LOCUS       NM_006682               4256 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens fibrinogen like 2 (FGL2), mRNA.
ACCESSION   NM_006682
VERSION     NM_006682.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4256)
  AUTHORS   Bennion,K.B., Liu,D., Dawood,A.S., Wyatt,M.M., Alexander,K.L.,
            Abdel-Hakeem,M.S., Paulos,C.M. and Ford,M.L.
  TITLE     CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous
            manner via ligation of FcgammaRIIB
  JOURNAL   Nat Commun 15 (1), 5280 (2024)
   PUBMED   38902261
  REMARK    GeneRIF: CD8[+] T cell-derived Fgl2 regulates immunity in a
            cell-autonomous manner via ligation of FcgammaRIIB.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4256)
  AUTHORS   Cherny,I., Hasin,P., Philosoph,L.K., Shahal-Zimra,Y., Gurion,R. and
            Rabizadeh,E.
  TITLE     Presence and activity of Fibrinogen like protein 2 in platelets
  JOURNAL   PLoS One 18 (5), e0285735 (2023)
   PUBMED   37200306
  REMARK    GeneRIF: Presence and activity of Fibrinogen like protein 2 in
            platelets.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4256)
  AUTHORS   Janssen,E., Alosaimi,M.F., Alazami,A.M., Alsuliman,A., Alaiya,A.,
            Al-Saud,B., Al-Mousa,H., Al-Zaid,T.J., Smith,E., Platt,C.D.,
            Alruwaili,H., Albanyan,S., Al-Mayouf,S.M. and Geha,R.S.
  TITLE     A homozygous truncating mutation of FGL2 is associated with immune
            dysregulation
  JOURNAL   J Allergy Clin Immunol 151 (2), 572-578 (2023)
   PUBMED   36243222
  REMARK    GeneRIF: A homozygous truncating mutation of FGL2 is associated
            with immune dysregulation.
REFERENCE   4  (bases 1 to 4256)
  AUTHORS   Denicolo,S., Nair,V., Leierer,J., Rudnicki,M., Kretzler,M.,
            Mayer,G., Ju,W. and Perco,P.
  TITLE     Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney
            Disease through Transcriptomics Data Analysis
  JOURNAL   Biomolecules 13 (1), 89 (2022)
   PUBMED   36671474
  REMARK    GeneRIF: Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic
            Kidney Disease through Transcriptomics Data Analysis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4256)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   6  (bases 1 to 4256)
  AUTHORS   Zeng,L., Dai,J., Ying,K., Zhao,E., Jin,W., Ye,Y., Dai,J., Xu,J.,
            Xie,Y. and Mao,Y.
  TITLE     Identification of a novel human angiopoietin-like gene expressed
            mainly in heart
  JOURNAL   J Hum Genet 48 (3), 159-162 (2003)
   PUBMED   12624729
REFERENCE   7  (bases 1 to 4256)
  AUTHORS   Yuwaraj,S., Ding,J., Liu,M., Marsden,P.A. and Levy,G.A.
  TITLE     Genomic characterization, localization, and functional expression
            of FGL2, the human gene encoding fibroleukin: a novel human
            procoagulant
  JOURNAL   Genomics 71 (3), 330-338 (2001)
   PUBMED   11170750
REFERENCE   8  (bases 1 to 4256)
  AUTHORS   Marazzi,S., Blum,S., Hartmann,R., Gundersen,D., Schreyer,M.,
            Argraves,S., von Fliedner,V., Pytela,R. and Ruegg,C.
  TITLE     Characterization of human fibroleukin, a fibrinogen-like protein
            secreted by T lymphocytes
  JOURNAL   J Immunol 161 (1), 138-147 (1998)
   PUBMED   9647217
REFERENCE   9  (bases 1 to 4256)
  AUTHORS   Ruegg,C. and Pytela,R.
  TITLE     Sequence of a human transcript expressed in T-lymphocytes and
            encoding a fibrinogen-like protein
  JOURNAL   Gene 160 (2), 257-262 (1995)
   PUBMED   7642106
REFERENCE   10 (bases 1 to 4256)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC033820.1 and AC007000.2.
            
            On Nov 22, 2018 this sequence version replaced NM_006682.2.
