LOCUS       NM_005248               2637 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens FGR proto-oncogene, Src family tyrosine kinase (FGR),
            transcript variant 1, mRNA.
ACCESSION   NM_005248
VERSION     NM_005248.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2637)
  AUTHORS   Shani,S., Goldstein,O., Gana-Weisz,M., Bar-Shira,A., Thaler,A.,
            Gurevich,T., Mirelman,A., Giladi,N., Alcalay,R.N. and
            Orr-Urtreger,A.
  TITLE     Variants in PSMB9 and FGR differentially affect Parkinson's disease
            risk in GBA and LRRK2 mutation carriers
  JOURNAL   Parkinsonism Relat Disord 111, 105398 (2023)
   PUBMED   37116292
  REMARK    GeneRIF: Variants in PSMB9 and FGR differentially affect
            Parkinson's disease risk in GBA and LRRK2 mutation carriers.
REFERENCE   2  (bases 1 to 2637)
  AUTHORS   Perez,I., Berndt,S., Agarwal,R., Castro,M.A., Vishnivetskiy,S.A.,
            Smith,J.C., Sanders,C.R., Gurevich,V.V. and Iverson,T.M.
  TITLE     A Model for the Signal Initiation Complex Between Arrestin-3 and
            the Src Family Kinase Fgr
  JOURNAL   J Mol Biol 434 (2), 167400 (2022)
   PUBMED   34902430
  REMARK    GeneRIF: A Model for the Signal Initiation Complex Between
            Arrestin-3 and the Src Family Kinase Fgr.
REFERENCE   3  (bases 1 to 2637)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2637)
  AUTHORS   Patel,R.K., Weir,M.C., Shen,K., Snyder,D., Cooper,V.S. and
            Smithgall,T.E.
  TITLE     Expression of myeloid Src-family kinases is associated with poor
            prognosis in AML and influences Flt3-ITD kinase inhibitor acquired
            resistance
  JOURNAL   PLoS One 14 (12), e0225887 (2019)
   PUBMED   31790499
  REMARK    GeneRIF: These studies show that Hck and Fgr expression influences
            inhibitor sensitivity and the pathway to acquired resistance in
            Flt3-ITD+ AML.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2637)
  AUTHORS   Shen,K., Moroco,J.A., Patel,R.K., Shi,H., Engen,J.R., Dorman,H.R.
            and Smithgall,T.E.
  TITLE     The Src family kinase Fgr is a transforming oncoprotein that
            functions independently of SH3-SH2 domain regulation
  JOURNAL   Sci Signal 11 (553) (2018)
   PUBMED   30352950
  REMARK    GeneRIF: Fgr is a transforming oncoprotein that functions
            independently of SH3-SH2 domain regulation
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2637)
  AUTHORS   Link,D.C., Gutkind,S.J., Robbins,K.C. and Ley,T.J.
  TITLE     Characterization of the 5' untranslated region of the human c-fgr
            gene and identification of the major myelomonocytic c-fgr promoter
  JOURNAL   Oncogene 7 (5), 877-884 (1992)
   PUBMED   1373875
REFERENCE   7  (bases 1 to 2637)
  AUTHORS   Patel,M.S., Mankoo,B.S. and Brickell,P.M.
  TITLE     A polymorphic microsatellite repeat is located close to the
            promoter region of the c-fgr proto-oncogene (FGR) at chromosome
            1p36.2-p36.1
  JOURNAL   Hum Mol Genet 1 (1), 65 (1992)
   PUBMED   1339476
REFERENCE   8  (bases 1 to 2637)
  AUTHORS   Biondi,A., Paganin,C., Rossi,V., Benvestito,S., Perlmutter,R.M.,
            Mantovani,A. and Allavena,P.
  TITLE     Expression of lineage-restricted protein tyrosine kinase genes in
            human natural killer cells
  JOURNAL   Eur J Immunol 21 (3), 843-846 (1991)
   PUBMED   1826268
REFERENCE   9  (bases 1 to 2637)
  AUTHORS   Patel,M., Faulkner,L., Katz,D.R. and Brickell,P.M.
