LOCUS       NM_001391957            5542 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens forkhead associated phosphopeptide binding domain 1
            (FHAD1), transcript variant 4, mRNA.
ACCESSION   NM_001391957
VERSION     NM_001391957.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5542)
  AUTHORS   Pineau,C., Hikmet,F., Zhang,C., Oksvold,P., Chen,S., Fagerberg,L.,
            Uhlen,M. and Lindskog,C.
  TITLE     Cell Type-Specific Expression of Testis Elevated Genes Based on
            Transcriptomics and Antibody-Based Proteomics
  JOURNAL   J Proteome Res 18 (12), 4215-4230 (2019)
   PUBMED   31429579
REFERENCE   2  (bases 1 to 5542)
  AUTHORS   Zhao,S., Geybels,M.S., Leonardson,A., Rubicz,R., Kolb,S., Yan,Q.,
            Klotzle,B., Bibikova,M., Hurtado-Coll,A., Troyer,D., Lance,R.,
            Lin,D.W., Wright,J.L., Ostrander,E.A., Fan,J.B., Feng,Z. and
            Stanford,J.L.
  TITLE     Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel
            Prognostic Biomarkers of Metastatic-Lethal Progression in Men
            Diagnosed with Clinically Localized Prostate Cancer
  JOURNAL   Clin Cancer Res 23 (1), 311-319 (2017)
   PUBMED   27358489
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL391094.12, AL158174.8 and AL031283.26.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000688493.1/ ENSP00000509124.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AL391094.12        39654-39826
            174-280             AL391094.12        44202-44308
            281-487             AL158174.8         21079-21285
            488-755             AL031283.26        9050-9317
            756-865             AL031283.26        16335-16444
            866-1102            AL031283.26        20856-21092
            1103-1226           AL031283.26        28264-28387
            1227-1357           AL031283.26        32708-32838
            1358-1447           AL031283.26        36029-36118
            1448-1552           AL031283.26        37475-37579
            1553-1660           AL031283.26        44103-44210
            1661-1744           AL031283.26        46710-46793
            1745-1897           AL031283.26        47928-48080
            1898-2093           AL031283.26        48997-49192
            2094-2164           AL031283.26        59132-59202
            2165-2317           AL031283.26        61387-61539
            2318-2425           AL031283.26        64734-64841
            2426-2533           AL031283.26        65067-65174
            2534-2641           AL031283.26        68693-68800
            2642-2749           AL031283.26        72528-72635
            2750-2923           AL031283.26        77761-77934
            2924-3149           AL031283.26        80129-80354
            3150-3234           AL031283.26        82293-82377
            3235-3341           AL031283.26        85478-85584
            3342-3501           AL031283.26        87114-87273
            3502-3634           AL031283.26        89021-89153
            3635-3764           AL031283.26        94153-94282
            3765-3892           AL031283.26        95254-95381
            3893-3988           AL031283.26        100352-100447
            3989-4209           AL031283.26        100882-101102
            4210-4375           AL031283.26        101679-101844
            4376-4456           AL031283.26        107702-107782
            4457-4510           AL031283.26        110861-110914
            4511-5542           AL031283.26        116948-117979
FEATURES             Location/Qualifiers
     source          1..5542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..5542
                     /gene="FHAD1"
                     /note="forkhead associated phosphopeptide binding domain
                     1"
                     /db_xref="GeneID:114827"
                     /db_xref="HGNC:HGNC:29408"
                     /db_xref="MIM:620889"
     exon            1..173
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            174..280
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..4627
