LOCUS       NM_001098794            3364 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens FHF complex subunit HOOK interacting protein 1B
            (FHIP1B), transcript variant 2, mRNA.
ACCESSION   NM_001098794
VERSION     NM_001098794.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3364)
  AUTHORS   Christensen,J.R., Kendrick,A.A., Truong,J.B., Aguilar-Maldonado,A.,
            Adani,V., Dzieciatkowska,M. and Reck-Peterson,S.L.
  TITLE     Cytoplasmic dynein-1 cargo diversity is mediated by the
            combinatorial assembly of FTS-Hook-FHIP complexes
  JOURNAL   Elife 10, e74538 (2021)
   PUBMED   34882091
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3364)
  AUTHORS   Mattera,R., Williamson,C.D., Ren,X. and Bonifacino,J.S.
  TITLE     The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate
            perinuclear distribution of AP-4 and its cargo ATG9A
  JOURNAL   Mol Biol Cell 31 (9), 963-979 (2020)
   PUBMED   32073997
REFERENCE   3  (bases 1 to 3364)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3364)
  AUTHORS   Xu,L., Sowa,M.E., Chen,J., Li,X., Gygi,S.P. and Harper,J.W.
  TITLE     An FTS/Hook/p107(FHIP) complex interacts with and promotes
            endosomal clustering by the homotypic vacuolar protein sorting
            complex
  JOURNAL   Mol Biol Cell 19 (12), 5059-5071 (2008)
   PUBMED   18799622
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA389621.1, AB051546.1 and
            BC030825.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001098794.1.
            
            Summary: The protein encoded by this gene is part of the
            FTS/Hook/FHIP (FHF) complex, which can interact with members of the
            homotypic vesicular protein sorting (HOPS) complex. This
            interaction suggests that the encoded protein is involved in
            vesicle trafficking. [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the mid-coding region, compared to variant 1,
            resulting in a shorter protein (isoform 2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051546.1, BC030825.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449352.7/ ENSP00000416918.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               DA389621.1         76-405
            331-1755            AB051546.1         311-1735
            1756-2234           BC030825.1         1744-2222
            2235-3364           AB051546.1         2215-3344
FEATURES             Location/Qualifiers
     source          1..3364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3364
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /note="FHF complex subunit HOOK interacting protein 1B"
                     /db_xref="GeneID:84067"
                     /db_xref="HGNC:HGNC:25378"
                     /db_xref="MIM:620229"
     exon            1..93
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /inference="alignment:Splign:2.1.0"
     exon            94..422
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..3203
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /note="isoform 2 is encoded by transcript variant 2; FTS
                     and Hook-interacting protein; family with sequence
                     similarity 160 member A2"
                     /codon_start=1
                     /product="FHF complex subunit HOOK-interacting protein 1B
