LOCUS       NM_001371116            6597 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens FH2 domain containing 1 (FHDC1), transcript variant 2,
            mRNA.
ACCESSION   NM_001371116 XM_006714393
VERSION     NM_001371116.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6597)
  AUTHORS   Wang,S., Wang,Y., Lu,J. and Wang,J.
  TITLE     LncRNA LINC00665 Promotes Ovarian Cancer Cell Proliferation and
            Inhibits Apoptosis via Targeting miR-181a-5p/FHDC
  JOURNAL   Appl Biochem Biotechnol 194 (9), 3819-3832 (2022)
   PUBMED   35524876
  REMARK    GeneRIF: LncRNA LINC00665 Promotes Ovarian Cancer Cell
            Proliferation and Inhibits Apoptosis via Targeting
            miR-181a-5p/FHDC.
REFERENCE   2  (bases 1 to 6597)
  AUTHORS   Copeland,S.J., McRae,A., Guarguaglini,G., Trinkle-Mulcahy,L. and
            Copeland,J.W.
  TITLE     Actin-dependent regulation of cilia length by the inverted formin
            FHDC1
  JOURNAL   Mol Biol Cell 29 (13), 1611-1627 (2018)
   PUBMED   29742020
REFERENCE   3  (bases 1 to 6597)
  AUTHORS   Copeland,S.J., Thurston,S.F. and Copeland,J.W.
  TITLE     Actin- and microtubule-dependent regulation of Golgi morphology by
            FHDC1
  JOURNAL   Mol Biol Cell 27 (2), 260-276 (2016)
   PUBMED   26564798
REFERENCE   4  (bases 1 to 6597)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 6597)
  AUTHORS   Young,K.G., Thurston,S.F., Copeland,S., Smallwood,C. and
            Copeland,J.W.
  TITLE     INF1 is a novel microtubule-associated formin
  JOURNAL   Mol Biol Cell 19 (12), 5168-5180 (2008)
   PUBMED   18815276
REFERENCE   6  (bases 1 to 6597)
  AUTHORS   Schymick,J.C., Scholz,S.W., Fung,H.C., Britton,A., Arepalli,S.,
            Gibbs,J.R., Lombardo,F., Matarin,M., Kasperaviciute,D.,
            Hernandez,D.G., Crews,C., Bruijn,L., Rothstein,J., Mora,G.,
            Restagno,G., Chio,A., Singleton,A., Hardy,J. and Traynor,B.J.
  TITLE     Genome-wide genotyping in amyotrophic lateral sclerosis and
            neurologically normal controls: first stage analysis and public
            release of data
  JOURNAL   Lancet Neurol 6 (4), 322-328 (2007)
   PUBMED   17362836
REFERENCE   7  (bases 1 to 6597)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 6597)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 6597)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FHDC1, mouse Fhdc1 and
            zebrafish fhdc1 genes in silico
  JOURNAL   Int J Mol Med 13 (6), 929-934 (2004)
   PUBMED   15138637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093599.6.
            
            On Jun 28, 2019 this sequence version replaced XM_006714393.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1477519.1,
                                           SRR14038196.3432709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000511601.6/ ENSP00000427567.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC093599.6         1103-1189
            88-715              AC093599.6         7708-8335
            716-777             AC093599.6         18279-18340
            778-880             AC093599.6         18997-19099
            881-966             AC093599.6         25345-25430
            967-1067            AC093599.6         25524-25624
            1068-1138           AC093599.6         27594-27664
            1139-1246           AC093599.6         27803-27910
            1247-1317           AC093599.6         29685-29755
            1318-1435           AC093599.6         32760-32877
            1436-1600           AC093599.6         37157-37321
            1601-6597           AC093599.6         39455-44451
FEATURES             Location/Qualifiers
     source          1..6597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..6597
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /note="FH2 domain containing 1"
