LOCUS       NM_013241               3813 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens formin homology 2 domain containing 1 (FHOD1),
            transcript variant 2, mRNA.
ACCESSION   NM_013241
VERSION     NM_013241.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3813)
  AUTHORS   Zhang,F., Wu,L., Feng,S., Zhao,Z., Zhang,K., Thakur,A., Xu,Z.,
            Liang,Q., Liu,Y., Liu,W. and Yan,Y.
  TITLE     FHOD1 is upregulated in glioma cells and attenuates ferroptosis of
            glioma cells by targeting HSPB1 signaling
  JOURNAL   CNS Neurosci Ther 29 (11), 3351-3363 (2023)
   PUBMED   37211949
  REMARK    GeneRIF: FHOD1 is upregulated in glioma cells and attenuates
            ferroptosis of glioma cells by targeting HSPB1 signaling.
REFERENCE   2  (bases 1 to 3813)
  AUTHORS   Lim,S.M., Cruz,V.E., Antoku,S., Gundersen,G.G. and Schwartz,T.U.
  TITLE     Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding
            modes for the FH3 domain of formins
  JOURNAL   Structure 29 (6), 540-552 (2021)
   PUBMED   33472039
  REMARK    GeneRIF: Structures of FHOD1-Nesprin1/2 complexes reveal alternate
            binding modes for the FH3 domain of formins.
REFERENCE   3  (bases 1 to 3813)
  AUTHORS   Heuser,V.D., Kiviniemi,A., Lehtinen,L., Munthe,S., Kristensen,B.W.,
            Posti,J.P., Sipila,J.O.T., Vuorinen,V., Carpen,O. and Gardberg,M.
  TITLE     Multiple formin proteins participate in glioblastoma migration
  JOURNAL   BMC Cancer 20 (1), 710 (2020)
   PUBMED   32727404
  REMARK    GeneRIF: Multiple formin proteins participate in glioblastoma
            migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3813)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3813)
  AUTHORS   Shi,X., Zhao,S., Cai,J., Wong,G. and Jiu,Y.
  TITLE     Active FHOD1 promotes the formation of functional actin stress
            fibers
  JOURNAL   Biochem J 476 (20), 2953-2963 (2019)
   PUBMED   31657439
  REMARK    GeneRIF: FHOD1 plays a critical role in the spatial and temporal
            coordination of cellular stress fiber dynamics without disrupting
            the formation of stress fiber networks.
REFERENCE   6  (bases 1 to 3813)
  AUTHORS   Tojo,H., Kaieda,I., Hattori,H., Katayama,N., Yoshimura,K.,
            Kakimoto,S., Fujisawa,Y., Presman,E., Brooks,C.C. and Pilch,P.F.
  TITLE     The Formin family protein, formin homolog overexpressed in spleen,
            interacts with the insulin-responsive aminopeptidase and profilin
            IIa
  JOURNAL   Mol Endocrinol 17 (7), 1216-1229 (2003)
   PUBMED   12677009
  REMARK    GeneRIF: FHOS mediates an interaction between GLUT4/IRAP
            (insulin-responsive aminopeptidase) -containing vesicles and the
            cytoskeleton and may participate in exocytosis and/or retention of
            this membrane compartment
REFERENCE   7  (bases 1 to 3813)
  AUTHORS   Koka,S., Neudauer,C.L., Li,X., Lewis,R.E., McCarthy,J.B. and
            Westendorf,J.J.
  TITLE     The formin-homology-domain-containing protein FHOD1 enhances cell
            migration
  JOURNAL   J Cell Sci 116 (Pt 9), 1745-1755 (2003)
   PUBMED   12665555
REFERENCE   8  (bases 1 to 3813)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   9  (bases 1 to 3813)
  AUTHORS   Westendorf,J.J.
  TITLE     The formin/diaphanous-related protein, FHOS, interacts with Rac1
            and activates transcription from the serum response element
  JOURNAL   J Biol Chem 276 (49), 46453-46459 (2001)
   PUBMED   11590143
REFERENCE   10 (bases 1 to 3813)
  AUTHORS   Westendorf,J.J., Mernaugh,R. and Hiebert,S.W.
