LOCUS       NM_022749               4316 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens FHF complex subunit HOOK interacting protein 2B
            (FHIP2B), transcript variant 1, mRNA.
ACCESSION   NM_022749
VERSION     NM_022749.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4316)
  AUTHORS   Ding,C.L., Qian,C.L., Qi,Z.T. and Wang,W.
  TITLE     Identification of retinoid acid induced 16 as a novel androgen
            receptor target in prostate cancer cells
  JOURNAL   Mol Cell Endocrinol 506, 110745 (2020)
   PUBMED   32014455
  REMARK    GeneRIF: Identification of retinoid acid induced 16 as a novel
            androgen receptor target in prostate cancer cells.
REFERENCE   2  (bases 1 to 4316)
  AUTHORS   Xu,Y.L., Ding,C.L., Qian,C.L., Qi,Z.T. and Wang,W.
  TITLE     Retinoid acid induced 16 deficiency aggravates colitis and
            colitis-associated tumorigenesis in mice
  JOURNAL   Cell Death Dis 10 (12), 958 (2019)
   PUBMED   31862898
  REMARK    GeneRIF: Retinoid acid induced 16 deficiency aggravates colitis and
            colitis-associated tumorigenesis in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4316)
  AUTHORS   Mavioglu,R.N., Kara,B., Akansel,G., Nalbant,G. and Tolun,A.
  TITLE     FAM160B1 deficit associated with microcephaly, severe intellectual
            disability, ataxia, behavioral abnormalities and speech problems
  JOURNAL   Clin Genet 96 (5), 456-460 (2019)
   PUBMED   31353455
  REMARK    GeneRIF: FAM160B1 deficit associated with microcephaly, severe
            intellectual disability, ataxia, behavioral abnormalities and
            speech problems.
REFERENCE   4  (bases 1 to 4316)
  AUTHORS   Ding,C.L., Xu,G., Tang,H.L., Zhu,S.Y., Zhao,L.J., Ren,H., Zhao,P.,
            Qi,Z.T. and Wang,W.
  TITLE     Anchoring of both PKA-RIIalpha and 14-3-3theta; regulates retinoic
            acid induced 16 mediated phosphorylation of heat shock protein 70
  JOURNAL   Oncotarget 6 (17), 15540-15550 (2015)
   PUBMED   25900241
  REMARK    GeneRIF: RAI16 interacted with the type II regulatory subunit of
            protein kinase A(PKA-RIIalpha), acting as a novel protein kinase A
            anchoring protein (AKAP). In addition, RAI16 also interacted with
            heat shock protein 70 (HSP70) and 14-3-3theta;.
REFERENCE   5  (bases 1 to 4316)
  AUTHORS   Wang,W., Zhao,L.J., Yang,Y., Wang,R.Y., Ren,H., Zhao,P., Zhou,W.P.
            and Qi,Z.T.
  TITLE     Retinoic acid induced 16 enhances tumorigenesis and serves as a
            novel tumor marker for hepatocellular carcinoma
  JOURNAL   Carcinogenesis 33 (12), 2578-2585 (2012)
   PUBMED   22971576
  REMARK    GeneRIF: Retinoic acid induced 16 enhances tumorigenesis and serves
            as a novel tumor marker for hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 4316)
  AUTHORS   Wen,Y., Liu,Y., Xu,Y., Zhao,Y., Hua,R., Wang,K., Sun,M., Li,Y.,
            Yang,S., Zhang,X.J., Kruse,R., Cichon,S., Betz,R.C., Nothen,M.M.,
            van Steensel,M.A., van Geel,M., Steijlen,P.M., Hohl,D., Huber,M.,
            Dunnill,G.S., Kennedy,C., Messenger,A., Munro,C.S., Terrinoni,A.,
            Hovnanian,A., Bodemer,C., de Prost,Y., Paller,A.S., Irvine,A.D.,
            Sinclair,R., Green,J., Shang,D., Liu,Q., Luo,Y., Jiang,L.,
            Chen,H.D., Lo,W.H., McLean,W.H., He,C.D. and Zhang,X.
  TITLE     Loss-of-function mutations of an inhibitory upstream ORF in the
            human hairless transcript cause Marie Unna hereditary hypotrichosis
  JOURNAL   Nat Genet 41 (2), 228-233 (2009)
   PUBMED   19122663
  REMARK    Erratum:[Nat Genet. 2009 Jun;41(6):762]
REFERENCE   7  (bases 1 to 4316)
  AUTHORS   van der Spek,P.J., Kremer,A., Murry,L. and Walker,M.G.