                     /gene="FHAD1"
                     /note="isoform 4 is encoded by transcript variant 4; FHA
                     domain-containing protein 1; forkhead-associated
                     domain-containing protein 1; forkhead-associated (FHA)
                     phosphopeptide binding domain 1"
                     /codon_start=1
                     /product="forkhead-associated domain-containing protein 1
                     isoform 4"
                     /protein_id="NP_001378886.1"
                     /db_xref="CCDS:CCDS90866.1"
                     /db_xref="GeneID:114827"
                     /db_xref="HGNC:HGNC:29408"
                     /db_xref="MIM:620889"
                     /translation="MKAYLKSAEGFFVLNKSTTIGRHENSDLVLQSPDIDNHHALIEY
                     NEAECSFVLQDFNSRNGTFVNECHIQNVAVKLIPGDILRFGSAGLTYELVIENPPPVS
                     FPWMRGPAPWPGPQPPRATQQPNQAPPPSHIPFHQGVQPAPMQRSWSQAFPRPTVVLP
                     ASHRRPVSANKEMFSFVVDDARKPPVIKQVWTNAMKLSEKSVAEGIPGAVPPAEIYVE
                     EDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQ
                     NEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNE
                     GENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCS
                     VLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTL
                     REKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAK
                     PFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSL
                     DSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLR
                     DLGILPSSPNKGFSLYLIYLLEHYKKLMSQAQELQIKFNSSQETQQSLLQEKLREHLA
                     EKEKLNEERLEQEEKLKAKIRQLTEEKAALEEYITQERNRAKETLEEERKRMQELESL
                     LAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEA
                     LESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEEL
                     ELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIM
                     VEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHH
                     KKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQ
                     EVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSS
                     LVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSS
                     SQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLD
                     LKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALE
                     LSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLK
                     NQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERM
                     EHQLCQEKRINRAIRQQKESVEEHELRNAKESTPCNCAFKEKDRQRRVFVEMVKNRMQ
                     NSNSQVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPSGKY"
     exon            281..487
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..755
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..865
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1102
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1226
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1357
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1447
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1552
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1660
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1744
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1897
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2093
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2164
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2317
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2425
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2533
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2641
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2749
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2923
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3149
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3234
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3341
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3501
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3634