  TITLE     Identification and characterization of a protein containing formin
            homology (FH1/FH2) domains
  JOURNAL   Gene 232 (2), 173-182 (1999)
   PUBMED   10352228
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN302043.1, BC033084.1,
            AB041046.1 and AA609867.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_013241.2.
            
            Summary: This gene encodes a protein which is a member of the
            formin/diaphanous family of proteins. The gene is ubiquitously
            expressed but is found in abundance in the spleen. The encoded
            protein has sequence homology to diaphanous and formin proteins
            within the Formin Homology (FH)1 and FH2 domains. It also contains
            a coiled-coil domain, a collagen-like domain, two nuclear
            localization signals, and several potential PKC and PKA
            phosphorylation sites. It is a predominantly cytoplasmic protein
            and is expressed in a variety of human cell lines. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2015].
            
            Transcript Variant: This variant lacks two alternate in-frame exons
            in the 5' coding region, compared to variant 1. It encodes isoform
            2, which lacks an internal in-frame segment and is shorter,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB041046.1, BC033084.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258201.9/ ENSP00000258201.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                CN302043.1         44-57
            15-2548             BC033084.1         1-2534
            2549-3806           AB041046.1         2560-3817
            3807-3813           AA609867.1         12-18               c
FEATURES             Location/Qualifiers
     source          1..3813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..3813
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /note="formin homology 2 domain containing 1"
                     /db_xref="GeneID:29109"
                     /db_xref="HGNC:HGNC:17905"
                     /db_xref="MIM:606881"
     exon            1..272
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..3566
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /note="isoform 2 is encoded by transcript variant 2;
                     FH1/FH2 domain-containing protein 1; formin homolog
                     overexpressed in spleen 1"
                     /codon_start=1
                     /product="FH1/FH2 domain-containing protein 1 isoform 2"
                     /protein_id="NP_037373.2"
                     /db_xref="CCDS:CCDS10834.1"
                     /db_xref="GeneID:29109"
                     /db_xref="HGNC:HGNC:17905"
                     /db_xref="MIM:606881"
                     /translation="MAGGEDRGDGEPVSVVTVRVQYLEDTDPFACANFPEPRRAPTCS
                     LDGALPLGAQIPAVHRLLGAPLKLEDCALQVSPSGYYLDTELSLEEQREMLEGFYEEI
                     SKGRKPTLILRTQLSVRVNAILEKLYSSSGPELRRSLFSLKQIFQEDKDLVPEFVHSE
                     GLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSDTIQWLYTLCASLSRLV
                     VKTALKLLLVFVEYSENNAPLFIRAVNSVASTTGAPPWANLVSILEEKNGADPELLVY
                     TVTLINKTLAALPDQDSFYDVTDALEQQGMEALVQRHLGTAGTDVDLRTQLVLYENAL
                     KLEDGDIEEAPGAGGRRERRKPSSEEGKRSRRSLEGGGCPARAPEPGPTGPASPVGPT
                     SSTGPALLTGPASSPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKARFLENVAAA
                     ETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPCVLLRAQ
                     RSLAPEPKEPLIPASPKAEPIWELPTRAPRLSIGDLDFSDLGEDEDQDMLNVESVEAG
