LOCUS       NM_021923               3105 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens fibroblast growth factor receptor like 1 (FGFRL1),
            transcript variant 3, mRNA.
ACCESSION   NM_021923
VERSION     NM_021923.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3105)
  AUTHORS   Sharma,P., Kaushik,V., Saraya,A. and Sharma,R.
  TITLE     Aberrant Expression of FGFRL1 in Esophageal Cancer and Its
            Regulation by miR-107
  JOURNAL   Asian Pac J Cancer Prev 24 (4), 1331-1341 (2023)
   PUBMED   37116156
  REMARK    GeneRIF: Aberrant Expression of FGFRL1 in Esophageal Cancer and Its
            Regulation by miR-107.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3105)
  AUTHORS   Wen,T., Hong,Y., Cui,Y., Pan,J., Wang,Y. and Luo,Y.
  TITLE     Downregulation of miR-210-3p Attenuates High Glucose-Induced
            Angiogenesis of Vascular Endothelial Cells via Targeting FGFRL1
  JOURNAL   Ophthalmic Res 66 (1), 913-920 (2023)
   PUBMED   37062273
  REMARK    GeneRIF: Downregulation of miR-210-3p Attenuates High
            Glucose-Induced Angiogenesis of Vascular Endothelial Cells via
            Targeting FGFRL1.
REFERENCE   3  (bases 1 to 3105)
  AUTHORS   Cho,H.W., Jin,H.S. and Eom,Y.B.
  TITLE     FGFRL1 and FGF genes are associated with height, hypertension, and
            osteoporosis
  JOURNAL   PLoS One 17 (8), e0273237 (2022)
   PUBMED   35980984
  REMARK    GeneRIF: FGFRL1 and FGF genes are associated with height,
            hypertension, and osteoporosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3105)
  AUTHORS   Gofin,Y., Mackay,L.P., Machol,K., Keswani,S., Potocki,L., Di
            Gregorio,E., Naretto,V.G., Brusco,A., Hernandez-Garcia,A. and
            Scott,D.A.
  TITLE     Evidence that FGFRL1 contributes to congenital diaphragmatic hernia
            development in humans
  JOURNAL   Am J Med Genet A 185 (3), 836-840 (2021)
   PUBMED   33443296
  REMARK    GeneRIF: Evidence that FGFRL1 contributes to congenital
            diaphragmatic hernia development in humans.
REFERENCE   5  (bases 1 to 3105)
  AUTHORS   Zheng,C., Shi,C.J., Du,L.J., Jiang,Y.H. and Su,J.M.
  TITLE     [Expression of fibroblast growth factor receptor like 1 protein in
            oral squamous cell carcinoma and its influence on tumor cell
            proliferation and migration]
  JOURNAL   Hua Xi Kou Qiang Yi Xue Za Zhi 38 (5), 558-565 (2020)
   PUBMED   33085242
  REMARK    GeneRIF: [Expression of fibroblast growth factor receptor like 1
            protein in oral squamous cell carcinoma and its influence on tumor
            cell proliferation and migration].
REFERENCE   6  (bases 1 to 3105)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 3105)
  AUTHORS   Trueb,B., Zhuang,L., Taeschler,S. and Wiedemann,M.
  TITLE     Characterization of FGFRL1, a novel fibroblast growth factor (FGF)
            receptor preferentially expressed in skeletal tissues
  JOURNAL   J Biol Chem 278 (36), 33857-33865 (2003)
   PUBMED   12813049
REFERENCE   8  (bases 1 to 3105)
  AUTHORS   Sleeman,M., Fraser,J., McDonald,M., Yuan,S., White,D.,
            Grandison,P., Kumble,K., Watson,J.D. and Murison,J.G.
  TITLE     Identification of a new fibroblast growth factor receptor, FGFR5
  JOURNAL   Gene 271 (2), 171-182 (2001)
   PUBMED   11418238
REFERENCE   9  (bases 1 to 3105)
  AUTHORS   Kim,I., Moon,S., Yu,K., Kim,U. and Koh,G.Y.
  TITLE     A novel fibroblast growth factor receptor-5 preferentially
            expressed in the pancreas(1)
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 152-156 (2001)
   PUBMED   11267671
REFERENCE   10 (bases 1 to 3105)
  AUTHORS   Wiedemann,M. and Trueb,B.