  TITLE     Are gene expression microarray analyses reliable? A review of
            studies of retinoic acid responsive genes
  JOURNAL   Genomics Proteomics Bioinformatics 1 (1), 9-14 (2003)
   PUBMED   15626329
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091171.15.
            
            On Nov 22, 2018 this sequence version replaced NM_022749.6.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.21157.1,
                                           SRR1803616.22296.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289921.8/ ENSP00000289921.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC091171.15        139624-139772
            150-228             AC091171.15        144914-144992
            229-401             AC091171.15        146811-146983
            402-506             AC091171.15        147990-148094
            507-629             AC091171.15        148191-148313
            630-872             AC091171.15        148542-148784
            873-1069            AC091171.15        148897-149093
            1070-1178           AC091171.15        149422-149530
            1179-1255           AC091171.15        149758-149834
            1256-1445           AC091171.15        150178-150367
            1446-1591           AC091171.15        151068-151213
            1592-1720           AC091171.15        151318-151446
            1721-1811           AC091171.15        151914-152004
            1812-1955           AC091171.15        152182-152325
            1956-2096           AC091171.15        152649-152789
            2097-2197           AC091171.15        153002-153102
            2198-4316           AC091171.15        153267-155385
FEATURES             Location/Qualifiers
     source          1..4316
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..4316
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /note="FHF complex subunit HOOK interacting protein 2B"
                     /db_xref="GeneID:64760"
                     /db_xref="HGNC:HGNC:16492"
                     /db_xref="MIM:620230"
     exon            1..149
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2336
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinoic acid induced 16; retinoic acid-induced protein
                     16; family with sequence similarity 160 member B2; protein
                     FAM160B2"
                     /codon_start=1
                     /product="FHF complex subunit HOOK-interacting protein 2B
                     isoform 1"
                     /protein_id="NP_073586.5"
                     /db_xref="CCDS:CCDS6021.2"
                     /db_xref="GeneID:64760"
                     /db_xref="HGNC:HGNC:16492"
                     /db_xref="MIM:620230"
                     /translation="MLSRLGALLQEAVGAREPSIDLLQAFVEHWKGITHYYIESTDES
                     TPAKKTDIPWRLKQMLDILVYEEQQQAAAGEAGPCLEYLLQHKILETLCTLGKAEYPP
                     GMRQQVFQFFSKVLAQVQHPLLHYLSVHRPVQKLLRLGGTASGSVTEKEEVQFTTVLC
                     SKIQQDPELLAYILEGKKIVGRKKACGEPTALPKDTTSHGDKDCSHDGAPARPQLDGE
                     SCGAQALNSHMPAETEELDGGTTESNLITSLLGLCQSKKSRVALKAQENLLLLVSMAS
                     PAAATYLVQSSACCPAIVRHLCQLYRSMPVFLDPADIATLEGISWRLPSAPSDEASFP
                     GKEALAAFLGWFDYCDHLITEAHTVVADALAKAVAENFFVETLQPQLLHVSEQSILTS
                     TALLTAMLRQLRSPALLREAVAFLLGTDRQPEAPGDNPHTLYAHLIGHCDHLSDEISI
                     TTLRLFEELLQKPHEGIIHSLVLRNLEGRPYVAWGSPEPESYEDTLDLEEDPYFTDSF
                     LDSGFQTPAKPRLAPATSYDGKTAVTEIVNSFLCLVPEEAKTSAFLEETGYDTYVHDA
                     YGLFQECSSRVASWGWPLTPTPLDPHEPERPFFEGHFLRVLFDRMSRILDQPYSLNLQ
                     VTSVLSRLALFPHPHIHEYLLDPYISLAPGCRSLFSVLVRVIGDLMQRIQRVPQFPGK
