,
            Greenhough,T.J., Holmskov,U. and Shrive,A.K.
  TITLE     Crystal structures of human immune protein FIBCD1 suggest an
            extended binding site compatible with recognition of
            pathogen-associated carbohydrate motifs
  JOURNAL   J Biol Chem 300 (1), 105552 (2024)
   PUBMED   38072065
  REMARK    GeneRIF: Crystal structures of human immune protein FIBCD1 suggest
            an extended binding site compatible with recognition of
            pathogen-associated carbohydrate motifs.
REFERENCE   2  (bases 1 to 3650)
  AUTHORS   Bhattacharya,S., Maupin,A.J., Schlosser,A.G., Fuchtbauer,E.M.,
            Gloria,Y.C., Weber,A.N.R., Holmskov,U., Moeller,J.B. and
            Templeton,S.P.
  TITLE     The role of FIBCD1 in response to Aspergillus fumigatus in lung
            epithelial cells
  JOURNAL   PLoS One 18 (3), e0282347 (2023)
   PUBMED   36888604
  REMARK    GeneRIF: The role of FIBCD1 in response to Aspergillus fumigatus in
            lung epithelial cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3650)
  AUTHORS   Fell,C.W., Hagelkruys,A., Cicvaric,A., Horrer,M., Liu,L.,
            Li,J.S.S., Stadlmann,J., Polyansky,A.A., Mereiter,S., Tejada,M.A.,
            Kokotovic,T., Achuta,V.S., Scaramuzza,A., Twyman,K.A., Morrow,M.M.,
            Juusola,J., Yan,H., Wang,J., Burmeister,M., Choudhury,B.,
            Andersen,T.L., Wirnsberger,G., Holmskov,U., Perrimon,N.,
            Zagrovic,B., Monje,F.J., Moeller,J.B., Penninger,J.M. and Nagy,V.
  TITLE     FIBCD1 is an endocytic GAG receptor associated with a novel
            neurodevelopmental disorder
  JOURNAL   EMBO Mol Med 14 (9), e15829 (2022)
   PUBMED   35916241
  REMARK    GeneRIF: FIBCD1 is an endocytic GAG receptor associated with a
            novel neurodevelopmental disorder.
REFERENCE   4  (bases 1 to 3650)
  AUTHORS   Graca,F.A., Rai,M., Hunt,L.C., Stephan,A., Wang,Y.D., Gordon,B.,
            Wang,R., Quarato,G., Xu,B., Fan,Y., Labelle,M. and Demontis,F.
  TITLE     The myokine Fibcd1 is an endogenous determinant of myofiber size
            and mitigates cancer-induced myofiber atrophy
  JOURNAL   Nat Commun 13 (1), 2370 (2022)
   PUBMED   35501350
  REMARK    GeneRIF: The myokine Fibcd1 is an endogenous determinant of
            myofiber size and mitigates cancer-induced myofiber atrophy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3650)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3650)
  AUTHORS   Shrive,A.K., Moeller,J.B., Burns,I., Paterson,J.M., Shaw,A.J.,
            Schlosser,A., Sorensen,G.L., Greenhough,T.J. and Holmskov,U.
  TITLE     Crystal structure of the tetrameric fibrinogen-like recognition
            domain of fibrinogen C domain containing 1 (FIBCD1) protein
  JOURNAL   J Biol Chem 289 (5), 2880-2887 (2014)
   PUBMED   24293368
  REMARK    GeneRIF: The high affinity ligand N-acetylmannosamine (ManNAc)
            binds FIBCD1 in the S1 site, predominantly via the acetyl group
            with the oxygen and acetamide nitrogen hydrogen-bonded to the
            protein and the methyl group inserted into a hydrophobic pocket.
REFERENCE   7  (bases 1 to 3650)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3650)
  AUTHORS   Thomsen,T., Moeller,J.B., Schlosser,A., Sorensen,G.L.,
            Moestrup,S.K., Palaniyar,N., Wallis,R., Mollenhauer,J. and
            Holmskov,U.
  TITLE     The recognition unit of FIBCD1 organizes into a noncovalently
            linked tetrameric structure and uses a hydrophobic funnel (S1) for
            acetyl group recognition
  JOURNAL   J Biol Chem 285 (2), 1229-1238 (2010)
   PUBMED   19892701
  REMARK    GeneRIF: The recognition unit of FIBCD1 organizes into a
            noncovalently linked tetrameric structure and uses a hydrophobic
            funnel (S1) for acetyl group recognition.
REFERENCE   9  (bases 1 to 3650)
  AUTHORS   Schlosser,A., Thomsen,T., Moeller,J.B., Nielsen,O., Tornoe,I.,
            Mollenhauer,J., Moestrup,S.K. and Holmskov,U.
  TITLE     Characterization of FIBCD1 as an acetyl group-binding receptor that
            binds chitin
  JOURNAL   J Immunol 183 (6), 3800-3809 (2009)
   PUBMED   19710473
  REMARK    GeneRIF: FIBCD1 is a high-affinity receptor for chitin and chitin
            fragments, and may play an important role in controlling the
            exposure of intestine to chitin and chitin fragments
REFERENCE   10 (bases 1 to 3650)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL161733.20 and BC032953.2.
