LOCUS       NM_033393               6593 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens FH2 domain containing 1 (FHDC1), transcript variant 1,
            mRNA.
ACCESSION   NM_033393 XM_005263319 XM_034262
VERSION     NM_033393.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6593)
  AUTHORS   Wang,S., Wang,Y., Lu,J. and Wang,J.
  TITLE     LncRNA LINC00665 Promotes Ovarian Cancer Cell Proliferation and
            Inhibits Apoptosis via Targeting miR-181a-5p/FHDC
  JOURNAL   Appl Biochem Biotechnol 194 (9), 3819-3832 (2022)
   PUBMED   35524876
  REMARK    GeneRIF: LncRNA LINC00665 Promotes Ovarian Cancer Cell
            Proliferation and Inhibits Apoptosis via Targeting
            miR-181a-5p/FHDC.
REFERENCE   2  (bases 1 to 6593)
  AUTHORS   Copeland,S.J., McRae,A., Guarguaglini,G., Trinkle-Mulcahy,L. and
            Copeland,J.W.
  TITLE     Actin-dependent regulation of cilia length by the inverted formin
            FHDC1
  JOURNAL   Mol Biol Cell 29 (13), 1611-1627 (2018)
   PUBMED   29742020
REFERENCE   3  (bases 1 to 6593)
  AUTHORS   Copeland,S.J., Thurston,S.F. and Copeland,J.W.
  TITLE     Actin- and microtubule-dependent regulation of Golgi morphology by
            FHDC1
  JOURNAL   Mol Biol Cell 27 (2), 260-276 (2016)
   PUBMED   26564798
REFERENCE   4  (bases 1 to 6593)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 6593)
  AUTHORS   Young,K.G., Thurston,S.F., Copeland,S., Smallwood,C. and
            Copeland,J.W.
  TITLE     INF1 is a novel microtubule-associated formin
  JOURNAL   Mol Biol Cell 19 (12), 5168-5180 (2008)
   PUBMED   18815276
REFERENCE   6  (bases 1 to 6593)
  AUTHORS   Schymick,J.C., Scholz,S.W., Fung,H.C., Britton,A., Arepalli,S.,
            Gibbs,J.R., Lombardo,F., Matarin,M., Kasperaviciute,D.,
            Hernandez,D.G., Crews,C., Bruijn,L., Rothstein,J., Mora,G.,
            Restagno,G., Chio,A., Singleton,A., Hardy,J. and Traynor,B.J.
  TITLE     Genome-wide genotyping in amyotrophic lateral sclerosis and
            neurologically normal controls: first stage analysis and public
            release of data
  JOURNAL   Lancet Neurol 6 (4), 322-328 (2007)
   PUBMED   17362836
REFERENCE   7  (bases 1 to 6593)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 6593)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 6593)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FHDC1, mouse Fhdc1 and
            zebrafish fhdc1 genes in silico
  JOURNAL   Int J Mol Med 13 (6), 929-934 (2004)
   PUBMED   15138637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093599.6.
            
            On or before Aug 10, 2020 this sequence version replaced
            XM_005263319.3, NM_033393.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1258902.1,
                                           SRR7346977.2634247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC093599.6         2583-2665
            84-711              AC093599.6         7708-8335
            712-773             AC093599.6         18279-18340
            774-876             AC093599.6         18997-19099
            877-962             AC093599.6         25345-25430
            963-1063            AC093599.6         25524-25624
            1064-1134           AC093599.6         27594-27664
            1135-1242           AC093599.6         27803-27910
            1243-1313           AC093599.6         29685-29755
            1314-1431           AC093599.6         32760-32877
            1432-1596           AC093599.6         37157-37321
            1597-6593           AC093599.6         39455-44451
FEATURES             Location/Qualifiers
     source          1..6593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..6593
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /note="FH2 domain containing 1"