                     /db_xref="GeneID:85462"
                     /db_xref="HGNC:HGNC:29363"
                     /db_xref="MIM:620268"
     exon            1..87
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..715
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..3649
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /note="inverted formin-1"
                     /codon_start=1
                     /product="FH2 domain-containing protein 1"
                     /protein_id="NP_001358045.1"
                     /db_xref="CCDS:CCDS34081.1"
                     /db_xref="GeneID:85462"
                     /db_xref="HGNC:HGNC:29363"
                     /db_xref="MIM:620268"
                     /translation="MHVMNCVSLVSDKENGNIATAPGFMIGQTPPPAPPPPPPPPPPS
                     PPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTTHMNGYSHLGKKKRMRSFFW
                     KTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSF
                     REAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPE
                     SEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDIT
                     VLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPG
                     MNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELHLLFVRTKSLKENIQ
                     RDGELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFR
                     DFCTKFNKAVKDNHDREAQELRQLQRLKEQEQKQRSWATGELGAFGRSSSENDVELLT
                     KKGAEGLLPFLHPRPISPSSPSYRPPNTRRSRLSLGPSADRELLTFLESSTGSPEEPN
                     KFHSLPRSSPRQARPTIACLEPAEVRHQDSSFAHKPQASGGQEEAPNPPSAQAHQLAA
                     AQPENHASAFPRARRQGVSVLRKRYSEPVSLGSAQSPPLSPLALGIKEHELVTGLAQF
                     NLQGSQGMEETSQLTLSDFSPMELESVGHRGPQSLSASSSSLTPMGRDALGSLSPALE
                     DGKAAPDEPGSAALGSVGSSDPENKDPRPLFCISDTTDCSLTLDCSEGTDSRPRGGDP
                     EEGGEGDGSMSSGVGEMGDSQVSSNPTSSPPGEAPAPVSVDSEPSCKGGLPRDKPTKR
                     KDVVAPKRGSLKEASPGASKPGSARRSQGAVAKSVRTLTASENESMRKVMPITKSSRG
                     AGWRRPELSSRGPSQNPPSSTDTVWSRQNSVRRASTGAEEQRLPRGSSGSSSTRPGRD
                     VPLQPRGSFKKPSAKPLRNLPRQKPEENKTCRAHSEGPESPKEEPKTPSVPSVPHELP
                     RVPSFARNTVASSSRSMRTDLPPVAKAPGITRTVSQRQLRVKGDPEDAAPKDSSTLRR
                     ASSARAPKKRPESAEGPSANTEAPLKARGAGERASLRRKDSSRTTLGRILNPLRK"
     exon            716..777
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..880
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..966
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1067
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1138
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1246
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1317
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1435
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1600
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..6597
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6576..6581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /note="hexamer: AATAAA"
     polyA_site      6597
                     /gene="FHDC1"
                     /gene_synonym="INF1"
                     /note="major polyA site"
ORIGIN      
        1 agtgaccggg aggaggcggc tacgccgaca caacggcggg aggctgcagc ggtctgcgcg
       61 ccgggagcgg gggcgcgctg gccgcgggtt tggaagagga cagttgccct ttattctggc
      121 ggcagatagc agcaggtgaa aaagtgctac acaagtttga tgtttgtgtc ttcttctcca
      181 aggccaagaa attatctcca taggaggcaa cagtactatg catgttatga attgtgtctc
      241 cttggtcagt gataaagaaa atgggaatat tgccacagca cctggattca tgattgggca
      301 gacacctcct ccagcacctc ctccacctcc tcctccaccc cctccatctc caccatgttc
      361 atgttcaagg gaagagtgtc cttcctcccc tcctccaccc ccaccacctc cacttcctgg
      421 ggagcctccc atcccacctc ccccaccagg cctaccccca actactcaca tgaacggcta
      481 cagccacctt ggtaagaaaa agcggatgag aagctttttt tggaaaacta ttccggagga