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..3764
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3892
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..3988
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3989..4209
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4375
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4376..4456
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4457..4510
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..5542
                     /gene="FHAD1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4730
                     /gene="FHAD1"
                     /note="major polyA site"
     polyA_site      4743
                     /gene="FHAD1"
                     /note="major polyA site"
     regulatory      4857..4862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FHAD1"
                     /note="hexamer: AATAGA"
     polyA_site      4877
                     /gene="FHAD1"
     regulatory      5521..5526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FHAD1"
                     /note="hexamer: AATAAA"
     polyA_site      5542
                     /gene="FHAD1"
ORIGIN      
        1 gttgccatgg caacgcgcgt acacaggccg gccgggcggg cggggtgccg ggtgcgagct
       61 ggagactccg cgggagcgcg gccgggaggc ttcgccccgg agctggcccg acgcctcccg
      121 agctggcagg gctctcggcg gaggtcggag cgtgggcttc ctcctcccgc cagggaaaac
      181 agagaggatg aaggcctatc taaagagcgc agaaggcttt tttgtcctaa ataaaagtac
      241 cacaattgga aggcatgaaa attcagacct tgttttacag tctcctgaca tcgacaacca
      301 ccatgcactc attgaatata acgaggcgga gtgcagcttt gttctccagg acttcaattc
      361 ccgcaacggc acgtttgtca acgagtgcca cattcaaaac gtggctgtga agctcatccc
      421 tggagacatc ctgagatttg ggtctgcagg gctgacctat gaactggtca ttgaaaatcc
      481 acctccggtc tctttcccat ggatgagggg cccagcacca tggccagggc cacagccacc
      541 tcgtgccaca cagcagccaa accaggcccc cccaccatca catatcccct tccaccaagg
      601 tgtccagcca gcaccgatgc aaaggagctg gtcccaggcc tttcccagac ccaccgtggt
      661 cctgccggcc tcccacaggc ggcctgtgag cgccaacaag gagatgttct cgttcgtggt
      721 ggacgacgcc cgcaagccac ccgtcatcaa gcaagtgtgg accaatgcca tgaaactgtc
      781 agaaaaatca gtggccgagg ggattcctgg ggcagttccc cctgcggaga tttatgtgga
      841 ggaggacttg gcccagcagg acaaggatga aataattctg ctgctgggaa aagaggtcag
      901 ccgtctctca gattatgaaa ttgaatccaa atacaaagac gtcataatag caaacctgca
      961 gaatgaagtg gctgagctga gtcagaaggt gtcagagacc accacctcca ggcagaatga
     1021 gaaggagatc tcgcagaagt gtcaggttct ggatgaagac atcgatgcca aacagaaaga
     1081 gatccagagc ttgaaaagcc agatcagtgc cctacagaaa ggctacagca aggtgctgtg
     1141 ccagaccctg tcagagcgga actcagaaat cacatccctg aagaatgagg gcgagaactt
     1201 aaagagagac aacgctatca catcagggat ggtgtcatct ttgcaaaaag acatattagc
     1261 aaaggatgag caagttcaac aactaaagga agaggtcagt cacctaaaaa gtcagaacaa
     1321 ggacaaggac caccagctgg aagcccttgg ctctagatgc tcggtgctaa aggaagagtt
     1381 aaaacaggaa gatgctcaca gggagctcag ggaagcccag gagaaagagt taaaactctg
     1441 caaaacccaa atccaagaca tggagaaaga aatgaagaag cttagggcag agctgaggaa
     1501 gagttgtact gaacaaagcg tgatctctag gactctgaga gaaaaaagca aggttgaaga
     1561 gaagcttcag gaggattcca gaaggaaatt gcttcagctg caagaaatgg ggaacagaga
     1621 gagcgtcatt aaaatcaatt tggagagggc agtaggtcag ctggagcact tcagaagtca
     1681 agtcatcaag gccacctatg gacgggcgaa gccgttccgg gacaagcccg tcaccgacca
     1741 acagttaata gagaaaatta cccaggtcac tgaggacaac atcaattttc agcagaaaaa
     1801 gtggaccctc cagaaagaga cccagctgag caactccaag caggaggaga ccaccgagaa
     1861 catcgagaag ctgaggacgt cgctggacag ctgccaggct tgcatgaaaa tatcctgttg
     1921 cagccatgac ctgaagaagg aggtcgacct tcttcagcac ctccaggtga gcccacctgt
     1981 ctcggggctc cagaaggtgg tgctggacgt cctgaggcac gcgctgtcct ggctggagga
     2041 ggtggagcag ctcctccggg acctcgggat cctgccctcc agccccaaca aagggttctc
     2101 tttgtatctg atatatcttc tggaacatta taaaaaactt atgagccagg cccaggaact
     2161 tcagatcaag ttcaacagtt ctcaggaaac tcagcagtct ttactgcagg aaaagctgcg
     2221 ggagcatctg gcagagaagg agaagctgaa cgaggagagg ctagagcaag aggagaagct