  TITLE     The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected
            B lymphocytes and in cells of the myelomonocytic and granulocytic
            lineages
  JOURNAL   Pathobiology 59 (4), 289-292 (1991)
   PUBMED   1652975
  REMARK    Review article
REFERENCE   10 (bases 1 to 2637)
  AUTHORS   Patel,M., Leevers,S.J. and Brickell,P.M.
  TITLE     Structure of the complete human c-fgr proto-oncogene and
            identification of multiple transcriptional start sites
  JOURNAL   Oncogene 5 (2), 201-206 (1990)
   PUBMED   1690869
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA139476.1, BC064382.1,
            BQ448283.1 and AL031729.16.
            
            On Nov 22, 2018 this sequence version replaced NM_005248.2.
            
            Summary: This gene is a member of the Src family of protein
            tyrosine kinases (PTKs). The encoded protein contains N-terminal
            sites for myristylation and palmitylation, a PTK domain, and SH2
            and SH3 domains which are involved in mediating protein-protein
            interactions with phosphotyrosine-containing and proline-rich
            motifs, respectively. The protein localizes to plasma membrane
            ruffles, and functions as a negative regulator of cell migration
            and adhesion triggered by the beta-2 integrin signal transduction
            pathway. Infection with Epstein-Barr virus results in the
            overexpression of this gene. Multiple alternatively spliced
            variants, encoding the same protein, have been identified.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) initiates at exon M4 and
            represents the longest transcript. It is expressed in
            myelomonocytic cells. Variants 1, 2, and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.151213.1,
                                           SRR1803613.85605.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374005.8/ ENSP00000363117.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                DA139476.1         32-87
            57-2404             BC064382.1         1-2348
            2405-2412           BQ448283.1         16-23               c
            2413-2637           AL031729.16        42213-42437
FEATURES             Location/Qualifiers
     source          1..2637
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..2637
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /note="FGR proto-oncogene, Src family tyrosine kinase"
                     /db_xref="GeneID:2268"
                     /db_xref="HGNC:HGNC:3697"
                     /db_xref="MIM:164940"
     exon            1..121
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            122..184
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            185..423
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1787
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /EC_number="2.7.10.2"
                     /note="proto-oncogene tyrosine-protein kinase FGR; c-src-2
                     proto-oncogene; c-fgr protooncogene; p55-c-fgr protein;
                     proto-oncogene c-Fgr; Gardner-Rasheed feline sarcoma viral
                     (v-fgr) oncogene homolog; v-fgr feline Gardner-Rasheed
                     sarcoma viral oncogene homolog"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fgr"
                     /protein_id="NP_005239.1"
                     /db_xref="CCDS:CCDS305.1"
                     /db_xref="GeneID:2268"
                     /db_xref="HGNC:HGNC:3697"
                     /db_xref="MIM:164940"
                     /translation="MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPA
                     SSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGE
                     KFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLS
                     PGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNS
                     VQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGD
                     VWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVT
                     EFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGE
                     RLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTE
                     LITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYL
                     QSFLEDYFTSAEPQYQPGDQT"
     exon            424..526