      541 gcaagttcga ggcaaaacca acatctggac cttggcagcc aggcaggaac atcactacca
      601 aattgataca aagaccattg aggagctctt tgggcagcag gaagacacca ccaagtcttc
      661 ccttcctagg agaggaagaa ctttaaattc atccttcaga gaagctcgag aagagattac
      721 tattttggat gcaaaacgga gcatgaacat tgggatattt cttaagcaat ttaagaagtc
      781 tcctcggtcc attgtagaag atattcatca aggaaaaagt gagcattatg gatcagagac
      841 cttgcgagaa tttcttaagt ttttgccaga gtcagaagag gtaaagaagt taaaagcgtt
      901 tagtggcgac gtgtcgaagc tgtctctggc agattccttt ctgtatggct taattcaggt
      961 gccaaactat tcacttcgga ttgaagccat ggtgctaaag aaggaatttc taccttcttg
     1021 ctcttctcta tatacagata taacagtttt aagaactgct ataaaagaac tgatgtcatg
     1081 tgaagagcta cattcaatat tacacttggt gctccaggct gggaatatca tgaatgcagg
     1141 agggtatgcc ggcaatgcag taggatttaa actgtcttct ttgctcaaat tggcagacac
     1201 aaaagcaaac aaacctggga tgaatctcct gcactttgtt gcacaggaag cccaaaagaa
     1261 agataccatt cttctaaact tttcagaaaa attgcatcat gttcagaaga ctgctagatt
     1321 atctctggag aacacggagg cagaactgca cttgctgttt gtcaggacaa aatcactaaa
     1381 agaaaacatc cagcgggatg gtgaactttg tcagcagatg gaagattttc ttcagtttgc
     1441 catagaaaag ctgagggaac tggaatgctg gaaacaagag ctccaggatg aggcctacac
     1501 ccttatagat tttttctgtg aagacaaaaa aaccatgaaa ctggatgaat gctttcagat
     1561 atttagagat ttctgtacca aattcaacaa agcagttaag gacaaccacg accgggaggc
     1621 gcaggagctg aggcagctgc agaggctgaa ggagcaggag cagaagcagc gctcctgggc
     1681 aactggggag ctgggggcat ttggccggag cagcagtgag aatgatgtgg agctgctgac
     1741 caagaagggt gcagagggcc tgctcccttt cctgcacccc aggcccatca gcccctccag
     1801 cccctcctac cggcccccga acacccgccg ctcccgcctc tccctgggtc cctctgctga
     1861 ccgggagctg ctgaccttct tggagagctc caccggcagc cctgaggagc ccaataagtt
     1921 ccacagcctg ccccggagca gcccccggca ggcccggccc acgatagcct gcctggagcc
     1981 tgcagaagtg aggcaccagg actccagctt tgcacacaaa cctcaggcct cggggggcca
     2041 ggaggaggcc cccaacccac cctcagcaca ggcgcaccag cttgcagccg cccagcctga
     2101 gaaccatgcc tctgccttcc ccagagctcg gcgccagggc gtcagtgtcc tccgaaagag
     2161 gtacagtgag ccggtgagcc tgggctcagc acagtcccct cctctctcgc cattggctct
     2221 gggaattaag gagcatgagc tggtgacagg gctggcccag ttcaacctcc agggttccca
     2281 gggcatggag gagacctccc agctgactct gagtgacttc agcccgatgg agctagagtc
     2341 tgtggggcat aggggcccgc agtccctcag tgccagcagc agcagcctga cacccatggg
     2401 cagagatgcc ctggggagtc tcagcccagc gctggaggat ggcaaggctg cccccgatga
     2461 gcctggaagt gcagctttgg gatctgtggg tagcagcgac cctgagaaca aagatcctag
     2521 acctctgttc tgcatctcgg acaccaccga ctgctcactg accctggact gctcagaggg
     2581 aaccgactcc agacccagag gcggggaccc ggaggaaggc ggggaagggg atggctccat
     2641 gtcctctggg gttggagaaa tgggggacag ccaagtctcc tccaacccta catccagccc
     2701 ccctggggag gctcctgccc ccgtctctgt ggatagtgag cccagctgca agggcggcct
     2761 gcccagggac aaacccacca aaaggaaaga tgttgtagca ccaaagagag gctccctgaa
     2821 agaggcgtct cccggggcct ccaagcccgg gagcgcccgg cggagccagg gggcagtggc
     2881 caagtctgtg cggaccctga ccgcctcaga gaacgagagc atgcgcaagg tcatgcccat
     2941 caccaagtcc agcagaggcg ccggctggag gcgaccagag ctgtcatccc gggggccctc
     3001 ccagaatccc cccagcagca cagatactgt gtggtcacgc cagaactccg tgcggagggc
     3061 ctccacaggc gccgaagagc agaggctgcc gcgggggagc agcggctcca gcagcacccg
     3121 tccggggagg gacgttcccc tgcagcccag gggttctttc aagaagccca gtgccaaacc
     3181 actcaggaac ctccccagac agaagcctga ggaaaataag acctgccgcg cccactccga
     3241 gggccctgag agtcccaaag aagagcccaa gaccccgtca gtgcccagcg tcccccacga
     3301 actaccccgt gtcccgagct ttgcccggaa cacagtggcc tcctcctctc gaagcatgag
     3361 aacagatctt cctcccgtgg ccaaagcccc cggcatcact cggacagtgt cgcagcggca
     3421 gctgagggtg aaaggggacc ccgaggatgc cgctcccaag gacagcagca ctttgaggcg
     3481 agccagcagt gcccgggccc ccaagaagcg cccagagtct gcggagggtc ccagtgccaa