                     /db_xref="GeneID:85462"
                     /db_xref="HGNC:HGNC:29363"
                     /db_xref="MIM:620268"
     exon            1..83
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            84..711
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..3645
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /note="inverted formin-1"
                     /codon_start=1
                     /product="FH2 domain-containing protein 1"
                     /protein_id="NP_203751.2"
                     /db_xref="CCDS:CCDS34081.1"
                     /db_xref="GeneID:85462"
                     /db_xref="HGNC:HGNC:29363"
                     /db_xref="MIM:620268"
                     /translation="MHVMNCVSLVSDKENGNIATAPGFMIGQTPPPAPPPPPPPPPPS
                     PPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTTHMNGYSHLGKKKRMRSFFW
                     KTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSF
                     REAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPE
                     SEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDIT
                     VLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPG
                     MNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELHLLFVRTKSLKENIQ
                     RDGELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFR
                     DFCTKFNKAVKDNHDREAQELRQLQRLKEQEQKQRSWATGELGAFGRSSSENDVELLT
                     KKGAEGLLPFLHPRPISPSSPSYRPPNTRRSRLSLGPSADRELLTFLESSTGSPEEPN
                     KFHSLPRSSPRQARPTIACLEPAEVRHQDSSFAHKPQASGGQEEAPNPPSAQAHQLAA
                     AQPENHASAFPRARRQGVSVLRKRYSEPVSLGSAQSPPLSPLALGIKEHELVTGLAQF
                     NLQGSQGMEETSQLTLSDFSPMELESVGHRGPQSLSASSSSLTPMGRDALGSLSPALE
                     DGKAAPDEPGSAALGSVGSSDPENKDPRPLFCISDTTDCSLTLDCSEGTDSRPRGGDP
                     EEGGEGDGSMSSGVGEMGDSQVSSNPTSSPPGEAPAPVSVDSEPSCKGGLPRDKPTKR
                     KDVVAPKRGSLKEASPGASKPGSARRSQGAVAKSVRTLTASENESMRKVMPITKSSRG
                     AGWRRPELSSRGPSQNPPSSTDTVWSRQNSVRRASTGAEEQRLPRGSSGSSSTRPGRD
                     VPLQPRGSFKKPSAKPLRNLPRQKPEENKTCRAHSEGPESPKEEPKTPSVPSVPHELP
                     RVPSFARNTVASSSRSMRTDLPPVAKAPGITRTVSQRQLRVKGDPEDAAPKDSSTLRR
                     ASSARAPKKRPESAEGPSANTEAPLKARGAGERASLRRKDSSRTTLGRILNPLRK"
     exon            712..773
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..876
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..962
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1063
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1134
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1242
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1313
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1431
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1596
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..6593
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6572..6577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /note="hexamer: AATAAA"
     polyA_site      6593
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /note="major polyA site"
ORIGIN      
        1 actcgcgttc agtttgctga ccccagcgcg gctccccggg gattcgcggc ccagccggtg
       61 gcggctgagc cggtggcttg ttggtttgga agaggacagt tgccctttat tctggcggca
      121 gatagcagca ggtgaaaaag tgctacacaa gtttgatgtt tgtgtcttct tctccaaggc
      181 caagaaatta tctccatagg aggcaacagt actatgcatg ttatgaattg tgtctccttg
      241 gtcagtgata aagaaaatgg gaatattgcc acagcacctg gattcatgat tgggcagaca
      301 cctcctccag cacctcctcc acctcctcct ccaccccctc catctccacc atgttcatgt
      361 tcaagggaag agtgtccttc ctcccctcct ccacccccac cacctccact tcctggggag
      421 cctcccatcc cacctccccc accaggccta cccccaacta ctcacatgaa cggctacagc
      481 caccttggta agaaaaagcg gatgagaagc tttttttgga aaactattcc ggaggagcaa