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            527..625
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..729
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            730..879
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1035
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1215
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1292
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1446
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1578
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..2637
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2378..2383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /note="hexamer: AGTAAA"
     polyA_site      2404
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /note="major polyA site"
     regulatory      2613..2618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
                     /note="hexamer: ATTAAA"
     polyA_site      2637
                     /gene="FGR"
                     /gene_synonym="c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr;
                     p58c-fgr; SRC2"
ORIGIN      
        1 cctgcccagc aggggcggcg gtcagaggcg ggcagcaccc cagttctccc cgcacgccgg
       61 cactcgcggc tgctggagcc ccggctggct caccccgggg ccgggcagaa ttgggctcca
      121 ggtctctgac ccctcccaag gatcatgccg cagccccact gacccaggag taggggccta
      181 agggcaggga acctggaatg ggctgtgtgt tctgcaagaa attggagccg gtggccacgg
      241 ccaaggagga tgctggcctg gaaggggact tcagaagcta cggggcagca gaccactatg
      301 ggcctgaccc cactaaggcc cggcctgcat cctcatttgc ccacatcccc aactacagca
      361 acttctcctc tcaggccatc aaccctggct tccttgatag tggcaccatc aggggtgtgt
      421 cagggattgg ggtgaccctg ttcattgccc tgtatgacta tgaggctcga actgaggatg
      481 acctcacctt caccaagggc gagaagttcc acatcctgaa caatactgaa ggtgactggt
      541 gggaggctcg gtctctcagc tccggaaaaa ctggctgcat tcccagcaac tacgtggccc
      601 ctgttgactc aatccaagct gaagagtggt actttggaaa gattgggaga aaggatgcag
      661 agaggcagct gctttcacca ggcaaccccc agggggcctt tctcattcgg gaaagcgaga
      721 ccaccaaagg tgcctactcc ctgtccatcc gggactggga tcagaccaga ggcgatcatg
      781 tgaagcatta caagatccgc aaactggaca tgggcggcta ctacatcacc acacgggttc
      841 agttcaactc ggtgcaggag ctggtgcagc actacatgga ggtgaatgac gggctgtgca
      901 acctgctcat cgcgccctgc accatcatga agccgcagac gctgggcctg gccaaggacg
      961 cctgggagat cagccgcagc tccatcacgc tggagcgccg gctgggcacc ggctgcttcg
     1021 gggatgtgtg gctgggcacg tggaacggca gcactaaggt ggcggtgaag acgctgaagc
     1081 cgggcaccat gtccccgaag gccttcctgg aggaggcgca ggtcatgaag ctgctgcggc
     1141 acgacaagct ggtgcagctg tacgccgtgg tgtcggagga gcccatctac atcgtgaccg
     1201 agttcatgtg tcacggcagc ttgctggatt ttctcaagaa cccagagggc caggatttga
     1261 ggctgcccca attggtggac atggcagccc aggtagctga gggcatggcc tacatggaac
     1321 gcatgaacta cattcaccgc gacctgaggg cagccaacat cctggttggg gagcggctgg
     1381 cgtgcaagat cgcagacttt ggcttggcgc gtctcatcaa ggacgatgag tacaacccct
     1441 gccaaggttc caagttcccc atcaagtgga cagccccaga agctgccctc tttggcagat
     1501 tcaccatcaa gtcagacgtg tggtcctttg ggatcctgct cactgagctc atcaccaagg
     1561 gccgaatccc ctacccaggc atgaataaac gggaagtgtt ggaacaggtg gagcagggct
     1621 accacatgcc gtgccctcca ggctgcccag catccctgta cgaggccatg gaacagacct
     1681 ggcgtctgga cccggaggag aggcctacct tcgagtacct gcagtccttc ctggaggact
     1741 acttcacctc cgctgaacca cagtaccagc ccggggatca gacatagcct gtccgggcat
     1801 caaccctctc tggcggtggc caccagtcct tgccaatccc cagagctgtt cttccaaagc
     1861 ccccaggctg gcttagaacc ccatagagtc ctagcatcac cgaggacgtg gctgctctga
     1921 caccacctag ggcaacctac ttgttttaca gatggggcaa aaggaggccc agagctgatc
     1981 tctcatccgc tctggcccca agcactattt cttccttttc cacttaggcc cctacatgcc
     2041 tgtagccttt ctcactccat ccccacccaa agtgctcaga ccttgtctag ttatttataa
     2101 aactgtatgt acctccctca cttctctcct atcactgctt tcctactctc cttttatctc
     2161 actctagtcc aggtgccaag aatttccctt ctaccctcta ttctcttgtg tctgtaagtt
     2221 acaaagtcag gaaaagtctt ggctggaccc ctttcctgct gggtggatgc agtggtccag
     2281 gactggggtc tgggcccagg tttgagggag aaggttgcag agcacttccc acctctctga
     2341 atagtgtgta tgtgttggtt tattgattct gtaaataagt aaaatgacaa tatgaatcct
     2401 caaaccatga aatacccttg aaccttcctt tgggagcggg ggtggtcaat agggggtgaa
     2461 cggacagata tggctacagg cagcagcagg ggaagctgga gagggcccta atgcctacca
     2521 agcacggggc atccaaggtg tggagtttta gaacacccag agtcccactg ctcatctgca
     2581 cgtgagttta gaagacaagc agctgaagat acattaaaat gtccccttcg ttgctga
//
