LOCUS       NM_001318895            1582 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens four and a half LIM domains 2 (FHL2), transcript
            variant 7, mRNA.
ACCESSION   NM_001318895
VERSION     NM_001318895.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1582)
  AUTHORS   Zhang,S., Zhang,L., Zhang,D., Guo,Y., Gao,Y., Jiang,Z., Li,S.,
            Liu,A., Cao,X., Tian,J., Zhao,S., Yu,Y., Yang,W., Bai,R., Huang,L.,
            Yan,H., Zhao,H. and Sun,J.
  TITLE     Four and a half LIM domains 2 (FHL2) attenuates tumorigenesis of
            gastrointestinal stromal tumors (GISTs) by negatively regulating
            KIT signaling
  JOURNAL   Mol Carcinog 63 (7), 1334-1348 (2024)
   PUBMED   38629424
  REMARK    GeneRIF: Four and a half LIM domains 2 (FHL2) attenuates
            tumorigenesis of gastrointestinal stromal tumors (GISTs) by
            negatively regulating KIT signaling.
REFERENCE   2  (bases 1 to 1582)
  AUTHORS   Wang,S., Liu,B., Su,Y., Wang,N., Dong,P., Xu,X., Huang,L., Li,S.,
            Gu,J., Qiu,Y., Deng,J., Lin,Z. and Zhou,Y.
  TITLE     FHL2 promotes the aggressiveness of lung adenocarcinoma by
            inhibiting autophagy via activation of the PI3K/AKT/mTOR pathway
  JOURNAL   Thorac Cancer 15 (8), 630-641 (2024)
   PUBMED   38323374
  REMARK    GeneRIF: FHL2 promotes the aggressiveness of lung adenocarcinoma by
            inhibiting autophagy via activation of the PI3K/AKT/mTOR pathway.
REFERENCE   3  (bases 1 to 1582)
  AUTHORS   Luan,X., Zhai,J., Li,S. and Du,Y.
  TITLE     Downregulation of FHL2 suppressed trophoblast migration, invasion
            and epithelial-mesenchymal transition in recurrent miscarriage
  JOURNAL   Reprod Biomed Online 48 (1), 103342 (2024)
   PUBMED   37945432
  REMARK    GeneRIF: Downregulation of FHL2 suppressed trophoblast migration,
            invasion and epithelial-mesenchymal transition in recurrent
            miscarriage.
REFERENCE   4  (bases 1 to 1582)
  AUTHORS   Xu,Z., Tian,M., Tan,Q., Hao,P., Gao,Z., Li,C. and Jin,N.
  TITLE     FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-beta
            Expression through Regulating IRF-3
  JOURNAL   Int J Mol Sci 25 (1), 353 (2023)
   PUBMED   38203523
  REMARK    GeneRIF: FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-beta
            Expression through Regulating IRF-3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1582)
  AUTHORS   Zhang,J., Zeng,Q. and She,M.
  TITLE     The roles of FHL2 in cancer
  JOURNAL   Clin Exp Med 23 (7), 3113-3124 (2023)
   PUBMED   37103649
  REMARK    GeneRIF: The roles of FHL2 in cancer.
            Review article
REFERENCE   6  (bases 1 to 1582)
  AUTHORS   Muller,J.M., Isele,U., Metzger,E., Rempel,A., Moser,M.,
            Pscherer,A., Breyer,T., Holubarsch,C., Buettner,R. and Schule,R.
  TITLE     FHL2, a novel tissue-specific coactivator of the androgen receptor
  JOURNAL   EMBO J 19 (3), 359-369 (2000)
   PUBMED   10654935
REFERENCE   7  (bases 1 to 1582)
  AUTHORS   Chan,K.K., Tsui,S.K., Ngai,S.M., Lee,S.M., Kotaka,M., Waye,M.M.,
            Lee,C.Y. and Fung,K.P.
