LOCUS       NM_004467               1237 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens fibrinogen like 1 (FGL1), transcript variant 1, mRNA.
ACCESSION   NM_004467 XM_937886 XM_943467
VERSION     NM_004467.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1237)
  AUTHORS   Liu,T.Y., Yan,J.S., Li,X., Xu,L., Hao,J.L., Zhao,S.Y., Hu,Q.L.,
            Na,F.J., Li,H.M., Zhao,Y. and Zhao,M.F.
  TITLE     FGL1: a novel biomarker and target for non-small cell lung cancer,
            promoting tumor progression and metastasis through KDM4A/STAT3
            transcription mechanism
  JOURNAL   J Exp Clin Cancer Res 43 (1), 213 (2024)
   PUBMED   39085849
  REMARK    GeneRIF: FGL1: a novel biomarker and target for non-small cell lung
            cancer, promoting tumor progression and metastasis through
            KDM4A/STAT3 transcription mechanism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1237)
  AUTHORS   Li,J.J., Wang,J.H., Tian,T., Liu,J., Zheng,Y.Q., Mo,H.Y., Sheng,H.,
            Chen,Y.X., Wu,Q.N., Han,Y., Liao,K., Pan,Y.Q., Zeng,Z.L., Liu,Z.X.,
            Yang,W., Xu,R.H. and Ju,H.Q.
  TITLE     The liver microenvironment orchestrates FGL1-mediated immune escape
            and progression of metastatic colorectal cancer
  JOURNAL   Nat Commun 14 (1), 6690 (2023)
   PUBMED   37872170
  REMARK    GeneRIF: The liver microenvironment orchestrates FGL1-mediated
            immune escape and progression of metastatic colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1237)
  AUTHORS   Yao,X.M., Zhang,F.H. and Liu,Y.
  TITLE     Clinical Significance and Prognostic Value of the Expression of
            LAG-3 and FGL1 in Esophageal Squamous Cell Carcinoma
  JOURNAL   Bull Exp Biol Med 174 (6), 774-778 (2023)
   PUBMED   37162630
  REMARK    GeneRIF: Clinical Significance and Prognostic Value of the
            Expression of LAG-3 and FGL1 in Esophageal Squamous Cell Carcinoma.
REFERENCE   4  (bases 1 to 1237)
  AUTHORS   Yang,C., Qian,Q., Zhao,Y., Huang,B., Chen,R., Gong,Q., Ji,H.,
            Wang,C., Xia,L., You,Z., Zhang,J. and Chen,X.
  TITLE     Fibrinogen-like protein 1 promotes liver-resident memory T-cell
            exhaustion in hepatocellular carcinoma
  JOURNAL   Front Immunol 14, 1112672 (2023)
   PUBMED   36993960
  REMARK    GeneRIF: Fibrinogen-like protein 1 promotes liver-resident memory
            T-cell exhaustion in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1237)
  AUTHORS   Tang,X.Y., Xiong,Y.L., Zhao,Y.B., Yang,J., Shi,A.P., Zheng,K.F.,
            Liu,Y.J., Shu,C., Jiang,T., Ma,N. and Zhao,J.B.
  TITLE     Dual immunological and proliferative regulation of immune
            checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the
            YY1-FGL1-MYH9 axis
  JOURNAL   Front Immunol 13, 1014053 (2022)
   PUBMED   36268014
  REMARK    GeneRIF: Dual immunological and proliferative regulation of immune
            checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the
            YY1-FGL1-MYH9 axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1237)
  AUTHORS   Saito,T., Ji,G., Shinzawa,H., Okumoto,K., Hattori,E., Adachi,T.,
            Takeda,T., Sugahara,K., Ito,J.I., Watanabe,H., Saito,K.,
            Togashi,H., Ishii,K., Matsuura,T., Inageda,K., Muramatsu,M. and
            Kawata,S.
  TITLE     Genetic variations in humans associated with differences in the
            course of hepatitis C
  JOURNAL   Biochem Biophys Res Commun 317 (2), 335-341 (2004)
   PUBMED   15063762
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1237)
  AUTHORS   Yan,J., Yu,Y., Wang,N., Chang,Y., Ying,H., Liu,W., He,J., Li,S.,
            Jiang,W., Li,Y., Liu,H., Wang,H. and Xu,Y.
  TITLE     LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated
            and has growth suppressor activity in hepatocellular carcinoma
  JOURNAL   Oncogene 23 (10), 1939-1949 (2004)
   PUBMED   14981537
  REMARK    GeneRIF: data demonstrated that liver-specific gene LFIRE-1/HFREP-1
            was frequently downregulated and might possess growth suppressor
            activity in HCC
REFERENCE   8  (bases 1 to 1237)
  AUTHORS   Zeng,L., Dai,J., Ying,K., Zhao,E., Jin,W., Ye,Y., Dai,J., Xu,J.,
            Xie,Y. and Mao,Y.
  TITLE     Identification of a novel human angiopoietin-like gene expressed
            mainly in heart
  JOURNAL   J Hum Genet 48 (3), 159-162 (2003)
   PUBMED   12624729
REFERENCE   9  (bases 1 to 1237)
  AUTHORS   Hara,H., Yoshimura,H., Uchida,S., Toyoda,Y., Aoki,M., Sakai,Y.,
            Morimoto,S. and Shiokawa,K.
  TITLE     Molecular cloning and functional expression analysis of a cDNA for
            human hepassocin, a liver-specific protein with hepatocyte
            mitogenic activity
  JOURNAL   Biochim Biophys Acta 1520 (1), 45-53 (2001)
   PUBMED   11470158
REFERENCE   10 (bases 1 to 1237)
  AUTHORS   Yamamoto,T., Gotoh,M., Sasaki,H., Terada,M., Kitajima,M. and
            Hirohashi,S.