                     KDIPAPSPPLPLLSGVPPPPPLPPPPPIKGPFPPPPPLPLAAPLPHSVPDSSALPTKR
                     KTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPVSVDTARLEHLFESRAKEVLPSK
                     KAGEGRRTMTTVLDPKRSNAINIGLTTLPPVHVIKAALLNFDEFAVSKDGIEKLLTMM
                     PTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGLAARLQLWAFKLDYDSMEREIA
                     EPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQSSGFELSYLEKVSEVKDTVRR
                     QSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLR
                     SLAKHELAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQAAREVR
                     IMQFCHTLREFALEYRTCRERVLQQQQKQATYRERNKTRGRMITETEKFSGVAGEAPS
                     NPSVPVAVSSGPGRGDADSHASMKSLLTSRPEDTTHNRRSRGMVQSSSPIMPTVGPST
                     ASPEEPPGSSLPSDTSDEIMDLLVQSVTKSSPRALAARERKRSRGNRKSLRRTLKSGL
                     GDDLVQALGLSKGPGLEV"
     exon            273..379
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            380..444
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            445..512
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            513..618
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            619..713
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            714..825
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            826..920
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1064
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1213
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1390
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1506
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..2117
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2273
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2456
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2576
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2738
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2929
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3122
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3285
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3483
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3813
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3789..3794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /note="hexamer: AATAAA"
     polyA_site      3813
                     /gene="FHOD1"
                     /gene_synonym="FHOS"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgcttt gagtagaagc tgcactgggg ccgggactcg gaggcgcgct gcgtgagccg
       61 gccgcagagc catggcgggc ggggaagacc gcggggacgg agagccggta tcagtggtga
      121 ccgtgagggt gcagtacctg gaagacaccg accccttcgc atgtgccaac tttccggagc
      181 cgcgccgggc ccccacctgc agcctggacg gggcgctgcc cttgggcgcg cagatacccg
      241 cggtgcaccg cctgctggga gcgccgctca agttggagga ttgtgctctg caagtgtctc
      301 cctccggata ctacctggac accgagctgt ccctggaaga gcagcgggag atgctggagg
      361 gcttctatga agagatcagc aaagggcgga agcccacgct gatccttcgg acccagctct
      421 ctgtgagggt caacgctatc ttggaaaagc tgtatagctc cagtggtcct gagctccgcc
      481 gctccctctt ctcactgaag cagatcttcc aggaggacaa agacctggtg cctgaatttg
      541 tgcattcaga ggggctgagc tgcctgatcc gtgtgggtgc tgctgccgac cacaactacc
      601 agagctacat ccttagagcg ctcggccagc tgatgctctt tgtggatgga atgctggggg
      661 tggtggccca cagtgacact attcagtggc tgtacacatt gtgtgccagc ctgtcccgct
      721 tggtggtgaa gacagccctg aagctgctgt tggtgtttgt agaatactcc gaaaacaacg
      781 caccgctgtt catccgtgca gtgaactctg tggccagcac caccggtgct cctccctggg
      841 ccaatctggt gtccatcctg gaggagaaga atggcgctga ccctgagttg ttggtgtaca
      901 cggtcaccct catcaacaag acgctggcgg cgctcccgga ccaggactcc ttctacgatg