  TITLE     Protein-protein interaction of FHL2, a LIM domain protein
            preferentially expressed in human heart, with hCDC47
  JOURNAL   J Cell Biochem 76 (3), 499-508 (2000)
   PUBMED   10649446
REFERENCE   8  (bases 1 to 1582)
  AUTHORS   Chan,K.K., Tsui,S.K., Lee,S.M., Luk,S.C., Liew,C.C., Fung,K.P.,
            Waye,M.M. and Lee,C.Y.
  TITLE     Molecular cloning and characterization of FHL2, a novel LIM domain
            protein preferentially expressed in human heart
  JOURNAL   Gene 210 (2), 345-350 (1998)
   PUBMED   9573400
REFERENCE   9  (bases 1 to 1582)
  AUTHORS   Genini,M., Schwalbe,P., Scholl,F.A., Remppis,A., Mattei,M.G. and
            Schafer,B.W.
  TITLE     Subtractive cloning and characterization of DRAL, a novel
            LIM-domain protein down-regulated in rhabdomyosarcoma
  JOURNAL   DNA Cell Biol 16 (4), 433-442 (1997)
   PUBMED   9150430
REFERENCE   10 (bases 1 to 1582)
  AUTHORS   Morgan,M.J. and Madgwick,A.J.
  TITLE     Slim defines a novel family of LIM-proteins expressed in skeletal
            muscle
  JOURNAL   Biochem Biophys Res Commun 225 (2), 632-638 (1996)
   PUBMED   8753811
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ266432.1 and AC108058.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 25, 2019 this sequence version replaced NM_001318895.2.
            
            Summary: This gene encodes a member of the four-and-a-half-LIM-only
            protein family. Family members contain two highly conserved,
            tandemly arranged, zinc finger domains with four highly conserved
            cysteines binding a zinc atom in each zinc finger. This protein is
            thought to have a role in the assembly of extracellular membranes.
            Also, this gene is down-regulated during transformation of normal
            myoblasts to rhabdomyosarcoma cells and the encoded protein may
            function as a link between presenilin-2 and an intracellular
            signaling pathway. Multiple alternatively spliced variants encoding
            different isoforms have been identified. [provided by RefSeq, Jan
            2016].
            
            Transcript Variant: This variant (7) differs in the 5' UTR compared
            to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the
            same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ266432.1, SRR14038194.2843946.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000530340.6/ ENSP00000433567.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               DQ266432.1         174-390
            218-218             AC108058.2         27704-27704         c
            219-1582            DQ266432.1         392-1755
FEATURES             Location/Qualifiers
     source          1..1582
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.2"
     gene            1..1582
                     /gene="FHL2"
                     /gene_synonym="AAG11; DRAL; FHL-2; SLIM-3; SLIM3"
                     /note="four and a half LIM domains 2"
                     /db_xref="GeneID:2274"
                     /db_xref="HGNC:HGNC:3703"
                     /db_xref="MIM:602633"
     exon            1..210
                     /gene="FHL2"
                     /gene_synonym="AAG11; DRAL; FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            211..261
                     /gene="FHL2"
                     /gene_synonym="AAG11; DRAL; FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            262..441
                     /gene="FHL2"
                     /gene_synonym="AAG11; DRAL; FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..1125
                     /gene="FHL2"
                     /gene_synonym="AAG11; DRAL; FHL-2; SLIM-3; SLIM3"
                     /note="isoform a is encoded by transcript variant 7;
                     down-regulated in rhabdomyosarcoma LIM protein;