  TITLE     Characterization of a novel protein (FGFRL1) from human cartilage
            related to FGF receptors
  JOURNAL   Genomics 69 (2), 275-279 (2000)
   PUBMED   11031111
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ277437.1, BC036769.1 and
            BC013955.2.
            
            On Sep 13, 2004 this sequence version replaced NM_021923.2.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor receptor (FGFR) family, where amino acid
            sequence is highly conserved between members and throughout
            evolution. FGFR family members differ from one another in their
            ligand affinities and tissue distribution. A full-length
            representative protein would consist of an extracellular region,
            composed of three immunoglobulin-like domains, a single hydrophobic
            membrane-spanning segment and a cytoplasmic tyrosine kinase domain.
            The extracellular portion of the protein interacts with fibroblast
            growth factors, setting in motion a cascade of downstream signals,
            ultimately influencing mitogenesis and differentiation. A marked
            difference between this gene product and the other family members
            is its lack of a cytoplasmic tyrosine kinase domain. The result is
            a transmembrane receptor that could interact with other family
            members and potentially inhibit signaling. Multiple alternatively
            spliced transcript variants encoding the same isoform have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) has an alternate 5' UTR, and
            encodes the same isoform, as compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ277437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AJ277437.1         1-81
            82-3081             BC036769.1         221-3220
            3082-3105           BC013955.2         2644-2667
FEATURES             Location/Qualifiers
     source          1..3105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..3105
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /note="fibroblast growth factor receptor like 1"
                     /db_xref="GeneID:53834"
                     /db_xref="HGNC:HGNC:3693"
                     /db_xref="MIM:605830"
     exon            1..101
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1537
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /EC_number="3.2.1.76"
                     /note="fibroblast growth factor receptor 5; FGF homologous
                     factor receptor; FGFR-like protein; FGF receptor-like
                     protein 1"
                     /codon_start=1
                     /product="fibroblast growth factor receptor-like 1
                     precursor"
                     /protein_id="NP_068742.2"
                     /db_xref="CCDS:CCDS3344.1"
                     /db_xref="GeneID:53834"
                     /db_xref="HGNC:HGNC:3693"
                     /db_xref="MIM:605830"
                     /translation="MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLG
                     RTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKAT
                     NGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI
                     ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGK
                     YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKP
                     VIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAG
                     MYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILG
                     TLLLWLCQAQKKPCTPAPAPPLPGHRPPGTARDRSGDKDLPSLAALSAGPGVGLCEEH
                     GSPAAPQHLLGPGPVAGPKLYPKLYTDIHTHTHTHSHTHSHVEGKVHQHIHYQC"
     exon            102..374
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     exon            375..455
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     exon            456..740
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1094
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..3088