      961 tgacggatgc actggagcag cagggcatgg aagcgctggt ccagcgccac ctgggcactg
     1021 cgggcactga cgtcgacctg cgcacgcagc ttgtgctcta cgagaacgcc ctgaaattgg
     1081 aggatggaga catcgaagaa gccccaggcg ctggtgggcg gcgggaacga cgaaagcctt
     1141 cttctgagga gggcaagagg agccgccgtt ctctggaagg cgggggctgc cccgcgcgtg
     1201 ccccggaacc tggccccaca ggccccgcct caccggtagg ccccacctct tccaccggcc
     1261 ccgccctgct gacaggcccc gcctccagcc ctgtgggccc tccctccggt ctccaagctt
     1321 cagtgaacct ttttcctacc atctctgtgg caccctcagc tgacacctcc agcgagagga
     1381 gcatctacaa agcccggttc ctggagaatg tggcggcagc agaaacagag aagcaggttg
     1441 cgctggccca gggccgggca gagacacttg ccggggccat gcccaatgag gcgggtggac
     1501 acccagatgc ccggcaactc tgggactccc cagagacagc ccctgcagcc agaacacccc
     1561 agagccctgc cccctgtgtc ctgctccggg cccagcgaag ccttgcacca gagcccaagg
     1621 agccactgat accagcaagc cccaaggctg agcccatctg ggagctccct acccgtgcac
     1681 ccaggctctc tattggggac ctggactttt cagatctagg ggaggatgaa gaccaggaca
     1741 tgctgaatgt agagtctgtg gaggctggga aagacatccc agctccctca cccccactgc
     1801 ccctgctctc gggagtaccc ccccctcccc cacttccacc tcccccaccc atcaaaggcc
     1861 ccttcccacc acctccacct ctacctctgg ctgcccctct tccccattca gtgcctgaca
     1921 gctcagccct ccccactaag aggaagacag taaaactttt ctggcgtgag ctgaagctgg
     1981 ctgggggcca tggagtctct gcaagccgct ttgggccctg cgccaccctc tgggcttcac
     2041 tggaccctgt ctcagtggac acggcccgac tggaacacct ctttgagtct cgtgccaaag
     2101 aggtgctgcc ctccaagaaa gctggagagg gccgccggac aatgaccaca gtgctggacc
     2161 ccaagcgcag caacgccatc aacatcggcc taaccacact gccacctgtg catgtcatta
     2221 aggctgctct gctcaacttt gatgagtttg ctgtcagcaa ggatggcatt gagaagctac
     2281 tgaccatgat gcccacggag gaagagcggc agaagattga ggaagcccag ctggccaacc
     2341 ctgacatacc cctgggccca gccgagaact tcctgatgac tcttgcctcc attggcggcc
     2401 tcgctgctcg tctacaactc tgggccttca agctggacta tgacagcatg gagcgggaaa
     2461 ttgctgagcc actgtttgac ctgaaagtgg gtatggaaca gctggtacag aatgccacct
     2521 tccgctgcat cctggctacc ctcctagcgg tgggcaactt cctcaatggc tcccagagca
     2581 gcggctttga gctgagctac ctggagaagg tgtcagaggt gaaggacacg gtgcgtcgac
     2641 agtcactgct acaccatctc tgctccctag tgctccagac ccggcctgag tcctctgacc
     2701 tctattcaga aatccctgcc ctgacccgct gtgccaaggt ggactttgaa cagctgactg
     2761 agaacctggg gcagctggag cgccggagcc gggcagccga ggagagcctg cggagcttgg
     2821 ccaagcatga gctggcccca gccctgcgtg cccgcctcac ccacttcctg gaccagtgtg
     2881 cccgccgtgt tgccatgcta aggatagtgc accgccgtgt ctgcaatagg ttccatgcct
     2941 tcctgctcta cctgggctac accccgcagg cggcccgtga agtgcgcatc atgcagttct
     3001 gccacacgct gcgggaattt gcgcttgagt atcggacttg ccgggaacga gtgctacagc
     3061 agcagcagaa gcaggccaca taccgtgagc gcaacaagac ccggggacgc atgatcaccg
     3121 agacagagaa gttctcaggt gtggctgggg aagcccccag caacccctct gtcccagtag
     3181 cagtgagcag cgggccaggc cggggagatg ctgacagtca tgctagtatg aagagtctgc
     3241 tgaccagcag gcctgaggac accacacaca atcgccgcag cagaggcatg gtccagagca
     3301 gctccccaat catgcccaca gtggggccct ccactgcatc cccagaagaa cccccaggct
     3361 ccagtttacc cagtgataca tcagatgaga tcatggacct tctggtgcag tcagtgacca
     3421 agagcagtcc tcgtgcctta gctgctaggg aacgcaagcg ttcccgcggc aaccgcaagt
     3481 ctttgagaag gacgttgaag agtgggctcg gagatgacct ggtgcaggca ctgggactaa
     3541 gcaagggtcc tggcctggag gtgtgaaggt gctgtatccc ggaaatctat ctggaccctg
     3601 gactgcagtg caggagatga cagagtgagg agggcccaga gcagaattct ggccccagaa
     3661 ctctgtgccc aggagccatg ccttgagcag tattagccgt gtgtgtatgc atgtgagtgt
     3721 gtgtgtatgt gtgtgtgtgc atgcatatgc atgtgcatgt gtgtgagctc cttgaacgca
     3781 cggagcaaaa taaaattttc ttagctaatc caa
//