                     isoform 2"
                     /protein_id="NP_001092264.1"
                     /db_xref="CCDS:CCDS44530.1"
                     /db_xref="GeneID:84067"
                     /db_xref="HGNC:HGNC:25378"
                     /db_xref="MIM:620229"
                     /translation="MERMNWLSRLASRGPGHRIPQGANLQTPVMADPETCLMVFKNHW
                     SQVVRILERQGPRAAPGGADDLSAVRNHTYQMLTLLAEDRAVPSAPTGPGPLLEFALH
                     EDLLTRVLTWQLQWDELGDGVEERRAEQLKLFEMLVSEARQPLLRHGPVREALLTLLD
                     ACGRPVPSSPALDEGLVLLLSQLCVCVAQEPSLLEFFLQPPPEPGAAPRLLLFSRLVP
                     FVHREGTLGQQARDALLLLMALSAGSPTVGRYIADHSYFCPVLATGLSALYSSLPRKI
                     EVPGDDWHCLRREDWLGVPALALFMSSLEFCNAVIQVAHPLVQKQLVDYIHNGFLVPV
                     MGPALHKTSVEEMIASTAYLELFLRSISEPALLRTFLRFLLLHRHDTHTILDTLVARI
                     GSNSRLCMVSLSLFRTLLNLSCEDVLLQLVLRYLVPCNHVMLSQKPAVRDVDLYGRAA
                     DKFLSLIPRCCRHHAPSPPRPEHASWARGPGSPSVDSSSVTTVPRPSTPSRLALFLRQ
                     QSLGGSESPGPAPCSPGLSASPASSPGRRPTPAEEPGELEDNYLEYLREARRGVDRCV
                     RACRTWSAPYDGERPSPEPSPFGSRTKKRSLLPEEDRNNVGEGEEEELGRRGRAGGAG
                     EGPGHLPPPQLNGVPGSWPEGAKKVRLVPKEGAGELLEGISEGMAGLEGFGQELRELE
                     VALSNGGTGSESPLEPPLPLEEEEAYESFTCPPEPPGPFLSSPLRTLNQLPSQPFTGP
                     FMAVLFAKLENMLQNSVYVNFLLTGLVAQLACHPQPLLRSFLLNTNMVFQPSVKSLLQ
                     VLGSVKNKIENFAASQEDFPALLSKAKKYLIARGKLDWAEGPAAGPAPRRSDPLVKSR
                     RPSLGELLLRHAHSPTRARQAAQLVLQPGRDGAGLGLSGGSPGASTPVLLTRGGAPER
                     QGEALRVKNAVYCAVIFPEFLKELAAISQAHAVTSPFLLETSEEGSGPLISGCGPLNP
                     "
     exon            423..1061
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1220
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1307
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1475
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1555
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1719
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..2499
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2678
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2841
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3364
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3346..3351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /note="hexamer: TATAAA"
     polyA_site      3364
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcgcttg agaagcgatg gcggcggcct gaactcacct aacaccgcag cagcaaccgg
       61 gcccggccag gttcggcgtt ccgtgagtga acgatttaga aatctggact ggccagtgac
      121 ctctgggctt gccattccag cctggtataa cctctggctc catgggcagc tactggctcc
      181 tacagaccgg atgaagcaga ctggagacac aagtggagaa aacctccagc tggcaaatcc
      241 tcagagtgta ggcctctggc tgccagtcct gcccagcctg cctcatggag aggatgaatt
      301 ggctgagcag actggcctcc cggggccctg ggcaccgtat acctcaaggg gccaatctcc
      361 aaaccccagt catggctgat cccgagacct gcctcatggt cttcaagaat cactggtccc
      421 aggtggtgcg aatcctggag cggcaaggcc ctcgggcagc tcctgggggt gcagacgatc
      481 tcagtgctgt gcgcaaccac acttaccaga tgttgacact gctggcagag gaccgtgcag
      541 ttccctcggc ccccacaggc cctgggcccc tgctggagtt tgctctgcac gaggatctgc
      601 tgacccgtgt gttgacatgg cagctgcaat gggatgagct tggggatggg gtcgaggaac
      661 ggcgggctga gcaactgaaa ctatttgaaa tgctagtgag cgaagctcgc cagccactgt