                     aging-associated gene 11; LIM domain protein DRAL;
                     skeletal muscle LIM-protein 3"
                     /codon_start=1
                     /product="four and a half LIM domains protein 2 isoform a"
                     /protein_id="NP_001305824.1"
                     /db_xref="CCDS:CCDS2070.1"
                     /db_xref="GeneID:2274"
                     /db_xref="HGNC:HGNC:3703"
                     /db_xref="MIM:602633"
                     /translation="MTERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECG
                     KPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQ
                     ECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAM
                     QCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYA
                     KKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCG
                     KDI"
     exon            442..616
                     /gene="FHL2"
                     /gene_synonym="AAG11; DRAL; FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            617..786
                     /gene="FHL2"
                     /gene_synonym="AAG11; DRAL; FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            787..973
                     /gene="FHL2"
                     /gene_synonym="AAG11; DRAL; FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1582
                     /gene="FHL2"
                     /gene_synonym="AAG11; DRAL; FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1561..1566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FHL2"
                     /gene_synonym="AAG11; DRAL; FHL-2; SLIM-3; SLIM3"
                     /note="hexamer: AATAAA"
     polyA_site      1582
                     /gene="FHL2"
                     /gene_synonym="AAG11; DRAL; FHL-2; SLIM-3; SLIM3"
                     /note="major polyA site"
ORIGIN      
        1 actcggccgg cagcggagcc gcagccacca gccgcccgcg ccctccagcc ccgtccggga
       61 gtccccggcc cgctgcggtg ccgtgagtac ctccaacccc ctgcgccccg gagggaggcc
      121 gaggggctta gccaccaggg ctcggaagtg ggggccgaat ccggtgcgag acccaaggag
      181 aggggagcag agccggagtt ggggagactg tggctgagaa ctgtgtcttc ctggagacta
      241 ggctggcatt ttgactttgg ggttgctgaa aagccaggag tcaaaatgac tgagcgcttt
      301 gactgccacc attgcaacga atctctcttt ggcaagaagt acatcctgcg ggaggagagc
      361 ccctactgcg tggtgtgctt tgagaccctg ttcgccaaca cctgcgagga gtgtgggaag
      421 cccatcggct gtgactgcaa ggacttgtct tacaaggacc ggcactggca tgaagcctgt
      481 ttccactgct cgcagtgcag aaactcactg gtggacaagc cctttgctgc caaggaggac
      541 cagctgctct gtacagactg ctattccaac gagtactcat ccaagtgcca ggaatgcaag
      601 aagaccatca tgccaggtac ccgcaagatg gagtacaagg gcagcagctg gcatgagacc
      661 tgcttcatct gccaccgctg ccagcagcca attggaacca agagtttcat ccccaaagac
      721 aatcagaatt tctgtgtgcc ctgctatgag aaacaacatg ccatgcagtg cgttcagtgc
      781 aaaaagccca tcaccacggg aggggtcact taccgggagc agccctggca caaggagtgc
      841 ttcgtgtgca ccgcctgcag gaagcagctg tctgggcagc gcttcacagc tcgcgatgac
      901 tttgcctact gcctgaactg cttctgtgac ttgtatgcca agaagtgtgc tgggtgcacc
      961 aaccccatca gcggacttgg tggcacaaaa tacatctcct ttgaggaacg gcagtggcat
     1021 aacgactgct ttaactgtaa gaagtgctcc ctctcactgg tggggcgtgg cttcctcaca
     1081 gagagggacg acatcctgtg ccccgactgt gggaaagaca tctgaattca acacagagaa
     1141 gttgctgctt gtgatctcac acacagattt ttatgttttc tttctcaccc aggcaatctt
     1201 gccttctggt ttcttccagc cacattgaga ctttcttcta gtgcttttca gtgatactca
     1261 cgtttgctta aaccctttag tgctttgtga tagttcagtc ccagggaaag agaaaactcg
     1321 ccctaggccc taggtgggaa gatggtttga aatttttgta atcgagtaag gcacacccaa
     1381 atgtaaaaat ccttttgaat gatgccttta taaatctttc tctcactgtc tatttaagtg
     1441 caattaacat atgtcacgaa cttgaaagtt ttctaaactc aataaggtaa tgaccagttg
     1501 ttatttacag ctctgtaacc tcccgttgcg tcaagtctaa accaagatta tgtgacttgc
     1561 aataaagtta ttcagaacag aa
//