                     LLLVRKQLTGQAPGEQLDHQTLLQGVVVLEEFCKELAAIAFVKFPPHDPRQNVSPAPE
                     GQV"
     exon            150..228
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            229..401
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            402..506
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..629
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..872
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1069
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1178
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1255
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1445
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1591
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1720
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1811
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1955
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2096
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2197
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..4316
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3763..3768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /note="hexamer: AATAAA"
     polyA_site      3785
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /note="major polyA site"
     regulatory      4132..4137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /note="hexamer: CATAAA"
     polyA_site      4156
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
     regulatory      4280..4285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /note="hexamer: AAGAAA"
     regulatory      4298..4303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
                     /note="hexamer: AATAAA"
     polyA_site      4303
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
     polyA_site      4316
                     /gene="FHIP2B"
                     /gene_synonym="FAI16; FAM160B2; RAI16; RAM160B2"
ORIGIN      
        1 gcccccctcg tcgcgccggg gccgccgggg ccacggggct gcctcctccg cctagagcgc
       61 tgccgccgcc gctttcgccc gggagccggg ggccgggcgc catcatgctg agccggctcg
      121 gggcgctgct gcaggaagcc gtgggggcgc gcgagcccag cattgacctg ctgcaggcct
      181 tcgtggagca ctggaagggc atcacgcact actacatcga gagcacagat gaaagcaccc
      241 ccgccaagaa gacagacatt ccctggcggc tgaagcagat gctggatatc ctggtgtatg
      301 aagagcagca gcaggcggcc gcgggtgagg cagggccctg cctggagtac ctgctgcagc
      361 acaagatcct ggagactctc tgcacgctgg gcaaggccga gtacccccca ggcatgcggc
      421 agcaggtgtt ccagttcttc agcaaggttc tggcgcaggt gcagcacccc ctgctgcatt
      481 acctcagcgt ccacaggcct gtgcagaaac tcctccgact tggtgggact gcttccggat
      541 ccgttacaga aaaggaggag gtgcagttca ccaccgtcct ctgctccaag atccagcagg
      601 acccagagct gctcgcctac atcctggaag gtaaaaagat tgtaggtagg aagaaagcat
      661 gcggagaacc cactgccctg cctaaggaca caaccagcca cggggacaag gactgctccc
      721 acgatggtgc tcctgccagg ccccagctgg acggggagtc ctgtggggcc caggccttga
      781 acagccacat gcctgctgag accgaggagc tggacggtgg gaccacagag agcaacctga
      841 ttacctccct gcttgggctg tgccagagca agaagagtcg ggtggccttg aaggcccagg
      901 agaacctgct gctcctggtg agcatggcct ccccagcagc tgccacctac ctggtacaga
      961 gcagcgcctg ctgccctgcg atcgtccggc acctttgcca gttgtaccgg tccatgcctg
     1021 tcttcctgga ccccgcagac attgccacct tagagggcat cagctggagg ttacccagtg
     1081 ccccgtctga tgaggcttcc ttccctggca aggaggcctt ggctgccttc ttgggctggt
     1141 ttgattactg cgaccacctc atcacagagg cacacacggt ggttgcggac gccttggcga
     1201 aggctgtggc tgagaacttc ttcgtggaga ccctgcagcc ccagctcctg cacgtgtccg
     1261 agcagagcat cttgacctcc accgccctcc tcacagccat gctgcgccag cttcgctccc
     1321 ctgcgctgct gcgggaggcc gtggctttcc tcctgggcac agaccggcag cctgaagccc