            
            On Nov 22, 2018 this sequence version replaced NM_032843.4.
            
            Summary: FIBCD1 is a conserved type II transmembrane endocytic
            receptor that binds chitin and is located primarily in the
            intestinal brush border (Schlosser et al., 2009 [PubMed
            19710473]).[supplied by OMIM, Apr 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032953.2, AY358311.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372338.9/ ENSP00000361413.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               AL161733.20        162227-162627       c
            402-874             BC032953.2         5-477
            875-912             AL161733.20        153227-153264       c
            913-2299            BC032953.2         516-1902
            2300-3650           AL161733.20        125820-127170       c
FEATURES             Location/Qualifiers
     source          1..3650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.12"
     gene            1..3650
                     /gene="FIBCD1"
                     /note="fibrinogen C domain containing 1"
                     /db_xref="GeneID:84929"
                     /db_xref="HGNC:HGNC:25922"
                     /db_xref="MIM:613357"
     exon            1..712
                     /gene="FIBCD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             641..2026
                     /gene="FIBCD1"
                     /codon_start=1
                     /product="fibrinogen C domain-containing protein 1"
                     /protein_id="NP_116232.3"
                     /db_xref="CCDS:CCDS6937.1"
                     /db_xref="GeneID:84929"
                     /db_xref="HGNC:HGNC:25922"
                     /db_xref="MIM:613357"
                     /translation="MVNDRWKTMGGAAQLEDRPRDKPQRPSCGYVLCTVLLALAVLLA
                     VAVTGAVLFLNHAHAPGTAPPPVVSTGAASANSALVTVERADSSHLSILIDPRCPDLT
                     DSFARLESAQASVLQALTEHQAQPRLVGDQEQELLDTLADQLPRLLARASELQTECMG
                     LRKGHGTLGQGLSALQSEQGRLIQLLSESQGHMAHLVNSVSDILDALQRDRGLGRPRN
                     KADLQRAPARGTRPRGCATGSRPRDCLDVLLSGQQDDGVYSVFPTHYPAGFQVYCDMR
                     TDGGGWTVFQRREDGSVNFFRGWDAYRDGFGRLTGEHWLGLKRIHALTTQAAYELHVD
                     LEDFENGTAYARYGSFGVGLFSVDPEEDGYPLTVADYSGTAGDSLLKHSGMRFTTKDR
                     DSDHSENNCAAFYRGAWWYRNCHTSNLNGQYLRGAHASYADGVEWSSWTGWQYSLKFS
                     EMKIRPVREDR"
     exon            713..1192
                     /gene="FIBCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1352
                     /gene="FIBCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1489
                     /gene="FIBCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1586
                     /gene="FIBCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1766
                     /gene="FIBCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..3650
                     /gene="FIBCD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3559..3564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FIBCD1"
                     /note="hexamer: AATAAA"
     polyA_site      3595
                     /gene="FIBCD1"
                     /note="major polyA site"
     polyA_site      3650
                     /gene="FIBCD1"
                     /note="major polyA site"
ORIGIN      
        1 gccctcgggg cccgccccgc gcatggtgac ttgtgtgagt ccggtccggg aggaagtttg
       61 tgcagaggcg ccgccggggg gctctcaggc ccctccggga gccagcagga gccgggccgc
      121 ccgcggctgt ttgctgccct ccggccggcc gcgttatctg ggggccagtt cggcctcctt
      181 tccctaggtc ttttcggagg cggagtttag tatccaagtc cgcgggtgtg agcgcgcgcg
      241 tgtgtgtgag tgtgtcgggg gaggccgagg ggagcaataa aaagcaaaga gagtccgaga
      301 ccagaaaaga tgcggagatt gagaaggagg gaggagggac gagggaggag agagaggagc
      361 gcgccgggga ggcgccggag ccgggagcgg ggacggcgcg cagcgcgagc ggcgggcgtt
      421 gggctggcgg ctttcgcgct cccgctcctg ctcccgcccg cacacagcgg cgcgctcatc