            
            Summary: The protein encoded by this gene is a secreted protein
            that is similar to the beta- and gamma-chains of fibrinogen. The
            carboxyl-terminus of the encoded protein consists of the
            fibrinogen-related domains (FRED). The encoded protein forms a
            tetrameric complex which is stabilized by interchain disulfide
            bonds. This protein may play a role in physiologic functions at
            mucosal sites. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.35522.1,
                                           SRR1660803.186075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248598.6/ ENSP00000248598.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1511              BC033820.1         3-1513
            1512-4254           AC007000.2         169969-172711       c
            4255-4256           AC007000.2         169967-169968       c
FEATURES             Location/Qualifiers
     source          1..4256
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..4256
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
                     /note="fibrinogen like 2"
                     /db_xref="GeneID:10875"
                     /db_xref="HGNC:HGNC:3696"
                     /db_xref="MIM:605351"
     exon            1..639
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1346
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
                     /note="fibrinogen-like protein 2; fibroleukin"
                     /codon_start=1
                     /product="fibroleukin precursor"
                     /protein_id="NP_006673.1"
                     /db_xref="CCDS:CCDS5591.1"
                     /db_xref="GeneID:10875"
                     /db_xref="HGNC:HGNC:3696"
                     /db_xref="MIM:605351"
                     /translation="MKLANWYWLSSAVLATYGFLVVANNETEEIKDERAKDVCPVRLE
                     SRGKCEEAGECPYQVSLPPLTIQLPKQFSRIEEVFKEVQNLKEIVNSLKKSCQDCKLQ
                     ADDNGDPGRNGLLLPSTGAPGEVGDNRVRELESEVNKLSSELKNAKEEINVLHGRLEK
                     LNLVNMNNIENYVDSKVANLTFVVNSLDGKCSKCPSQEQIQSRPVQHLIYKDCSDYYA
                     IGKRSSETYRVTPDPKNSSFEVYCDMETMGGGWTVLQARLDGSTNFTRTWQDYKAGFG
                     NLRREFWLGNDKIHLLTKSKEMILRIDLEDFNGVELYALYDQFYVANEFLKYRLHVGN
                     YNGTAGDALRFNKHYNHDLKFFTTPDKDNDRYPSGNCGLYYSSGWWFDACLSANLNGK
                     YYHQKYRGVRNGIFWGTWPGVSEAHPGGYKSSFKEAKMMIRPKHFKP"
     exon            640..4256
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1490..1495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
                     /note="hexamer: AATAAA"
     polyA_site      1511
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
                     /note="major polyA site"
     regulatory      3995..4000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
                     /note="hexamer: AATAAA"
     regulatory      4008..4013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
                     /note="hexamer: AATATA"
     regulatory      4022..4027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
                     /note="hexamer: AAGAAA"
     polyA_site      4023
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
     polyA_site      4027
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
     polyA_site      4041
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
     regulatory      4186..4191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
                     /note="hexamer: TATAAA"
     polyA_site      4207
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
     regulatory      4229..4234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
                     /note="hexamer: ATTAAA"
     polyA_site      4256
                     /gene="FGL2"
                     /gene_synonym="pT49; T49"
ORIGIN      
        1 ctgctggggt gagcagcact gtaaagatga agctggctaa ctggtactgg ctgagctcag
       61 ctgttcttgc cacttacggt tttttggttg tggcaaacaa tgaaacagag gaaattaaag
      121 atgaaagagc aaaggatgtc tgcccagtga gactagaaag cagagggaaa tgcgaagagg
      181 caggggagtg cccctaccag gtaagcctgc cccccttgac tattcagctc ccgaagcaat
      241 tcagcaggat cgaggaggtg ttcaaagaag tccaaaacct caaggaaatc gtaaatagtc
      301 taaagaaatc ttgccaagac tgcaagctgc aggctgatga caacggagac ccaggcagaa
      361 acggactgtt gttacccagt acaggagccc cgggagaggt tggtgataac agagttagag
      421 aattagagag tgaggttaac aagctgtcct ctgagctaaa gaatgccaaa gaggagatca
      481 atgtacttca tggtcgcctg gagaagctga atcttgtaaa tatgaacaac atagaaaatt
      541 atgttgacag caaagtggca aatctaacat ttgttgtcaa tagtttggat ggcaaatgtt