      541 gttcgaggca aaaccaacat ctggaccttg gcagccaggc aggaacatca ctaccaaatt
      601 gatacaaaga ccattgagga gctctttggg cagcaggaag acaccaccaa gtcttccctt
      661 cctaggagag gaagaacttt aaattcatcc ttcagagaag ctcgagaaga gattactatt
      721 ttggatgcaa aacggagcat gaacattggg atatttctta agcaatttaa gaagtctcct
      781 cggtccattg tagaagatat tcatcaagga aaaagtgagc attatggatc agagaccttg
      841 cgagaatttc ttaagttttt gccagagtca gaagaggtaa agaagttaaa agcgtttagt
      901 ggcgacgtgt cgaagctgtc tctggcagat tcctttctgt atggcttaat tcaggtgcca
      961 aactattcac ttcggattga agccatggtg ctaaagaagg aatttctacc ttcttgctct
     1021 tctctatata cagatataac agttttaaga actgctataa aagaactgat gtcatgtgaa
     1081 gagctacatt caatattaca cttggtgctc caggctggga atatcatgaa tgcaggaggg
     1141 tatgccggca atgcagtagg atttaaactg tcttctttgc tcaaattggc agacacaaaa
     1201 gcaaacaaac ctgggatgaa tctcctgcac tttgttgcac aggaagccca aaagaaagat
     1261 accattcttc taaacttttc agaaaaattg catcatgttc agaagactgc tagattatct
     1321 ctggagaaca cggaggcaga actgcacttg ctgtttgtca ggacaaaatc actaaaagaa
     1381 aacatccagc gggatggtga actttgtcag cagatggaag attttcttca gtttgccata
     1441 gaaaagctga gggaactgga atgctggaaa caagagctcc aggatgaggc ctacaccctt
     1501 atagattttt tctgtgaaga caaaaaaacc atgaaactgg atgaatgctt tcagatattt
     1561 agagatttct gtaccaaatt caacaaagca gttaaggaca accacgaccg ggaggcgcag
     1621 gagctgaggc agctgcagag gctgaaggag caggagcaga agcagcgctc ctgggcaact
     1681 ggggagctgg gggcatttgg ccggagcagc agtgagaatg atgtggagct gctgaccaag
     1741 aagggtgcag agggcctgct ccctttcctg caccccaggc ccatcagccc ctccagcccc
     1801 tcctaccggc ccccgaacac ccgccgctcc cgcctctccc tgggtccctc tgctgaccgg
     1861 gagctgctga ccttcttgga gagctccacc ggcagccctg aggagcccaa taagttccac
     1921 agcctgcccc ggagcagccc ccggcaggcc cggcccacga tagcctgcct ggagcctgca
     1981 gaagtgaggc accaggactc cagctttgca cacaaacctc aggcctcggg gggccaggag
     2041 gaggccccca acccaccctc agcacaggcg caccagcttg cagccgccca gcctgagaac
     2101 catgcctctg ccttccccag agctcggcgc cagggcgtca gtgtcctccg aaagaggtac
     2161 agtgagccgg tgagcctggg ctcagcacag tcccctcctc tctcgccatt ggctctggga
     2221 attaaggagc atgagctggt gacagggctg gcccagttca acctccaggg ttcccagggc
     2281 atggaggaga cctcccagct gactctgagt gacttcagcc cgatggagct agagtctgtg
     2341 gggcataggg gcccgcagtc cctcagtgcc agcagcagca gcctgacacc catgggcaga
     2401 gatgccctgg ggagtctcag cccagcgctg gaggatggca aggctgcccc cgatgagcct
     2461 ggaagtgcag ctttgggatc tgtgggtagc agcgaccctg agaacaaaga tcctagacct
     2521 ctgttctgca tctcggacac caccgactgc tcactgaccc tggactgctc agagggaacc
     2581 gactccagac ccagaggcgg ggacccggag gaaggcgggg aaggggatgg ctccatgtcc
     2641 tctggggttg gagaaatggg ggacagccaa gtctcctcca accctacatc cagcccccct
     2701 ggggaggctc ctgcccccgt ctctgtggat agtgagccca gctgcaaggg cggcctgccc
     2761 agggacaaac ccaccaaaag gaaagatgtt gtagcaccaa agagaggctc cctgaaagag
     2821 gcgtctcccg gggcctccaa gcccgggagc gcccggcgga gccagggggc agtggccaag
     2881 tctgtgcgga ccctgaccgc ctcagagaac gagagcatgc gcaaggtcat gcccatcacc
     2941 aagtccagca gaggcgccgg ctggaggcga ccagagctgt catcccgggg gccctcccag
     3001 aatcccccca gcagcacaga tactgtgtgg tcacgccaga actccgtgcg gagggcctcc
     3061 acaggcgccg aagagcagag gctgccgcgg gggagcagcg gctccagcag cacccgtccg
     3121 gggagggacg ttcccctgca gcccaggggt tctttcaaga agcccagtgc caaaccactc
     3181 aggaacctcc ccagacagaa gcctgaggaa aataagacct gccgcgccca ctccgagggc
     3241 cctgagagtc ccaaagaaga gcccaagacc ccgtcagtgc ccagcgtccc ccacgaacta
     3301 ccccgtgtcc cgagctttgc ccggaacaca gtggcctcct cctctcgaag catgagaaca
     3361 gatcttcctc ccgtggccaa agcccccggc atcactcgga cagtgtcgca gcggcagctg
     3421 agggtgaaag gggaccccga ggatgccgct cccaaggaca gcagcacttt gaggcgagcc
     3481 agcagtgccc gggcccccaa gaagcgccca gagtctgcgg agggtcccag tgccaacacg
     3541 gaggcccctc tgaaggccag aggggctggg gaaagggcct ccctccgtcg gaaggactcc