     3541 cacggaggcc cctctgaagg ccagaggggc tggggaaagg gcctccctcc gtcggaagga
     3601 ctccagtcgg accacgctgg ggagaatcct caatccctta cggaagtgat gggtgcctgt
     3661 cctctcctgc ctcctgggat tcagacggtg aagactgact tctgggacga ggatggggaa
     3721 agaggcagca tgtctttgtt acagataaag cagccactgg tgccactgct agtgacgctg
     3781 ttgggatggc acagtccagg aggcctgtgg actgcagcct gctgtgctga gccctgctgc
     3841 agtccagcgt ccagatggat gcacgttcac tactgtgacg gccgcacctc ccccatgcac
     3901 cccaccctcc cccaaagccc ggatcccgag aaagatttag taggagtgta aagtgacatt
     3961 cttatgaaac aagtcaaaaa agtttttttc aggccagttt ttatatatca aagactttct
     4021 ttttaatata aaaattagct aggtgcagtg gttcatgcct gtaatccagc actttgggag
     4081 gctaagatga gtggattgct tgagcctagg agttcgagac cagcctaggc aacatggaga
     4141 aaccccgtct ctatcagaaa tacaaaattt agccgagtgt ggtggcacat gcctgtggcc
     4201 ccagccactc tgaacgctga gatgggaagg tcacttgagc ccaggacccc accactgcac
     4261 tccagcctgg atgacagagt gagaccttgt ctcaaacaaa acaaaacaaa aatgaaatgt
     4321 tctagttttg gttccttttg cagagtgaaa tgcctcccag gaaaaaaata catatgtatt
     4381 tttttgcgac agggtcgtgc tcttgtctcc cagactggac tgcagtggca caatcatagc
     4441 tcactgcagc tttgacctcc cagacccaag tgatcctccc acctcagcct ccctcagagc
     4501 tgggactaca ggcgtgcacc accacgcctg gttaattgtt tttttttaat ttatcttttg
     4561 tagagatggg atctcactat gttgctcagg ctgatctcga gctcctgggc tcaagtgatc
     4621 ctcccacctc agcctcccaa agtgctggga ttacaggtgt gagccaccac acttggccag
     4681 tatatcctca gtatgaagat atttttatct tcctgtgttc tctggcttca gagtttcacc
     4741 tgcccacaca gggtccgttg ctggcaactg gacttcccca taagccttgg gtatcctgtg
     4801 atgggctgtg tctccctgaa gattgtctgg cttgcccact tctccgtgca tgactctggg
     4861 tgtgagtctg tctaggaaca ggagggaaag ttggactcag acagaaatca gatgcttcca
     4921 tgtattcagg gcgcgcattg tgagcagtgg agtatgagcc ttgagggcct catggttgca
     4981 gggcaggctt ccctgcagat gggtggcagc ccctggtaga atgctggatt tctctggaat
     5041 ctagaagtgc catattttag tggaaaggca tcagggctgt ttgacagtgt gcgtctttcc
     5101 aatcccatgt tcctccattc gtgtgtctgt tataaaactg agtgaaggct gctatgacct
     5161 gtgttcactc tggttacagg gaggtgcaaa ccattctgtc tcccagcctt tcttctctct
     5221 ttgtgtgctc ccagcacttc cttcttttct aacatggcct ggagagagtc tctctctcct
     5281 tgtctctgtc tcttaataat agtttttaac gtggacatct cttccttggt acagtggttt
     5341 ttaaatactg agaagaacca agtcaggttt tttaaagcag actaaaagca tgaaattgct
     5401 ttcagaagaa tgtatatcat cgggaaaagt tcgggggcag agtgggggaa tcaggcttta
     5461 ttcaaaagaa acagttgaaa acatgggact ttttctaccc aatgcccatt tcacgactcc
     5521 tctgagacta attgggaaac ggggaaattc ttggaatttt ttttttaaga aacttttttg
     5581 tgtttttttt aattttaggt cacttattag tgaaacctca ttttagatct gacattggta
     5641 gatagatgga tttaggcaaa tatgatgcgt ttgtggggaa tccacgtggt tgacgttaga
     5701 acctcccttc tgcagactgt tgcctgtcat ctaagcgaat tggaaatgct gagcttccat
     5761 aagtcagctg agttttaaag gtaaacgtta tggctgaaat agtaaagcac ctgaccacaa
     5821 aacctcttgt aaaaacagcc ctgagtaggt atttccaggg ctccacaaag ttgcttatgg
     5881 gaatcctgag ctgcttttca ccatctcaag aagcctaaga agttatatat ttaatcaggt
     5941 agacaaaaca gttcaaagca taaggtccat ggtggtggaa aatggatgca agtgattcta
     6001 agtttgtgga tttgtggata gcagagggat cgggacctct tggaggaacc ctgggtacca
     6061 agctcccagg cccttcctct atcatggatg ctgggtgact ttgggaagtc accacctctt
     6121 cccaagcctg tttcccatat cacagatgtg gggccatggc ctcgatgatg gtctccacag
     6181 gtctttccac ctctgtgagt ccaagtcagg tcaatcagca aggacccatc tctgccctgg
     6241 gtcagctcct cagaaccaac ccccagcatc tctaaagcaa aagcctcacc tcaagggctg
     6301 ctcagaagag agcaccttca gcatgagttg ttgctggaag atctaataag ctgtgtttcc
     6361 tgggaagtgg tgctttactt agccctgtgg acaacttctc tatgcatctg tgtgagcaga
     6421 tgatcattgt attacctttt atcggtagta agcttggaaa aataatttaa gaatacaatg
     6481 gagaaatgta aataagtatc tatgtaaatt tgtttaaaat aaactgaatg tatttaatgg
     6541 tccatttata tgttctttta tgtaacatgt agtttaataa agttcctgtt tatgaga
//