      721 tgcggcatgg tccagttcgt gaggctctgc tcaccctgct ggatgcctgt ggccgccctg
      781 tgcccagtag cccagcactg gatgaaggct tggtgctact tctcagccag ctgtgtgttt
      841 gtgtggccca ggagccttca ttgctcgagt tcttcctgca gccacctcct gagcctggag
      901 ccgctccccg tcttcttctc ttttctcgcc ttgtcccttt tgtgcatcga gagggcaccc
      961 tgggccagca ggcccgtgat gccctacttc ttctcatggc tttgtcagct gggagcccca
     1021 ctgtgggccg ctacatcgcg gatcactctt acttctgccc ggtgctggcc acagggctca
     1081 gtgccctgta ctcatcactg cctcgaaaga ttgaggttcc aggggatgat tggcactgtc
     1141 tgcgacggga agactggctg ggagtgccag cccttgcact cttcatgagt tccctggagt
     1201 tctgcaatgc agtaattcag gtggctcacc ccctggtgca gaagcagttg gttgattata
     1261 tccataatgg gttcctggtg cctgtcatgg gtcctgcctt gcacaagacc tctgtggagg
     1321 agatgatcgc cagtaccgcc tatctggaac ttttcctacg gagtatctca gagcctgctt
     1381 tgctccgtac cttcctgcga ttcctgttgt tgcaccggca tgacacccac accatcctcg
     1441 acaccctcgt tgctcgtatt ggcagtaact cccggctctg catggtctct ctgagtctct
     1501 tcaggaccct cctgaacctc agctgtgagg atgtcctgct gcagctggtt ctcaggtatc
     1561 ttgttccatg taaccacgtt atgctgagcc agaagccggc tgttcgtgat gtggacctat
     1621 atggacgagc agctgacaag tttctctccc taatcccacg ctgttgtcgg caccacgccc
     1681 ccagcccacc tcgtccagag catgcctcat gggcacgagg tcctggaagc ccaagtgtgg
     1741 actcctcttc tgtgacgaca gtaccccggc cctccacacc atctcgtctg gctctcttcc
     1801 tgcggcagca gagcctgggt ggctctgagt ctccaggccc agccccttgc tcaccagggc
     1861 tttctgcatc ccccgcctcc agccctggcc gacggcctac ccctgcagag gagcctggag
     1921 agctggaaga caattacctg gagtatctgc gtgaggcacg tcgtggtgtg gaccgctgtg
     1981 tccgagcctg ccgtacctgg tctgccccct atgatggcga gcggccctct cctgagccca
     2041 gtccttttgg ctcccggact aagaaacgca gcctactgcc tgaggaggac aggaacaacg
     2101 tgggggaagg ggaggaggaa gagctgggga ggagggggcg ggctgggggt gcaggggagg
     2161 gccctggtca cctgccccct ccccagctca atggagtgcc aggatcatgg cctgaggggg
     2221 ccaagaaggt tcgtctggtg ccaaaggagg gagctgggga actgctagag ggcatctccg
     2281 agggcatggc aggactagag ggctttgggc aggagctccg ggagctagag gtggcattga
     2341 gcaatggggg aactggctca gagtccccct tagaacctcc actgcccctt gaggaggagg
     2401 aggcctacga gagcttcacc tgtccccctg agccccctgg ccccttcctc agcagccctt
     2461 tgcggactct caaccagctg ccaagccagc ccttcactgg ccccttcatg gctgtgctct
     2521 ttgccaaact cgagaacatg ctgcagaact ccgtctatgt caacttcctg ctgacggggc
     2581 tggtggccca gctggcctgt cacccccagc ccctgctccg ctctttcctg ctcaacacca
     2641 acatggtctt ccagcccagt gtcaagtccc tgctgcaggt gctgggctct gtgaagaata
     2701 agattgagaa ctttgcggct tcccaggagg acttcccagc actgctgtcc aaagccaaga
     2761 agtacctcat tgcccgtggc aagttggact gggctgaggg ccctgcagca ggacctgccc
     2821 cacgccgttc tgatccccta gtgaagagcc ggaggccatc cttgggggag ttactcctgc
     2881 ggcatgcaca cagtccaacc agggcccggc aggcggcaca attggtcctt cagcctgggc
     2941 gagacggagc aggacttggc ctaagtgggg gctcccctgg ggcttcaact ccagttctac
     3001 tcacccgggg cggggcccct gaacgccaag gtgaggctct tcgagtcaag aatgctgtct
     3061 actgtgcagt cattttccct gaatttctca aggagttggc tgccatctcc caggctcatg
     3121 ccgtcacctc gcctttcttg ttggagactt cagaggaagg atctggccct ctcatctcag
     3181 gctgtgggcc cctcaatcct taactttctt ccatggacaa tcagggccat gggtggcccg
     3241 ggctggggct agggcacagg ctccttttta tgtttggagg cagtggcaaa aggacttttt
     3301 aatttatttc agatgaatgt tttatggaga acttgttgca atatgtataa aagggaaatc
     3361 tcta
//