     1381 ccggggacaa cccccacacc ctgtatgctc atctcatcgg gcattgtgac cacctctctg
     1441 atgagatcag catcaccaca ctccggctgt ttgaggagct gctgcagaag ccccacgagg
     1501 ggatcatcca cagcctggtc ctgcgcaacc ttgagggccg cccttacgtg gcctggggct
     1561 caccagagcc tgagagctat gaggacaccc tagacctgga ggaagacccc tacttcaccg
     1621 acagcttcct ggattccggc tttcaaactc ccgcaaagcc tcgcctagct cctgctacca
     1681 gttacgatgg caaaacagca gtgaccgaga tcgtcaacag tttcctgtgc ctggtccccg
     1741 aggaagccaa gacctctgcc ttcctggagg agacaggcta tgacacatac gtccacgatg
     1801 cttatggcct gttccaggag tgcagctccc gcgtcgcctc ctggggctgg cctctgaccc
     1861 ccacaccttt ggacccccat gagcccgagc gacctttctt cgagggccac ttcctccgag
     1921 tgctgtttga ccgcatgtcc cggattctgg atcagccata cagcctgaac ctgcaggtga
     1981 cctcggtcct gtcccggctt gccctcttcc cccaccccca tattcatgag tacctgctgg
     2041 atccgtacat cagcctggcc cccggctgca ggagcctatt ctccgtgttg gtgagggtga
     2101 tcggggactt gatgcagaga atccagaggg taccccagtt cccaggcaag ctgctcctgg
     2161 tgcgcaagca gttgacgggc caggctcctg gggagcagct ggaccaccag accctcctcc
     2221 agggcgtggt ggtgctggag gagttctgca aggagctggc tgccattgcc ttcgtcaagt
     2281 ttcccccaca tgatcctcgc cagaacgtct ccccagcccc ggaagggcag gtctgagcca
     2341 gcaccagggc ggtgggagac tcctgtccac acctctgccc cagagctgcc tcctgcctgg
     2401 cactgccgcc acactcccct cctgggatgg ggcttctgct cccgggctca ctcaaggaga
     2461 ctgcggcatg ttgaccacac cagactgggt ttcagggaat gggcatgcca ggtgccaagg
     2521 agccaaacag atggctttcc aggcagcaag gtccttgggg ccttcttgga ggagcttggg
     2581 tgacagccag gtgagcaccc agaccccaga ccctcatgtg ctgtgtgcct ggccccttct
     2641 gtactggcca tttgtggcca gggccaagcc tgtgactcaa ctccaggggc aagatgggga
     2701 gtgagctgat ggctccgaga ctggtcagga gcccaggcca gtgagatggg gcctggagcc
     2761 ttgtctgtgt cacattaggt accatgggag ctgctgagac ctgacatttt gtcccctgcc
     2821 tacatggctt ggcccatgga gaaggagcag tgaatgggat cgtcggggaa gcccctcttc
     2881 ctgctctgct cccctggaaa ctgttgcaaa actcccagcc gcctcatggc aaatgcccaa
     2941 agcatgttcc gcacccaggc gggggcccct gctaatgaga accttggtgc agctgcagcc
     3001 aggaggggag cgggcccagg agccaggctc aggtccagct ggttcctctc tggcgccttc
     3061 tgaacccgtc tcagcaggtc cacagcacct gggcagaggt cagagaccag gggaggccgg
     3121 gccttgccct cccttctgcc cagggcccag tgttcttgat agaagaccct tctggggagc
     3181 cagggagctc aggggacaga taagggaagg acgccccctg actccaggcc cctgagcctg
     3241 gcgggaagtg gctgcggccc aggcagccag tcctggtggt gttctccctg catgccctcc
     3301 gtggctgggc tgccacccca cccggcccga atctgtcttg acctgcagga atacacgggc
     3361 ggcgccaggc attacctcac agcgggacta cacagttgct ggctttgctc ctgggcaagg
     3421 aggagcaggc cagagcctct tttgcttcct tttcttgccc atgccgcttc tagaagccag
     3481 gcacaggttg ccaagaggtg acacgaaaca ggaggaaact cagtgacctc tgcctctccc
     3541 acattcctcc ccgcggggga ggacctcgcc gctctgaaga gcaccgtgca catgtgggtg
     3601 cacaaacgtg ggtgttggtg tggacggggc gcagatctcc gtggatgaac tgcgtctgga
     3661 ctcttagatt cataaaatat tcgagggttt gggagtcaca gaccctcccc tctcctcagt
     3721 gcactttggc atttgcacgg tgtcttcccc ggacagcaca gcaataaatg gtgtgattgc
     3781 gtggacaccg tggctctgtt cttggccaag tttccccacc ttctgcccag gactccactg
     3841 ctaattcggg cccatcttcc tccccaagga agacaaattc tttttctagc gctgcagcag
     3901 ggaggtgggg tgggcggtaa acagacaggc tctggcagtg cagatctgct gatcctcagc
     3961 gcctgccagg agccagactc ttggcggagc agtgccactt ctgctgggct gacctgcagc
     4021 ggagagtctg cccaccccgg agacaccatg agggaatgga ccacgtggga gcatctgtgt
     4081 gcaagtctca tttgggtgtg tttatgctgc gtgttgtatg cctgttttag tcataaagta
     4141 ggcctgatat ttaaaacctt gtctttaagt tcaaggctgc agtgagccga ttgcaccact
     4201 gcactccagc ctgggcaata gagtaagacc ctgtctaaaa aaaaaaaaaa aaaatttcac
     4261 aggtgtgttc tcagggaaaa agaaaagtta acacataaat aaaccctttg tcctca
//