      481 ctcacacgcc cgcccgctcc cgggccgccc cggcgcgggg cacagaggcg gggacccggc
      541 ggacagagcg cgccccgcgc ccgcgcccgc gcccaccccg tctcctttgc gctccgcagc
      601 ggcgcgcctc gcccggcgcc cccgccagtc ctgccggaag atggtcaacg accggtggaa
      661 gaccatgggc ggcgctgccc aacttgagga ccggccgcgc gacaagccgc agcggccgag
      721 ctgcggctac gtgctgtgca ccgtgctgct ggccctggct gtgctgctgg ctgtagctgt
      781 caccggtgcc gtgctcttcc tgaaccacgc ccacgcgccg ggcacggcgc ccccacctgt
      841 cgtcagcact ggggctgcca gcgccaacag cgccctggtc actgtggaaa gggcggacag
      901 ctcgcacctc agcatcctca ttgacccgcg ctgccccgac ctcaccgaca gcttcgcacg
      961 cctggagagc gcccaggcct cggtgctgca ggcgctgaca gagcaccagg cccagccacg
     1021 gctggtgggc gaccaggagc aggagctgct ggacacgctg gccgaccagc tgccccggct
     1081 gctggcccga gcctcagagc tgcagacgga gtgcatgggg ctgcggaagg ggcatggcac
     1141 gctgggccag ggcctcagcg ccctgcagag tgagcagggc cgcctcatcc agcttctctc
     1201 tgagagccag ggccacatgg ctcacctggt gaactccgtc agcgacatcc tggatgccct
     1261 gcagagggac cgggggctgg gccggccccg caacaaggcc gaccttcaga gagcgcctgc
     1321 ccggggaacc cggccccggg gctgtgccac tggctcccgg ccccgagact gtctggacgt
     1381 cctcctaagc ggacagcagg acgatggcgt ctactctgtc tttcccaccc actacccggc
     1441 cggcttccag gtgtactgtg acatgcgcac ggacggcggc ggctggacgg tgtttcagcg
     1501 ccgggaggac ggctccgtga acttcttccg gggctgggat gcgtaccgag acggctttgg
     1561 caggctcacc ggggagcact ggctagggct caagaggatc cacgccctga ccacacaggc
     1621 tgcctacgag ctgcacgtgg acctggagga ctttgagaat ggcacggcct atgcccgcta
     1681 cgggagcttc ggcgtgggct tgttctccgt ggaccctgag gaagacgggt acccgctcac
     1741 cgtggctgac tattccggca ctgcaggcga ctccctcctg aagcacagcg gcatgaggtt
     1801 caccaccaag gaccgtgaca gcgaccattc agagaacaac tgtgccgcct tctaccgcgg
     1861 tgcctggtgg taccgcaact gccacacgtc caacctcaat gggcagtacc tgcgcggtgc
     1921 gcacgcctcc tatgccgacg gcgtggagtg gtcctcctgg accggctggc agtactcact
     1981 caagttctct gagatgaaga tccggccggt ccgggaggac cgctagactg gtgcaccttg
     2041 tccttggccc tgctggtccc tgtcgcccca tccccgaccc cacctcactc tttcgtgaat
     2101 gttctccacc cacctgtgcc tggcggaccc actctccagt agggaggggc cgggccatcc
     2161 ctgacacgaa gctccctggg ccggtgaagt cacacatcgc cttctcgccg tccccacccc
     2221 ctccatttgg cagctcactg atctcttgcc tctgctgatg ggggctggca aacttgacga
     2281 ccccaactcc tgcctgcccc cactgtgact ccggtgctgt ttgccgtccc ctggccagga
     2341 tggtggagtc tgccccaggc accctctgcc ctgcccggcc aaatacccgg cattatgggg
     2401 acagagagca gggggcagac agcacccctg gagtcctcct agcagatcgt ggggaacgtc
     2461 aggtctctct gaggtcaggt ctgaggccag tatcctccag ccctcccaat gccaaccccc
     2521 accccgtttc cctggtgccc agagaaccca cctctccccc aagggcctca gcctggctgt
     2581 gggctgggtg gccccatcct accaggccct gaggtcagga tggggagctg ctgcctttgg
     2641 ggacccacgc tccaaggctg agaccagttc cctggaggcc acccaccctg tgccccggca
     2701 ggcctggggt ctgcagtcct cttacctgct gtgcccacct gctctctgtc tcaaatgagg
     2761 cccaacccat cccccaccca gctcccggcc gtcctcctac ctggggcagc tggggctgcc
     2821 atcccatttc tcctgcctct ggaaggtggg tggggccctg caccgtgggg ctggactgcg
     2881 ctaatgggaa gctcttggtt ttctgggctg gggcctaggc agggctggga tgaggcttgt
     2941 acaaccccca ccaccaattt cccagggact ccagggtcct gaggcctccc aggagggcct
     3001 tgggggtgat gaccccttcc ctgaggtggc tgtctccatg aggaggccaa cccttgccat
     3061 tgaccgtggc cacctggacc caggccaggc ccggcccggc gagtggtcaa gggacaggga
     3121 ccacctcacc gggcaaatgg ggtcgggggg actggggcac cagaccaggc accacctgga
     3181 cactttcttg ttgaatcctc ccaacaccca gcacgctgtc atccccactc cttgtgtgca
     3241 cacatgcaga ggtgagaccc gcaggctccc aggaccagca gccacaaggg cagggctgga
     3301 gccgggtcct cagctgtctg ctcagcagcc ctggacccgc gtgcgttacg tcaggcccag
     3361 atgcagggcg gcttttccaa ggcctcctga tggggggcct ccgaaagggc tggagtcagc
     3421 cttggggagc tgcctagcag cctctcctcg ggcaggaggg gaggtggctt cctccaaagg
     3481 acacccgatg gcaggtgcct agggggtgtg gggttccgtt ctcccttccc ctcccactga
     3541 agtttgtgct taaaaaacaa taaatttgac ttggcaccac tgggggttgg tgggagaggc
     3601 cgtgtgacct ggctctctgt cccagtgcca ccaggtcatc cacatgcgca
//