     3601 agtcggacca cgctggggag aatcctcaat cccttacgga agtgatgggt gcctgtcctc
     3661 tcctgcctcc tgggattcag acggtgaaga ctgacttctg ggacgaggat ggggaaagag
     3721 gcagcatgtc tttgttacag ataaagcagc cactggtgcc actgctagtg acgctgttgg
     3781 gatggcacag tccaggaggc ctgtggactg cagcctgctg tgctgagccc tgctgcagtc
     3841 cagcgtccag atggatgcac gttcactact gtgacggccg cacctccccc atgcacccca
     3901 ccctccccca aagcccggat cccgagaaag atttagtagg agtgtaaagt gacattctta
     3961 tgaaacaagt caaaaaagtt tttttcaggc cagtttttat atatcaaaga ctttcttttt
     4021 aatataaaaa ttagctaggt gcagtggttc atgcctgtaa tccagcactt tgggaggcta
     4081 agatgagtgg attgcttgag cctaggagtt cgagaccagc ctaggcaaca tggagaaacc
     4141 ccgtctctat cagaaataca aaatttagcc gagtgtggtg gcacatgcct gtggccccag
     4201 ccactctgaa cgctgagatg ggaaggtcac ttgagcccag gaccccacca ctgcactcca
     4261 gcctggatga cagagtgaga ccttgtctca aacaaaacaa aacaaaaatg aaatgttcta
     4321 gttttggttc cttttgcaga gtgaaatgcc tcccaggaaa aaaatacata tgtatttttt
     4381 tgcgacaggg tcgtgctctt gtctcccaga ctggactgca gtggcacaat catagctcac
     4441 tgcagctttg acctcccaga cccaagtgat cctcccacct cagcctccct cagagctggg
     4501 actacaggcg tgcaccacca cgcctggtta attgtttttt tttaatttat cttttgtaga
     4561 gatgggatct cactatgttg ctcaggctga tctcgagctc ctgggctcaa gtgatcctcc
     4621 cacctcagcc tcccaaagtg ctgggattac aggtgtgagc caccacactt ggccagtata
     4681 tcctcagtat gaagatattt ttatcttcct gtgttctctg gcttcagagt ttcacctgcc
     4741 cacacagggt ccgttgctgg caactggact tccccataag ccttgggtat cctgtgatgg
     4801 gctgtgtctc cctgaagatt gtctggcttg cccacttctc cgtgcatgac tctgggtgtg
     4861 agtctgtcta ggaacaggag ggaaagttgg actcagacag aaatcagatg cttccatgta
     4921 ttcagggcgc gcattgtgag cagtggagta tgagccttga gggcctcatg gttgcagggc
     4981 aggcttccct gcagatgggt ggcagcccct ggtagaatgc tggatttctc tggaatctag
     5041 aagtgccata ttttagtgga aaggcatcag ggctgtttga cagtgtgcgt ctttccaatc
     5101 ccatgttcct ccattcgtgt gtctgttata aaactgagtg aaggctgcta tgacctgtgt
     5161 tcactctggt tacagggagg tgcaaaccat tctgtctccc agcctttctt ctctctttgt
     5221 gtgctcccag cacttccttc ttttctaaca tggcctggag agagtctctc tctccttgtc
     5281 tctgtctctt aataatagtt tttaacgtgg acatctcttc cttggtacag tggtttttaa
     5341 atactgagaa gaaccaagtc aggtttttta aagcagacta aaagcatgaa attgctttca
     5401 gaagaatgta tatcatcggg aaaagttcgg gggcagagtg ggggaatcag gctttattca
     5461 aaagaaacag ttgaaaacat gggacttttt ctacccaatg cccatttcac gactcctctg
     5521 agactaattg ggaaacgggg aaattcttgg aatttttttt ttaagaaact tttttgtgtt
     5581 ttttttaatt ttaggtcact tattagtgaa acctcatttt agatctgaca ttggtagata
     5641 gatggattta ggcaaatatg atgcgtttgt ggggaatcca cgtggttgac gttagaacct
     5701 cccttctgca gactgttgcc tgtcatctaa gcgaattgga aatgctgagc ttccataagt
     5761 cagctgagtt ttaaaggtaa acgttatggc tgaaatagta aagcacctga ccacaaaacc
     5821 tcttgtaaaa acagccctga gtaggtattt ccagggctcc acaaagttgc ttatgggaat
     5881 cctgagctgc ttttcaccat ctcaagaagc ctaagaagtt atatatttaa tcaggtagac
     5941 aaaacagttc aaagcataag gtccatggtg gtggaaaatg gatgcaagtg attctaagtt
     6001 tgtggatttg tggatagcag agggatcggg acctcttgga ggaaccctgg gtaccaagct
     6061 cccaggccct tcctctatca tggatgctgg gtgactttgg gaagtcacca cctcttccca
     6121 agcctgtttc ccatatcaca gatgtggggc catggcctcg atgatggtct ccacaggtct
     6181 ttccacctct gtgagtccaa gtcaggtcaa tcagcaagga cccatctctg ccctgggtca
     6241 gctcctcaga accaaccccc agcatctcta aagcaaaagc ctcacctcaa gggctgctca
     6301 gaagagagca ccttcagcat gagttgttgc tggaagatct aataagctgt gtttcctggg
     6361 aagtggtgct ttacttagcc ctgtggacaa cttctctatg catctgtgtg agcagatgat
     6421 cattgtatta ccttttatcg gtagtaagct tggaaaaata atttaagaat acaatggaga
     6481 aatgtaaata agtatctatg taaatttgtt taaaataaac tgaatgtatt taatggtcca
     6541 tttatatgtt cttttatgta acatgtagtt taataaagtt cctgtttatg aga
//