     2281 caaagccaaa atcaggcaac tgacggaaga gaaggcggct ttggaggagt acattactca
     2341 agagagaaac agagcgaaag agactttaga ggaagaacgg aagagaatgc aagaactgga
     2401 gagcctcctg gcccagcaga agaaggcttt ggcgaaaagc attacccagg agaagaacag
     2461 agtgaaggaa gcattagagg aagagcagac aagagtccaa gagctggagg aacgcttggc
     2521 ccgccagaag gaggttttgg agagcagcat agcccatgaa aaaagaaaag caaaggaagc
     2581 cttggagtcg gaaaagagaa aagttcagga tctggagaac catttaaccc aacagaagga
     2641 gatctcagag agcaacattg cgtacgagaa acgcaaagca aaggaggcca tggagaagga
     2701 aaagaaaaag gtgcaagacc tggagaatcg cttaaccaag cagaaagagg aattagaatt
     2761 aaaagagcaa aaagaggacg ttttaaataa taaattaagt gacgcactgg ccatggttga
     2821 agagactcag aaaacaaagg caactgaaag tctaaaagca gagagcctcg ccttgaaatt
     2881 aaatgaaaca ttagccgaac tggaaactac caagacaaaa atgatcatgg tggaagagcg
     2941 gctaatcctg cagcagaaga tggtaaaggc cctccaggat gagcaggaat cacagagaca
     3001 cgggtttgaa gaagagatca tggaatataa ggagcaaatc aaacagcacg cccagacaat
     3061 tgtgagcctc gaagagaaac tccagaaagt cactcagcac cataaaaaaa tagaaggcga
     3121 gattgcaaca ttgaaggaca atgacccagc cccaaaggag gaaaggccgc aagaccctct
     3181 ggtggctccc atgacagaga gcagtgccaa agacatggcg tacgaacatc tgatagatga
     3241 cttattggct gctcagaagg aaattctgtc tcagcaggaa gtcatcatga agttaaggaa
     3301 agaccttacc gaagcccaca gcagaatgtc ggatttgaga ggggagctaa acgagaagca
     3361 gaagatggaa ctggagcaga acgtggtgct ggtccagcag cagagcaagg agctgagtgt
     3421 gctcaaggag aagatggccc agatgagcag cctggtagaa aagaaagatc gggagctgaa
     3481 ggcccttgag gaggcactca gggcttccca agagaaacac agactccagc tgaacacaga
     3541 gaaggaacag aagccccgga agaagaccca gacgtgtgac acctctgtgc agatagaacc
     3601 cgtccacact gaggccttct ccagcagcca agagcagcaa tccttcagcg atctaggggt
     3661 caggtgcaaa gggtcccggc acgaggaggt cattcagcgt cagaaaaagg ccttatctga
     3721 acttcgagcg cgaattaaag aactcgagaa ggcgcgctca ccagatcata aagaccacca
     3781 gaatgaatca tttctagatt taaagaacct cagaatggaa aacaatgtcc agaaaatact
     3841 actggatgca aaaccggatt tgccaactct ctcaagaata gagatcctag cgcctcagaa
     3901 tggcctttgc aacgcaaggt tcggctcagc catggagaag tcagggaaga tggatgtggc
     3961 tgaggcttta gagctcagtg aaaagctgta cctggatatg agcaaaaccc tcggaagtct
     4021 catgaacatc aagaatatgt caggccacgt gtccatgaaa tacctctccc gccaggagag
     4081 ggagaaggtc aaccagcttc gacaaaggga cctcgacctg gtgtttgata agatcaccca
     4141 actcaagaac cagctgggga ggaaagagga gctgttgaga ggatatgaaa aggacgttga
     4201 acagctcagg cggagcaaag tgtccattga gatgtaccag tcgcaggtgg caaagctgga
     4261 ggatgatatc tacaaagagg ccgaagagaa ggccctgctg aaggaggccc tggagcgcat
     4321 ggagcaccag ctgtgccagg agaagaggat caacagggcc atccggcagc agaaggaaag
     4381 tgtagaggag cacgaactga gaaacgcaaa agaatcgaca ccttgcaact gtgccttcaa
     4441 agagaaagac aggcagagac gagtatttgt agagatggtg aagaacagga tgcagaactc
     4501 aaattcccag gttggaacca gaaaagcctc cctaaagatg gaccaagaaa gagagatgct
     4561 gaggaaagag acctccagca agtccagcca gagccttttg cattctaagc ccagtggaaa
     4621 gtactagaga aacctcgtcc caccaggcct catgtgatcc tctgtgagtt catgtgactc
     4681 ttctgtgtca tctgtgtcaa aatactgagt tgcttttgta agtctttaaa gattgttacc
     4741 ctagtgtttc atttcctaga ccagtatttt gaacaatatt atattttgga gactgtgggg
     4801 agaagggttc ttctttaaaa atacctatga atgtacacga actcaggtat atgaagaata
     4861 gaagtgtgta acccagatgt ccaggcctgg tagatataat tatgtggtcc acgttgggtc
     4921 atgatgttcc caaatatcaa acctcctaag acttccaaca gactcacact tgagaaaacc
     4981 taagacttgt actggagcct cagggcagaa ttgtaacctt ggagctctca gggccttggg
     5041 atagtgaatt caagtctccg ttatggcctg gcaggatggc tcatgcctgt aatctcagca
     5101 ctttgggagg ccgaggcagg cggattataa gatcaggagt ttgagaccag cctggcaaac
     5161 atagtgaata cctgtctcta ctaaaaatac aaaaattagc caggtgtggt ggcacatgcc
     5221 tgtagtccca gctacacagg aggctgaggt gggagaatca cttgaaccta ggaggcagag
     5281 gttgcagtga gccaagacca cgccattgca cgccagccta acagagtgag actctgtctt
     5341 taaaaaaaaa aaaaaatggc tgggcctgta atcccagcta ctcgggaggc tgagacagga
     5401 gaatcacttc aacccgggag gtgatgattg cagggagcca agatcacaca actgcactct
     5461 agcctgagtg acagagcaag actccatctc aaaaaaaaaa aaaaaaaatc tgtttattgt
     5521 aataaattta gaacaccaat ca
//