      601 caaagtgtcc cagccaagaa caaatacagt cacgtccagt tcaacatcta atatataaag
      661 attgctctga ctactacgca ataggcaaaa gaagcagtga gacctacaga gttacacctg
      721 atcccaaaaa tagtagcttt gaagtttact gtgacatgga gaccatgggg ggaggctgga
      781 cagtgctgca ggcacgtctc gatgggagca ccaacttcac cagaacatgg caagactaca
      841 aagcaggctt tggaaacctc agaagggaat tttggctggg gaacgataaa attcatcttc
      901 tgaccaagag taaggaaatg attctgagaa tagatcttga agactttaat ggtgtcgaac
      961 tatatgcctt gtatgatcag ttttatgtgg ctaatgagtt tctcaaatat cgtttacacg
     1021 ttggtaacta taatggcaca gctggagatg cattacgttt caacaaacat tacaaccacg
     1081 atctgaagtt tttcaccact ccagataaag acaatgatcg atatccttct gggaactgtg
     1141 ggctgtacta cagttcaggc tggtggtttg atgcatgtct ttctgcaaac ttaaatggca
     1201 aatattatca ccaaaaatac agaggtgtcc gtaatgggat tttctggggt acctggcctg
     1261 gtgtaagtga ggcacaccct ggtggctaca agtcctcctt caaagaggct aagatgatga
     1321 tcagacccaa gcactttaag ccataaatca ctctgttcat tcctccaggt attcgttatc
     1381 taatagggca attaattcct tcagcacttt agaatatgcc ttgtttcata tttttcatag
     1441 ctaaaaaatg atgtctgacg gctaggttct tatgctacac agcatttgaa ataaagctga
     1501 aaaacaatgc attttaaagg agtcctttgt tgttatgctg ttatccaatg aacacttgca
     1561 agcaattagc aatattgaga attatacatt agatttacaa ttcttttaat ttctattgaa
     1621 actttttcta ttgcttgtat tacttgctgt atttaaaaaa taattgttgg ctgggtgtgg
     1681 tagctcacgc ctgtaatccc agcactttgg aatgtcaagg caggcagatc acttgaggtc
     1741 aggagtttga gaccagcctg gccaaacatg tgaaacgctg tctctattaa aaatacaaaa
     1801 attagccggg catggtggta catgcctgta atcctagcta cttgggaggc tgaggcagga
     1861 gaatcgcttg aacctgagag gaagaggttg cagtgagcca agactgagcc actgcactcc
     1921 agcatgggtg acagagaaaa ctctgtctca aacaaaaaaa taataaaatt tattcagtag
     1981 gctggattct acacaaagta atctgtattt gggccatgat ttaagcacat ctgaaggtat
     2041 atcactcttt tcaggctata attatttggg taatcttcat tctgagacaa acttaatcta
     2101 tatcatttac tttgcaacag aacaacccta cagcattttg gttcccagac taagggaact
     2161 aatatctata taattaaact tgttcattta tcattcatga aatataaaat acttgtcatt
     2221 taaaccgttt aaaaatgtgg tagcataatg tcaccccaaa aagcattcag aaagcaatgt
     2281 aactgtgaag accagggttt aaaggtaatt catttatagt ttataactcc ttagatgttt
     2341 gatgttgaaa actgctttaa catgaaaatt atcttcctct gctctgtgtg aacaatagct
     2401 tttaatttaa gattgctcac tactgtacta gactactggt aggttttttt ggggggggtg
     2461 ggtagggata tgtgggtaat gaagcattta cttacaggct atcatactct gaggccaatt
     2521 ttatctccaa agcaataata tcattaagtg attcacttca tagaaggcta agtttctcta
     2581 ggacagatag aaaacatgaa ttttgaaata tatagaacag tagttaaaat actatatatt
     2641 tcaaccctgg ctggtagatt gcttatttta ctatcagaaa ctaaaagata gatttttacc
     2701 caaacagaag tatctgtaat ttttataatt catcaattct ggaatgctat atataatatt
     2761 taaaagactt tttaaatgtg tttaatttca tcatcgtaaa aagggatcat ctcagagaga
     2821 acagcagtat tctgcgtatt tttaaaaatg ctctagagta acatttgaag taattcactg
     2881 tagtgtatgc cagtcctaga aataattttt ttaatttctg gtgtctgttt ctaatacact
     2941 aaccaagttt tcaaaatata tttacaaaga tgcatcttta cccattattt taaaatgatt
     3001 aaggaggata gttgcttcag gtaacaagct aatttttcaa atattaggcc cttacagaac
     3061 tatttagtca aaaagtaaga tattccttta aaatatataa cccaaagctt tcagttaaac
     3121 atgatatatc acaaatacta ttaaaatgtt aaagagaaat gcaaatagca ttaaatgatg
     3181 accaaaatgt aaaatattgt agatttcaaa agctgtgtct ctattaggtg ggataccaaa
     3241 tgtaaatgat gtaactgacg ttgtttttta ctttttactt tttaaaaaag actaaaaacg
     3301 ttttgatatt atacaatgta tttgtttcag ataaggtcat tgtcatttag tatatataat
     3361 taatatatgt acaagtttaa gtaaattcct gtgagtaaaa atggacttat cacaaaacat
     3421 agttctaaag aaaggtatat gctcatatac acggtgtcca ttaatttaat gggaactagg
     3481 tataacttca ggagaatttg gcaaataatt cattaatcca tgtaaatatt caaaagcttg
     3541 ttctatccac attatttcaa gggatcactt tatttttcat tatactttca cagcactttt
     3601 ctagtaaatt ctgtaacaca gaaattccat tttggaatca tttcatgtta ccaataattc
     3661 tagactttta taacatttaa catgttgatg gaaatagatt acatctgcta gaaccttttg
     3721 ccttaactat tcaccaatat atgctaatat tcataaatat ggattgactg tttacaaaca
     3781 ttagaatctt gtcttggttc cattttgatg gctaatattt gttatcttaa ttaagactat
     3841 ttctgaggtc atgattactt gaaaatattg actaaaactg ggtccttaga aattccaggt
     3901 ggagctgatt tacctatgac tgaggggaaa aaaaaatcaa attttactga taatagtaat
     3961 gctccaaatg aattaatgac acatctgttc aataaataaa gagcttaaat atacaaaaca
     4021 taagaaatct gggcaacaaa acttgtggtc tttacttttg aatagctacc caagaaaagg
     4081 ttttaaaggt aaaagttatg agtaatgtca tcacaataag ctcttgttta aaattctttt
     4141 cttttatgta taattaggtt tatgtttcat gtctttttaa aaccttataa aagatttaat
     4201 tatcacatct attcttcaat gtggaaatat taaatattgt tggttgtaaa ataata
//