  TITLE     Molecular cloning and initial characterization of a novel
            fibrinogen-related gene, HFREP-1
  JOURNAL   Biochem Biophys Res Commun 193 (2), 681-687 (1993)
   PUBMED   8390249
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG618053.1, D87342.1,
            AF042354.1 and AC087273.5.
            
            On Nov 22, 2018 this sequence version replaced NM_004467.3.
            
            Summary: Fibrinogen-like 1 is a member of the fibrinogen family.
            This protein is homologous to the carboxy terminus of the
            fibrinogen beta- and gamma- subunits which contains the four
            conserved cysteines of fibrinogens and fibrinogen related proteins.
            However, this protein lacks the platelet-binding site,
            cross-linking region and a thrombin-sensitive site which are
            necessary for fibrin clot formation. This protein may play a role
            in the development of hepatocellular carcinomas. Four alternatively
            spliced transcript variants encoding the same protein exist for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) appears to be the
            predominantly expressed transcript. It lacks an exon in the 5' UTR
            and has an alternate exon at the 5' end compared to the longest
            variant (4). All four variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225616.1, SRR5189652.91177.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590, SAMEA2162895
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000427924.5/ ENSP00000401952.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-579               BG618053.1         16-594
            580-1234            D87342.1           490-1144
            1235-1235           AF042354.1         1285-1285
            1236-1237           AC087273.5         80461-80462
FEATURES             Location/Qualifiers
     source          1..1237
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..1237
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
                     /note="fibrinogen like 1"
                     /db_xref="GeneID:2267"
                     /db_xref="HGNC:HGNC:3695"
                     /db_xref="MIM:605776"
     exon            1..78
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            79..158
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1034
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
                     /note="hepassocin; hepatocyte-derived fibrinogen-related
                     protein 1; hepatocellular carcinoma-related sequence;
                     fibrinogen-like protein 1; liver fibrinogen-related
                     protein 1"
                     /codon_start=1
                     /product="fibrinogen-like protein 1 precursor"
                     /protein_id="NP_004458.3"
                     /db_xref="CCDS:CCDS6004.1"
                     /db_xref="GeneID:2267"
                     /db_xref="HGNC:HGNC:3695"
                     /db_xref="MIM:605776"
                     /translation="MAKVFSFILVTTALTMGREISALEDCAQEQMRLRAQVRLLETRV
                     KQQQVKIKQLLQENEVQFLDKGDENTVIDLGSKRQYADCSEIFNDGYKLSGFYKIKPL
                     QSPAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWKDYENGFGNFVQKHGEYWLGNKN
                     LHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDSLAGN
                     FHPEVQWWASHQRMKFSTWDRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSGPYT
                     AKTDNGIVWYTWHGWWYSLKSVVMKIRPNDFIPNVI"
     exon            159..339
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..499
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..597
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..686
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..874
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1237
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1215..1220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
                     /note="hexamer: AATAAA"
     polyA_site      1216
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
                     /note="major polyA site"
     polyA_site      1237
                     /gene="FGL1"
                     /gene_synonym="HFREP1; HP-041; HPS; LFIRE-1; LFIRE1"
ORIGIN      
        1 aatgcagtta caggatcctg ggaagcagag tgtctggatg gaacctgagc tgggtctctg
       61 actcacttct gactttagtt ttttcaaggg ggaacatggc aaaggtgttc agtttcatcc
      121 ttgttaccac cgctctgaca atgggcaggg aaatttcggc gctcgaggac tgtgcccagg
      181 agcagatgcg gctcagagcc caggtgcgcc tgcttgagac ccgggtcaaa cagcaacagg
      241 tcaagatcaa gcagcttttg caggagaatg aagtccagtt ccttgataaa ggagatgaga
      301 atactgtcat tgatcttgga agcaagaggc agtatgcaga ttgttcagag attttcaatg
      361 atgggtataa gctcagtgga ttttacaaaa tcaaacctct ccagagccca gcagaatttt
      421 ctgtttattg tgacatgtcc gatggaggag gatggactgt aattcagaga cgatctgatg
      481 gcagtgaaaa ctttaacaga ggatggaaag actatgaaaa tggctttgga aattttgtcc
      541 aaaaacatgg tgaatattgg ctgggcaata aaaatcttca cttcttgacc actcaagaag
      601 actacacttt aaaaatcgac cttgcagatt ttgaaaaaaa tagccgttat gcacaatata
      661 agaatttcaa agttggagat gaaaagaatt tctacgagtt gaatattggg gaatattctg
      721 gaacagctgg agattccctt gcggggaatt ttcatcctga ggtgcagtgg tgggctagtc
      781 accaaagaat gaaattcagc acgtgggaca gagatcatga caactatgaa gggaactgcg
      841 cagaagaaga tcagtctggc tggtggttta acaggtgtca ctctgcaaac ctgaatggtg
      901 tatactacag cggcccctac acggctaaaa cagacaatgg gattgtctgg tacacctggc
      961 atgggtggtg gtattctctg aaatctgtgg ttatgaaaat taggccaaat gattttattc
     1021 caaatgtaat ttaattgctg ctgttgggct ttcgtttctg caattcagct ttgtttaaag
     1081 tgatttgaaa aatactcatt ctgaacatat ccatgcgcaa tcatgataac tgttgtgagt
     1141 agtgcttttc attcttctca cttgcctttg ttacttaatg tgctttcagt acagcagata
     1201 tgcaatattc accaaataaa tgtagactgt gttaata
//