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3088
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /note="major polyA site"
ORIGIN      
        1 ccccaggtcc ggacaggccg agatgacgcc gagccccctg ttgctgctcc tgctgccgcc
       61 gctgctgctg ggggccttcc cgccggccgc cgccgcccga ggccccccaa agatggcgga
      121 caaggtggtc ccacggcagg tggcccggct gggccgcact gtgcggctgc agtgcccagt
      181 ggagggggac ccgccgccgc tgaccatgtg gaccaaggat ggccgcacca tccacagcgg
      241 ctggagccgc ttccgcgtgc tgccgcaggg gctgaaggtg aagcaggtgg agcgggagga
      301 tgccggcgtg tacgtgtgca aggccaccaa cggcttcggc agcctgagcg tcaactacac
      361 cctcgtcgtg ctggatgaca ttagcccagg gaaggagagc ctggggcccg acagctcctc
      421 tgggggtcaa gaggaccccg ccagccagca gtgggcacga ccgcgcttca cacagccctc
      481 caagatgagg cgccgggtga tcgcacggcc cgtgggtagc tccgtgcggc tcaagtgcgt
      541 ggccagcggg caccctcggc ccgacatcac gtggatgaag gacgaccagg ccttgacgcg
      601 cccagaggcc gctgagccca ggaagaagaa gtggacactg agcctgaaga acctgcggcc
      661 ggaggacagc ggcaaataca cctgccgcgt gtcgaaccgc gcgggcgcca tcaacgccac
      721 ctacaaggtg gatgtgatcc agcggacccg ttccaagccc gtgctcacag gcacgcaccc
      781 cgtgaacacg acggtggact tcggggggac cacgtccttc cagtgcaagg tgcgcagcga
      841 cgtgaagccg gtgatccagt ggctgaagcg cgtggagtac ggcgccgagg gccgccacaa
      901 ctccaccatc gatgtgggcg gccagaagtt tgtggtgctg cccacgggtg acgtgtggtc
      961 gcggcccgac ggctcctacc tcaataagct gctcatcacc cgtgcccgcc aggacgatgc
     1021 gggcatgtac atctgccttg gcgccaacac catgggctac agcttccgca gcgccttcct
     1081 caccgtgctg ccagacccaa aaccgccagg gccacctgtg gcctcctcgt cctcggccac
     1141 tagcctgccg tggcccgtgg tcatcggcat cccagccggc gctgtcttca tcctgggcac
     1201 cctgctcctg tggctttgcc aggcccagaa gaagccgtgc acccccgcgc ctgcccctcc
     1261 cctgcctggg caccgcccgc cggggacggc ccgcgaccgc agcggagaca aggaccttcc
     1321 ctcgttggcc gccctcagcg ctggccctgg tgtggggctg tgtgaggagc atgggtctcc
     1381 ggcagccccc cagcacttac tgggcccagg cccagttgct ggccctaagt tgtaccccaa
     1441 actctacaca gacatccaca cacacacaca cacacactct cacacacact cacacgtgga
     1501 gggcaaggtc caccagcaca tccactatca gtgctagacg gcaccgtatc tgcagtgggc
     1561 acgggggggc cggccagaca ggcagactgg gaggatggag gacggagctg cagacgaagg
     1621 caggggaccc atggcgagga ggaatggcca gcaccccagg cagtctgtgt gtgaggcata
     1681 gcccctggac acacacacac agacacacac actgcctgga tgcatgtatg cacacacatg
     1741 cgcgcacacg tgctccctga aggcacacgt acgcacacac gcacatgcac agatatgccg
     1801 cctgggcaca cagataagct gcccaaatgc acgcacacgc acagagacat gccagaacat
     1861 acaaggacat gctgcctgaa catacacacg cacacccatg cgcagatgtg ctgcctggac
     1921 acacacacac acacggatat gctgtctgga cgcacacacg tgcagatatg gtatccggac
     1981 acacacgtgc acagatatgc tgcctggaca cacagataat gctgccttga cacacacatg
     2041 cacggatatt gcctggacac acacacacac acgtgtgcac agatatgctg tctggacacg
     2101 cacacacatg cagatatgct gcctggacac acacttccag acacacgtgc acaggcgcag
     2161 atatgctgcc tggacacacg cagatatgct gtctagtcac acacacacgc agacatgctg
     2221 tccggacaca cacacgcatg cacagatatg ctgtccggac acacacacgc acgcagatat
     2281 gctgcctgga cacacacaca gataatgctg cctcaacact cacacacgtg cagatattgc
     2341 ctggacacac acatgtgcac agatatgctg tctggacatg cacacacgtg cagatatgct
     2401 gtccggatac acacgcacgc acacatgcag atatgctgcc tgggcacaca cttccggaca
     2461 cacatgcaca cacaggtgca gatatgctgc ctggacacac gcagactgac gtgcttttgg
     2521 gagggtgtgc cgtgaagcct gcagtacgtg tgccgtgagg ctcatagttg atgagggact
     2581 ttccctgctc caccgtcact cccccaactc tgcccgcctc tgtccccgcc tcagtccccg
     2641 cctccatccc cgcctctgtc ccctggcctt ggcggctatt tttgccacct gccttgggtg
     2701 cccaggagtc ccctactgct gtgggctggg gttgggggca cagcagcccc aagcctgaga
     2761 ggctggagcc catggctagt ggctcatccc cactgcattc tccccctgac acagagaagg
     2821 ggccttggta tttatattta agaaatgaag ataatattaa taatgatgga aggaagactg
     2881 ggttgcaggg actgtggtct ctcctggggc ccgggacccg cctggtcttt cagccatgct
     2941 gatgaccaca ccccgtccag gccagacacc accccccacc ccactgtcgt ggtggcccca
     3001 gatctctgta attttatgta gagtttgagc tgaagccccg tatatttaat ttattttgtt
     3061 aaacatgaaa gtgcatcctt tccctccaaa aaaaaaaaaa aaaaa
//
